Clinical trials: Functional Disorder
Bloating, Rifaximin
Rifaximin Treatment in Bloating Predominant Functional Bowel Disorders
This randomized, double-blind, placebo-controlled trial will evaluate the effects of a 14-day course of rifaximin on bloating symptoms, gut microbiota, microbial metabolites, and intestinal gases in adults with Rome V irritable…
- Conditions
- Bloating, Rifaximin, Functional Bowel Disorder, Irritable Bowel Syndrome
- Trial name
- NCT07522255
- Testing
- Rifaximin (drug)
- Where
- Thailand
- Volunteers
- 78 people
- Sponsor
- Mahidol University
Constipation - Functional, Abdominal Distension
Stress Ball and Video Distraction During Pediatric Enema
This randomized controlled trial aims to evaluate the effects of stress ball use and video distraction during enema administration on fear, anxiety, and pain levels in children treated in the pediatric emergency department.
- Trial name
- SAVE (NCT07695428)
- Testing
- Stress Ball, Video Distraction
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Manisa Celal Bayar University
Migraine, Musculoskeletal Pain
Overlapping Pain Trajectory Study
The goal of this observational study is to learn about spatial and temporal nociceptive filtering in adolescents with chronic overlapping pain conditions (COPCs). The main questions it aims to answer are: 1.
- Conditions
- Migraine, Musculoskeletal Pain, Functional Abdominal Pain Disorders, Chronic Pain
- Trial name
- COPC (NCT05752396)
- Testing
- Conditioned Pain Modulation, Offset Analgesia, Spatial Summation
- Where
- United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Epilepsy, Functional Neurological Disorder
EXercise-induced PhysioLogical Adaptations In Neurological Disorders
The goal of this study is to investigate how a one-time exercise session influences different parameters of brain function in people with neurological diseases compared to healthy volunteers.
- Conditions
- Epilepsy, Functional Neurological Disorder, Mild Cognitive Impairment, Dementia
- Trial name
- EXPLAIN (NCT07883720)
- Testing
- Acute Exercise
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Motility Disorder, Gastroparesis
Body Surface Gastric Mapping to Evaluate Patients With Upper Gastrointestinal Symptoms and Controls
This is an analytical validation observational cohort study is designed to provide evidence of: safety and reliability of Body Surface Gastric Mapping using the Gastric Alimetry System (GAS), normal reference values, and…
- Conditions
- Motility Disorder, Gastroparesis, Functional Dyspepsia, Cyclical Vomiting
- Trial name
- NCT05812339
- Testing
- Gastric Alimetry System
- Where
- Canada
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Functional Dyspepsia, Probiotics
Efficacy of Clostridium Butyricum in Alleviating Anxiety and Depression in Patients With Functional Dyspepsia
Objective: This study aims to evaluate the effectiveness of Clostridium butyricum in improving anxiety and depression in patients diagnosed with functional dyspepsia according to the Rome IV criteria.
- Conditions
- Functional Dyspepsia, Probiotics, Depression, Anxiety
- Trial name
- NCT07182890
- Testing
- Clostridium butyricum
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Functional Dyspepsia, Probiotics
Efficacy of Bacillus Coagulans in Alleviating Anxiety and Depression in Patients With Functional Dyspepsia
Objective: This study aims to evaluate the effectiveness of Bacillus coagulans in improving anxiety and depression in patients diagnosed with functional dyspepsia according to the Rome IV criteria.
- Conditions
- Functional Dyspepsia, Probiotics, Depression, Anxiety
- Trial name
- NCT07187492
- Testing
- Bacillus coagulans
- Where
- China
- Volunteers
- 181 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Multiple Sclerosis, Functional Neurological Disorders
Bridging Gaps in the Multidimensional Assessment and Management of Overlapping Symptoms in Multiple Sclerosis and Functional Motor Disorders: Prevalence and Rehabilitation Effectiveness
Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system that may cause a broad range of motor and non-motor symptoms.
- Trial name
- NCT07856485
- Testing
- Functional Motor Disorder-Specific Multidisciplinary Rehabilitation, Conventional Multiple Sclerosis Rehabilitation
- Where
- 2 sites in Italy
- Volunteers
- 192 people
- Sponsor
- IRCCS San Raffaele
Irritable Bowel Syndrome, Inflammatory Bowel Diseases
A Personalized Approach to Abdominal Pain in Irritable Bowel Syndrome
Apart from its use to provide insight in IBS disease courses and in clinical research, ESM can provide patients with feedback about individual triggers of their symptoms, and thereby function as part of a personalized therapeutic…
- Conditions
- Irritable Bowel Syndrome, Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- PERCEPTIvE (NCT05998577)
- Testing
- ESM and Traqq
- Where
- Netherlands
- Volunteers
- 120 people
- Sponsor
- Maastricht University Medical Center
Constipation - Functional, Constipation
The ReVo Study: Low-volume vs High-volume Rectal Irrigation
Rectal irrigation, which is the introduction of warm tap water through the anal canal into the rectum to initiate defaecation, is recommended to be considered in patients with chronic constipation, which is refractory to…
- Conditions
- Constipation - Functional, Constipation, Constipation by Outlet Obstruction, Defecation Disorder
- Trial name
- ReVo (NCT06100055)
- Testing
- Rectal Irrigation
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Functional Neurological Disorders, Multiple Sclerosis
Assessment of the Frequency of Functional Neurological Disorders in Multiple Sclerosis and Analysis of Clinical and Psychological Determinants
Multiple sclerosis (MS) and functional neurological disorders (FND) share clinical features, which may result in FND being overlooked in patients with MS.
- Trial name
- FTNF-SEP (NCT07849816)
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Functional Neurological Symptom Disorder
Measuring Change in Individuals With Functional Neurological Symptom Disorder
Functional Neurological Symptom Disorders (FNSD) are one of the commonest reasons why patients are referred to neurologists. They are as disabling as neurological disorders causing similar symptoms related to more readily…
- Trial name
- NCT07864454
- Testing
- STH Specialist Neurology Pyschotherapy
- Where
- United Kingdom
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Functional Gastrointestinal Disorders
Exploring Novel Therapeutic Approaches for Disorders of Gut-Liver-Brain Interaction-H1/H2
Functional dyspepsia (FD) is associated with inflammatory responses caused by the release of histamine from eosinophils and mast cells, leading to increased intestinal mucosal permeability, which is a key pathogenic mechanism.
- Trial name
- NCT07857941
- Testing
- Famotidine, Levocetirizine, Fuyuan Gasmin
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Irritable Bowel Syndrome (IBS), Functional Dyspepsia
Interactive Effects of Early-Life Stress, Diet, and Metabolism on Gastrointestinal Dysfunction With Neuropsychiatric Symptoms
The goal of this observational case-control study is to learn how stressful experiences, dietary habits, and blood nutrient levels are associated with gastrointestinal symptoms and symptoms of depression and anxiety in adults…
- Conditions
- Irritable Bowel Syndrome (IBS), Functional Dyspepsia, Inflammatory Bowel Disease (IBD), Gastroparesis
- Trial name
- NCT07852819
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shandong University
Functional Neurological Symptom Disorder, Functional Seizures
Accelerated TMS for Seizure-Type Functional Neurologic Disorders
The purpose of this project is to assess the feasibility, tolerability, and preliminary efficacy of using an accelerated, intermittent theta burst stimulation (a-iTBS-rTMS) protocol targeting the left dorsolateral prefrontal…
- Trial name
- FND-seiz (NCT07059325)
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Medical University of South Carolina
Functional Gastrointestinal Disorders (FGIDs), Irritable Bowel Syndrome (IBS)
Mechanism of FODMAP Restriction on FGID Patients
Brief Summary : The goal of this clinical trial is to investigate the effects of differing FODMAP diets on gut microbiota, gut barrier function, symptom severity, quality of life, and psychological status in FGID patients.
- Conditions
- Functional Gastrointestinal Disorders (FGIDs), Irritable Bowel Syndrome (IBS), Functional Dyspepsia
- Trial name
- BRIDGE (NCT07000227)
- Testing
- Low FODMAP diet, Gentle FODMAP diet, Traditional Dietary Advice
- Where
- Malaysia
- Volunteers
- 60 people
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Bodily Distress Syndrome, Functional Somatic Disorder
DISTRESS Trial Functional Disorders - the DISTRESS Trial
A Diagnostic Clinic for Functional Somatic Disorders (FSD) has been set up at the outpatient diagnostic center at Regionshospitalet Silkeborg.
- Trial name
- DISTRESS (NCT06025617)
- Testing
- Diagnostic evaluation at the Diagnostic Clinic for Functional Disorders, Diagnostic as usual
- Where
- Denmark
- Volunteers
- 290 people
- Sponsor
- Regionshospitalet Silkeborg
Functional Abdominal Pain Disorders, Irritable Bowel Syndrome (IBS)
Feasibility Study of a Guided Imagery Therapy Mobile Application for Functional Abdominal Pain Disorders in Children
Chronic abdominal pain is common among children, and the majority of cases are attributed to functional abdominal pain disorders. One approach to treating these disorders is by using psychological therapies.
- Conditions
- Functional Abdominal Pain Disorders, Irritable Bowel Syndrome (IBS), Functional Gastrointestinal Disorders (FGIDs), Gastrointestinal and Digestive Disorder
- Trial name
- NCT07222943
- Testing
- Guided Imagery Therapy
- Where
- 2 sites in United States
- Volunteers
- 63 people
- Sponsor
- Baylor College of Medicine
Binge Eating Behaviour, Eating Disorders
Biobehavioral Mechanisms of Activity and Loss of Control Eating in Children
Loss of control eating in children and adolescents is associated with a host of negative physical and psychological health outcomes and a prognostic marker for development of eating disorders.
- Conditions
- Binge Eating Behaviour, Eating Disorders, Physical Activity, Functional Magnetic Resonance Imaging (fMRI)
- Trial name
- NCT07823153
- Testing
- Go/No-go task, Visual food task, Emotion regulation task
- Where
- 3 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Dallas
Low Back Pain, Functional Motor Disorder
Ultrasound-guided Percutaneous Electrical Stimulation for Gluteus Muscle Dysfunction After Low Back Pain Episode
Percutaneous ultrasound-guided neuromodulation (US-guided PNM) is the electrical stimulation of a peripheral nerve at some point along its pathway or at a muscular motor point under the guidance of an ultrasound probe with a…
- Trial name
- NCT06873386
- Testing
- Valera & Minaya protocol, High-frequency US-guided PNM
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- Marc Badia