Clinical trials: Frailty/Sarcopenia
Sarcopenia, Muscle Loss
Counteracting Age-related Loss of Skeletal Muscle Mass
Up to approximately 205 (dependent on drop-out rate) healthy elderly individuals (at least 65 years old) are recruited as subjects.
- Trial name
- CALM (NCT02034760)
- Testing
- Heavy Resistance Training, Light Intensity Training, Protein Whey
- Where
- Denmark
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Frail Elderly Syndrome, Emergencies
Frailty and Sarcopenia Outcomes in Emergency General Surgery
1. A retrospective scoping cohort review of adult patients undergoing emergency laparotomy/laparoscopy for acute gastrointestinal (GI) pathology who have had a CT scan of the abdomen(+/- pelvis).
- Conditions
- Frail Elderly Syndrome, Emergencies, Surgery, Sarcopenia
- Trial name
- FrOGS (NCT03534765)
- Testing
- CT abdomen +/- pelvis, Edmunton Frailty Score, Emergency laparotomy for general surgical pathology
- Where
- 10 sites in United Kingdom
- Volunteers
- 294 people
- Sponsor
- Yeovil District Hospital NHS Foundation Trust
Sarcopenia
The Importance of Additional Protein to Benefit More From Training During and After Hospitalization
The purpose of the study is to investigate if an increased protein intake, in the form of a protein-enriched, milk-based supplement, can enhance the beneficial effect of resistance training, offered during hospitalization and 12…
- Trial name
- PEPOP (NCT02717819)
- Testing
- Protein, Resistance training, Vitamin D
- Where
- 3 sites in Denmark
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Forskningsenheden
Frailty, Sarcopenia
Study of The Effects of Testosterone in Frail Elderly Men
The study aims to determine the effects of testosterone on muscle function, mobility, activities of daily living and overall quality of life
- Trial name
- NCT00190060
- Testing
- Transdermal testosterone gel (Testogel 1% )
- Where
- United Kingdom
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Manchester University NHS Foundation Trust
Sarcopenia
A Study of Muscle Strength Maintenance in Older Adults
This research study is being done to see whether losartan can prevent the decrease in strength associated with aging. Muscle loss is associated with aging and has multiple symptoms such as weakness, slowness, and fatigue…
- Trial name
- NCT01989793
- Testing
- Losartan
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Geriatric Diseases
Increased Focus on Protein Intake Among Geriatric Patients
Up to approximately 38 (unknown drop-out rate) geriatric patients (at least 65 years old) are recruited from a Geriatric ward at Slagelse Sygehus.
- Trial name
- NCT03075189
- Testing
- Whey protein supplement
- Where
- Denmark
- Volunteers
- 18 people
- Sponsor
- University of Copenhagen
Sarcopenia
The Role of Muscle Protein Breakdown in the Regulation of Muscle Quality in Frail Elderly Individuals
The purpose of this study is to investigate mechanisms underlying the reduction in muscle quality (the ratio between muscle strength and muscle size) with aging, and to investigate how these factors are affected by strength…
- Trial name
- NCT03326648
- Testing
- Strength training, Protein supplementation
- Where
- Norway
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Truls Raastad
Sarcopenia, Muscle Loss
Effect of Strength Training and Protein Ingestion in Old Versus Very-old
From 3 interventiongroups in the project with ClinicalTrials.gov ID NCT02034760, namely: HRTW: Heavy Strength Training x3/week \& 20g whey protein twice daily.
- Trial name
- NCT02105922
- Testing
- Heavy Resistance Training, Light Intensity Training, Protein Whey
- Where
- Denmark
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Sarcopenia, Hypogonadism
TOM: Testosterone in Older Men With Sarcopenia
The purpose of this study is to determine whether testosterone replacement in older men with low testosterone levels will increase muscle strength, improve physical performance and overall sense of well being, and reduce fatigue.
- Conditions
- Sarcopenia, Hypogonadism, Muscular Diseases
- Trial name
- NCT00240981
- Testing
- Topical testosterone gel 1% (active formulation)
- Where
- 2 sites in United States
- Volunteers
- 209 people
- Sponsor
- Boston Medical Center
Ambulatory Geriatric Outpatients at High Risk of Frailty
Impact of Chronic Disease Control and Aging Psychology on Outcomes of Frailty-Sarcopenia Syndrome in Ambulatory Geriatric Patients
Pursuant to our previous longitudinal study (ClinicalTrials.gov ID: NCT02073370) in geriatric outpatients cooperated with the Department of Family Medicine, Department of Geriatrics and Gerontology, National Taiwan University…
- Trial name
- NCT02160093
- Where
- Taiwan
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Critical Illness, Sarcopenia
Effects of Frailty, Sarcopenia and Muscle Wasting on Outcomes of Patients in the Surgical Intensive Care Unit
The primary aim of the study is to evaluate consequences of frailty in critically ill patients. We hypothesize that a higher frailty index (based on published questionnaires) predicts a longer surgical intensive care unit and…
- Conditions
- Critical Illness, Sarcopenia, Muscle Wasting
- Trial name
- NCT02270502
- Testing
- Ultrasound Philips CX50, Frailty Index Questionnaire, Muscle strength tests
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Massachusetts General Hospital
Sarcopenia, Hip Fracture
Hyperprotein Nutritional Intervention in Elderly Patients With Hip Fracture and Sarcopenia
1. RATIONALE The unique characteristic of our study lies in the attempt to reverse the functional impairment experienced by sarcopenic patients with hip fracture using nutritional intervention.
- Trial name
- HIPERPROT (NCT01404195)
- Testing
- Ensure Plus Advance
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- Hospital Viamed Valvanera, Spain
Sarcopenia, Hip Fracture
Prevalence and Pathophysiology of Sarcopenia in the Elderly Patient With Hip Fracture
Sarcopenia is the loss of muscle mass and function that accompanies aging. The term sarcopenia comes from the Greek "sarx" (flesh) and "penia" (loss).
- Conditions
- Sarcopenia, Hip Fracture, Frailty
- Trial name
- PREFISSARC (NCT01477086)
- Where
- Spain
- Volunteers
- 198 people
- Sponsor
- Hospital Viamed Valvanera, Spain
Ageing
Effect of Strength Training and Protein Supplementation on Muscles in the Very-old
Three months intervention study, investigating the effect of nutrient supplementation (including 20g of milk protein) twice daily with or without additional heavy resistance exercise three times weekly on muscle size, structure…
- Trial name
- 83+ (NCT01997320)
- Testing
- Heavy resistance exercise and nutrition, Nutrition supplement
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Frailty, Sarcopenia
Clinical Evaluation, Biomarkers and Metabolomics of Sarcopenia in Frail Older Adults at Ambulatory Clinics
Sarcopenia related mobility dysfunction was a preventable presentation in transitional variation of frailty. However, the definition, associated risk factors, clinical course and outcome of sarcopenia in Taiwanese older adults…
- Trial name
- EC0991002-E (NCT02073370)
- Where
- Taiwan
- Volunteers
- 350 people
- Sponsor
- National Taiwan University Hospital
Physical Disability
Multi-ingredient Nutrition Supplement in Older Adults
The aims of the present study are: i. To conduct a population study of body composition, muscle function and ability to undertake activities of daily living in elderly Irish individuals ii.
- Trial name
- NCT02001831
- Testing
- Supplement
- Where
- Ireland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Sarcopenia, Muscle Weakness
HORMA: Hormonal Regulators of Muscle and Metabolism in Aging
The purpose of this study is to determine the relationship of deficiencies in testosterone and growth hormone to loss of muscle mass (sarcopenia) and functional impairment during aging and whether there is an interaction of these…
- Conditions
- Sarcopenia, Muscle Weakness, Frailty
- Trial name
- NCT00183040
- Testing
- Topical testosterone, Recombinant human growth hormone
- Where
- 2 sites in United States
- Volunteers
- 108 people
- Sponsor
- National Institute on Aging (NIA)