Clinical trials: Frailty in Aging
Frailty
A Study of Human Allogeneic Bone-marrow-derived Mesenchymal Stromal Cell Product (StromaForte) in Patients With Aging Frailty
The goal of this phase I/II clinical trial is to evaluate the safety and tolerability of intravenous infusion of human allogeneic bone-marrow-derived mesenchymal stromal cell product StromaForte in patients with aging frailty.
- Trial name
- NCT06070532
- Testing
- Human Allogeneic Bone-Marrow-Derived Mesenchymal Stromal Cell Product (StromaForte)
- Where
- The Bahamas
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cellcolabs Clinical LTD.
Frailty, Disability Physical
Functional Decline and QoL in People Aging with HIV in Asia
This is a multi-center prospective cross-sectional study to determine the burden of decline in intrinsic capacity and functional ability, and the prevalence of geriatric syndromes, such as frailty, and disability in adult people…
- Conditions
- Frailty, Disability Physical, HIV/AIDS
- Trial name
- NCT04212884
- Where
- 2 sites in Hong Kong
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Frailty, Motoric Cognitive Risk Syndrome
Cognitive Prefrail and Frailty, and Motoric Cognitive Risk Syndrome: Prevalence and Association With Incident Adverse Health Events
We defined a new and early condition in the spectrum of cognitive frailty: the "cognitive-prefrailty" which is a combination of prefrailty stage and subjective cognitive impairment (SCI).
- Conditions
- Frailty, Motoric Cognitive Risk Syndrome, Cognitive-prefrailty
- Trial name
- NCT04275817
- Testing
- Data collection
- Where
- Canada
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Jewish General Hospital
Frailty Syndrome, Aging
Safety and Preliminary Efficacy of Adipose-Derived Stem Cell Secretome in Frailty (VinVital)
This is a Phase I, open-label, non-randomized clinical trial to evaluate the safety and preliminary efficacy of adipose-derived mesenchymal stem cell secretome capsules (VinVital) in patients with frailty syndrome.
- Trial name
- VinVital (NCT07856602)
- Testing
- VinVital
- Volunteers
- 20 people
- Sponsor
- Vinmec Research Institute of Stem Cell and Gene Technology
Frailty Syndrome, Older Adults, Balance
Effectiveness of Immersive Virtual Reality Combined With Occupational Therapy in Reducing Fall Risk and Frailty Among Older Adults
Population aging is a growing global phenomenon that poses significant challenges to healthcare systems, particularly in preventing falls and managing frailty among older adults.
- Conditions
- Frailty Syndrome, Older Adults, Balance, Fall Prevention in Healthy Aging
- Trial name
- VIRTO-FRAIL (NCT07060677)
- Testing
- Inmersive Virtual Reality, Conventional occupational therapy sessions
- Where
- 2 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Universidad Rey Juan Carlos
Aging, Frailty
Effect of Infections and Global DNA Methylation on Frailty Trajectories in Hospitalized Older Patients (INFRAGEN)
This prospective multicenter study aims at exploring the impact of infections on intra-hospital and 3-month changes in the frailty profile of older inpatients.
- Conditions
- Aging, Frailty, Telomere Shortening, Inflammation
- Trial name
- INFRAGEN (NCT06430073)
- Volunteers
- 340 people
- Sponsor
- University Hospital of Ferrara
Nursing Caries, Old Age; Debility
Multifactorial Study of the Relationship Between the Conditions of Life and the Incidence of Risk of Falling
HYPOTHESIS: The incidence of risk of falls is related to the living conditions of elderly people in the community. OBJECTIVES: To study the relationship between living conditions and the incidence of risk of falls in older adults…
- Conditions
- Nursing Caries, Old Age; Debility, Aging Disorder
- Trial name
- NCT04301713
- Testing
- Evaluation of rik of falls
- Where
- Spain
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Healthy Ageing, Frailty
An Intrinsic Capacity Identification and Management Programme for Older Adults in Singapore's Primary Care
The IMPACTFrail program is an intrinsic capacity (IC) identification and management program for mildly frail older adults. Specifically, it delivers the three-tier approach recommended in the National Frailty Strategy Policy…
- Trial name
- IMPACTFrail (NCT06753643)
- Testing
- The IMPACTFrail programme
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Geriatric Education and Research Institute
Frailty
Safety, Efficacy of FFP From Healthy Donors to Ameliorate Frailty and Enhance Immune Function in Older Individuals
1. Primary Objective To determine the safety and tolerability of 12 once monthly transfusions of GMFFP (Granulocyte - Colony Stimulating Factor (G-CSF) Mobilized Fresh Frozen Plasma harvested from young, healthy donors), given to…
- Trial name
- NCT03458429
- Testing
- GMFFP
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dipnarine Maharaj
Aging, Frailty
Cognitive-Motor Exergame Training in Frail Adults
This international multicentre pragmatic randomized controlled trial (RCT) aims to evaluate the effectiveness of personalized, home-based cognitive-motor training using exergames in improving cognitive and motor functions in…
- Trial name
- SMART (NCT07074639)
- Testing
- Personalized, home-based motor-cognitive exergame training, Otago Exercise Program
- Where
- Switzerland
- Volunteers
- 344 people
- Sponsor
- Eleftheria Giannouli
Frailty, Sarcopenic Obesity
Diet and Exercise Plus Metformin to Treat Frailty in Obese Seniors
The continuing increase in prevalence of obesity in older adults including many older Veterans has become a major health concern.
- Conditions
- Frailty, Sarcopenic Obesity, Aging
- Trial name
- DEMFOS (NCT04221750)
- Testing
- Lifestyle therapy, Metformin Hydrochloride, Healthy Lifestyle
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Old Age; Debility, Aging
Virtual Reality Training to Increase Rehabilitative Exercise in Seniors
Seniors are at risk for reduced independence and lowered quality of life after injury or illness. Gains in strength, stamina, balance, cardiovascular fitness and confidence resulting from regular exercise can help seniors to…
- Trial name
- NCT04083885
- Testing
- Virtual Reality
- Where
- 7 sites in Canada
- Volunteers
- 47 people
- Sponsor
- Bruyère Health Research Institute.
Old Age; Debility
Older People Gait: Physiomechanics and Functionality
The aim of study is to investigate gait in active elderly people regarding the kinematic parameters of gait, indicators of physical fitness and quality of life.
- Trial name
- NCT04348539
- Testing
- Balance training
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Delirium in Old Age, Delirium in the Intensive Care Unit
Multi-Component Delirium Prevention Bundle in Older Cardiac Intensive Care Unit Patients
The goal of this randomized controlled clinical trial is to learn whether a structured delirium prevention protocol can reduce the occurrence of delirium in older adults admitted to the cardiac intensive care unit (CICU).
- Conditions
- Delirium in Old Age, Delirium in the Intensive Care Unit, Delirium Confusional State, Delirium
- Trial name
- CICUDEL (NCT07776184)
- Testing
- Multicomponent Delirium Prevention Bundle, Control Group
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Tel Aviv Medical Center
Frailty, Sarcopenia
Effect of a Multicomponent Therapeutic Exercise Program in Primary Care on Frailty and Sarcopenia in Older Adults
Background: Frailty and sarcopenia are common conditions in older adults that increase the risk of disability, dependence, and hospitalizations.
- Conditions
- Frailty, Sarcopenia, Aging, Exercises Therapy
- Trial name
- FRACTEP-65 (NCT07132632)
- Testing
- 12-week multicomponent therapeutic exercise program including supervised and home-based sessions focused on strength, balance, mobility, and aerobic capacity
- Volunteers
- 60 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
HIV, Frailty
Improving Physical Ability and Cellular Senescence Elimination in HIV
This clinical trial is a Phase II study designed to test the safety and effectiveness of a combination of dasatinib and quercetin (D+Q) in improving physical function for people with HIV who are frail or prefrail.
- Conditions
- HIV, Frailty, Prefrail, Aging Problems
- Trial name
- IPACE-HIV (NCT07144293)
- Testing
- Dasatinib, Quercetin
- Where
- 24 sites in United States
- Volunteers
- 82 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Frailty
Pilot-testing the Effect of Magnetic Mitohormesis Therapy for Treating Frailty in Older Adults
Thirty (30) adults with limited physical function will be recruited to participate in a double-blind pilot randomized controlled crossover trial in which all participants will receive 12-weeks of twice weekly MMT treatment in the…
- Trial name
- NCT05930470
- Testing
- Magnetic Mitohormesis Therapy
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Auburn University
Sarcopenia, Frailty
Muscle Biopsies in Healthy Volunteers
Background: In individuals as they age, changes in muscle tissue can significantly affect their muscle strength and exercise endurance.
- Conditions
- Sarcopenia, Frailty, Aging
- Trial name
- NCT01431677
- Testing
- Muscle Biopsy
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Frailty
South Korean Study to Prevent Frailty and Aging-related Diseases Through Lifestyle Intervention
The goal of this feasibility randomized controlled trial is to investigate the applicability of software that aims to improve symptoms of frailty by implementing customized interventions such as physical exercise and cognitive…
- Trial name
- SUPERAGING (NCT06891573)
- Testing
- Lifestyle Management
- Where
- 3 sites in South Korea
- Volunteers
- 40 people
- Sponsor
- Seong Hye Choi, MD
Frail Elderly Syndrome, Mood
FOCUS Guidelines and Adherence to Physical Activity in Ageing Women.
The study aimed at assessing whether the guidelines from the European project FOCUS had an effect on adherence to a physical activity program in older women.
- Conditions
- Frail Elderly Syndrome, Mood, Quality of Life, Cognitive Decline
- Trial name
- NCT03981965
- Testing
- Physical activity
- Where
- Spain
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Valencia