Clinical trials: Frailty in Adult Surgery
Cardiac Surgery, Nursing Care
Frailty and Dependency in Older Adults Undergoing Cardiac Surgery
Frailty and dependency are common conditions among older adults undergoing cardiac surgery and may adversely affect postoperative recovery and readiness for hospital discharge.
- Conditions
- Cardiac Surgery, Nursing Care, Perioperative Care
- Trial name
- NCT07755254
- Where
- Turkey (Türkiye)
- Volunteers
- 187 people
- Sponsor
- Aydin Adnan Menderes University
Hip Fracture Surgeries, Geriatric Assessment
ASA or CFS for ICU Prediction in Geriatric Hip Fracture
The aim of this retrospective study is to compare the efficacy of the American Society of Anesthesiologists (ASA) physical status classification and the Clinical Frailty Scale (CFS) in predicting postoperative intensive care unit…
- Conditions
- Hip Fracture Surgeries, Geriatric Assessment, Frailty at Older Adults, Intensive Care
- Trial name
- NCT07522541
- Testing
- Routine Surgical and Anesthetic Mnagement.
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Postoperative Delirium (POD), Frailty at Older Adults
Preoperative Lymphocyte-to-Monocyte Ratio and Postoperative Delirium by Frailty Status in Older Surgical Patients
Both frailty and a reduced preoperative lymphocyte-to-monocyte ratio (LMR) are known risk factors for postoperative delirium (POD). However, whether the relationship between LMR and POD varies by frailty status remains unclear.
- Conditions
- Postoperative Delirium (POD), Frailty at Older Adults, Lymphocyte
- Trial name
- NCT07322744
- Where
- China
- Volunteers
- 6,475 people
- Sponsor
- Chinese PLA General Hospital
Frailty, Sarcopenia
Frailty and Muscle Strength Tests in Older Adults Undergoing Major Surgery
The goal of this observational study is to learn if simple tests for frailty and muscle strength can help predict which older adults (age 65 and older) are at higher risk for problems after major abdominal surgery.
- Conditions
- Frailty, Sarcopenia, Sarcopenia in Elderly, Muscle Strength
- Trial name
- NCT06988176
- Testing
- Frailty assessment, nutrition assessment, cognition assessment, muscle strength testing
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of North Carolina, Chapel Hill
Frailty, Resilience
Older Adults' Recovery Dynamics After Cardiac Surgery
Population aging has increased the number of older adults exposed to interventions with high physiological demand, which are associated with frequent adverse outcomes such as delirium, organ dysfunction, and delayed functional…
- Conditions
- Frailty, Resilience, Cardiac Surgery Recovery
- Trial name
- ODYSSEY (NCT07793708)
- Where
- Chile
- Volunteers
- 75 people
- Sponsor
- University of Chile
Postoperative Mortality, Frailty at Older Adults
Predictive Value of Frailty Scores and Admission Laboratory Markers for Postoperative ICU Mortality
This prospective observational study aims to evaluate the predictive value of the Clinical Frailty Scale (CFS), the Katz Activities of Daily Living (ADL) scale, and admission laboratory markers for postoperative mortality among…
- Conditions
- Postoperative Mortality, Frailty at Older Adults, Activities of Daily Living, Postoperative Complications
- Trial name
- GERI-MORTAL (NCT07279519)
- Where
- Turkey (Türkiye)
- Volunteers
- 393 people
- Sponsor
- Malatya Egitim Ve Arastirma Hastanesi
Frailty in Older Adults, All Cause Mortality
Postoperative Frailty Trajectories and One-Year Mortality in Older Surgical Patients
Frailty is a key predictor of adverse outcomes in older surgical patients, yet its longitudinal evolution and potentially reversible nature remain underexplored in perioperative settings.
- Conditions
- Frailty in Older Adults, All Cause Mortality, Trajectory
- Trial name
- NCT07322809
- Where
- China
- Volunteers
- 4,417 people
- Sponsor
- Chinese PLA General Hospital
Surgery, Old Age; Debility
Pre-surgical Protocol for Frail Elderly People in Order to Reduce Hospitalization Days (APOPM).
Elderly people (EP) have increased, as well as life expectancy at birth. In Chile there are more than 2 million 800 thousand EP, which corresponds to 1/6 of the Chilean population.
- Conditions
- Surgery, Old Age; Debility, Frail Elderly Syndrome, Post-Operative Confusion
- Trial name
- APOPM (NCT04770259)
- Testing
- Timely pre-surgical conditioning
- Where
- 2 sites in Chile
- Volunteers
- 87 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Colo-rectal Cancer
NURSE-led Geriatric Assessment in Older Colorectal Cancer Patients
Older colorectal cancer patients frequently present with frailty, comorbidity, and other age-related vulnerabilities that may affect treatment tolerance and outcomes.
- Trial name
- NURSE-GA (NCT07872787)
- Testing
- Nurse-led Geriatric Assessment
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- Helse Stavanger HF
Frailty in Adult Surgery, Frailty Syndrome
Validity of Frailty Screening Tools as a Measure for Postoperative Outcomes
Frailty is a common geriatric syndrome defined as a clinical state of decreased physiologic reserve resulting in increased vulnerability to stressors.
- Conditions
- Frailty in Adult Surgery, Frailty Syndrome, Elective Surgery
- Trial name
- NCT07367828
- Testing
- Intermediate/major elective surgery
- Where
- Iceland
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Iceland
Frailty, Cardiac Surgery
Frailty and Ultrasound-Guided Central Venous Catheterization Difficulty in Adult Cardiac Surgery Patients
This prospective observational study aims to evaluate the association between preoperative frailty and the procedural difficulty of ultrasound-guided internal jugular vein catheterization in adult patients undergoing elective…
- Conditions
- Frailty, Cardiac Surgery, Central Venous Catheter
- Trial name
- FRAILCVC (NCT07701538)
- Testing
- Ultrasound-Guided Internal Jugular Vein Catheterization
- Where
- Turkey (Türkiye)
- Volunteers
- 280 people
- Sponsor
- Ankara City Hospital Bilkent
Frailty in Adult Surgery
Functional Capacity Through HRV in Multimodal Rehabilitation for Adult Surgery
This prospective, observational cohort study investigates heart rate variability (HRV) monitoring using the Analgesia Nociception Index (ANI) monitor in adult patients undergoing major surgery within a multimodal rehabilitation…
- Trial name
- PreANI (NCT06436417)
- Testing
- Analgesia Nociception Index (ANI) Monitor, Trimodal Prehabilitation
- Where
- Spain
- Volunteers
- 490 people, healthy volunteers welcome
- Sponsor
- Investigation Group Anesthesia, Resuscitation, And Perioperative Medicine of Aragon
Frailty in Adult Surgery, Frail Elderly Syndrome
Patient's Database: Prepare for Your Surgery Program
Frailty is a multidimensional syndrome that predominantly affects older people and people with long-term treatments such as cancer and chronic pain.
- Conditions
- Frailty in Adult Surgery, Frail Elderly Syndrome, Database, Perioperative Care
- Trial name
- NCT06857981
- Testing
- Clinical data collection
- Where
- 2 sites in Chile
- Volunteers
- 120 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Frailty in Adult Surgery, Frailty Syndrome
Modified Essential Frailty Toolset in Older Adults Undergoing Major Elective Surgery
Frailty is a common geriatric syndrome associated with reduced physiological reserve and increased vulnerability to surgical stress.
- Conditions
- Frailty in Adult Surgery, Frailty Syndrome, Elective Surgeries, Readmission Rates
- Trial name
- NCT07452263
- Testing
- Major elective surgery
- Where
- Iceland
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Iceland
Postoperative Delirium (POD), Frailty at Older Adults
Associations of Postoperative Delirium With Perioperative Frailty Worsening and Their Combined Effect on 1-Year Mortality in Older Surgical Patients
Postoperative delirium (POD) is a frequent complication in older surgical patients and is associated with adverse outcomes, while frailty is also highly prevalent during the perioperative period.
- Conditions
- Postoperative Delirium (POD), Frailty at Older Adults, Mortality, Recovery of Function
- Trial name
- NCT07259850
- Where
- China
- Volunteers
- 6,196 people
- Sponsor
- Chinese PLA General Hospital
Cognitive Impairment, Frail Older Adults
Cognitive Fraility and Biomarkers in Older Patients
this study aimed to investigate the association between cognitive fraility and selected plasma and cerebrospinal fluid biomarkers related to neurodegenetaion and neuroinflammation in older adult patients undergoing elective…
- Conditions
- Cognitive Impairment, Frail Older Adults, Orthopaedic Surgery
- Trial name
- NCT07184073
- Testing
- assessment Mini mental state examination, assessment FRAIL scale, collecting cerebrospinal fluid during regional anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 129 people
- Sponsor
- Baskent University
Gastric Cancer (GC), Frailty in Adult Surgery
Temporal Transformation Mechanism and Intervention Strategies of Frail-related Dietary Behaviors in Older Gastric Cancer Survivors
The investigators invite participants to participate in the research project "Research on the Maintenance Mechanism and Intervention Strategies of Dietary Behavior Changes Related to Frailty in Elderly Gastric Cancer Survivors".
- Trial name
- NCT07176455
- Testing
- Anti-frailty dietary behavior intervention
- Where
- China
- Volunteers
- 438 people
- Sponsor
- Nanjing Medical University