Clinical trials: Gastro-esophageal Reflux, open to volunteers
GERD, Gastroesophageal Reflux
Compassionate Use of Domperidone for Refractory Gastroparesis
The purpose of this program is to allow the use of domperidone in children from 12 to 21 years of age with symptoms related to motility disorders and Gastroesophageal reflux disease (GERD) who have failed all the standard…
- Conditions
- GERD, Gastroesophageal Reflux, Gastroparesis
- Trial name
- NCT04699591
- Testing
- Domperidone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Jose Cocjin
GERD (Gastroesophageal Reflux Disease), NERD
New Topical tReatment Options for Symptomatic patiEnts With Nonerosive gastroesophageaL Reflux dIsease (The RELIEF Trial)
The goal of this randomized, double-blind, single-center clinical trial RELEIF is to learn if medical devices work to decrease symptoms of gastroesophageal reflux disease (GERD) in adults' patients.
- Conditions
- GERD (Gastroesophageal Reflux Disease), NERD, Heartburn, Regurgitation, Gastric
- Trial name
- RELIEF (NCT07624383)
- Testing
- Esophageal barrier medical device
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Cellmedis
Early Gastric Cancer, Adenocarcinoma of the Stomach
SPADE Clinical Trial.
Purpose: This multicenter, prospective, single-arm phase 2 clinical trial aims to evaluate the safety, feasibility, and clinical outcomes of the SPADE operation (Spade-Shaped Anastomosis) in patients undergoing laparoscopic or…
- Conditions
- Early Gastric Cancer, Adenocarcinoma of the Stomach, Proximal Gastric Cancer, SPADE Operation
- Trial name
- SPADE (NCT07892183)
- Testing
- Spade-Shaped Anastomosis after Laparoscopic or Robotic Proximal Gastrectomy Using Double Suture Anchoring between the Posterior Wall of the Esophagus and the Anterior Wall of the Stomac
- Where
- South Korea
- Volunteers
- 159 people
- Sponsor
- National Cancer Center, Korea
Gastro Esophageal Reflux
Observational Registry of Transoral Incisionless Fundoplication (TIF) for Gastroesophageal Reflux Disease (GERD)
This observational registry aims to: 1) record the TIF interventions in patients with esophageal or extra-esophageal symptoms; 2) to monitor the therapy response through the clinical experience in terms of effect on the use and…
- Trial name
- TIF/2021 (NCT05066594)
- Testing
- Transoral incisionless fundoplication
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS San Raffaele
Gastro Esophageal Reflux
Prevalence of Symptomatic Gastroesophageal Reflux Disease in Czech Children (Czech GERDKids)
This study aims to determine the prevalence of symptomatic gastroesophageal reflux disease (GERD) in children aged 8-9 years and 12-13 years in the Czech Republic.
- Trial name
- Czech GERDKids (NCT07482969)
- Where
- Czechia
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Motol
Gastro Esophageal Reflux
The Effect of Inspiratory Muscle Training in People With Gastroesophageal Reflux Disease
The present Randomized Control Trial will be a single centric, two arm parallel equivalence randomized controlled. Participants will be assigned to either the Inspiratory MuscleTraining (IMT) group (investigation) or to Sham IMT…
- Trial name
- NCT07131397
- Testing
- Inspiratory Muscle Traing
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- University of West Attica
Gastric Adenocarcinoma, Adenocarcinoma of the Esophagogastric Junction
Sino-Russian Comparison of Outcomes After Proximal Gastrectomy With Double-Tract Reconstruction
This two-center retrospective observational cohort study compares Chinese and Russian patients who underwent curative proximal gastrectomy with double-tract reconstruction for proximal gastric adenocarcinoma or Siewert type…
- Trial name
- RUSCHI-DTR (NCT07800819)
- Testing
- Proximal gastrectomy with double-tract reconstruction
- Where
- 2 sites in China, Russia
- Volunteers
- 250 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Functional Gastrointestinal Disorders, Gastroesophageal Reflux
Prevalence and Natural History of Functional Gastrointestinal Disorders Among At-risk Infants.
The goal of this observational study is to learn about the prevalence and characteristics of functional gastrointestinal disorders (FGID) in at risk infants (former preterm infants and those with birth asphyxia) during the first…
- Conditions
- Functional Gastrointestinal Disorders, Gastroesophageal Reflux, Constipation - Functional, Diarrhea
- Trial name
- FUSID (NCT06031025)
- Testing
- Questionnaire, clinical examination
- Where
- Italy
- Volunteers
- 71 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Obesity & Overweight, Gastroesophageal Reflux (GERD)
Transit Bipartition After Sleeve Gastrectomy
This prospective, single-center study will evaluate adults undergoing revisional conversion from sleeve gastrectomy to intestinal transit bipartition.
- Conditions
- Obesity & Overweight, Gastroesophageal Reflux (GERD), Weight Recurrence, Bariatric Surgery
- Trial name
- BTT-SLEEVE (NCT07728682)
- Testing
- Conversion to Intestinal Transit Bipartition
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Hospital das Clínicas de Ribeirão Preto
Gastroesophageal Reflux Disease, GERD
Real-life Study of Changes of Gastroesophageal Reflux Disease Manifestations Due to Behavioural and Diet Adherence
This study is aimed to investigate the role of long-term diet adherence on manifestations of gastroesophageal reflux disease
- Conditions
- Gastroesophageal Reflux Disease, GERD, Gastroesophageal Erosion, Erosive Esophagitis
- Trial name
- NCT04255693
- Testing
- diet adherence, No diet adherence, Change in physical activity
- Where
- Russia
- Volunteers
- 150 people
- Sponsor
- Federal State Budgetary Scientific Institution
Reflux Disease, Gastro-Esophageal, Vomiting, Postoperative
Antireflux Suture In One Anastomsis Gastric Bypass
To prevent refulx symptoms in a type of bariatric surgery, a suture is taken.there is no enough evidence in support of or against the suture.
- Trial name
- NCT07148492
- Testing
- Antireflux suture, No Antireflux suture
- Where
- Pakistan
- Volunteers
- 316 people, healthy volunteers welcome
- Sponsor
- Khyber Teaching Hospital
Reflux Disease, Gastro-Esophageal
POLAR-STUDY: Polish AntiReflux Study
The goal of this observational study is to evaluate the current practice and outcomes of surgical treatment for gastroesophageal reflux disease (GERD) in adults undergoing antireflux surgery in Poland.
- Trial name
- POLAR (NCT07711912)
- Testing
- Prospective Clinical Observation and Follow-up
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- University of Warmia and Mazury in Olsztyn
Gastric Ultrasound, Gastric Ultrasound in Chronic Opioid Use (≥2 Weeks)
Does Pre-operative Gastric Ultrasound Influence Anaesthetic Decision-Making in Chronic Pain Patients? A Prospective Observational Cohort.
Gastric POCUS has been validated and shown to be an accurate diagnostic tool in both healthy individuals and medically complex patient populations.
- Conditions
- Gastric Ultrasound, Gastric Ultrasound in Chronic Opioid Use (≥2 Weeks), Gastric Ultrasound in Poorly Controlled Acute-on-chronic Pain, Gastric Ultrasound in Acute Opioid Administration Within 24 Hours Prior to the Procedure
- Trial name
- NCT07537582
- Where
- United Arab Emirates
- Volunteers
- 140 people
- Sponsor
- Danat Al Emarat Hospital
Gastro-oesophageal Reflux Disease
LINX vs Fundoplication
Reflux disease can severely impact upon quality-of-life and lead to complications, including ulceration of the oesophagus. It is often controlled with self-help measures and medication. However, sometimes surgery is recommended.
- Trial name
- GOLF (NCT07093359)
- Testing
- Laparoscopic or robotic LINX procedure, Laparoscopic or robotic fundoplication
- Where
- 5 sites in United Kingdom
- Volunteers
- 460 people
- Sponsor
- University of Oxford
Anesthesia
Electrical Acupoint Stimulation on Gastric Reflux During I-gel Ventilation
This study will compare the effects of transcutaneous acupoint electrical stimulation versus no stimulation on intraoperative gastric reflux in patients undergoing general anesthesia with i-gel airway device ventilation.
- Trial name
- ASGARD-igel (NCT07338448)
- Testing
- transcutaneous electrical acupoint stimulation, electrodes attachment
- Volunteers
- 116 people
- Sponsor
- Air Force Military Medical University, China
GERD
Mechanisms Preventing Pharyngeal Reflux
The overall goal is to define and characterize the manometric characteristics of UES incompetence associated with objectively documented pharyngeal reflux. The investigators will use endoscopic reflux detection as gold standard.
- Trial name
- NCT05696184
- Testing
- Concurrent manometry/impedance/pH with video pharyngo-laryngoscopy, Slow and rapid intra-esophageal infusion
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
GERD
Pre- and Post-Therapy Evaluation of Air-Associated Symptoms in Patients With Gastro-esophageal Reflux Disease (GERD): Assessing the Role of Speech and Language Therapy
Patients with gastroesophageal reflux disease (GERD) may present with concomitant gas-related symptom (GRS) such as supragastric or gastric belching, and aerophagia.
- Trial name
- LAS (NCT07634614)
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Prof Urs Zingg
Gastro Esophageal Reflux Disorder
Safety, PK, and PD Comparison of UI059 and UIC202201 in Healthy Volunteers
A randomized, open-label, multiple-dose, crossover phase 1 clinical trial to compare and evaluate the safety, pharmacokinetics and pharmacodynamics characteristics after oral administration of UI059 and UIC202201 in healthy adult…
- Trial name
- NCT07727629
- Testing
- UI059, UIC202201
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Korea United Pharm. Inc.
Esophagitis, Reflux
Clinical Trial of Reconstruction After Proximal Gastrectomy
1) To explore a simple, safe, post-proximal gastrectomy reconstruction method with good absorption and digestive function in order to improve patients' postoperative quality of life; 2) To fill the gap in the comparison of…
- Trial name
- NCT05418920
- Testing
- left-opening single-flap technique, double-flap group technique
- Volunteers
- 250 people
- Sponsor
- Oncogastroenterology Committee of Chinese
Reflux Esophagitis
A Prospective Cohort Study on Endoscopic Features of Upper Gastrointestinal Tract at High Altitude (Zaduo County)
To prospectively enroll participants undergoing gastroscopy at Zaduo County People's Hospital and perform paired analyses with matched cases from Jilin Province.
- Trial name
- NCT07755384
- Testing
- Sedated gastroscopy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Jilin University