Clinical trials: Functional Disorder
Functional Neurological Symptom Disorder
Cognitive Disengagement Syndrome in Functional Neurological Symptom Disorder
This cross-sectional observational case-control study aims to investigate symptoms of sluggish cognitive tempo (SCT), also known as cognitive disengagement syndrome (CDS), in adults diagnosed with Functional Neurological Symptom…
- Trial name
- NCT07451821
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Elazığ Mental Health and Diseases Hospital
Refractory Constipation, Somatic Symptom Disorder (DSM-5)
Evaluation of Fluoxetine for Refractory Constipation With Somatic Symptom Disorder Features
This single-center, randomized, double-blind, placebo-controlled trial evaluates the efficacy and safety of fluoxetine (40 mg/day) versus placebo in 194 adults with refractory chronic constipation exhibiting Somatic Symptom…
- Conditions
- Refractory Constipation, Somatic Symptom Disorder (DSM-5), Functional Constipation (FC)
- Trial name
- REFLECT (NCT06506136)
- Testing
- Fluoxetine
- Volunteers
- 194 people
- Sponsor
- Zhifeng Zhao, PhD
Functional Neurological Disorders
Functional Neurological Disorders in Patients Admitted in Stroke Units
Functional neurological disorders are an important subgroup of patients with stroke mimics admitted to stroke unit.Their clinical profile and outcome are poorly known.
- Trial name
- NEUROFON (NCT04662372)
- Testing
- Description
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Functional Gastrointestinal Disorders (FGIDs), Infant Discomfort
Effects of Goat Milk Formula on Gastrointestinal Comfort and Growth in Infants
Infant gastrointestinal discomfort is common in early life and can affect feeding, sleep, and overall well-being. Goat milk formula, due to its unique protein composition and smaller fat globules, may be easier to digest and…
- Trial name
- NCT07778927
- Testing
- Goat Milk Formula, Cow Milk Formula
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Functional Neurological Disorder, Conversion Disorder
Restoring Independence With Stimulation-Enhanced Treatment for People With Functional Neurological Disorder
The goal of this clinical trial is to test a new treatment for adults with walking problems due to Functional Neurological Disorder (FND).
- Trial name
- RISE-FND (NCT07769970)
- Testing
- Stimulation-Enhanced Physical Therapy, Active Comparator
- Where
- New Zealand
- Volunteers
- 60 people
- Sponsor
- University of Auckland, New Zealand
Intestinal Functional Disorder, Inflammation
Lactiplantibacillus Plantarum PD01 Supplementation Reduces Microplastics and Microplastic-associated Chemicals in Humans
The study attempts to conduct randomized double-blind controlled trials to understand whether daily exposure to microplastics (MPs) can cause potential impacts on human health, explore whether the intake of Lactiplantibacillus…
- Trial name
- NCT07416214
- Testing
- Probiotics (Lactiplantibacillus plantarum PD01)
- Where
- China
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Fudan University
Functional Gastrointestinal Disorders
Functional GI Disease Registry
The goal of this study is to establish a prospective observational cohort of individuals with functional GI disorders (functional constipation, irritable bowel syndrome, chronic nausea, functional diarrhea, and functional…
- Trial name
- FGIDR (NCT05295446)
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Massachusetts General Hospital
Functional Neurological Disorder
Clinical Evaluation of HRV Biofeedback in Functional Neurological Disorders Compared to Placebo
Evaluation of the clinical effects of the Heart Rate Variability biofeedback training with patients suffering from Functional neurological Disorders compared with placebo.
- Trial name
- HRV_BFB_FND (NCT06422819)
- Testing
- Heart rate variability Biofeedback [HRV-BFB], Pseudo HRV-BFB
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Functional Gastrointestinal Disorders (FGIDs), Weight Loss
Effects of Multi-strain Bacillus Spore Probiotics on Growth, Digestive Function, and Gut Microbiota in Cesarean-Delivered Neonates
Infants born by cesarean section commonly show early weight loss and slower recovery of birth weight, together with characteristic patterns of gut microbiota dysbiosis marked by reduced Bifidobacterium and Bacteroides and…
- Trial name
- NCT07320287
- Testing
- RO water, LiveSpo PREG-MOM, LiveSpo CONSY
- Where
- Vietnam
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Anabio R&D
Functional Movement Disorder
Non-invasive Intermittent Theta Burst Stimulation of the Dorsolateral Prefrontal Cortex in Functional Movement Disorders
Background: Functional movement disorders (FMD) involve involuntary movements that are not due to a recognized neurological or medical cause. FMD can cause major disability.
- Trial name
- NCT05155059
- Testing
- MagStim
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Inflammatory Bowel Disease, Ulcerative Colitis Type, Functional Disorder of Gastrointestinal Tract
Evaluation of the Effects of Colipral on Microbiota Gut Composition in Patients Presenting With Ulcerative Colitis During Remission Phase and Functional Disorders
The study is a double-blind, placebo-controlled, crossover, randomised trial, in which enrolled subjects will be included for 18 months.
- Trial name
- COLIPRAL (NCT07751081)
- Testing
- Food Supplement Colipral in film-coated tablets containing Escherichia coli 5C LMG S-33222
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Padova
Functional Gastrointestinal Disorders
Effect of Fecal Microbiota Transplantation (FMT) in Pediatric Functional Gastrointestinal Disorders
Safety and efficacy of FMT in Pediatric Functional Gastrointestinal Disorders
- Trial name
- FGIDs (NCT05753774)
- Testing
- FMT, Conventional drugs
- Where
- China
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Biao Zou
Functional Somatic Disorder, Somatic Symptom Disorder
Does the First Interview Matter: A Comparing Life Stress Interview Versus a Standard Psychiatric Intake Interview for Patients With Functional Somatic Disorder
Functional somatic syndromes (e.g. irritable bowel syndrome, fibromyalgia) and medically unexplained symptoms (e.g. chronic primary pain) are very common in primary care.
- Trial name
- NCT06149182
- Testing
- Life stress interview according to EAET, Psychiatric interview according to "region stockholm - basutredning"
- Where
- Sweden
- Volunteers
- 189 people
- Sponsor
- Daniel Maroti
Functional Somatic Disorder, Somatic Symptom Disorder
Internet Based Emotional Awareness and Expression Therapy for Functional Somatic Disorder With and Without Therapist Support
Functional somatic syndromes (e.g. irritable bowel syndrome, fibromyalgia) and medically unexplained symptoms (e.g. chronic primary pain) are very common in primary care.
- Conditions
- Functional Somatic Disorder, Somatic Symptom Disorder, Functional Somatic Syndromes
- Trial name
- NCT06301360
- Testing
- Internet based Emotional Awareness and Expression Therapy (I-EAET)
- Where
- 2 sites in Sweden
- Volunteers
- 150 people
- Sponsor
- Daniel Maroti
Persistent Physical Symptoms (PPS), Functional Somatic Disorder
Emotional Awareness and Expression Therapy for Patients With Persistent Physical Symptoms in Routine Psychiatric Care: A Pilot Study
Emotional Awareness and Expression Therapy (EAET) has emerged as a promising approach for addressing persistent physical symptoms (PPS).
- Conditions
- Persistent Physical Symptoms (PPS), Functional Somatic Disorder, Functional Somatic Syndromes, Somatic Symptom Disorder (DSM-5)
- Trial name
- EAET for PPS (NCT06631911)
- Testing
- Emotional Awareness and Expression Therapy (EAET)
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Daniel Maroti
Somatic Symptom and Related Disorders, Somatic Symptom Disorder
Telehealth Group-based Emotional Awareness and Expression Therapy for Patients With Persistent Physical Symptoms: A Pilot Study
Delivering Emotional Awareness and Expression Therapy (EAET) through digital or telehealth platforms in a group format offers several key advantages.
- Conditions
- Somatic Symptom and Related Disorders, Somatic Symptom Disorder, Functional Somatic Disorder, Functional Somatic Syndrome
- Trial name
- NCT06631963
- Testing
- Emotional Awareness and Expression Therapy
- Where
- Sweden
- Sponsor
- Daniel Maroti
Somatic Symptom Disorder, Persistent Physical Symptoms
ISTDP for Patients With Treatment Resistance PPS
Intensive Short-Term Psychodynamic Psychotherapy (ISTDP) for Treatment-Resistant Persistent Physical Symptoms is a therapeutic approach designed to help patients whose physical symptoms have not responded to traditional medical…
- Conditions
- Somatic Symptom Disorder, Persistent Physical Symptoms, Functional Somatic Syndrome, Functional Somatic Disorder
- Trial name
- NCT06682104
- Testing
- Individual intensive short term psychodynamic therapy
- Where
- Sweden
- Volunteers
- 25 people
- Sponsor
- Daniel Maroti
Functional Neurological Disorder
Psilocybin in Functional Neurological Disorder
The goal of this study is to learn about the brain network response in people who have functional neurological disorder who are administered with a single dose of the psychedelic psilocybin with therapeutic support.
- Trial name
- PsiFUND (NCT05723276)
- Testing
- Psilocybin
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- King's College London
Functional Neurological Disorder, Motor Symptoms
Investigating the Neurophysiology of the Motor System and the Feasibility of Vagus Nerve Stimulation in Functional Neurological Disorder (FND)
This clinical study will test if adding a non-invasive stimulation of the vagus nerve through the ear during physiotherapy brings an improvement to FND (Functional Neurological Disorder) patients with motor symptoms.
- Trial name
- TMS-VNS (NCT07710677)
- Testing
- Vagial Nerve Stimulation (VNS) active stimulation
- Where
- Switzerland
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Fribourg
Functional Neurological Disorder
Pilot Neurobehavioral Therapy for Functional Neurological Disorder
The goal of this pilot randomized clinical trial is to learn if Neurobehavioral Therapy (NBT) works to treat motor functional neurological disorder (mFND) (also referred to as functional motor disorder).
- Trial name
- NBT for mFND (NCT06873698)
- Testing
- Neuro-behavioral Therapy, Standard Medical Care (SMC)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Rhode Island Hospital