Clinical trials: GAD
Major Depressive Disorder, Generalized Anxiety Disorder
The Modular Protocol for Mental Health (MPMH)
Currently, our best psychological treatments for anxiety and mood disorders only focus on individual diagnoses. So, there are separate treatments for Panic Disorder, or Depressive Disorder, or Social Anxiety, etc.
- Conditions
- Major Depressive Disorder, Generalized Anxiety Disorder, Posttraumatic Stress Disorder, Social Anxiety Disorder
- Trial name
- MPMH (NCT03143634)
- Testing
- The Modular Protocol for Mental Health, Treatment-as-usual
- Where
- United Kingdom
- Volunteers
- 43 people
- Sponsor
- Medical Research Council Cognition and Brain Sciences Unit
Generalized Anxiety Disorder
Cognitive Behavior Treatment of Older Adults With Generalized Anxiety Disorder in Primary Care
The purpose of this study is to determine whether cognitive behavior treatment (CBT) can be delivered effectively by providers of different expertise levels in adults age 60 and older in a primary care setting.
- Trial name
- NCT00765219
- Testing
- CBT, Usual Care
- Where
- United States
- Volunteers
- 222 people
- Sponsor
- Baylor College of Medicine
Generalized Anxiety Disorder
Relapse-prevention Study With Lu AA21004 (Vortioxetine) in Patients With Generalized Anxiety Disorder
The study will evaluate the long-term maintenance of efficacy of Lu AA21004 in patients with Generalized Anxiety Disorder (GAD) who responded to acute treatment with Lu AA21004.
- Trial name
- NCT00788034
- Testing
- Lu AA21004
- Where
- 81 sites in Argentina, Chile and 9 more
- Volunteers
- 459 people
- Sponsor
- H. Lundbeck A/S
Obsessive-Compulsive Disorder, Generalized Anxiety Disorder
Memantine Treatment for Obsessive-compulsive Disorder and Generalized Anxiety Disorder
The objective of this study was to obtain preliminary open-label data on the efficacy and tolerability of memantine, an anti-glutamatergic medication with a unique pharmacodynamic profile, in individuals with OCD and individuals…
- Trial name
- NCT00674219
- Testing
- Memantine
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of California, Los Angeles
Generalized Anxiety Disorder, Social Phobia
Effectiveness of Six Sessions CBT for Adolescents With Emotional Problems in Community Clinics
Background: There is need for more effectiveness studies concerning treatment of emotional symptom problems indicating anxiety and depression in adolescents.
- Conditions
- Generalized Anxiety Disorder, Social Phobia, Agoraphobia, Depression
- Trial name
- SMART (NCT02150265)
- Testing
- SMART manual cognitive behavioral therapy
- Where
- Norway
- Volunteers
- 163 people
- Sponsor
- University of Tromso
Generalized Anxiety Disorder
Safety & Efficacy Study of Quetiapine Fumarate (SEROQUEL®) vs. Placebo in Generalized Anxiety Disorder
The purpose of this study is to demonstrate that quetiapine SR (SEROQUEL®) is efficacious and safe in the acute treatment of patients with Generalized Anxiety Disorder.
- Trial name
- TITANIUM (NCT00329264)
- Testing
- Quetiapine fumarate
- Where
- 58 sites in United States
- Volunteers
- 876 people
- Sponsor
- AstraZeneca
Generalized Anxiety Disorder
A Trial of the Efficacy and Safety of Fixed Doses of SEP-363856 in Adults With Generalized Anxiety Disorder
This is a global, phase 3, randomized, double-blind, parallel-group, 3-arm, placebo-controlled, multicenter study designed to compare the efficacy, safety, and tolerability of fixed doses of SEP-363856 (50 and 75 milligrams per…
- Trial name
- NCT07759128
- Testing
- SEP-363856
- Where
- 17 sites in United States
- Volunteers
- 576 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Anxiety Disorders, Generalized Anxiety Disorder
Motivational Interviewing and Cognitive Behavioural Therapy for Generalized Anxiety Disorder
The current study examines whether change-readiness, and consequently treatment outcome, can be enhanced in Cognitive Behavioral Therapy (CBT) for severe Generalized Anxiety Disorder (GAD) by adding a brief course of Motivational…
- Trial name
- NCT01488799
- Testing
- Motivational Interviewing and Cognitive Behavioural Therapy
- Where
- 2 sites in Canada
- Volunteers
- 85 people
- Sponsor
- York University
Generalized Anxiety Disorder
Exercise Training for the Treatment of Generalized Anxiety Disorder
The purpose of this study is to compare the effects of 6 weeks of endurance or strength training and a wait list comparison condition on symptoms of Generalized Anxiety Disorder (GAD).
- Trial name
- NCT00953654
- Testing
- Strength Training, Endurance Training
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Georgia
Anxiety, Anxiety Acute
Anxiety Skills Study
The purposes of this study are: (1) to identify baseline predictors of relative success in cognitive, behavioral, and mindfulness-based treatments for anxiety, (2) explore who benefits from a brief, video-based skill training…
- Conditions
- Anxiety, Anxiety Acute, Anxiety Chronic, Anxiety and Mood Disorders
- Trial name
- NCT07774481
- Testing
- Cognitive therapy, Behavioral therapy, Mindfulness-based therapy
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Ohio State University
Depression / Major Depressive Disorder, Anxiety Disorder (Panic Disorder or GAD)
Feasibility and Preliminary Outcomes of Compassion-Focused Group Therapy for Depression and Anxiety
This pilot study evaluated the feasibility and preliminary outcomes of compassion-focused group therapy (CFT) for adults with depression and/or anxiety who continued to experience symptoms despite previous treatment.
- Trial name
- NCT07876453
- Testing
- Compassion-Focused Group Therapy (CFT)
- Where
- Sweden
- Volunteers
- 21 people
- Sponsor
- Karolinska Institutet
Generalized Anxiety Disorder
Cognitive-Behavioral Therapy and Escitalopram for Generalized Anxiety Disorder(GAD)
The goals of this pilot study are as follows: 1) To disseminate and examine the effectiveness of a manualized, individual, cognitive-behavioral psychotherapy (CBT) for adults with Generalized Anxiety Disorder(GAD), 2) to test the…
- Trial name
- NCT00219349
- Testing
- Cognitive Behavioral Therapy, escitalopram
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- New York State Psychiatric Institute
Anxiety
Comparison of Pregabalin Versus Venlafaxine XR and Placebo in the Treatment of Generalized Anxiety Disorder
The purpose of the study is to compare pregabalin to Venlafaxine XR and placebo in the treatment of generalized anxiety disorder.
- Trial name
- NCT00151450
- Testing
- Pregabalin, Venlafaxine XR
- Where
- 45 sites in Belgium, Canada and 6 more
- Volunteers
- 390 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Generalized Anxiety Disorder
A Trial of the Safety and Tolerability of SEP-363856 in Adults With Generalized Anxiety Disorder
This is a global, Phase 3, multicenter, open-label extension trial designed to evaluate the long-term safety, tolerability and efficacy of SEP-363856 administered at doses of 50 milligrams (mg) or 75 mg per day in adult…
- Trial name
- NCT07786454
- Testing
- SEP-363856
- Where
- 2 sites in United States
- Volunteers
- 1,120 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Generalized Anxiety Disorder, Major Depressive Disorder
Simplified Cognitive Behavioral Therapy for Generalized Anxiety Disorder and Depression
This trial attempts to evaluate the treatment efficacy of Simplified Cognitive Behavioral Therapy (SCBT) and its safety among schizophrenia patients. Half of participants will be randomized to accept SCBT.
- Trial name
- NCT03329287
- Testing
- SCBT, SSRIs and/or SNRIs
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Shanghai Mental Health Center
Neurological Syndromes With GAD-Ab, Organ-specific Autoimmune Diseases
Autoimmunity in Patients With GAD-Ab and Their Relatives
A group of poorly studied immune-mediated neurological syndromes are associated with antibodies against glutamic-acid decarboxylase (GAD-Ab).
- Trial name
- FamilyGAD (NCT04104620)
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
Generalized Anxiety Disorder
Treatment of Adults With Generalized Anxiety Disorder Using Glutamine
The objective of this randomized clinical trial is to examine the efficacy of L-glutamine for the treatment of generalized anxiety disorder compared versus placebo.
- Trial name
- NCT04274114
- Testing
- L Glutamine
- Where
- Mexico
- Volunteers
- 38 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Generalized Anxiety Disorder
An Open-label Study to Investigate the Absorption, Metabolism and Excretion of Radiolabeled PD 0332334 in Six Healthy Male Volunteers
The purpose of this study is to investigate the absorption, metabolism and excretion of [14C] PD 0332334 to characterize plasma, fecal and urinary radioactivity and identify any metabolites of [14C] PD 0332334.
- Trial name
- NCT00537615
- Testing
- PD 0332334
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Pfizer
Generalized Anxiety Disorder, Social Anxiety Disorder
Cannabinoids for the Treatment of Anxiety Disorders: An 8-Week Pilot Study
This proposed study aims to evaluate the efficacy of a daily oral cannabinoid oil preparation in treating symptoms of DSM-5 anxiety disorders, using a two-arm, 8-week randomized, placebo-controlled trial in adults aged 21-65…
- Conditions
- Generalized Anxiety Disorder, Social Anxiety Disorder, Panic Disorder, Agoraphobia
- Trial name
- NCT04569760
- Testing
- 50:2 mg(CBD:THC)/ml - Cannabinoid Oil Oral Preparation- titrated as tolerated up to a maximum 8mls twice daily (200 mg- 800 mg total dose)
- Where
- Canada
- Sponsor
- McMaster University
Healthy Volunteers, Generalized Anxiety Disorder (GAD)
A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of ABBV-932 in Healthy Adult Participants, Participants With Generalized Anxiety Disorder (GAD) and Participants With Bipolar Disorder (BPD)
The purpose of this study is to assess the pharmacokinetics, safety, and tolerability following multiple ascending oral doses of ABBV-932 or placebo in healthy adult participants, participants with Generalized Anxiety Disorder…
- Conditions
- Healthy Volunteers, Generalized Anxiety Disorder (GAD), Bipolar Disorder (BPD)
- Trial name
- MAD (NCT06024239)
- Testing
- ABBV-932
- Where
- 3 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- AbbVie