Clinical trials: Frozen Sections
Frozen Sections, Indocyanine Green (ICG)
A PROSPECTIVE, SINGLE-CENTERED, ASSESSOR-BLINDED STUDY TO EVALUATE THE CLINICAL EFFICACY OF THE PROPOSED CELL/TISSUE HISTOPATHOLOGY PROCESSOR CCELL (CONFOCAL FLUORESCENCE ENDOMICROSCOPY) FOR INTRAOPERATIVE DIAGNOSIS IN BRAIN TUMORS
The primary objective of this single-center study is to demonstrate the performance of cCeLL, used in real time, compared to frozen section analysis.
- Conditions
- Frozen Sections, Indocyanine Green (ICG), Brain Tumor
- Trial name
- NCT07254845
- Testing
- cCeLL In vivo, Indocyanine Green
- Volunteers
- 30 people
- Sponsor
- VPIX Medical
Lung Adenocarcinoma, Frozen Section
Sublobar Resection for Adenocarcinoma in Situ/Minimally Invasive Adenocarcinoma Diagnosed by Intraoperative Frozen Section (ECTOP-1019)
This is a clinical trial from Eastern Cooperative Thoracic Oncology Project (ECTOP), numbered as ECTOP-1019. The goal of this clinical trial is to confirm the therapeutic effect of sublobar resection for AIS/MIA diagnosed by…
- Conditions
- Lung Adenocarcinoma, Frozen Section, Sublobar Resection
- Trial name
- NCT06031181
- Testing
- Sublobar Resection
- Where
- China
- Volunteers
- 390 people
- Sponsor
- Fudan University
Lung Cancer
Precision Diagnosis for Intraoperative Frozen Section of Early Stage Lung Cancer
The purpose of this study is: 1. To establish a set of diagnostic criteria of intraoperative frozen section of early stage lung adenocarcinoma, including clinicopathologic and molecular characteristics. 2.
- Trial name
- NCT02941003
- Testing
- microscope, immunostaining, NGS
- Where
- China
- Volunteers
- 540 people
- Sponsor
- Shanghai Chest Hospital
Prostate Cancer
Nerve-sparing, Robot-assisted Radical Prostatectomy Using a Personalized, 3D-printed Prostate Model for Selective Resection of Positive Surgical Margins
To optimize precision for secondary resection (SR) in frozen section (FS) controlled nerve-sparing robot-assisted radical prostatectomy (NS-RARP) by using a personalized 3D-printed prostate model.
- Trial name
- AURORA (NCT05960669)
- Testing
- 3D model guided secondary resection
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University Hospital, Basel, Switzerland
Breast Cancer
Evaluation of Breast Cancer Surgical Margins Using Optical Spectroscopy
This study will apply optical spectroscopy to intraoperative margin assessment during surgery for breast cancer. We hypothesize that a combination of fluorescence spectroscopy and diffuse reflectance spectroscopy will reliably…
- Trial name
- NCT00214292
- Testing
- fluorescence spectroscopy and diffuse spectroscopy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Wisconsin, Madison
Breast Cancer
Omitting vs. Doing Intraoperative Frozen Section Biopsy for Margin Status in Breast Conserving Surgery
Study phase: 3 Indication: Breast cancer patients undergoing breast conserving surgery Primary objectives: To determine the effect of selective omission of intraoperative margin evaluation via frozen section on margin positive…
- Trial name
- OFF-MAP (NCT03975179)
- Testing
- Omission of intraoperative frozen section biopsy for margin status, Frozen section biopsy for margin status
- Where
- 2 sites in South Korea
- Volunteers
- 1,292 people
- Sponsor
- Samsung Medical Center
Benign Brain Tumor, Malignant Brain Tumor
Evaluation of cCeLL-Ex Vivo Confocal Microscopy for Real-time Brain Tumor Diagnosis
Intra-operative evaluation of residual brain tumor currently relies on frozen-section histopathology, which typically requires 20-30 minutes for tissue processing and interpretation, prolonging operative time and increasing…
- Trial name
- cCeLLExvivo (NCT06098248)
- Testing
- cCeLL - Ex vivo
- Where
- 4 sites in Canada, South Korea
- Volunteers
- 285 people
- Sponsor
- VPIX Medical
Head and Neck Carcinoma, Frozen Section Management
Optimization of Communication Between Surgery and Pathology
The aim of the study is to investigate the extent to which the oncological safety of frozen sections can be improved through visual communication between head and neck surgery and pathology.
- Trial name
- DigiComSurg (NCT07378345)
- Testing
- visual description of frozen section results during surgery
- Where
- Germany
- Volunteers
- 155 people
- Sponsor
- Heidelberg University
Lymph Node Metastasis, Breast Cancer
Sensitivity and Predictive Value of Frozen Section of Sentinel Lymph Node Biopsy in Post Neoadjuvant Setting
Axillary lymph node status is one of the most important prognostic factors in primary breast carcinomas. Sentinel lymph node biopsy has been increasing in post neoadjuvant setting when axillary nodes show good clinical and…
- Trial name
- NCT06401590
- Testing
- FROZEN SENTINEL LYMPH NODE BIOPSY
- Where
- Pakistan
- Volunteers
- 286 people
- Sponsor
- Aga Khan University
Colo-rectal Cancer
Safety & Efficacy of a Novel Asymmetrical Linear Stapler (NALS) for Securing Distal Resection Margin in Laparoscopic Rectal Cancer Surgery: Pilot Study
Through the use of a novel asymmetrical linear stapler (NALS, Meditulip co. Ltd.), we aim to prove that true distal margins greater than 1cm may be harvested more readily and easily compared to the conventional staplers.
- Trial name
- NCT06709170
- Testing
- Novel asymmetrical linear stapler, Signia™
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Lung Adenocarcinoma, Surgical Procedure, Unspecified
Intraoperative Frozen Section Pathology to Guide Surgical Treatment for Lung Adenocarcinoma (ECTOP-1015)
This study is one of Eastern Cooperative Thoracic Oncology Projects (ECTOP-1015). The goal of this clinical trial is to confirm the concordance rate between intra-operative frozen section pathological diagnosis and post-operative…
- Conditions
- Lung Adenocarcinoma, Surgical Procedure, Unspecified, Pathology
- Trial name
- NCT05794711
- Testing
- Surgical resection
- Where
- China
- Volunteers
- 1,063 people
- Sponsor
- Fudan University
Frozen Sections, Indocyanine Green
Multi-center Study on CCeLL-In Vivo's Clinical Efficacy for Intraoperative Brain Tumor Diagnosis.
The primary objective of this study is to demonstrate the non-inferiority of cCeLL compared to frozen section analysis. The investigational device is intended for use with indocyanine green (ICG) for fluorescence imaging as an…
- Conditions
- Frozen Sections, Indocyanine Green, Brain Tumor
- Trial name
- PRECISION (NCT06867978)
- Testing
- cCeLL In vivo, Indocyanine Green
- Volunteers
- 100 people
- Sponsor
- VPIX Medical
Papillary Thyroid Cancer, Lymph Node Metastasis
Frozen Section-Guided Selective Ipsilateral Central Neck Dissection in Bethesda V-VI Thyroid Nodules
The goal of this observational pilot cohort study is to evaluate the feasibility and clinical implications of frozen section analysis-guided selective ipsilateral central neck dissection in adult patients undergoing primary…
- Trial name
- NCT07659717
- Testing
- Frozen section analysis (FSA)
- Where
- Italy
- Volunteers
- 66 people
- Sponsor
- Eleonora Lori, MD
Breast Neoplasms
Frozen Section Examination of Sentinel Lymph Nodes in Breast Cancer
This prospective randomized clinical study evaluates the role of intraoperative frozen section examination of sentinel lymph nodes in patients with breast cancer.
- Trial name
- NCT07591506
- Testing
- Intraoperative Frozen Section Examination of Sentinel Lymph Node, Routine Postoperative Histopathological Evaluation of Sentinel Lymph Node
- Where
- Turkey (Türkiye)
- Volunteers
- 142 people
- Sponsor
- Izmir City Hospital
Lymph Node Metastases, Non-small Cell Lung Cancer Stage I
Mediastinal Staging Accuracy of a Selective Lymphadenectomy Strategy in Early Stage NSCLC (ECTOP-1003)
This is a clinical trial from Eastern Cooperative Thoracic Oncology Project (ECTOP), numbered as ECTOP-1003. Systemic mediastinal lymphadenectomy is deemed indispensable in lung cancer surgery for accurate staging and complete…
- Trial name
- NCT03216551
- Testing
- Intra-operative frozen section
- Where
- China
- Volunteers
- 1,076 people
- Sponsor
- Fudan University
Oral Squamous Cell Carcinoma
Toluidine Blue Versus Frozen Sections for Assessment of Tumor Margins in Oral Squamous Cell Carcinoma
The purpose of this study is to test the accuracy of toluidine blue in the assessment of intraoperative tumor margin after excision of oral squamous cell carcinoma(OSCC)in comparison to H\&E stain on frozen section.
- Trial name
- NCT03554967
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Event of Undetermined Intent (Y21-Y33)
Diagnostic Value of Bronchoscopic and Thoracoscopic Frozen Section Biopsies in Patients With Pleuropulmonary Tumors
Lung cancer is the second most commonly diagnosed cancer worldwide, after breast cancer, and its incidence continues to grow. Flexible bronchoscopy is the diagnostic tool of choice to diagnose endobronchial malignancies.
- Trial name
- NCT05385419
- Testing
- Bronchoscopic and thoracoscopic frozen section biopsies
- Volunteers
- 96 people
- Sponsor
- Assiut University
Basal Cell Carcinoma
Confocal Microscopy Evaluation of Margin Clearance in Basal Cell Carcinomas in Mohs Surgery
This study is comparing the accuracy and speed of the Vivascope 2500 ex-vivo fluorescent confocal microscope with frozen section Mohs histology in evaluating clear margins in basal cell carcinoma in Mohs surgery.
- Trial name
- FCM-P (NCT03610620)
- Testing
- Vivascope 2500 ex-vivo fluorescent confocal microscope
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Julie Dawson
Lung Neoplasms, Carcinoma, Non-Small-Cell Lung
Radiomics Multifactorial Biomarker for Pulmonary Nodules
The investigators aim to investigate the utility of radiomics to differentiate malignant nodules from benign nodules and invasive adenocarcinoma from non-invasive adenocarcinoma.
- Conditions
- Lung Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Diseases, Neoplasms
- Trial name
- RMBPN (NCT03872362)
- Testing
- radiomics
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Maastricht University
Intracranial Tumor
Comparison of Fluorescein-INtra-VItal Microscopy Versus Conventional Frozen Section Diagnosis for intraOperative Histopathological Evaluation
With the appliance of the in-vivo microscopy after Fluorescein staining, the investigators hypothesize that the preliminary in-vivo histopathological diagnostic accuracy is not inferior to conventional frozen section analysis…
- Trial name
- INVIVO (NCT04597801)
- Testing
- Alcon
- Where
- 3 sites in Germany
- Volunteers
- 210 people
- Sponsor
- Technical University of Munich