Clinical trials: Functional Neurological Disorders
Parkinson Disease
Relationship of Dopamine to Cognitive Function in Parkinson's Disease
This study will examine how the brain chemical dopamine affects memory, reasoning, and other thought processes in people with Parkinson's disease with and without dementia and in healthy control subjects.
- Trial name
- NCT00094601
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Obstructive Sleep Apnea
Effect of Upper Airway Stimulation on Vascular Function in Obstructive Sleep Apnea
This study will evaluate the effect of hypoglossal nerve stimulation (HGNS) on different measures of cardiovascular function in patients with obstructive sleep apnea (OSA).
- Trial name
- NCT03051165
- Testing
- Hypoglossal Nerve Stimulation Treatment Withdrawal
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Emory University
Cerebral Palsy, Hemiplegia
Effect of Baby-CIMT in Infants Younger Than 12 Months
A randomized control trial investigating if an early intervention program of modified Constraint Induced Movement Therapy for babies, Baby-CIMT, performed before 12 months of age will improve hand function in children with risk…
- Conditions
- Cerebral Palsy, Hemiplegia, Children
- Trial name
- B-CIMT (NCT01864811)
- Testing
- Baby-CIMT, Baby-Massage
- Where
- Sweden
- Volunteers
- 35 people
- Sponsor
- Karolinska Institutet
Healthy Volunteer, Muscular Atrophy, Spinal
Ability of Muscle Imaging and Motor Function Measure (MFM) to Detect Changes in Disease Progression in Ambulant Spinal Muscular Atrophy Patients Compared to Healthy Volunteers.
This non-drug, single center, 24-week, longitudinal study in ambulant spinal muscular atrophy (SMA) patients and in age- and gender-matched healthy volunteers will assess the detection of disease progression by magnetic resonance…
- Trial name
- NCT02044029
- Where
- Switzerland
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Traumatic Brain Injury
Home-Based Exergame Motor-Cognitive Rehabilitation for Traumatic Brain Injury
The goal of this clinical trial is to evaluate the effectiveness of a home-based cognitive-motor telerehabilitation program in individuals with traumatic brain injury (TBI) following discharge from intensive inpatient…
- Trial name
- HOME-TBI (NCT07733336)
- Testing
- HOME-EXER telerehabilitation protocol, OUT-REHAB rehabilitation protocol
- Where
- 2 sites in Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Sarcopenia
Nutritional Intervention for Age-related Muscular Function and Strength Losses-Study 2
Men and women lose muscle mass and strength with age. Loss of muscle mass and strength is accompanied by a loss of muscle function which can lead to diminished quality of life and more importantly can lead to serious fall…
- Trial name
- NCT02043171
- Testing
- HMB plus Vitamin D, Non-Exercise, Exercise
- Where
- United States
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Metabolic Technologies Inc.
Cerebral Tumor
Brain Areas of Cognitive Functions: a Study in Awake Surgery
This research project focuses on low-level cognitive functions such as perception (auditory, visual, etc.) and high-level cognitive functions (memory, language, temporal estimation, etc.).
- Trial name
- BRAIN-MAP (NCT07170436)
- Testing
- Short version of cognitive testing during surgery
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Toulouse
Postoperative Delirium, Cognitive Function Abnormal
EEG Characteristics and Postoperative Delirium
The goal of this [type of study: observational study ] is to [compare Energy differences in various bands of intraoperative electroencephalogram in elderly patients with postoperative delirium and non delirium.] in [describe…
- Conditions
- Postoperative Delirium, Cognitive Function Abnormal, PSI, Frailty
- Trial name
- NCT06102967
- Testing
- delirium
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Zhuo Liu
Delirium, Cognition Disorders
Non-sedation Versus Sedation With a Daily Wake-up Trial in Critically Ill Patients Receiving Me-chanical Ventilation - Effects on Cognitive Function
Through many years, the standard care has been to use continuous sedation of critically ill patients during mechanical ventilation.
- Trial name
- NCT02035436
- Testing
- Non-sedation, Control: Sedation
- Where
- Denmark
- Volunteers
- 205 people
- Sponsor
- Palle Toft
Neurocognitive Disorders
MEMORA-Caregiver : Risk Factors of Caregiver Burden Among Patients With Neurocognitive Disorders or Subjective Cognitive Complaint
The investigators will investigate which patients' characteristics are associated with caregivers burden and its evolution for outpatients visiting a memory clinic, in particular how functional autonomy, behavioral and…
- Trial name
- MEMORA (NCT02825732)
- Where
- France
- Volunteers
- 1,300 people
- Sponsor
- Hospices Civils de Lyon
Parkinson Disease
Deep Brain Stimulation in Parkinson's Disease: Motor and Functional Outcomes
Introduction: Parkinson's Disease (PD) is a progressive neurodegenerative condition characterized by classic motor symptoms, such as bradykinesia, rigidity, resting tremor, and postural instability, which directly compromise the…
- Trial name
- NCT07567599
- Testing
- Deep Brain Stimulation
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of Minas Gerais
Carpal Tunnel Syndrome
The Effect of High-intensity Laser Therapy in Patients With Carpal Tunnel Syndrome.
The aim of this study is to evaluate the effects of high intensity laser therapy (HILT) on pain, functional status, hand grip strength and median nerve cross-sectional area in ultrasonography in patients with carpal tunnel…
- Trial name
- NCT05678595
- Testing
- high-intensity laser therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Necmettin Erbakan University
Low Back Pain, Chronic
Comparative Effects of Group Based Exercises with and Without Cognitive Functional Therapy on Clinical Outcomes in Patients with Chronic Low Back Pain
1.1Research objective The objective of the study is to find the comparative effects of group based exercises with and without cognitive functional therapy on clinical outcomes in patients with chronic low back? 1.2 Hypothesis…
- Trial name
- NCT06759675
- Testing
- group based exercise with Cognitive functional therapy, Group based exercise
- Volunteers
- 40 people
- Sponsor
- University of Faisalabad
Cerebral Palsy
International Classification of Functioning, Disability and Health and Lower Extremity Orthoses in Cerebral Palsy
International Classification of Functioning, Disability and Health (ICF) is a coding system developed to describe the health status of individuals in a universal way.
- Trial name
- NCT03876730
- Testing
- ICF CP Core Set
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Hacettepe University
Functional Dysphonia, Voice Disorders
Dysphonia, Distress, and Perceived Control: Technology Based Assessment and Intervention
The purpose of this study is to pilot test a version of the intervention that has been tailored for participants with dysphonia.
- Conditions
- Functional Dysphonia, Voice Disorders, Dysphonia
- Trial name
- NCT03576365
- Testing
- VOICE Intervention Arm, Information-Only Arm
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- University of Minnesota
Stroke, Stroke (CVA) or TIA
Comparative Effects of Somatosensory Stimulation and Task Based Mirror Therapy in Post Stroke Patients
This randomized controlled trial will be conducted at the Department of Physical Therapy, DHQ Hospital Sheikhupura, over duration of eleven months.
- Conditions
- Stroke, Stroke (CVA) or TIA, Upper Limb Function
- Trial name
- NCT07578844
- Testing
- Somatosensory Stimulation, Mirror Therapy:
- Where
- Pakistan
- Volunteers
- 24 people
- Sponsor
- Riphah International University
Breast Cancer, Head and Neck Cancer
Docetaxel in Treating Patients With Solid Tumors and Abnormal Liver Function
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of docetaxel in treating patients with advanced solid…
- Conditions
- Breast Cancer, Head and Neck Cancer, Lung Cancer, Ovarian Cancer
- Trial name
- NCT00002901
- Testing
- docetaxel
- Where
- 3 sites in United States
- Sponsor
- City of Hope Medical Center
Fibromyalgia, Irritable Bowel Syndrome
Exercise Interventions and Dietary Advice in Fibromyalgia and IBS
Fibromyalgia (FM) is a chronic disorder marked by widespread musculoskeletal pain, fatigue, sleep disturbances, and cognitive difficulties. Patients often experience hyperalgesia, allodynia, and muscle weakness.
- Trial name
- FM-IBS (NCT06923800)
- Testing
- Combined Exercise Program + A specific nutritional plan for individuals with IBS, Aerobic Exercise + A specific nutritional plan for individuals with IBS
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Subacromial Impingement Syndrome
Effects of Exercise Trainings on Pain, Function and AHD in Patients With SPS
Abnormal reduction of the AHD has been considered as one of the possible mechanisms in the aetiology of subacromial pain syndrome.
- Trial name
- NCT03494192
- Testing
- Scapula Retraction Exercise Group, Scapula Retraction +Glenohumeral Rotational Exercise Group
- Where
- Turkey (Türkiye)
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Down Syndrome (DS)
Normalization of dyrk1A and APP Function as an Approach to Improve Cognitive Performance and Decelerate AD Progression in DS Subjects: Epigallocatechin Gallate as Therapeutic Tool
Epigallocatechin-3-gallate (EGCG), the major catechin in green tea, is postulated to modulate dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) and amyloid beta precursor protein (APP) gene overexpression in…
- Trial name
- NCT01699711
- Testing
- Epigallocatechin-3-gallate (EGCG)
- Where
- Spain
- Volunteers
- 87 people
- Sponsor
- Parc de Salut Mar