Clinical trials: Fragility Fractures
Osteoporosis, Fragility Fractures
Osteoporosis Coordinator for Low Volume Community Hospitals
A Regional Osteoporosis Coordinator located at Women's College Hospital will follow-up with low trauma fracture patients from 30 smaller community hospitals across Ontario.
- Trial name
- ROCKET (NCT00511693)
- Testing
- centralized osteoporosis coordinator, fall prevention
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Ontario Ministry of Health and Long Term Care
Pelvic Fractures, Fragility Fractures of the Pelvis (FFP)
Assessment of Treatment Variability for Pelvic Ring Fragility Fractures
Fragility fractures of the pelvic ring are a common injury associated with poor patient outcomes and high healthcare costs. Management of these injuries is evolving with increasing frequency of operative stabilization of the…
- Trial name
- Pelvis ATV (NCT07351123)
- Testing
- Surgical stabilization of pelvic fracture, Closed treatment of pelvic fracture
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Maryland, Baltimore
Osteoporosis Risk, Fracture of Femur
Prediction Model of Hip Fragility Fracture Realistic Data From a Traumatology Department and Orthogeriatric Ward.
The aim of the project is to build a prediction model of hip fragility fracture using hospital data routinely collected in the traumatology department from the last 12 years and up to date Explainable Artificial Intelligence…
- Conditions
- Osteoporosis Risk, Fracture of Femur, Fragility
- Trial name
- NCT06545487
- Testing
- BLOOD SAMPLE
- Where
- Chile
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidad de Valparaiso
Hip Fractures
Effects of Music on Acute Postoperative Pain Intensity and Mobility After Fragility Hip Fracture
Music has been proven to be beneficial in postoperative care by reducing pain. The effects of music listening to reduce pain postoperatively are well studied among cases undergoing elective orthopaedic surgery.
- Trial name
- NCT06277102
- Testing
- music listening
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Hospital Authority, Hong Kong
Osteoporosis, Bone Loss
Bone Microarchitectural Database Constitution From HR-pQCT Device in Clinical Situation Potentially Associated With Bone Loss
Bone fracture occurrence is associated with an increasing of morbidity and mortality. Some factors of fracture occurrence have been highlighted.
- Trial name
- DMPOs (NCT02532439)
- Testing
- HR-pQCT, DEXA, pQCT
- Where
- France
- Volunteers
- 287 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Vertebral Compression Fracture, Compression Fracture
STAND - Study of the AGN1 LOEP SV Kit Compared to PMMA in Patients With Vertebral Compression Fractures
This is a multicenter, single-blinded, randomized controlled clinical trial evaluating the safety and efficacy of the AGN1 LOEP SV Kit for the treatment of painful vertebral compression fragility fractures (VCFs).
- Conditions
- Vertebral Compression Fracture, Compression Fracture, Vertebral Compression
- Trial name
- NCT04835428
- Testing
- Treatment Group: AGN1 LOEP SV Kit, Control Group: PMMA bone cement
- Where
- 12 sites in United States
- Volunteers
- 408 people
- Sponsor
- AgNovos Healthcare, LLC
Type 2 Diabetes Mellitus and Fragility Fractures
A Prospective Cohort Study:Forecast Fracture Risk With a Serum Marker of Type 2 Diabetes in Guangzhou Community
The objective of this study is to find out the biochemical markers which have independent predictive value of fragility fractures risk with Type 2 diabetes in Guangzhou community and evaluate bone strength better and increase the…
- Trial name
- NCT03456271
- Where
- 5 sites in China
- Volunteers
- 99 people
- Sponsor
- Zhujiang Hospital
Hip Fractures
Structured Tailored Rehabilitation After Hip Fragility Fracture
Why the investigators are doing this study? The best approach to rehabilitation after a broken hip is not known. A new approach could improve outcomes by tailoring rehabilitation to patient needs.
- Trial name
- STRATIFY (NCT06014554)
- Testing
- Low-risk subgroup, Medium-risk subgroup, High-risk subgroup
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- King's College London
Fragility Fractures of the Pelvis (FFP), Osteoporosis
Robot Assisted Minimally Invasive Treatment Versus Conventional Surgery for FFP3-4 Fragility Fractures of the Pelvis in Elderly Patients
This prospective randomized controlled trial aims to compare the efficacy and safety of robot assisted minimally invasive treatment versus conventional surgery in elderly patients with FFP3-4 fragility fractures of the pelvis.
- Trial name
- NCT07639619
- Testing
- Robot Assisted Minimally Invasive Fixation, Conventional Open Fixation
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Junbo Liang
Kidney Diseases, Dialysis; Complications
PRevEnting FracturEs in REnal Disease - 1
PREFERRED-1 is a pilot study designed to determine the feasibility of a large randomized, pragmatic, open-label, comparative-effectiveness trial of denosumab for the prevention of fragility fractures in people receiving…
- Conditions
- Kidney Diseases, Dialysis; Complications, Fragility Fracture, Chronic Kidney Disease-Mineral and Bone Disorder
- Trial name
- PREFERRED-1 (NCT05096195)
- Testing
- Denosumab 60 mg/ml, Calcium and vitamin D prophylaxis, Monitoring of post-injection calcium and phosphate
- Where
- 6 sites in Canada
- Volunteers
- 60 people
- Sponsor
- Western University, Canada
Geriatric Patients
The Effect of Training Prepared in Line With Fracture Liaison Service Model on Frailty in Hip Surgery Patients
This study is a randomized controlled experimental research with pretest-posttest control group. The aim of this study is to evaluate the effect of the training prepared in line with the fracture liaison service model on the…
- Trial name
- NCT05900804
- Testing
- Training Prepared in Line with the Fracture Liaison Service Model
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people
- Sponsor
- Aydin Adnan Menderes University
Accidental Falls, Fractures
Falls With Fracture : Role of Cognitive Disorders and Comparison With Bone Fragility
The purpose of this study is to determine whether cognitive disorders are a risk factor for a fracture after a fall independently of a bone fragility.
- Trial name
- CFC (NCT02292316)
- Testing
- gait and cognitive assessments, blood sample, osteodensitometry
- Where
- 2 sites in France
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Femoral Fragility Fractures, Malnutrition
The Taste and Acceptability of a High Protein Ice Cream Compared With Hospital Milkshake Nutritional Supplement
This study aims to compare the acceptability of a new high protein, fortified, ice cream called Nottingham-Ice cream (N-ICE CREAM) with a standard milkshake-style oral nutritional supplement (ONS); Fortisip Compact Protein in…
- Trial name
- NCT05711277
- Testing
- Standard milkshake ONS (Fortisip Compact Protein), High protein, fortified, ice cream
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Fragility Fracture
MyNOURISH: Hydrolysed Collagen Supplementation in Older Adults With Fragility Fractures
The goal of this clinical trial is to learn whether hydrolysed collagen supplementation (PROTÉGEN Plus) within multidisciplinary care can improve nutrition and recovery in older adults with fragility fractures.
- Trial name
- MyNOURISH (NCT07347236)
- Testing
- Hydrolysed Collagen (PROTÉGEN Plus), Standard Multidisciplinary Care
- Where
- Malaysia
- Volunteers
- 76 people
- Sponsor
- Hospital Pengajar Universiti Putra Malaysia
Osteoporosis
Recognizing Osteoporosis and Its Consequences in Quebec (ROCQ) Programme
The aim of the ROCQ programme is to improve the use of evidence based osteoporosis diagnostic and treatment strategies for women 50 years and over who have suffered a fragility fracture.
- Trial name
- NCT00359047
- Testing
- Documentation, Video
- Where
- Canada
- Volunteers
- 2,830 people
- Sponsor
- CHU de Quebec-Universite Laval
Pelvic Trauma, Pelvic Fracture
A Snapshot Audit of Traumatic Pelvic Ring Injuries
Multicenter, snapshot cohort studies or audits have the ability to gather large patient numbers in short time periods from many healthcare systems with different resources or practices of care concerning one specific surgical…
- Conditions
- Pelvic Trauma, Pelvic Fracture, Fragility Fractures of the Pelvis (FFP)
- Trial name
- NCT06540339
- Testing
- Snapshot-audit studies do not necessitate any intervention in the defined cohorts.
- Volunteers
- 500 people
- Sponsor
- University Hospital, Aachen
Fractures Related to Skeleton Fragility
Fracture Prediction by Opportunistic Screening for Osteoporosis
Fractures related to skeleton fragility (i.e. osteoporotic fractures) represent a growing health problem, as the life expectancy and thus the number of frail elderly subjects is increasing.
- Trial name
- OPPORTOS (NCT03570177)
- Where
- France
- Volunteers
- 173,720 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Lower Extremity Fractures, Pelvis
PROactive HEALing in High-Risk Pelvic and Non-hip Lower Extremity Fragility Fractures (PRO HEAL Pilot)
Fragility fractures are common in older adults with weakened bone. At least 1 in 3 females and 1 in 5 males will sustain a fragility fracture in their lifetime, and over 80% of fractures in Canadians aged 50 years and older are…
- Conditions
- Lower Extremity Fractures, Pelvis, Acetabulum
- Trial name
- PRO HEAL Pilot (NCT06303284)
- Testing
- subcutaneous Teriparatide injection
- Where
- Canada
- Volunteers
- 54 people
- Sponsor
- University of Calgary
Pelvis; Fracture
Surgical Treatment of Pelvis in Fragility Fracture in Germany: a Prospective, National, Multicenter, Observational, Comparative Cohort Study Comparing Isolated Posterior Versus Combined Anterior-posterior Surgical Fracture Stabilization
Over a period of approximately two years, patients above the age of 65 who have suffered from an FFP equal to or higher than type IIc FFP, according to Rommens and Hofmann, will be eligible for inclusion.
- Trial name
- AO TOP (NCT06550934)
- Testing
- Fracture stabilization
- Volunteers
- 420 people
- Sponsor
- AO Innovation Translation Center
Post-Menopausal Osteoporosis
Intra-venous Zoledronic Acid Once Yearly
The study will assess the real life effectiveness of zoledronic acid in the management of patients with osteoporosis over 4 years of treatment.
- Trial name
- IVORY (NCT00984893)
- Testing
- zoledronic acid, Any oral bisphosphonates marketed in Canada
- Where
- 3 sites in Canada
- Volunteers
- 1,551 people
- Sponsor
- Novartis Pharmaceuticals