Clinical trials: Functional Neurological Disorder
Alzheimer Disease, Dementia
Brain Safe: Consumer Intervention to Reduce Exposure to Drugs Linked to Alzheimer's Disease
This study is an RCT to evaluate the effectiveness of Brain Safe on reducing anticholinergic exposure. Over 42 months, the trial will enroll 700 community-dwelling older adults who were prescribed one or more strong…
- Trial name
- NCT04121858
- Testing
- Brain Safe App, Attention Control App
- Where
- 2 sites in United States
- Volunteers
- 706 people
- Sponsor
- Indiana University
Postoperative Delirium, PD
Perioperative Cognitive Function - Dexmedetomidine and Cognitive Reserve
Elderly patients who undergo anesthesia and non-cardiac surgery are subject to deterioration of brain function including the development of postoperative delirium (PD) and postoperative cognitive dysfunction (POCD).
- Conditions
- Postoperative Delirium, PD, Postoperative Cognitive Dysfunction, POCD
- Trial name
- NCT00561678
- Testing
- Precedex (Dexmedetomidine)
- Where
- 10 sites in United States
- Volunteers
- 404 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Spinal Cord Injuries
Intermittent Hypoxia to Enhance Motor Function After Spinal Cord Injury
This study will examine if acute intermittent hypoxia (brief episodes of breathing lower oxygen), which has been shown to enhance plasticity and motor output, can enhance functional outcomes and muscle activation in individuals…
- Trial name
- NCT03071393
- Testing
- Hypoxia via Hypoxico Hyp-123
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- University of Florida
Traumatic Brain Injury
Effectiveness of Amantadine Hydrochloride for Treatment of Severe Traumatic Brain Injury (TBI)
This is a controlled trial of amantadine to improve level of function following severe traumatic brain injury. The purpose of this study is: 1.
- Trial name
- NCT00970944
- Testing
- Amantadine Hydrochloride
- Where
- 11 sites in United States, Denmark and 1 more
- Volunteers
- 184 people
- Sponsor
- JFK Medical Center
Partial Epilepsy
Effects of Eslicarbazepine Acetate (Esl, Bia 2-093) on Cognitive Function in Children With Partial Onset Seizures
To evaluate the effects of eslicarbazepine acetate on cognition in comparison with placebo as adjunctive therapy in children aged 6 to 16 years old with refractory partial-onset seizures.
- Trial name
- NCT01527513
- Testing
- Eslicarbazepine acetate (BIA 2-093)
- Where
- 36 sites in Italy, Netherlands and 3 more
- Volunteers
- 123 people
- Sponsor
- Bial - Portela C S.A.
Stroke, Upper Extremity Paresis
Synchronized Brain and Hand Stimulation After Stroke
Among the 795,000 individuals who sustain a stroke annually in the United States, 65% continue to experience moderate-to-severe impairments in one hand six months or more, which limits their ability to perform daily tasks.
- Trial name
- NCT04502290
- Testing
- Combined Non-invasive brain stimulation and functional electrical hand stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Amit Sethi
Stroke, Physical Disability
Concomitant Sensory Stimulation During Therapy to Enhance Hand Functional Recovery Post Stroke
The objective of this study is to determine if combining vibration with hand task practice is superior to hand task practice alone.
- Trial name
- NCT04569123
- Testing
- real stimulation, No stimulation
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Medical University of South Carolina
Muscular Atrophy, Spinal
Safety and Efficacy of Intravenous OAV101 (AVXS-101) in Pediatric Patients With Spinal Muscular Atrophy (SMA) (OFELIA)
This was a phase IV Open-label, single-arm, single-dose, multicenter study, to evaluate the safety, tolerability and efficacy of intravenous administration of OAV101 (AVXS-101) in patients with SMA with bi-allelic mutations in…
- Trial name
- OFELIA (NCT05073133)
- Testing
- OAV101
- Where
- 5 sites in Argentina, Brazil
- Volunteers
- 16 people
- Sponsor
- Novartis Pharmaceuticals
Irritable Bowel Syndrome
Olorinab in Irritable Bowel Syndrome With Predominant Constipation (IBS-C) and Irritable Bowel Syndrome With Predominant Diarrhea (IBS-D)
The purpose of this study is to determine whether olorinab is a safe and effective treatment for abdominal pain in participants with irritable bowel syndrome (IBS).
- Trial name
- CAPTIVATE (NCT04043455)
- Testing
- Olorinab
- Where
- 69 sites in United States
- Volunteers
- 273 people
- Sponsor
- Arena Pharmaceuticals
Spinal Cord Injury
Patterned Functional Electrical Stimulation (FES) Ergometry of Arm and Shoulder in Individuals With Spinal Cord Injury
To determine whether functional electrical stimulation (FES) promotes neurological and physical recovery in patients with spinal cord injury (SCI).
- Trial name
- NCT01005615
- Testing
- Non-FES Upper Extremity Exercise, RT300-SLSA, from Restorative Therapies, Inc.
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Stroke, Cerebrovascular Disorders
Cost-effectiveness of Forced Aerobic Exercise for Stroke Rehabilitation
The purpose of this study is to investigate whether aerobic exercise improves the participant's ability to recover function in the arm and leg affected by the participant's stroke.
- Conditions
- Stroke, Cerebrovascular Disorders, Brain Diseases, Central Nervous System Diseases
- Trial name
- NCT03819764
- Testing
- Aerobic Exercise, Upper Extremity Repetitive Task Practice
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The Cleveland Clinic
Mild Cognitive Impairment, Memory Disorders
A Study of HD-tDCS and Cognitive Training to Improve Cognitive Function in MCI
The primary objective of this project is to assess the feasibility of multi-field, extended HD-tDCS (MFE-HD-tDCS) with simultaneous computerized CT as a viable intervention to improve cognitive function in patients with MCI.
- Conditions
- Mild Cognitive Impairment, Memory Disorders, Memory Loss
- Trial name
- NCT04246164
- Testing
- HD-tDCS combined with CT
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Medical College of Wisconsin
Fall Patients, Delirium
Implementation of Multidisciplinary Assessments for Geriatric Patients in an ED Observation Unit
This project will implement a 2 step protocol for multidisciplinary geriatric assessment in the Emergency Department (ED). Candidate: Dr.
- Conditions
- Fall Patients, Delirium, Quality of Life, Functional Status
- Trial name
- IMAGE (NCT04068311)
- Testing
- Geriatric Screening tools
- Where
- United States
- Volunteers
- 373 people
- Sponsor
- Ohio State University
Temporomandibular Joint Dysfunction Syndrome, Chronic Pain
Restoring Masticatory Function to Treat Chronic Pain
The primary endpoint will be the average change in pain score from baseline to the three- and six-month assessments. Efficacy will be demonstrated by superior pain relief with the active treatment compared with the placebo.
- Trial name
- MAP (NCT02144233)
- Testing
- Occlusal adjustment
- Where
- 2 sites in Spain
- Volunteers
- 77 people
- Sponsor
- Urbano Santana Penin, MD, DDS, PhD
Psychogenic Non-epileptic Seizures, Motivational Interviewing
Motivational Interviewing to Enhance Adherence of Patients With Psychogenic Non-epileptic Seizures
All subjects will attend an initial clinic visit with the neuropsychiatrist and epileptologist. At the end of this visit, those subjects randomized to motivational interviewing will be questioned using standardized motivational…
- Trial name
- NCT02598076
- Testing
- motivational interviewing, standard psychotherapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Brigham and Women's Hospital