Clinical trials: Ganglion
PARKINSON DISEASE (Disorder), Parkinson s Disease
Effects of Accelerated rTMS On Motor and Cognitive Function in Parkinson's Disease
Parkinson's disease (PD) is a brain disorder that causes progressive problems with movement, such as slowness, stiffness, tremor, and difficulty walking. Many people with PD also develop problems with thinking and memory.
- Trial name
- NCT07554833
- Testing
- TMS
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- San Francisco Neurology and Sleep Center
Parkinson Disease, Healthy Volunteers
Pilot Study to Evaluate ActiMyo Measured Activity in Parkinson Disease Patients & Healthy Volunteers
Pre-QuantiPark is a pilot study to evaluate the reliability and responsiveness of ActiMyo measured activity in PD patients. The purpose of the study is to provide validation of the ActiMyo, an innovative home-recording device…
- Trial name
- Pre-QuantiPark (NCT02785978)
- Testing
- Levodopa acute challenge, Controlled environment tests (series of tasks of everyday life), Standardized scales: MDS-UPDRS (Part II to IV) and RDRS
- Where
- 3 sites in France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Institut de Myologie, France
Parkinson's Disease
Study of Parkinson's Early Stage With Deferiprone
The goal of this study is to evaluate the effects of deferiprone, an iron-chelating drug, in patients with Parkinson's disease. Participants will be randomized to receive one of four different dosages of deferiprone or placebo…
- Trial name
- SKY (NCT02728843)
- Testing
- Deferiprone
- Where
- 20 sites in Canada, France and 2 more
- Volunteers
- 140 people
- Sponsor
- ApoPharma
Parkinson Disease, Parkinsonism
Non-motor Symptoms and Brain Dopamine Transporter Binding
This project aims to clarify the role non-motor symptoms in the development of Parkinson's disease (PD) and to improve diagnostics at very early stages of PD.
- Trial name
- NMDAT (NCT02650843)
- Testing
- DAT SPECT imaging
- Volunteers
- 455 people
- Sponsor
- Turku University Hospital
Parkinson Disease, Intestinal Bacteria Flora Disturbance
Resistant Maltodextrin for Gut Microbiome in Parkinson's Disease: Safety and Tolerability Study
This study will evaluate the safety and tolerability of a dietary fiber, resistant maltodextrin, in people with Parkinson's disease.
- Conditions
- Parkinson Disease, Intestinal Bacteria Flora Disturbance, Dietary Modification
- Trial name
- NCT03667404
- Testing
- Resistant maltodextrin, maltodextrin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwestern University
Parkinson's Disease
Ambulatory Assessment of Motor State in Patients With Parkinson's Disease in Real Daily Life
Patients with Parkinson's disease (PD) suffer from motor fluctuations and levodopa induced dyskinesia. The prupose of this study is to evaluate the effect of an automatic system to assess the motor state of PD patients in real…
- Trial name
- NCT00184808
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Radboud University Medical Center
Parkinson Disease
Assessment of Pupil Light Responses in Patients With Parkinson Disease
Parkinson diseases (PD) is the second most common degenerative disease of the central nervous system. The development of early diagnostic biomarkers may help identify at-risk individuals and allow precocious interventions at the…
- Trial name
- NCT04117555
- Testing
- Pupil response to light stimuli
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Sheba Medical Center
Parkinson's Disease
DBS of the MLR for Gait and Balance Disorders in PD Patients
Gait and balance disorders represent the main motor disability in advanced Parkinson's disease. These symptoms are less or unresponsive to levodopa treatment and are considered to be a contraindication for deep brain stimulation…
- Trial name
- GAITPARK (NCT02931097)
- Testing
- Deep brain stimulation
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Parkinson's Disease, Pergolide
Observational Study of Heart Valve Disease in Patients With Parkinson's Disease Treated With Pergolide
The purpose of this study is to determine whether patients with Parkinson's disease and treated with pergolide have a higher risk of heart valve disease compared to patients with Parkinson's disease not treated with pergolide.
- Trial name
- NCT00202657
- Testing
- echocardiography
- Where
- France
- Volunteers
- 149 people
- Sponsor
- Société Française de Cardiologie
Parkinson Disease
Determination of the Minimal Detectable Change of the Parkinson's Disease Questionnaire-8
This study is conducted to determine how many units of improvement the Parkinson's Disease Questionnaire-8 (PDQ-8), used to evaluate the quality of life of Parkinson's patients, should have to express a significant change in the…
- Trial name
- NCT06487364
- Testing
- Rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Emre Şenocak
Tourette Syndrome
Strengthening Tourette Treatment OPtions Using TMS to Improve CBIT, a Double-blind, Randomized, Controlled Study
This pilot study will investigate the clinical and neurophysiological effects of repetitive transcranial magnetic stimulation (rTMS) followed by comprehensive behavioral intervention for tics (CBIT) in adult patients with…
- Trial name
- STOP-TIC (NCT05705999)
- Testing
- transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- West Virginia University
Parkinson Disease
Deep Brain Stimulation (DBS) of the Pedunculopontine Nucleus (PPN)
This is a mechanistic study to determine the differential effects of the dopaminergic and cholinergic systems on attention, gait, and balance.
- Trial name
- PPNGB01 (NCT04605263)
- Testing
- STN-PPN DBS Surgery, Deep Brain Stimulation Surgery (DBS)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Parkinson Disease
Effects of Different Percentages Body Weight Supported Treadmill Training on Gait, Balance, Quality of Life and Fatigue in Parkinson's Disease
Body weight supported treadmill training (BWSTT) is an important rehabilitative choice for neurologically impaired subjects such as Parkinson's disease (PD).
- Trial name
- NCT03799887
- Testing
- 0% unweighed BWSTT, 10% unweighed BWSTT, 20% unweighed BWSTT
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Hitit University
Hot Flashes, Menopause
Pilot Study of Stellate Ganglion Injection to Provide Relief From Hot Flushes
This study is being done to determine whether stellate ganglion injection with local anesthetic (the study procedure) can reduce the number and severity of hot flashes in women who have hot flashes.
- Trial name
- NCT00992914
- Testing
- Sympathetic nerve block with 1% lidocaine 1-2 ml, Superficial subcutaneous injection
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Parkinson's Disease
Carbidopa-Levodopa (CD-LD) ER Alone or in Combination With CD-LD IR to IPX066 Followed by IPX066 Extension Safety Study
The study had three distinct parts and is described as follows: Part 1: To evaluate the dose conversion from CD-LD ER taken alone or in combination with CD-LD IR to IPX066 in subjects with advanced PD To evaluate the utility of…
- Trial name
- NCT01411137
- Testing
- IPX066
- Where
- 8 sites in United States
- Volunteers
- 43 people
- Sponsor
- Impax Laboratories, LLC
Parkinson's Disease
Exercise for People With Parkinson's Disease
This randomized, controlled exercise intervention with three groups compares two exercise approaches to standard of care. Supervised interventions are administered for four months, with emphasis on patients adopting exercise…
- Trial name
- NCT01257945
- Testing
- Aerobic Exercise, Flexibility and Function exercise program, Home exercise program
- Where
- United States
- Volunteers
- 163 people
- Sponsor
- University of Colorado, Denver
Dementias With Lewy Bodies
A Study to Determine the Metabolism and Elimination of [14C]E2027 in Healthy Male Participants
The primary objective of the study is to achieve mass balance recovery of [14C]-radiolabel in urine and feces and to identify and quantify the main elimination pathways of E2027.
- Trial name
- NCT04023877
- Testing
- E2027
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Parkinson Disease
Convection Enhanced Delivery of CSF in DBS for Parkinson's
This study will evaluate safety foremost but also the distribution and initial effectiveness of infusion-enhanced, MRI-guided DBS for patients with medication-refractory, Parkinson's disease
- Trial name
- NCT03540134
- Testing
- Intracerebral Infusion of Autologous Cerebral Spinal Fluid
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Jeff Elias, MD
Parkinson's Disease
Mesenchymal Stem Cells Transplantation to Patients With Parkinson's Disease
The study is a phase I/II trial designed to establish the safety and efficacy of intravenous administration of autologous bone marrow derived mesenchymal stem cells to patients with Parkinson's disease.
- Trial name
- NCT01446614
- Testing
- bone marrow derived mesenchymal stem cells
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Parkinson Disease
The Impact of Dancing in Parkinson's Disease
This clinical study intends to confirm the results of previous studies showing the positive effect of dance on patients with Parkinson's disease on both mental and physical health via a randomized controlled trial.
- Trial name
- NCT05175365
- Testing
- Dance
- Where
- 3 sites in Belgium
- Volunteers
- 68 people
- Sponsor
- Centre Hospitalier Universitaire de Liege