Clinical trials: Fissure in Ano
Chronic Anal Fissure
Percutaneous Tibial Nerve Stimulation - an Alternative Treatment Option for Chronic Therapy Resistant Anal Fissure
At a tertiary referral centre, 10 patients (4 male and 6 female; mean age 49.8 years) were given neuromodulation via the posterior tibial nerve to the sacral nerve for 30 min on 10 consecutive days.
- Trial name
- NCT03554421
- Testing
- Percutaneous tibial nerve stimulation
- Volunteers
- 10 people
- Sponsor
- Region Skane
Anal Fissure Chronic
Comparative Outcomes of Inj Botox Alone vs Inj Botox Combined With Fissurectomy and Anoplasty in the Management of Chronic Anal Fissure
Chronic anal fissure is a common benign anorectal condition characterized by severe pain during defecation, rectal bleeding, and reduced quality of life.
- Trial name
- NCT07665528
- Testing
- Botulinum Toxin Type A (BOTOX) Injection, Botulinum Toxin Type A (BOTOX) Injection, Fissurectomy and Anoplasty
- Where
- Pakistan
- Volunteers
- 108 people
- Sponsor
- Islamabad Medical and Dental College
Chronic Anal Fissure
Closed Versus Open Lateral Internal Sphincterotomy for Chronic Anal Fissure
This randomized controlled trial will compare closed versus open lateral internal sphincterotomy (LIS) under spinal anesthesia in patients with chronic anal fissure.
- Trial name
- LIS-CLOSED Tri (NCT07496216)
- Testing
- Closed Lateral Internal Sphincterotomy, Open Lateral Internal Sphincterotomy
- Where
- Pakistan
- Volunteers
- 160 people
- Sponsor
- Services Hospital, Lahore
Chronic Anal Fissure
Diltiazem Hydrochloride Cream for Anal Fissure
A Phase III, multicentre, randomised, double blind, placebo-controlled study in subjects having anal fissure (AF) with AF-related pain.
- Trial name
- NCT01217515
- Testing
- Diltiazem hydrochloride 4% cream, Diltiazem hydrochloride 2% cream
- Where
- 27 sites in Bulgaria, Germany and 4 more
- Volunteers
- 465 people
- Sponsor
- S.L.A. Pharma AG
Pharmacokinetics, Healthy Subjects
Pharmacokinetics Trial of Isosorbide Mononitrate 0.5% Gel for Intra Anal Application in Healthy Subjects
This is a Phase I trial to evaluate pharmacokinetics and safety of Isosorbide Mononitrate gel for intra anal administration in healthy subjects.
- Trial name
- NCT04729088
- Testing
- Isosorbide mononitrate
- Volunteers
- healthy volunteers welcome
- Sponsor
- Biolab Sanus Farmaceutica
Perianal Fistula, Fissure in Ano
Perianal Nerval Block in Proctological Interventions
The aim of this study is to evaluate whether a local perianal block performed during a proctological intervention can reduce the postoperative pain.
- Conditions
- Perianal Fistula, Fissure in Ano, Hemorrhoids
- Trial name
- NCT03405922
- Testing
- 40 mL Ropivacain 0.5%
- Where
- Switzerland
- Volunteers
- 166 people
- Sponsor
- University Hospital, Basel, Switzerland
Fissure in Ano
Percutaneous Tibial Nerve Stimulation (PTNS) for the Treatment of Chronic Anal Fissure
Chronic anal fissure rarely heals spontaneously. About 50% heal on administration om topical muscle relaxants (e.g. diltiazem) and/or injection of Botulinum toxin, but for the remainder of patients surgery (with lateral internal…
- Trial name
- NCT04604483
- Testing
- PTNS
- Where
- Sweden
- Volunteers
- 52 people
- Sponsor
- Region Skane
Chronic Anal Fissure, Hemorrhoidal Disease
Female Sexual Function After Surgery for Benign Perianal Diseases
Benign perianal diseases such as chronic anal fissure, hemorrhoidal disease, and cryptoglandular anal fistula may negatively affect female sexual function through pain, bleeding, discharge, discomfort, and impairment in quality…
- Conditions
- Chronic Anal Fissure, Hemorrhoidal Disease, Cryptoglandular Anal Fistula
- Trial name
- PERISEX (NCT07666035)
- Testing
- Surgical Treatment for Benign Perianal Diseases
- Volunteers
- 120 people
- Sponsor
- Gazi University
Focus: Anal Incontinence After Lateral Sphincterotomy for Chronic Anal Fissure
Ultrasound Guided Lateral Sphincterotomy: Long Term Results
Ultrasound guided placement of the knife intersphincteric increases accuracy and safety during sphincterotomy. Secondly 3-D ultrasound visualizes that the internal anal sphincter is divided.
- Trial name
- NCT02020915
- Testing
- lateral sphincterotomy, ultrasound guided lateral sphincterotomy
- Where
- Denmark
- Volunteers
- 28 people
- Sponsor
- Hvidovre University Hospital
Fissure;Anal, Fistula;Rectal
Efficacy and Safety of CLIFE1 Gel in Benign Anorectal Surgery
Double-blinded multicenter randomized clinical trial to evaluate the efficacy and safety of CLIFE2 (lidocaine, referred as treatment A) respect CLIFE1 (lidocaine plus diclofenac, referred as treatment B) in benign anorectal…
- Conditions
- Fissure;Anal, Fistula;Rectal, Hemorrhoids
- Trial name
- NCT02961855
- Testing
- anesthesics plus antiinflammatory, CLIFE1, local anesthesics, CLIFE2
- Volunteers
- 120 people
- Sponsor
- Hospital de Viladecans
Hemorrhoids, Hemorrhoidal Disease
War-Drill Model Guided Treatment of Hemorrhoids With Nimsai Herbal (NAJ)
This study investigated a new understanding of hemorrhoid formation and evaluated a novel systemic treatment. For 200 years, hemorrhoids were conventionally understood as isolated swollen veins.
- Trial name
- NAJ (NCT07034820)
- Testing
- Nimsai Herbal
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Nimsai Academia
Chronic Anal Fissure
Comparison of Lateral Internal Sphincterotomy Techniques for Chronic Anal Fissure
This prospective randomized controlled trial compares three lateral internal sphincterotomy (LIS) techniques in patients with chronic anal fissure refractory to medical treatment: (1) Spasm-Controlled LIS (serial small…
- Trial name
- SPHINX (NCT07520552)
- Testing
- Spasm-Controlled Lateral Internal Sphincterotomy, Lateral Internal Sphincterotomy up to Fissure Apex, Lateral Internal Sphincterotomy up to Dentate Line
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Çanakkale Onsekiz Mart University
Chronic Anal Fissure
E-CEL UVEC Treatment for Anal Fissures
This clinical trial is being conducted by investigators who are colorectal surgeons. Eligible study participants will receive the experimental treatment E-CEL UVEC cells by direct injection into the anal fissure.
- Trial name
- NCT06456073
- Testing
- E-CEL UVEC cells (AB-207)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Pain
Glyceryl Trinitrate Ointment vs Posterior Tibial Nerve Stimulation in the Treatment of Anal Fissure
A prospective randomized study was performed. Compliance with the treatment and healing rate of chronic anal fissure in patients receiving glyceryl trinitrate ointment (GTO) and subjects undergoing percutaneous posterior tibial…
- Trial name
- NCT02700438
- Testing
- Glyceryl trinitrate ointment, Urgent PC Neuromodulation System®
- Volunteers
- 80 people
- Sponsor
- Hospital General Universitario Elche
Chronic Anal Fissure
Postero-lateral Internal Sphincterotomy vs Botulinum Toxin Injection in the Treatment of Chronic Anal Fissure
We hypothesized that optimization of the dose of the Botulinum toxin injection (BT) and standardization of the technique of lateral internal sphincterotomy to posterolateral internal sphincterotomy (PIAS) could, in turn, report a…
- Trial name
- NCT03920449
- Testing
- Botulinum Toxins, Posterolateral internal sphincterotomy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Fistula-in-ano, Rectal Polyp
Trial on Use of Coloshield in Transanal and Anal Surgery
In various transanal and anal procedures it is desirable to clean the operating field from stool contamination. Thus mechanical bowel preparation is not well tolerated by patients. Enema does not provide sufficient effect.
- Conditions
- Fistula-in-ano, Rectal Polyp, Rectal Adenoma, Hemorrhoids
- Trial name
- NCT02579330
- Testing
- Coloshield, Control
- Where
- Switzerland
- Volunteers
- 22 people
- Sponsor
- Daniel Steinemann, MD
Puerperal Infection, Fever
Diet and Lifestyle Intervention Study in Postpartum Women in China
Previous studies have shown "Doing the month", a traditional practice for postpartum women in China and other Asian countries, may be associated with higher prevalence of postpartum problems.
- Conditions
- Puerperal Infection, Fever, Constipation, Hemorrhoids
- Trial name
- NCT01039051
- Testing
- Diet and Lifestyle Intervention in Chinese Postpartum Women
- Where
- 3 sites in China
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Huazhong University of Science and Technology
Fissure in Ano
The Role of Fitostimoline Proctogel in Symptoms Relief and Healing in Patients Affected by Anal Fissure
Evaluate the effectiveness of fitostimoline proctogel in the anal fissure healing and in the need for invasive interventions (primary endpoints) and in the healing of the fissure (secondary endpoint) using Fitostimoline in…
- Trial name
- NCT04714684
- Testing
- Fitostimoline proctogel, Fitostimoline proctogel + muscle relaxant
- Volunteers
- 100 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Chronic Anal Fissure
RELIEF Study: Resolving Fissures With Lateral Internal Sphincterotomy
The goal of this observational study is to learn how a common surgery called lateral internal sphincterotomy (LIS) affects people with chronic anal fissures, a painful tear near the anus.
- Trial name
- RELIEF (NCT06984601)
- Testing
- Lateral Internal Sphincterotomy (LIS)
- Volunteers
- 300 people
- Sponsor
- Turkish Society of Colon and Rectal Surgery
Fissure in Ano, Diarrhea
The Efficacy of Asacol (Mesalazine) Suppository on the Treatment of Diarrhea-Induced Acute Fissure
Anal fissure define as a superficial tearing in mucosa on the anoderm surface distal to dentate line . The most important factor is hard stool passing with trauma to anal mucosa.
- Trial name
- NCT05091775
- Testing
- Asacol is used to treat and prevent mild to moderate acute fissure disease
- Where
- Iran
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Shiraz University of Medical Sciences