Clinical trials: Gastroenteritis, active
Children With Medical Complexity, Respiratory Tract Infections (RTI)
Automatic Versus As-Needed Follow-up After Hospitalization for Children With Medical Complexity
Children with medical complexity often receive a recommendation to see an outpatient clinician soon after leaving the hospital. It is uncertain whether every child needs this routine visit or whether follow-up can be guided by…
- Conditions
- Children With Medical Complexity, Respiratory Tract Infections (RTI), Urinary Tract Infection (UTI), Acute Gastroenteritis
- Trial name
- AFTERCARE (NCT07864636)
- Testing
- Automatic follow-up recommendation, As-needed follow-up recommendation
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Seattle Children's Hospital
Inflammatory Bowel Disease, Colitis, Ulcerative
A Study to Generate Real-world Evidence of Guselkumab Effectiveness in Inflammatory Bowel Disease in Germany
The purpose of this study is to characterize participants with Crohn's Disease (CD) and Ulcerative Colitis (UC) treated with Guselkumab in a real-world setting, and to assess the clinical effectiveness (how well the treatment…
- Conditions
- Inflammatory Bowel Disease, Colitis, Ulcerative, Crohn's Disease
- Trial name
- GORGEOUS (NCT07102368)
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Janssen-Cilag G.m.b.H
Feasibility Study, Vaccine Immune Response
How Gut Health Affects Immune Responses to the Oral Rotavirus Vaccine in Adults in Zambia
The Rotavirus SpatioTrasncriptomics (Rota-Omics) study is a multidisciplinary research project aimed at understanding why oral rotavirus vaccines perform less effectively in some low- and middle-income countries, including…
- Conditions
- Feasibility Study, Vaccine Immune Response, Rota Virus Gastroenteritis, Transcriptomics
- Trial name
- Rota-Omics (NCT07626606)
- Testing
- Rotarix®,
- Where
- Zambia
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Centre for Infectious Disease Research in Zambia
Norovirus Infections, Norovirus Gastroenteritis
A Study to Evaluate INT101 in Healthy Adults for the Prevention of Norovirus Gastroenteritis
This study is being conducted to evaluate the safety and immunogenicity of INT101, an investigational vaccine intended to prevent norovirus gastroenteritis, in healthy adults.
- Trial name
- INT-101 (NCT07818629)
- Testing
- INT101 Low Dose, INT101 High Dose
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- InThera Inc. Korea
Diarrhea, Gastroenteritis
Rifaximin 200 mg Plus Oral Rehydration vs Oral Rehydration Alone in Children With Acute Diarrhea
The goal of this clinical trial is to learn how rifaximin 200 mg is processed in the body (pharmacokinetics) in children 6 to 11 years old with acute diarrhea that may be caused by bacteria.
- Conditions
- Diarrhea, Gastroenteritis, Bacterial Infection, Acute Diarrhea
- Trial name
- NCT07285785
- Testing
- Rifaximin 200 mg Tablet, Oral Rehydration Therapy (ORT)
- Where
- 10 sites in United States
- Volunteers
- 54 people
- Sponsor
- Bausch Health Americas, Inc.
Crohn Disease
Autologous Stem Cell Transplant for Crohn's Disease
Crohn's Disease (CD) is an inflammatory bowel disease. It can lead to significant complications and discomfort in the stomach and intestines.
- Trial name
- NCT03219359
- Testing
- Autologous stem cell transplant, Cyclophosphamide, Thymoglobulin
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Aaron Etra
Gastroenteritis Acute, Diagnostic Communication
Antimicrobial Stewardship Effects of Interpretive Comments for Faecal PCR Tests
Bacterial gastroenteritis is a common condition seen in Aotearoa New Zealand, which is typically diagnosed by PCR testing on a stool sample. Most causes of bacterial gastroenteritis (e.g.
- Trial name
- NCT07701135
- Testing
- Interpretive comment on laboratory report
- Where
- 4 sites in New Zealand
- Volunteers
- 10,000 people
- Sponsor
- Medical Research Institute of New Zealand
Eosinophilic Gastritis (EoG), Eosinophilic Duodenitis (EoD)
A Study to Learn How Well Dupilumab Works in Adult and Adolescent Participants With Eosinophilic Gastritis With or Without Eosinophilic Duodenitis and the Side Effects it May Have
This study is researching an experimental drug called dupilumab. The study is focused on participants with active eosinophilic gastritis (EoG) with or without eosinophilic duodenitis (EoD).
- Conditions
- Eosinophilic Gastritis (EoG), Eosinophilic Duodenitis (EoD), Eosinophilic Gastrointestinal Disease (EGID), Eosinophilic Gastroenteritis
- Trial name
- ENGAGE (NCT05831176)
- Testing
- Dupilumab
- Where
- 53 sites in United States, Canada and 2 more
- Volunteers
- 22 people
- Sponsor
- Regeneron Pharmaceuticals
Gastroenteritis Acute, Dehydration
Balanced Crystalloid vs Normal Saline in Pediatric Acute Gastroenteritis
Acute gastroenteritis (AGE) is among the most common reasons for paediatric emergency visits. Children with significant dehydration often require intravenous (IV) fluid therapy.
- Conditions
- Gastroenteritis Acute, Dehydration, Acidosis, Metabolic, Diarrhea
- Trial name
- NCT07610382
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Aydin Adnan Menderes University
Acute Gastroenteritis, Norovirus Acute Gastroenteritis
A Study to Investigate the Safety and Efficacy of mRNA-1403 in Participants ≥18 Years of Age for the Prevention of Acute Gastroenteritis
The primary objectives of this study are to evaluate the safety and reactogenicity of mRNA-1403, and to demonstrate the efficacy of mRNA-1403 to prevent protocol-defined moderate or severe norovirus acute gastroenteritis (AGE)…
- Trial name
- Nova 301 (NCT06592794)
- Testing
- mRNA-1403
- Where
- 283 sites in United States, Australia and 5 more
- Volunteers
- 37,864 people, healthy volunteers welcome
- Sponsor
- ModernaTX, Inc.
Intra Abdominal Infections, Appendicitis Acute
Diagnosis of Abdominal Pain Using RNA Levels: The NATURAL Study
The NATURAL Study is a prospective, observational, pragmatic study of RNA biomarkers of infections to aid in the diagnosis of abdominal pain.
- Conditions
- Intra Abdominal Infections, Appendicitis Acute, Pyelonephritis, Diverticulitis
- Trial name
- NATURAL (NCT07579312)
- Testing
- TruNAV, an RNA-based blood test for host immune activation by infections
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- True Bearing Diagnostics, Inc.
Eosinophilic Esophagitis, Eosinophilic Gastroenteritis
Eosinophilic Gastrointestinal Disorders Registry
The purpose of this study is to learn more about Eosinophilic Gastrointestinal Disorders (EGIDs). With this registry we hope to find out more about the symptoms that patients have during their treatment, the quality of life they…
- Conditions
- Eosinophilic Esophagitis, Eosinophilic Gastroenteritis, Eosinophilic Colitis, Eosinophilic Gastrointestinal Disease
- Trial name
- NCT05199532
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Acute Gastroenteritis
Fortified Oral Rehydration Therapy for Pediatric Diarrhea
The goal of this clinical trial is to compare amino acid-fortified oral rehydration therapy (ORT) to the standard of care ORT in pediatric patients with acute gastroenteritis (AGE).
- Trial name
- fORT (NCT06137014)
- Testing
- Fortified Oral Rehydration Therapy, Standard of Care Oral Rehydration Therapy
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Paul A Breslin
Gastroenteritis Acute, Gastrointestinal Symptoms
Diagnostic PCR Panel in Children With Acute Gastrointestinal Symptoms
This investigator-initiated randomized controlled trial compares the clinical impact of real time PCR of fecal samples in children with acute gastrointestinal symptoms at a pediatric emergency room.
- Conditions
- Gastroenteritis Acute, Gastrointestinal Symptoms, Abdominal Pain/ Discomfort, Vomiting in Infants and/or Children
- Trial name
- RealCAGI RCT (NCT07280624)
- Testing
- Multiplex PCR gastrointestinal panel
- Volunteers
- 526 people
- Sponsor
- University of Oulu
Pneumonia, Urinary Tract Infections
Follow-up Automatically vs. As-Needed Comparison (FAAN-C) Trial
Compare the effectiveness of automatic vs as-needed (PRN) post-hospitalization follow-up for children who are hospitalized for common infections.
- Conditions
- Pneumonia, Urinary Tract Infections, Soft Tissue Infections, Gastroenteritis
- Trial name
- FAAN-C (NCT05471908)
- Testing
- As-needed follow up, Automatic follow-up
- Where
- 14 sites in United States
- Volunteers
- 2,674 people
- Sponsor
- University of Utah
Eosinophilic Gastrointestinal Disorders (EGIDs), Eosinophilic Esophagitis
OMEGA: Outcome Measures in Eosinophilic Gastrointestinal Disorders Across the Ages
The purpose of this observational study is to find the best measures to define how well a person with eosinophilic disorder is doing.
- Conditions
- Eosinophilic Gastrointestinal Disorders (EGIDs), Eosinophilic Esophagitis, Eosinophilic Gastritis, Eosinophilic Gastroenteritis
- Trial name
- OMEGA (NCT02523118)
- Where
- 19 sites in United States
- Volunteers
- 1,350 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Gastroenteritis, Gastrointestinal Diseases
Burden of Recreational Water Illness Due to Exposure to Cyanobacteria and Their Toxins in Freshwater Beaches in Canada
Swimming and other recreational water activities at public beaches are increasingly popular leisure activities among Canadians. However, harmful algal blooms caused by blue-green algae (i.e., cyanobacteria) have also been…
- Conditions
- Gastroenteritis, Gastrointestinal Diseases, Eye Infections, Skin Infections
- Trial name
- NCT06579170
- Testing
- Cyanobacteria exposure during water contact
- Where
- 4 sites in Canada
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Toronto Metropolitan University
Rotavirus Gastroenteritis
PhaseⅡClinical Trial of Oral Hexavalent Reassortant Rotavirus Attenuated Live Vaccine (Vero Cells)
The Phase II clinical trial of the oral hexavalent reassortant rotavirus attenuated live vaccine (Vero Cells) will be conducted in infants aged 6 to 12 weeks.
- Trial name
- NCT06967272
- Testing
- Oral hexavalent reassortant rotavirus attenuated live vaccine, Oral pentavalent reassortant rotavirus attenuated live vaccine (controlled)
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Sinovac Life Sciences Co., Ltd.
Ulcerative Colitis (UC)
A Long-Term Registry of Humira® (Adalimumab) in Patients With Moderately to Severely Active Ulcerative Colitis (UC)
This is a registry study to evaluate the long-term safety and effectiveness of adalimumab in patients with moderately to severely active UC who are treated as recommended in the product label.
- Trial name
- LEGACY (NCT01848561)
- Where
- 512 sites in United States, Australia and 19 more
- Volunteers
- 8,250 people
- Sponsor
- AbbVie
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- 2 sites in United States, Australia
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health