Clinical trials: Fractional Flow Reserve
Coronary Artery Disease
Evaluation of Health Economics for Noninvasive Coronary Fractional Flow Reserve Measurement Technology
To determine whether, in a Chinese population of patients presenting to Wuhan Asia Heart Hospital, Fractional Flow Reserve Derived from Coronary Computed Tomography Angiography (CT-FFR) as a default test is noninferior in terms…
- Trial name
- NCT05593120
- Testing
- CT-FFR, Routine care
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Shenzhen Raysight Intelligent Medical Technology Co., Ltd.
Coronary Disease
Prospective Evaluation of MyocaRdial PerFUSion ComputEd Tomography Trial
The purpose of this study is to evaluate safety and effectiveness of CTP(computed tomography perfusion) guided revascularization vs FFR(Fractional flow reserve) guided revascularization
- Trial name
- PERFUSERCT (NCT02208388)
- Testing
- computed tomography perfusion guided treatment, Fractional flow reserve guided treatment
- Where
- 7 sites in South Korea
- Volunteers
- 1,000 people
- Sponsor
- Young-Hak Kim, MD, PhD
Coronary Artery Disease, Acute Coronary Syndrome
PRESSUREwire Study
The purpose of this study is to understand routine use of FFR (Fractional Flow Reserve) and alternate indices in clinical practice.
- Trial name
- NCT02935088
- Testing
- Fractional Flow Reserve
- Where
- 71 sites in United States, Austria and 13 more
- Volunteers
- 2,217 people
- Sponsor
- Abbott Medical Devices
Coronary Artery Disease, NSTEMI - Non-ST Segment Elevation MI
FFR Driven Complete Revascularization Versus Usual Care in NSTEMI Patients and Multivessel Disease
To compare FFR guided complete revascularization during the index procedure with usual care in non-STEMI patients with multivessel disease.
- Conditions
- Coronary Artery Disease, NSTEMI - Non-ST Segment Elevation MI, Fractional Flow Reserve, Myocardial, Myocardial Revascularization
- Trial name
- SLIM (NCT03562572)
- Testing
- Ischemia driven revascularization, Usual care group
- Where
- 9 sites in Czechia, Hungary and 1 more
- Volunteers
- 476 people
- Sponsor
- Zuyderland Medisch Centrum
Diagnosis Coronary Artery Disease
Diagnostic Performances of Computed TomographIc Coronary Angiography and Intravascular Ultrasound
Diagnostic purposes of the coronary angiography is to detect stenosis (anatomy) and to detect ischemia related stenosis (function). Coronary angiography (CAG) is a gold standard invasive techniques, but has several limitations.
- Trial name
- IMAGES-FFR (NCT01400230)
- Testing
- diagnostic procedures CCTA, CAG, IVUS and FFR
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Seoul National University Hospital
Ischemic Heart Disease
Impact of Dynamic CoROnary RoADmap System for Guidance of Instantaneous Wave-Free Ratio or Fractional Flow Reserve
In patients with 50-90% stenosis of the coronary artery, the coronary roadmap (dynamic roadmap) is performed when the conventional fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) are performed.
- Trial name
- ROAD-IFR (NCT05682118)
- Testing
- roadmap, iFR/FFR
- Where
- South Korea
- Volunteers
- 226 people
- Sponsor
- Yonsei University
Coronary Disease, Coronary Stenosis
A Comparison of Fractional Flow Reserve-Guided Percutaneous Coronary Intervention and Coronary Artery Bypass Graft Surgery in Patients With Multivessel Coronary Artery Disease
The purpose of this study is to determine whether Fractional flow reserve (FFR, (coronary pressure wire-based index for assessing the ischemic potential of a coronary lesion)-guided percutaneous coronary intervention (PCI) in…
- Trial name
- FAME 3 (NCT02100722)
- Testing
- FFR guided PCI, CABG, Resolute Integrity Stent
- Where
- 46 sites in United States, Australia and 14 more
- Volunteers
- 1,500 people
- Sponsor
- Stanford University
Coronary Artery Disease Left Main, Coronary Artery Disease
Fractional Flow Reserve Versus Angiography for Treatment-Decision and Evaluation of Significant Left MAIN Coronary Artery Disease
The primary purpose of the study was to determine whether the 2-year probability of major adverse cardiac events (primary composite outcome) differed significantly between patients who underwent angiography-guided Percutaneous…
- Trial name
- FATE-MAIN (NCT05829889)
- Testing
- FFR-Guided PCI, Angiography-Guided PCI
- Where
- 49 sites in Hong Kong, India and 3 more
- Volunteers
- 960 people
- Sponsor
- Seung-Jung Park
Coronary Stenosis, Angina Pectoris
Evaluation of the Correlation Between the Coronary Stenosis Degree With FFRCT and the Grade of Stable Angina Pectoris
Angina pectoris is the most common clinical manifestation of coronary heart disease（CHD）, which is the main feature of chest pain caused by transient myocardial ischemia.
- Trial name
- NCT02802046
- Testing
- Computed tomographic angiography of coronary artery
- Volunteers
- 20 people
- Sponsor
- Guiyang No.4 People's Hospital
Coronary Disease
Diagnostic Accuracy of CT-FFR Compared to Invasive Coronar Angiography With Fractional Flow Reserve
Invasive coronary angiography is currently considered gold standard in the assessment of coronary artery disease although the method has limitations.
- Trial name
- NCT03045601
- Testing
- CT-FFR, Stress echocardiography
- Where
- Norway
- Volunteers
- 182 people
- Sponsor
- St. Olavs Hospital
Myocardial Infarction
Functional Coronary Angiography Guided Revascularization in STEMI
The goal of this multicenter randomized clinical trial is to test the superiority in terms of efficacy of the Angiography-derived fractional flow reserve (AIR) over that based on conventional angiography (ANGIO) strategy in the…
- Trial name
- AIR-STEMI (NCT05818475)
- Testing
- Angiography-guided PCI, Angiography-derived FFR PCI indication and planning
- Where
- 22 sites in Italy, Pakistan
- Volunteers
- 1,823 people
- Sponsor
- University Hospital of Ferrara
Cardiac Allograft Vasculopathy
Early Post Transplant Cardiac Allograft Vasculopathy
Heart transplantation is an effective life-saving treatment for patients with end-stage heart disease. After a transplant, the new heart may develop narrowing in the arteries, causing heart failure, heart attacks and abnormal…
- Trial name
- ECAV (NCT03217786)
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Coronary Disease, Echocardiography
Meta-Analysis of Stress Myocardial Perfusion Imaging
Background: Detection of coronary artery disease (CAD) is important due to its high prevalence and its medical and economic implications.
- Conditions
- Coronary Disease, Echocardiography, Fractional Flow Reserve, Myocardial, Hemodynamics
- Trial name
- NCT03180060
- Where
- Mexico
- Volunteers
- 23,051 people
- Sponsor
- American British Cowdray Medical Center
Atherosclerosis
Hemodynamic Change of Coronary Atherosclerotic Plaque After Evolocumab Treatment
Compelling evidences indicate that lipid-lowering therapy can reduce the high-risk plaque feathers and improve the coronary flow reserve.
- Trial name
- NCT04416425
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Zibo Central Hospital
Acute ST Segment Elevation Myocardial Infarction, Prognosis
Predictive Value of Combining AccuIMR and AccuFFR in Patients With STEMI
Patients with acute myocardial infarction were enrolled retrospectively. The fractional flow reserve (AccuFFR) and microcirculatory resistance index (AccuIMR) based on coronary angiography were analyzed, and the relationship…
- Trial name
- NCT06435728
- Testing
- AccuIMR and AccuFFR
- Where
- China
- Volunteers
- 1,297 people
- Sponsor
- Peking University Third Hospital
Coronary Artery Disease
CCTA-FFR Registry for Risk Prediction
The investigators sought to investigate the prognostic implication of qualitative and quantitative plaque analysis on coronary CT angiography (CCTA) according to fractional flow reserve (FFR).
- Trial name
- NCT04037163
- Testing
- Fractional flow reserve, Coronary CT angiography
- Volunteers
- 747 people
- Sponsor
- Seoul National University Hospital
Coronary Artery Stenosis
Validation of Stenosis Assessment by Coronary Artery Computed Tomography Against Invasive Measurements of Fractional Flow Reserve in Patients With Significant Coronary Artery Stenoses
This study will evaluate the effectiveness of CorCTA by comparing the results of the test with another imaging method called Fractional Flow Reserve (FFR), which is done as a part of the cardiac catheterization.
- Trial name
- NCT00817102
- Testing
- FFR, IVUS, VH, or combination of the three
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Piedmont Healthcare
Coronary Artery Disease, Myocardial Ischemia
Pressure Guidewire Comparison
Fractional flow reserve (FFR) is the current gold standard for correct decision making with respect to revascularization in the catheterization laboratory.
- Trial name
- NCT04802681
- Testing
- FFR-measurement with different pressure guidewires
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Lokien van Nunen
Stable Angina, Non ST Segment Elevation Myocardial Infarction
INsTantenous wavE-Free Ratio-guided PCI Versus Fractional Flow REserve-Guided PCI in rouTine Clinical Practice, Prospective, Multicenter Registry
The current study sought to evaluate the clinical relevance of iFR-guided strategy in real world clinical practice using unrestricted study population from stable angina to acute coronary syndrome including acute ST-segment…
- Conditions
- Stable Angina, Non ST Segment Elevation Myocardial Infarction, ST-segment Elevation Myocardial Infarction, Silent Myocardial Ischemia
- Trial name
- INTERPRET (NCT03338309)
- Testing
- Instantaneous wave-free ratio measurement
- Where
- 4 sites in South Korea
- Volunteers
- 1,200 people
- Sponsor
- Samsung Medical Center
Coronary Artery Disease, Cardiovascular Diseases
Functional Diagnostic Accuracy of Quantitative Flow Ratio in Tandem Lesions and Virtual Stenting
Quantitative Flow Ratio (QFR) is a novel method for evaluating the functional significance of coronary stenosis. Virtual stent implantation technique combined with QFR was recently developed to predict the functional significance…
- Conditions
- Coronary Artery Disease, Cardiovascular Diseases, Myocardial Ischemia, Arterial Occlusive Diseases
- Trial name
- FORTRESS (NCT03405506)
- Testing
- Quantitative Flow Ratio (QFR)
- Where
- China
- Volunteers
- 308 people
- Sponsor
- Pulse Medical Imaging Technology (Shanghai) Co., Ltd