Clinical trials: Gastrointestinal Discomfort
Gastrointestinal Discomfort, Bloating
Multi-strain Probiotic Supplement for Digestive Comfort and Well-being in Healthy Women
This study looks at whether a daily probiotic supplement can help improve mild-to-moderate stomach and digestive symptoms, such as gas and bloating, in women who also experience symptoms commonly associated with hormonal…
- Trial name
- NCT07831317
- Testing
- Active: Multi-strain probiotic dietary supplement
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Daily Nouri
Gut Health
A Study to Evaluate the Effects of a Butyrate-Polyphenol Formulation on Gut Health and Associated Symptoms
The purpose of the study is to evaluate the efficacy of a butyrate/polyphenol formulation on modulation of the gut microbiome and gastrointestinal symptoms using questionnaires in individuals with self-reported gastrointestinal…
- Trial name
- NCT07371975
- Testing
- Butyrate + Polyphenol Formulation
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Supplement Formulators, Inc.
Functional Dyspepsia, Epigastric Pain Syndrome
Cognitive Behavioral Therapy for Functional Dyspepsia (Epigastric Pain Syndrome and Postprandial Distress Syndrome Subtypes)
The goal of this clinical trial is to learn whether adding Cognitive Behavioral Therapy (CBT) to standard medical treatment can improve symptoms in adults with Functional Dyspepsia.
- Conditions
- Functional Dyspepsia, Epigastric Pain Syndrome, Postprandial Distress Syndrome
- Trial name
- FD-CBT (NCT07577089)
- Testing
- Optimized Standard Treatment (OPT), Cognitive Behavioral Therapy + Optimized Standard Treatment (CBT + OPT)
- Volunteers
- 90 people
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Abdominal Pain/ Discomfort, Irritable Bowel Syndrome
The Mechanism Underlying the Analgesic Effect of the Music of IBS Pain
The proposed pilot study aims to assess the underlying mechanisms of the MBI on IBS pain and the feasibility of using novel technology in the outcome measurements.
- Trial name
- NCT06706778
- Testing
- Music intervention
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Yale University
Gastrointestinal Disorders
To Assess the Effect of Collagen on Gastrointestinal Discomfort in Healthy Adults With Gastrointestinal Symptoms.
This study will enroll healthy adults with perceived gastrointestinal symptoms to evaluate the effect of collagen peptides compared to placebo.
- Trial name
- NCT06937801
- Testing
- Collagen Peptide
- Where
- Canada
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Rousselot BVBA
Diagnostic Esophagogastroduodenoscopy
Alprazolam as Conscious Sedation for Upper Gastrointestinal Endoscopy
Diagnostic esophagogastroduodenoscopy is an uncomfortable and stressful procedure for most of the patients. Various methods are available for sedation during this procedure.
- Trial name
- NCT01949038
- Testing
- Oral alprazolam, Sublingual alprazolam
- Where
- Iran
- Volunteers
- 220 people
- Sponsor
- Isfahan University of Medical Sciences
Dysbiosis
Evidence Based Probiotic Therapy of Proton Pump Inhibitor Induced Dysbiosis
In this study the investigators aim to test whether an evidence based probiotic is able to revert proton pump inhibitor induced dysbiosis of the gut microbiome.
- Trial name
- EBP (NCT05836155)
- Testing
- Intervention
- Where
- Austria
- Volunteers
- 53 people
- Sponsor
- Medical University of Graz
Pain, Anal Cancer
High-Resolution Anoscopy Perceived Discomfort Study
Study should determine if performing the less uncomfortable part of the exam (the perianal exam) results in less recalled discomfort if performed last vs. if performed first.
- Trial name
- NCT04083053
- Testing
- Perianal Exam, high-resolution anoscopy (HRA) with biopsy
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Wake Forest University Health Sciences
Gastric Cancer
Gastric Decompression After Sub-total Gastrectomy
The purpose of this study is to test the utility of the nasogastric tube, which is used to decompress and as "guardian" of gastro-jejunal anastomosis, in patients undergoing distal subtotal gastrectomy for gastric cancer with…
- Trial name
- NCT01073046
- Testing
- Naso-Gastric/Jejunal Tube
- Where
- Italy
- Volunteers
- 276 people
- Sponsor
- Catholic University, Italy
Digestive System Disorders
A Study to Determine if Aquamin (as AquaCal and AquaPT) Improves Digestive Discomfort
Digestive discomfort includes gastrointestinal symptoms such as abdominal pain, altered bowel habit, flatulence and bloating and can sometimes result from slower intestinal transit and other digestive irregularities.
- Trial name
- NCT01770808
- Testing
- AquaCal, AquaPT
- Where
- Ireland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University College Cork
Constipation, Gastrointestinal Discomfort
Clinical Evaluation of the Effects of EpiCor on Digestive Comfort
Previous in vitro studies suggest that EpiCor is well fermented in the colon and has prebiotic potential. The repeated long-term administration of low doses of EpiCor in the Simulator of the Human Intestinal Microbial Ecosystem…
- Trial name
- NCT03051399
- Testing
- EpiCor
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- ProDigest
Unidentified Gastrointestinal Discomfort Following Dairy Consumption
The Effect of Pasteurized; Pasteurized and Homogenized and UHT Treated Homogenized Cow's Milk on Gastrointestinal Symptoms in Sensitive Adults
This study aims to investigate differences in digestion rates and gastrointestinal problems caused by pasteurized; pasturized and homogenized as well as UHT-treated homogenized cow's milks in healthy adults by diary of symptoms…
- Trial name
- NCT03010904
- Testing
- Dietary intervention
- Where
- 2 sites in Finland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Turku
Gut Health
A Study to Assess the Effect of the Natural Orange Extract in Individuals With Gastrointestinal Discomfort
A Randomized, Double-Blind, Two-Arm, Placebo-Controlled Clinical Study to assess the Effect of the Natural Orange Extract in Individuals with Gastrointestinal Discomfort
- Trial name
- NCT06658717
- Testing
- Investigational product (IP): Natural orange extract
- Where
- 3 sites in India
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Irritable Bowel Syndrome
Probiotics in Intestinal Bacterial Overgrowth
The aim of the present study is to demonstrate the effect of a mixture of four species of probiotics (Saccharomyces boulardii, Bifidobacterium lactis BB-12, Lactobacillus acidophilus LA-5 and Lactobacillus plantarum) in patients…
- Trial name
- NCT02204891
- Testing
- Probiotics in SIBO, Probiotics
- Where
- Greece
- Volunteers
- 26 people
- Sponsor
- University of Athens
Functional Gastrointestinal Disorders (FGIDs), Infant Discomfort
Effects of Goat Milk Formula on Gastrointestinal Comfort and Growth in Infants
Infant gastrointestinal discomfort is common in early life and can affect feeding, sleep, and overall well-being. Goat milk formula, due to its unique protein composition and smaller fat globules, may be easier to digest and…
- Trial name
- NCT07778927
- Testing
- Goat Milk Formula, Cow Milk Formula
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Gastritis, Peptic Ulcer Disease
Frequent Ketamine Use and Gastrointestinal, Liver and Biliary Sequelae
30% of ketamine users complain of abdominal discomfort. Long-term ketamine use is associated with hepatotoxicity and pathologic changes to the biliary tract.
- Conditions
- Gastritis, Peptic Ulcer Disease, Cholangiopathy, Liver Fibrosis
- Trial name
- NCT02165488
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- The University of Hong Kong
Diagnostic Esophagogastroduodenoscopy
Premedication With Alprazolam and Midazolam for Upper Gastrointestinal Endoscopy
Diagnostic upper GI endoscopy can be uncomfortable and stressful for many patients. Various methods are available for sedation during this procedure.
- Trial name
- NCT03130842
- Testing
- Sublingual alprazolam, Oral midazolam
- Where
- Iran
- Volunteers
- 136 people
- Sponsor
- Isfahan University of Medical Sciences
Colorectal Cancer, Adenomas
Colonoscopy Screening Using a Novel Slim Colonoscope - a Randomized Controlled Trial
The purpose of this study is to compare the performance of a new prototype colonoscope with a standard colonoscope used world-wide today.
- Trial name
- NCT01370928
- Testing
- Olympus PCF-Y0014-L, Standard colonoscope
- Where
- Norway
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Sorlandet Hospital HF
Irritable Bowel Syndrome
A Six-month Study to Compare Outcome Differences and Visceral Response ... Irritable Bowel Syndrome
The purpose of this study is to assess the effect of participation in one of the following interventions: (1) IBS Stress Management; (2) IBS Symptom Management; or (3) IBS Educational Training on improving IBS associated…
- Trial name
- NCT00368771
- Testing
- IBS Stress Management, IBS Symptom Management, IBS Educational Training
- Volunteers
- 163 people
- Sponsor
- University of California, Los Angeles
Healthy Volunteers
The Effect of Wheat Germ on Gastrointestinal Discomfort, Blood Cholesterol and Postprandial Glycaemic Response
Wheat germ is a by-product of the wheat-milling industry with high nutritional value and therefore could be used as a raw source for the preparation of food products such as bread, cookies, muffins, etc.
- Trial name
- NCT02405507
- Testing
- wheat bread with wheat germ, wheat bread without wheat germ
- Where
- 2 sites in Portugal
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto