Clinical trials: Fluid Therapy
Critically Ill, Acute Kidney Injury
Comparison of Biphozyl® and Phoxilium® as a Replacement Fluid During CVVH for AKI in Adults and Their Effects on pH-, Bicarbonate-levels and Respiratory Situation
The primary objectives of the BiPhox-Trial are to demonstrate, that the use of Biphozyl® as a replacement fluid in adult critically ill acute kidney injury (AKI) patients, results in a lower rate of pH excursions and of…
- Conditions
- Critically Ill, Acute Kidney Injury, Renal Replacement Therapy, Continuous Renal Replacement Therapy
- Trial name
- NCT04071171
- Testing
- CVVH with Phoxilium® in the first 48h after randomization, CVVH with Biphozyl® in the first 48h after randomization, CVVH with Phoxilium® in the second 48h after randomization (after previous 48h with Biphozyl®)
- Where
- Austria
- Volunteers
- 88 people
- Sponsor
- Medical University Innsbruck
Goal Directed Fluid Therapy
Stroke Volume Variation and Plethysmography Variability Index as Goal Directed Fluid Therapy in Major Oncosurgeries
Patients were allotted to two Groups , SVV Guided Fluid Therapy Group received intraoperative fluids to maintain SVV <11 , and PVI Guided Group received intraoperative Fluids to maintain PVI<11
- Trial name
- SVV PVI GDFT (NCT05142163)
- Testing
- Intraoperative SVV Guided Fluid Therapy, Intraoperative PVI Guided Fluid Therapy
- Where
- India
- Volunteers
- 68 people
- Sponsor
- Rajiv Gandhi Cancer Institute & Research Center, India
Goal-directed Fluid Therapy
Stroke Volume Variation- Guided Hemodynamic Therapy Versus Oxygen Extraction Ratio-guided Hemodynamic Therapy
The FloTrac/Vigileo is a minimal invasive device assessing flow based hemodynamic parameters by pulse contour analysis based on the radial artery pressure signal.
- Trial name
- NCT05487924
- Testing
- SVV-GDHT, O2ER-GDHT, conventional care
- Volunteers
- 610 people
- Sponsor
- Beijing Tongren Hospital
Newborn Complication, Hyponatremia of Newborn
Comparison of the Isotonic and Hypotonic Intravenous Maintenance Fluids In Term Newborns: Neofluid Study
Considering the physiological changes in fluid and electrolyte balance and providing proper support are one of the important aspects of neonatal intensive care.
- Conditions
- Newborn Complication, Hyponatremia of Newborn, Hypernatremia of Newborn, Fluid Therapy
- Trial name
- NEOFLUID (NCT04781361)
- Testing
- Intravenous isotonic fluid - NaCl 131-154 mmol/L in 5% dextrose, Intravenous Hypotonic fluid- Sodium Chloride < 130 mmol/L
- Where
- Turkey (Türkiye)
- Volunteers
- 420 people
- Sponsor
- Dokuz Eylul University
Sepsis, Emergency Medical Services
Orange Park Out-of-Hospital Quality Improvement Study for Improving CMS Sepsis Core Measures
The goal of this quality improvement study is to measure the impact of incorporation of a manual rapid fluid infuser (RFI) for intravenous crystalloid infusion in patients with suspected sepsis in the prehospital interval.
- Conditions
- Sepsis, Emergency Medical Services, Quality Improvement, Shock, Septic
- Trial name
- NCT05961137
- Testing
- Incorporation of Rapid Fluid Infusion Device in Prehospital Suspected Sepsis Protocol, Conventional Prehospital Suspected Sepsis Protocol
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Orange Park Medical Center
Cardiorenal Syndrome, Acute Kidney Injury
Effect on Kidney Function Recovery Guiding Decongestion With VExUS in Patients With Cardiorenal Syndrome 1
During cardiorenal syndrome type 1 (CRS1) vascular congestion is the major contributor to worsening renal function, but promoting decongestion with routine clinical evaluation is ineffective in some patients.
- Conditions
- Cardiorenal Syndrome, Acute Kidney Injury, Decompensated Heart Failure, Fluid Overload
- Trial name
- NCT05927285
- Testing
- Vexus, Control group
- Where
- Mexico
- Volunteers
- 140 people
- Sponsor
- Hospital Civil de Guadalajara
Fluid Therapy, Brain Edema
Effects of Intraoperative GDFT on the Postoperative Brain Edema
Whether a fluid protocol aiming for protecting vital organ perfusion or fluid restriction is favorable to post-craniotomy outcomes such as brain edema remains uncertain.
- Conditions
- Fluid Therapy, Brain Edema, Brain Tumor
- Trial name
- NCT03323580
- Testing
- GDFT, traditional fluid therapy
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Beijing Tiantan Hospital
Goal-directed Fluid Therapy
Effect of SVV-guided Fluid Therapy on Outcomes After Major Abdominal Surgery
The investigators conduct this randomized assessor-blinded controlled trial to evaluate the effect of SVV-guided fluid therapy on postoperative morbidity and mortality in comparison with conventional fluid therapy after major…
- Trial name
- NCT03940144
- Testing
- the enhanced flow-based hemodynamic parameters of the FloTrac/Vigileo device
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Beijing Tongren Hospital
Fluid Therapy, Postoperative Period
Effects of Restrictive Fluid Strategy on Postoperative Oliguric Pancreatic Surgery Patients
Reduced urinary output is a common postoperative issue for patients going through major surgery such as pancreatic surgery. Commonly this is treated by increasing fluid administration to the patients and sometimes also diuretics.
- Conditions
- Fluid Therapy, Postoperative Period, Postoperative Complications, Pancreas Disease
- Trial name
- NCT03553394
- Testing
- Ringer's Acetate
- Where
- Sweden
- Volunteers
- 53 people
- Sponsor
- Uppsala University
Thoracic Surgery, Fluid-therapy
GDT-PPV Protocol in Thoracic Surgery
Peri-operative fluid-therapy is extremely important in thoracic surgery, because excessive administration of fluids during one-lung ventilation is correlated to an increasing risk of postoperative respiratory complications.
- Trial name
- NCT04865874
- Testing
- PPV-GDT, Zero-balance
- Where
- Italy
- Volunteers
- 88 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Periodontitis Chronic Generalized Severe, Hyperlipidemia
Effects of Non-surgical Periodontal Therapy on Severe Periodontitis and Hyperlipidemia
This study was a single-center, non-randomized, parallel-group design clinical trial, and each group was assigned a 1:1 ratio with or without hyperlipidemia.
- Conditions
- Periodontitis Chronic Generalized Severe, Hyperlipidemia, Gingival Crevicular Fluid, Serum
- Trial name
- NCT05548933
- Testing
- non-surgical periodontal therapy
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Fluid Therapy
Goal Directed and Liberal Fluid Therapy
The aim is to compare intraoperative goal directed fluid therapy (GDFT) versus liberal fluid therapy in patients undergoing elective colorectal surgery by using noninvasive electrical cardiometry.
- Trial name
- NCT05487222
- Testing
- ICON
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Goal Directed Therapy, Fluid Therapy
Goal Directed Therapy Versus Standard Care in Lung Resection Surgery (GDT-thorax Study).
The primary aim of this study is to quantify and compare the hemodynamic control of cardiac index in patients who receive either goal-directed therapy or standard hemodynamic management in lung resection surgery
- Trial name
- GDT-thorax (NCT03245372)
- Testing
- Standard care, Goal directed therapy
- Where
- Spain
- Volunteers
- 31 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Microcirculation, Fluid Therapy
Effects of Fluid Therapy on Microcirculatory Reactivity
Through preoperative fluid therapy, to investigate whether it can alleviate the microcirculation dysfunction after induction of anesthesia, and reduce the incidence of perioperative fluid therapy-related complications, thereby…
- Trial name
- NCT04982016
- Testing
- crystal therapy, colloid therapy
- Volunteers
- 126 people
- Sponsor
- Beijing Anzhen Hospital
Aged, 75 and Over, Aged
The Absorption Rate of Subcutaneous Infused Fluid
The purpose of the study is to examine the rate of absorption of subcutaneous infused fluid in older adults when acutely ill compared to when they are not acutely ill.
- Conditions
- Aged, 75 and Over, Aged, Hypodermoclysis, Fluid Therapy
- Trial name
- ABSU (NCT04536324)
- Testing
- Subcutaneous parenteral hydration
- Where
- Denmark
- Volunteers
- 6 people
- Sponsor
- Aalborg University Hospital
Fluid Therapy
TEE as a Guide for Fluid Optimization in Major Abdominal Oncosurgery
Transesophageal echocardiography (TEE) as guide for tailoring perioperative fluid therapy to achieve individualized hemodynamic endpoint, target hemodynamic goals of stroke volume index (SVI) greater than 35 mL/m2 and cardiac…
- Trial name
- VTI SVV (NCT03140540)
- Testing
- TEE guided fluid therapy will be administered, Stroke volume variation guided intravenous fluid.
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Rajiv Gandhi Cancer Institute & Research Center, India
Septic Shock, Hemodynamic Instability
Whether a Minimal Volume Could Predict Fluid Responsiveness Using Thermodilution by PAC in Septic Shock Patients
Assessment of fluid responsiveness (FR) is to detect whether patient could benefit from fluid therapy. Mini fluid challenge has been widely used in clinical practice to prevent patients from volume overload.
- Conditions
- Septic Shock, Hemodynamic Instability, Fluid Therapy
- Trial name
- NCT04515511
- Testing
- 4% gelatin
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking Union Medical College Hospital
Stroke Volume Variation, Pulse Pressure Variation
SVV and PPV Predict Fluid Responsiveness in Mechanically Ventilated Elderly Patients Under General Anesthesia
Although individualized or goal-directed approach has been advocated, a reliable index is still required to help monitor the volume status timely and efficiently.
- Conditions
- Stroke Volume Variation, Pulse Pressure Variation, Fluid Responsiveness, Fluid Therapy
- Trial name
- NCT04388995
- Testing
- volume expansion
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Chinese PLA General Hospital
Fluid Therapy, Monitoring, Intraoperative
Assessing Fluid Responsiveness With PWTT
Pulse wave Transit time (PWTT) is a parameter calculated from ECG and pulseoximeter. It is supposed to help assessing the preload Status and guide intraoperative fluid therapy.
- Trial name
- NCT03280953
- Testing
- Assessing fluid responsiveness by PWTT value
- Where
- Germany
- Volunteers
- 38 people
- Sponsor
- Johannes Gutenberg University Mainz
Goal-Directed Fluid Therapy, Hemodynamic Monitoring
Comparison of Goal-directed and Liberal Fluid Management
Background: The investigators aim is to indicate that the "goal directed fluid management" is more effective for open abdominal surgeries by performing perioperative hemodynamic monitorisation using a minimal invasive pulse…
- Conditions
- Goal-Directed Fluid Therapy, Hemodynamic Monitoring, Fluid Management
- Trial name
- NCT04265014
- Testing
- Goal-directed fluid treatment, Liberal Fluid Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital