Clinical trials: Free Tissue Transfer
Toe Transfer, Free Tissue Flap
Long Term Follow up of Toe-to-hand Transfers
Toe transfers are perceived to have changed the landscape of the injured hand over the last half century, yet there are limited validated data that unequivocally support the functional role of toe transfers after traumatic…
- Conditions
- Toe Transfer, Free Tissue Flap, Patient Reported Outcome Measures
- Trial name
- NCT06487676
- Testing
- Toe transfer, Replantation
- Volunteers
- 75 people
- Sponsor
- Chang Gung Memorial Hospital
Hantavirus Pulmonary Infection, Immunisation
Andes Virus DNA Vaccine for the Prevention of Hantavirus Pulmonary Syndrome Using the PharmaJet Stratis(R) Needle-Free Injection Delivery Device
This is a Phase 1, randomized, placebo controlled, double-blind, dose escalation trial of 48 males and non-pregnant females, 18-49 years old, inclusive, who are in good health and meet all eligibility criteria.
- Trial name
- NCT03682107
- Testing
- Andes virus DNA vaccine
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Oxygen Supply Absent
Monitoring Free Tissue Transfer Hemodynamics Using NIRS
Free tissue transfer (FTT) is a surgical procedure for repairing cancer resection wounds. Free tissue transfer usually involves taking skin from one area of the body (e.g.
- Trial name
- NCT06661525
- Testing
- Free Flap NIRS
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- University of British Columbia
Head and Neck Cancer, Free Tissue Transfer
Local Infusion of Ropivacaine for Post-Op Pain Control After Osseocutaneous Free Flaps
Head and neck oncologic surgery often requires the use of free tissue transfer, or microvascular reconstruction, to reconstruct defects created by tumor resections.
- Trial name
- NCT03349034
- Testing
- Ropivicaine, Local Saline Infusion
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Free Tissue Transfer, Mandible Reconstruction
Traditional Versus Computerized Mandibular Reconstruction
This study will test the accuracy of computerized custom mandibular reconstruction to traditional methods of mandibular reconstruction using a vascularized osteocutaneous fibula flap.
- Conditions
- Free Tissue Transfer, Mandible Reconstruction, Computerized Customization
- Trial name
- NCT02913807
- Testing
- Customized Jigs and Plates, Hand Contoured Osteotomies and Reconstruction Bars
- Where
- United States
- Sponsor
- Boston Medical Center
Microsurgery, Lymphedema
CONNECT: A Multi-Cohort, Prospective Investigation of the Symani® Surgical System
The objective of this clinical study is to evaluate the Symani System's safety and effectiveness for microsurgical anastomosis during free tissue transfer surgery and lymphatic surgery.
- Conditions
- Microsurgery, Lymphedema, Free Tissue Transfer
- Trial name
- CONNECT (NCT06866197)
- Testing
- Symani Surgical System
- Where
- Australia
- Volunteers
- 180 people
- Sponsor
- MMI (Medical Microinstruments, Inc.)
Postpartum Pain, Postpartum Depression
Neuraxial Preservative Free Morphine for Normal Spontaneous Vaginal Delivery
Patients presenting for normal spontaneous vaginal delivery who have a neuraxial anesthestic will be randomized to receive preservative free morphine or saline placebo after delivery.
- Conditions
- Postpartum Pain, Postpartum Depression, Opioid Consumption
- Trial name
- NCT04017442
- Testing
- Preservative Free Morphine, Saline
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Breast Neoplasms, Ischemia-Reperfusion Injury
DIEP Flap Breast Reconstruction: Perioperative Biomarkers and Outcomes
Brief Summary This observational study will follow patients who undergo DIEP flap breast reconstruction to better understand a common surgical challenge called ischemia-reperfusion (I/R) injury.
- Conditions
- Breast Neoplasms, Ischemia-Reperfusion Injury, Postoperative Complications, Wound Healing
- Trial name
- NCT07263347
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Hubei Cancer Hospital
Agitation, Delirium
Dexmedetomidine to Prevent Agitation After Free Flap Surgery
Reconstruction using microvascular free tissue flap has been an important management in patients with maxillofacial tumor. It is often characterised as long operation time, more traumatic and require restriction of patient's head…
- Trial name
- NCT01904760
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking University
Mastectomy, Breast Reconstruction
Sensation After Nipple Sparing Mastectomy and Breast Reconstruction With or Without Neurotized Free Tissue Transfer
Tissue Expander/Implant Reconstruction: The purpose of this study is to determine how and when nerve sensation to the breast skin returns after mastectomy.
- Trial name
- NCT03135392
- Testing
- Breast Reconstruction with Artificial Implant, Autologous Breast Reconstruction, Neurotization
- Where
- United States
- Sponsor
- Case Comprehensive Cancer Center
Neoplasm, Oral, Osteoradionecrosis of Jaw
Jaw Reconstruction With Printed Titanium and Free Tissue Transfer
JaW PrinT is a prospective observational cohort study evaluating the effectiveness of two different techniques of mandibular reconstruction.
- Conditions
- Neoplasm, Oral, Osteoradionecrosis of Jaw, Mandibular Diseases, Jaw Cancer
- Trial name
- JaW PrinT (NCT03905005)
- Testing
- Mandibular reconstruction with free tissue transfer.
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of South Wales
Reconstructive Surgical Procedures, Tissue Transplantation
Monitoring of Tissue Transfer Flaps by Modulated Imaging (MI) Spectroscopy
Tissue transfer flaps are a method of moving tissue from a donor location to a recipient location. In the case of a free tissue transfer flaps, the blood vessels to the transferred tissues are detached and then re-attached to…
- Trial name
- NCT00633503
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- University of California, Irvine
Head and Neck Cancer, Free Tissue Transfer
Early Feeding After Oral Cavity Reconstruction
This is a prospective single-arm non-inferiority trial evaluating surgical outcomes in subjects who are fed in the first days after oral cavity reconstructive surgery.
- Trial name
- NCT04787939
- Testing
- Early Feeding
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Psoriasis
Triamcinolone Acetonide Injections in Mild-to-moderate Chronic Plaque Psoriasis With a Novel Needle-free Drug-delivery System
This is an observational pilot study comparing triamcinolone acetonide injections with the investigational Med-jet needle-free drug-delivery system as an alternative to using a conventional syringe and needle in patients with…
- Trial name
- NCT04410237
- Testing
- Med-Jet, Traditional Syringe
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University Hospitals Cleveland Medical Center
Breast Reconstruction
Single Centre Study to Compare Harmonic Scalpel to Conventional Diathermy in Free Tissue Transfer Breast Reconstruction
The purpose of this single centre study is to evaluate whether the use of Harmonic Synergy Dissecting Hook (Harmonic Scalpel) in breast reconstruction surgery is superior to conventional diathermy in terms of improving ease and…
- Trial name
- HARMONIC001 (NCT00778947)
- Testing
- Harmonic Synergy Dissecting Hook (Harmonic Scalpel), Electrocautery Diathermy
- Where
- United Kingdom
- Sponsor
- St Andrew's Centre for Plastic Surgery
Head and Neck Cancer, Patients Requiring a Free Flap Surgery
A Prospective Study Evaluating the Use of Intraoperative Stroke Volume Variation Via the FloTrac Device to Guide Fluid and Vasopressor Management in Head and Neck Free Flaps
This study aims to investigate whether the intraoperative use of the FloTrac device to guide fluid and vasopressor management during head and neck free flap surgery improves postoperative outcome.
- Trial name
- NCT02186938
- Testing
- FloTrac
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Medical University of South Carolina
Oral Cancer, Head and Neck Cancer
Assessment of the Effects of Pressors on Graft Blood Flow After Free Tissue Transfer Surgery
Following surgery to remove tumours of the head and neck, patients undergo reconstruction with free flaps - tissue that is taken from elsewhere in the body and given a new blood supply by attaching it to vessels in the neck.
- Conditions
- Oral Cancer, Head and Neck Cancer, Free Flap, Hypotension
- Trial name
- Free4Flow (NCT01418118)
- Testing
- Epinephrine, Norepinephrine, Dobutamine
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Oxford University Hospitals NHS Trust
Open Fracture of Foot, Tumor
Randomized Study on the Effects of Moderate Anaemia in Free Microvascular Tissue Transfer
The evaluation of Perfusion of free flaps in patients with moderate anaemia and possible reduction of the transfusion threshold. Trial with surgical intervention
- Trial name
- NCT01848431
- Where
- Switzerland
- Sponsor
- University of Zurich
Dental Implant
Using Buccal Pad of Fat Free Tissue Transfer With Immediate Implant Placement
Implants placed immediately after tooth extraction usually present challenges in obtaining soft tissue coverage with high risk of bacterial invasion, wound dehiscence and subsequently adverse effect on the success rate of the…
- Trial name
- NCT04415619
- Testing
- Xenograft bone substitute (Osteo-biol)
- Volunteers
- 10 people
- Sponsor
- Alexandria University
Alopecia Areata
Needle-free Delivery of Intralesional Triamcinolone for Pediatric Alopecia Areata
This is an interventional pilot study assessing the tolerability of needle-free delivery administration of ILTA with the Med-Jet as an alternative to conventional syringe and needle in patients with patchy pediatric alopecia…
- Trial name
- NCT05278858
- Testing
- MedJet Device with intralesional triamcinolone
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University Hospitals Cleveland Medical Center