Clinical trials: Functional Constipation
Constipation
An Evaluation of the Efficacy and Safety of Tegaserod 6 mg Bid Given Orally to Chinese Patients With Chronic Constipation
Tegaserod is an aminoguanidine indole compound and a member of a new class of 5-hydroxytryptamine (5-HT) agonists. Activation of 5-HT4 receptors triggers the release of neurotransmitters from the enteric nerves which in turn…
- Trial name
- NCT00139568
- Testing
- Tegaserod
- Where
- Switzerland
- Volunteers
- 600 people
- Sponsor
- Novartis
Constipation, Irritable Bowel Disease
Relationship Between Interoception and Postural Control in Constipation-Predominant Irritable Bowel Syndrome
This cross-sectional, observational, controlled comparative study aims to investigate the relationship between interoception and postural control in individuals with constipation-predominant irritable bowel syndrome (IBS-C) and…
- Trial name
- NCT07870915
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Stroke Rehabilitation
Visceral Mobilization and Functional Constipation in Stroke Survivors
The aim of the present study was to evaluate the effect of visceral mobilization on symptoms of functional constipation and static balance in stroke survivors.
- Trial name
- NCT03031977
- Testing
- visceral mobilization
- Volunteers
- 30 people
- Sponsor
- University of Sorocaba
Functional Constipation, Gastric Emptying
Effect of TU-100 on Rectal Compliance, Rectal Sensation and Small Bowel and Colonic Transit in Females With Constipation
The purpose of this study is to assess the dose-related effects of TU-100, a botanical agent that modulates gastrointestinal nerves, on rectal compliance, rectal sensation thresholds and small bowel and colonic transit in female…
- Conditions
- Functional Constipation, Gastric Emptying, Whole Gut Transit, Small Bowel Transit
- Trial name
- NCT01139216
- Testing
- Daikenchuto (TU-100)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Tsumura USA
Gastrointestinal Symptoms, Constipation
Impact of Weizmannia (Bacillus) Coagulans JBI-YZ6.3 on Gut Health and Fecal Microbiome Changes
This study will evaluate the effects of supplementation with Weizmannia (Bacillus) coagulans JBI-YZ6.3 on gastrointestinal health in healthy, physically active adults.
- Conditions
- Gastrointestinal Symptoms, Constipation, Gut Health, Gastrointestinal Function
- Trial name
- WIZ (NCT07388264)
- Testing
- Weizmannia (Bacillus) coagulans JBI-YZ6.3
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Lindenwood University
Functional Constipation, Emotional Problems
Early Screening of Emotional, Behavioral and Autism Spectrum Disorders in Children With Functional Constipation.
A significant group of children with functional constipation (FC) continues to have symptoms despite recommended standard therapy. Underlying psychiatric problems could explain therapy resistance.
- Conditions
- Functional Constipation, Emotional Problems, Behavioural Problems, Developmental Disorder
- Trial name
- NCT03614000
- Testing
- Screening Questionnaires
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitair Ziekenhuis Brussel
Constipation - Functional
Safety, Tolerability and Pharmacokinetics of CDD-2101 in Health Volunteers
This is a single-center, randomized, double-blind, placebo-controlled, single-dose study to confirm the safety, tolerability and pharmacokinetic profile of CDD-2101 in healthy subjects.
- Trial name
- NCT06570668
- Testing
- CDD-2101
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre for Chinese Herbal Medicine Drug Development Limited
Functional Constipation, Gastrointestinal Disease
Efficacy and Safety of Vibrating Capsule in Patients With Functional Constipation
The safety and efficacy of vibrating capsule (VC) in promoting defecation by mechanical stimulation of the gastrointestinal walls have been elucidated in animal studies and pilot clinical studies.
- Conditions
- Functional Constipation, Gastrointestinal Disease, Capsule Endoscopy
- Trial name
- NCT04671264
- Testing
- Sallowing VC during six weeks
- Where
- China
- Volunteers
- 107 people
- Sponsor
- Changhai Hospital
Chronic Idiopathic Constipation, Functional Constipation
Botulinum Toxin Injection Versus Anal Myectomy in Management of Idiopathic Constipation
Chronic idiopathic constipation is most common cause of Constipation in childhood with numerous cases in Egypt. Numerous conservative measures were tried but many fail.
- Trial name
- NCT02361749
- Testing
- Botulinum Toxin, Anal Myectomy
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Fecal Incontinence, Constipation
Studies in Patients With Defecatory Disorders
Defecatory disorders like chronic constipation and faecal incontinence affect 25% of the population with rising incidence. Defecatory disorders pose a major health care burden and are poorly recognized and treated.
- Trial name
- NCT03317938
- Testing
- Fecobionics
- Where
- 2 sites in Hong Kong
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- Giome
Functional Constipation
Effect of Ileal Bile Acid Transporter Inhibitor in Functional Constipation
This is a single-center, randomized, parallel group, double-blind, placebo-controlled, dose response, pharmacodynamic and pharmacokinetic study evaluating the effects of A3309 on gastric, intestinal and colonic transit in…
- Trial name
- NCT01038687
- Testing
- A3309
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Michael Camilleri, MD
Pelvic Floor Dysfunctions
Effectiveness of Modern Physical Agents in the Treatment of Pelvic Floor Dysfunctions
This clinical trial aims to determine whether adding modern physical agents (high-intensity laser therapy, magnetotherapy, radial shock wave therapy, kinesiotaping) in conjunction with classical rehabilitation interventions…
- Trial name
- EMPHAT-PFD (NCT06800222)
- Testing
- modern agents rehab, classical rehab
- Where
- Lithuania
- Volunteers
- 250 people
- Sponsor
- Lithuanian University of Health Sciences
Prader-Willi Syndrome, Constipation
The Intestinal Function in People With Prader-Willi Syndrome
The projects aim is to investigate the intestinal function of patients suffering from Prader-Willi Syndrome. The methods used are ultrasonographic measurement of the rectal diameter and gastrointestinal transit time
- Conditions
- Prader-Willi Syndrome, Constipation, Incontinence
- Trial name
- NCT01523288
- Where
- Denmark
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Autism Spectrum Disorder
Efficacy of Vivomixx on Behaviour and Gut Function in Autism Spectrum Disorder
The purpose of this study is to assess the effects of 3 months supplementation with the multi strain probiotic Vivomixx on the overall function, aberrant behaviours and frequency of gastrointestinal symptoms in children with…
- Trial name
- VIVO-ASD (NCT03369431)
- Testing
- Vivomixx
- Where
- United Kingdom
- Volunteers
- 69 people
- Sponsor
- University College, London
Diabetes Mellitus, Constipation - Functional
Effects of Lactulose on Gut Microbiota and Metabolism in Diabetic Constipated Patients
Constipation is the most common gastrointestinal manifestation in diabetic patients. Emerging evidence suggests that gut microbiota dysbiosis may contribute to the pathogenesis of diabetes, highlighting the need to investigate…
- Trial name
- NCT07065942
- Testing
- Lactulose oral solution, Live Combined B. Subtilis and E. Faecium Enteric-coated Capsules
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital
Constipation - Functional
Evaluation of the Safety of Lubiprostone in Pediatric Participants Aged ≥ 6 Years to < 18 Years With Functional Constipation
A study of the safety of lubiprostone in pediatric participants aged ≥ 6 Years to < 18 years diagnosed with functional constipation.
- Trial name
- NCT02766777
- Testing
- Lubiprostone
- Where
- 13 sites in United States
- Volunteers
- 87 people
- Sponsor
- Sucampo Pharma Americas, LLC
Constipation
Effects of Alpha-1 Antagonist, Stress and Relaxation on Anorectal Functions
This study is designed to better understand the effects of effects of stress, relaxation, and a medication alfuzosin on bowel control and emptying in healthy people and patients with bowel problems.
- Trial name
- NCT01834729
- Testing
- Alfuzosin
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Functional Colonic Disease, Fecal Incontinence
Effect of Lumbo-sacral Magnetic Stimulation on Colonic Motility
The purpose of this study is to evaluate the effect of sacral nerve magnetic stimulation on the colonic motility in healthy subjects, in incontinent and constipated patients.
- Trial name
- NCT00213317
- Testing
- lombo-sacral magnetic stimulation
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Irritable Bowel Syndrome Characterized by Constipation
Food Supplement Physiomanna® Baby in Pediatric Patients
The primary objective is to assess the efficacy and safety of the Food Supplement Physiomanna® Baby in pediatric patients with a history of functional constipation The secondary objective of the trial is to evaluate the adherence…
- Trial name
- NCT02732743
- Testing
- Physiomanna® Baby
- Where
- Romania
- Volunteers
- 45 people
- Sponsor
- Iuppa Industriale Srl
Bowel Function Dissatisfaction
Impact of a Dried Vegetable on Bowel Function and Gut Microbiota
A randomized, placebo-controlled, parallel, double-blind trial with three intervention arms and a period of four intervention-weeks that assesses the intake of different dosages of a complex fiber product on bowel function via…
- Trial name
- HappYFiber (NCT05473793)
- Testing
- Dried chicory root particles
- Where
- Netherlands
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Wageningen University