Clinical trials: Frailty
Cognitive Dysfunction
Use of Electrophysiological Markers to Predict Post-operative Cognitive Dysfunction
As the population ages and medical progress is made, many elderly patients that previously would not have been candidates for surgery are now undergoing operations.
- Trial name
- NCT04512989
- Testing
- Cognitive assesment using MOCA test
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Frailty in Adult Surgery, Frailty Syndrome
Modified Essential Frailty Toolset in Older Adults Undergoing Major Elective Surgery
Frailty is a common geriatric syndrome associated with reduced physiological reserve and increased vulnerability to surgical stress.
- Conditions
- Frailty in Adult Surgery, Frailty Syndrome, Elective Surgeries, Readmission Rates
- Trial name
- NCT07452263
- Testing
- Major elective surgery
- Where
- Iceland
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Iceland
Alzheimer Disease (AD), Cardio Vascular Disease
Arlington Longitudinal Optimal Healthy Aging Study (ALOHA)
The Arlington Longitudinal Optimal Healthy Aging (ALOHA) Study is a community-based research project led by the Marymount University Center for Optimal Aging (MCOA).
- Conditions
- Alzheimer Disease (AD), Cardio Vascular Disease, Mild Cognitive Impairment (MCI), Frailty Syndrome
- Trial name
- ALOHA (NCT07180147)
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Marymount University
Heart Failure, Aortic Stenosis
The Role of Cardiac Mechanics, Biomarkers and Frailty in Aortic Stenosis
The role of cardiac mechanics, circulating biomarkers and frailty in predicting outcomes in patients with aortic stenosis after aortic valve replacement (SCRABLES -The 2-Parts Study) Part I: Observational study to characterize…
- Trial name
- SCRABLES (NCT02856620)
- Testing
- Observational only
- Where
- Canada
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Christine Henri
Sarcopenia, Memory Loss
Effects of Multidomain Training of Health With Aging (Train-Old)
The current study aims to determine the effect of a multidomain intervention (physical fitness, motivational and cognitive training) on body composition, sarcopenia, cardiovascular health, physical fitness, functional capacity…
- Conditions
- Sarcopenia, Memory Loss, Muscular Atrophy, Cardiovascular Diseases
- Trial name
- Train-Old (NCT05481346)
- Testing
- Multidomain training
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universidad de Almeria
Ageing, Disability
The Beijing Longitudinal Disability Survey in Community Elderly
The goal of this observational study is to establish the prospective cohort of the Beijing Longitudinal Disability Survey in Community Elderly (BLINDSCE) to explore the high-risk factors and preventive interventions for…
- Conditions
- Ageing, Disability, Cognitive Impairment, Frailty
- Trial name
- BLINDSCE (NCT06863727)
- Where
- China
- Volunteers
- 1,962 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Frail Elderly Syndrome
Development of Clinical Indicators From the Swiss RAI-HC
The project aims at deriving frailty (FI) and complexity (CI) indices from data collected with the Resident Instrument Assessment - Home Care adapted for Switzerland (RAI-HC).
- Trial name
- IndiRAI (NCT03139162)
- Testing
- Swiss RAI-HC assessment
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- School of Health Sciences Geneva
Older Adults
Frailty, Geriatric Syndromes and Care Pathways of Older Adults Living With HIV in West Africa
With currently available antiretroviral therapy, people living with HIV (PLWHIV) are living longer. This exposure to HIV and combination antiretroviral therapy may accelerate the aging of this population, thus increasing the…
- Trial name
- NCT07355413
- Where
- 6 sites in Burkina Faso, Côte d’Ivoire and 1 more
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
Oral Manifestations
The Oral Biomechanical Functions of Hong Kong Healthy Adults
Hong Kong and Japan are similar in terms of facing the super-ageing society. Maintaining oral function in elderly is particularly important because it affects social, physical and mental health to the people and to the society.
- Trial name
- NCT05549648
- Testing
- Home oral excrise
- Where
- Hong Kong
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Chronic Subdural Hematoma
Association Between Dietary Factors and Chronic Subdural Hematoma (DISH)
A prospective, multicenter, case control trial is designed to compare difference in dietary and nutritional factors in patients with and without chronic subdural hematoma.
- Trial name
- DISH (NCT05599217)
- Testing
- Dietary and nutritional questionnaire, Neurological function, cognitive function, and life quality assessment, Peripheral blood test
- Where
- 4 sites in China
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Frailty
High Intensity Interval Training (HIIT) to Reduce Frailty and Enhance Resilience in Older Veterans
Frailty is defined as a greater susceptibility to stressors resulting from age-related impairments in adaptive biological systems.
- Trial name
- HIIT@Home (NCT05625204)
- Testing
- Center based attention (stretching only) control, Center based HIIT, Home based HIIT
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Functional Disability, Dynapenia
Exercise Based on Proprioceptive Neuromuscular Facilitation in Older Individuals
The goal of this clinical trial was to determine whether an intervention using resisted sit-to-stand and walking exercises with Proprioceptive Neuromuscular Facilitation (PNF) techniques improved gait and sit-to-stand in older…
- Conditions
- Functional Disability, Dynapenia, Sarcopenia in Elderly
- Trial name
- NCT06690944
- Testing
- Proprioceptive Neuromuscular Facilitation, Physical exercise without proprioceptive neuromuscular facilitation control group
- Where
- Brazil
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Blood Pressure, Frailty
Acute Effects of Low and High-Speed Resistance Training on Blood Pressure in Older Adults: A Crossover Study
The first study was a randomized crossover trial that compared the acute effects of High Speed Resistance Exercise (HSRE) and Traditional Resistance Exercise (TRE) on blood pressure parameters in a sample of frail older adults.
- Trial name
- NCT05310006
- Testing
- Exercise
- Where
- Brazil
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Frailty, Aging
Effect of Multicomponent Exercises VIVIFRAIL® in Older Adults
This study employs a randomized, controlled, paired, single-blind clinical trial design. The targeted demographic comprises individuals aged 60 and above.
- Conditions
- Frailty, Aging, Physical Disability
- Trial name
- NCT06271239
- Testing
- Intervention group (ViviFrail), Group Suggestions for a Healthy Life (CG)
- Where
- 4 sites in Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidade Católica do Rio Grande do Sul
Frail Elderly, Malnutrition
Healthy Life for Frail Malnourished Seniors Performed Together With Trained Lay Buddies
Background: In elderly subjects frailty and malnutrition are very common and can lead to serious health hazards, increase mortality, morbidity, dependency, institutionalization and a reduced quality of life.
- Trial name
- NCT01991639
- Testing
- Nutritional and physical activity intervention
- Where
- Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
To Investigate the Mortality of the Frailty Patients
Hospital Ederly Life Program for Surgical Patients
Frailty is the clinically recognizable medical condition, also called syndrome or phenotype, that is, the result of processes leading to an increased vulnerability for serious deteriorations in health and the diminished ability…
- Trial name
- NCT03792373
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Zhongda Hospital
Depression, Sleep Quality
Effect of Music Activities on Depression and Sleep Quality in Frail Older Adults
This study aims to examine the effects of music activities on depression and sleep quality among frail older adults, and to develop a standardized music activity protocol suitable for use in adult day care centers.
- Conditions
- Depression, Sleep Quality, Frailty
- Trial name
- NCT07049445
- Testing
- Music Activity Program
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Chung Hsing University
Frailty
Comparing Frailty Care Pathways in Rural Primary Care: a Feasibility Study
Primary Care General Practitioners (GPs) are always looking at ways to improve the care of older people and ways to prevent older people from losing their independence.
- Trial name
- NCT05849870
- Testing
- Frailty care pathway for older people in a rural primary care setting
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Aberystwyth University
Fraility, COPD (Chronic Obstructive Pulmonary Disease)
Respiratory Exercises in Frail Elderly COPD Patients
Purpose: This study evaluated the impact of a structured intervention on frailty, lung function, physical capacity, and dyspnea in elderly COPD patients.
- Conditions
- Fraility, COPD (Chronic Obstructive Pulmonary Disease), Older Adults (65 Years and Older)
- Trial name
- NCT07472530
- Testing
- breathing exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Çankırı Karatekin University
Frailty in Adult Surgery, Frailty Syndrome
Validity of Frailty Screening Tools as a Measure for Postoperative Outcomes
Frailty is a common geriatric syndrome defined as a clinical state of decreased physiologic reserve resulting in increased vulnerability to stressors.
- Conditions
- Frailty in Adult Surgery, Frailty Syndrome, Elective Surgery
- Trial name
- NCT07367828
- Testing
- Intermediate/major elective surgery
- Where
- Iceland
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Iceland