Clinical trials: Fissure in Ano
Chronic Anal Fissure
Topical Nitroglycerin Versus Lateral Internal Sphincterotomy for Chronic Anal Fissure
Chronic anal fissure is a tear in the lining of the anal canal that can cause pain during and after defecation. This randomized controlled trial will compare topical 0.2% nitroglycerin ointment with lateral internal…
- Trial name
- NCT07884916
- Testing
- Topical 0.2% Glyceryl Trinitrate (Nitroglycerin) Ointment, Lateral Internal Sphincterotomy
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- Sheikh Zayed Federal Postgraduate Medical Institute
Anal Fissure Chronic
Ultrasound Assessment After Surgery for Chronic Anal Fissure
Chronic anal fissure is a painful tear in the lining of the anal canal that may not heal with medication or other non-surgical treatments. Lateral internal sphincterotomy (LIS) is a commonly used surgical treatment.
- Trial name
- NCT07809711
- Where
- Spain
- Volunteers
- 66 people
- Sponsor
- Hospital Clínico Universitario de Valencia
Chronic Anal Fissure
AI-Assisted Written Information in Chronic Anal Fissure
This single-center, prospective, 1:1 randomized, parallel-group controlled superiority trial compares standard verbal counseling with AI-assisted written patient information in adults with primary chronic anal fissure receiving…
- Trial name
- AF-AI (NCT07701811)
- Testing
- AI-assisted written patient information, Standardized verbal counseling
- Where
- Turkey (Türkiye)
- Volunteers
- 220 people
- Sponsor
- Sanliurfa Education and Research Hospital
Morbid Obesity, Anorectal Diseases
GLP-1 Receptor Agonists and Early Proctologic Effects in Morbid Obesity
Prospective observational cohort study evaluating the early proctologic effects of GLP-1 receptor agonist therapy in morbidly obese patients.
- Conditions
- Morbid Obesity, Anorectal Diseases, Drug-Related Side Effects and Adverse Reactions, Constipation
- Trial name
- GLP-PROCT (NCT07668765)
- Testing
- GLP-1 receptor agonist therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Gazi University
Perianal Crohn Disease, Perianal Fistula
The Impact of Perianal Disease on Patient's Sex Life
Perianal diseases, such as perianal abcesses, anal fistulae and perianal Crohn's disease, are often associated with significant physical symptoms, including pain and chronic drainage.
- Conditions
- Perianal Crohn Disease, Perianal Fistula, Fistula in Ano, Perianal Abscess
- Trial name
- SEXTON (NCT07519850)
- Testing
- Patient Reported Outcome Assessment (Questionnaires)
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- AHEPA University Hospital
Chronic Anal Fissure
Combined Method of Surgical Treatment of Anal Fissure
The purpose of this study is to improve treatment outcomes for patients with chronic anal fissure.
- Trial name
- NCT07268261
- Testing
- excision of the anal fissure with further relaxation of the internal sphincter with botulinum toxin A
- Where
- Russia
- Volunteers
- 122 people
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Hemorrhoids, Hemorrhoidal Disease
War-Drill Model Guided Treatment of Hemorrhoids With Nimsai Herbal (NAJ)
This study investigated a new understanding of hemorrhoid formation and evaluated a novel systemic treatment. For 200 years, hemorrhoids were conventionally understood as isolated swollen veins.
- Trial name
- NAJ (NCT07034820)
- Testing
- Nimsai Herbal
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Nimsai Academia
Hemorrhoid, Anal Fistulas
Effect of Listening to Standardized Music Sequences on Preventing Postoperative Pain in Proctologic Surgery
The study, "Effect of Listening to Standardized Music Sequences on Preventing Postoperative Pain in Proctologic Surgery," aims to evaluate the impact of preoperative listening to standardized music sequences on postoperative pain…
- Conditions
- Hemorrhoid, Anal Fistulas, MUSICAL THERAPY, Anal Fissure and Fistula
- Trial name
- MUSICOPROCTO (NCT06798155)
- Testing
- Standardized Music Listening Therapy
- Where
- 2 sites in Reunion
- Volunteers
- 550 people
- Sponsor
- Clinique Saint-Vincent
Anal Fistula, Anal Fissure Chronic
Effect of Enhanced Recovery After Surgery for Benign Anorectal Conditions
This study aims to assess the role of Enhanced recovery after surgery(ERAS) protocol in reducing postoperative urine retention (POUR) after surgery for benign anorectal conditions.
- Conditions
- Anal Fistula, Anal Fissure Chronic, Haemorrhoid, Enhanced Recovery After Surgery (ERAS) Protocol
- Trial name
- NCT06803550
- Testing
- Enhanced recovery after surgery protocol, Routine pathway
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Anal Fissure
Comparative Evaluation of MEBO Ointment and Topical Diltiazem Ointment in the Treatment of Acute Anal Fissure
No study to date has compared topical DTZ to MEBO ointment in the treatment of anal fissure. Therefore, the present study aims to compare the efficacy and safety of DTZ to MEBO in the treatment of acute anal fissure.
- Trial name
- MEBO (NCT04153032)
- Testing
- Diltiazem, Mebo
- Where
- Lebanon
- Volunteers
- 183 people
- Sponsor
- American University of Beirut Medical Center
Anal Fissure Chronic, Anal Fissure
Effect of Phenytoin Cream on Wound Healing After Anal Fissure Surgery.
This study aims to compare the effect of phenytoin cream on wound healing after anal fissure surgery compared to control group.
- Conditions
- Anal Fissure Chronic, Anal Fissure, Wound Healing
- Trial name
- RCT (NCT06633185)
- Testing
- phenytoin cream, no phenytoin cream
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Mansoura University
Anal Fissure Chronic
The Efficacy of Botulinum Toxin Alone Versus Combined Botulinum Toxin and Topical Diltiazem in Chronic Anal Fissure
Anal fissure (AF) is a painful tear extending from the anal canal to the dentate line. Although the exact pathophysiology is not known, an increase in anal tonus, decreased ano-dermal blood flow and local ischemia are possible…
- Trial name
- NCT05797220
- Testing
- Botulinum Toxin Type A Injection [Botox], Botulinum Toxin Type A Injection [Botox] + Diltiazem Hydrochloride 20 Mg/G Rectal Gel
- Where
- Turkey (Türkiye)
- Volunteers
- 217 people
- Sponsor
- Istanbul Medipol University Hospital
Anorectal Diseases, Hemorrhoids
Comparative Analysis of Hypobaric Versus Hyperbaric Bupivacaine for Spinal Anesthesia in Day-Case Anorectal Surgery
Spinal anesthesia for anorectal surgery ( fistulotomy, fissure repair, pilonidal sinus excision,hemorrhoidectomy..) is a popular and widely used method characterized by rapid onset, delivery, easy mobilization and short hospital…
- Conditions
- Anorectal Diseases, Hemorrhoids, Anal Polyp, Pilonidal Sinus
- Trial name
- NCT05409820
- Testing
- use of different spinal anesthesia techniques
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ankara City Hospital Bilkent
Inflammatory Bowel Diseases, Anal Fissure
Laser Versus Surgery in Anal Diseases in Inflammatory Bowel Patients
This is a randomized comparative clinical trial carried out to compare between laser ablation and surgery in treating anal diseases in inflammatory bowel diseases patients and find out if one is superior to the other.
- Conditions
- Inflammatory Bowel Diseases, Anal Fissure, Hemorrhoids
- Trial name
- NCT06216223
- Testing
- treatment of anal diseases in inflammatory bowel patients, Laser, traditional surgery
- Where
- Egypt
- Volunteers
- 108 people
- Sponsor
- Zagazig University
Hemorrhoid Pain, Haemorrhoid Inflammation
Efficacy and Safety of CONAN® Proctological Cream for Treatment of Haemorrhoidal Disease
Aim of the study is to assess the efficacy, safety and tolerability of CONAN® (Proctological Cream, Medical Device, Omikron Italia Srl) on most frequent symptoms in grade 1-2 of haemorrhoidal disease and anal fissures.
- Trial name
- NCT05984641
- Testing
- CONAN® Proctological Cream
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Omikron Italia S.r.l.
Fissure in Ano
Percutaneous Tibial Nerve Stimulation (PTNS) for the Treatment of Chronic Anal Fissure
Chronic anal fissure rarely heals spontaneously. About 50% heal on administration om topical muscle relaxants (e.g. diltiazem) and/or injection of Botulinum toxin, but for the remainder of patients surgery (with lateral internal…
- Trial name
- NCT04604483
- Testing
- PTNS
- Where
- Sweden
- Volunteers
- 52 people
- Sponsor
- Region Skane
Hemorrhoids, Anal Fissure and Fistula
Pudendal Nerve Block With Bupivacaine Alone and Bupivacaine With Methylene Blue for Postoperative Analgesia
Study Description: The goal of this clinical trial is to compare the duration of postoperative pain relief achieved with two different approaches to pudendal nerve block in patients undergoing elective perianal surgery.
- Conditions
- Hemorrhoids, Anal Fissure and Fistula, Perianal Abscess, Perianal Fistula
- Trial name
- NCT05990569
- Testing
- Ultrasound guided Pudendal nerve block
- Where
- Nepal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nepal Mediciti Hospital
Hemorrhoids, Anal Fistula
Could Preoperative Assessment of Physical and Psychological Status Help Predict Pain After Anorectal Surgery?
The aim of this single-center prospective observational trial is to study the influence of physical and psychological factors on the intensity of pain syndrome after anorectal interventions and to determine the association…
- Conditions
- Hemorrhoids, Anal Fistula, Anal Fissure, Incontinence
- Trial name
- NCT06049524
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Center of Endourology "Endocenter"
Fissure in Ano
Use of Fototherapy in the Treatment of Fissure in Ano
The eligible population consisted of individuals with anal fissure awaiting surgical intervention. Individuals aged 18 years or older were included, diagnosed with anal fissure and who voluntarily agreed to participate in the…
- Trial name
- NCT05993793
- Testing
- Fototherapy
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Centro de Atenção ao Assoalho Pélvico
Anal Fissure, Constipation
Efficacy of Polyethylene Glycol vs Lactulose With Isabgol in Acute Fissure-in-Ano: PEGASIS Trial
The existing literature stresses the better efficacy of polyethylene glycol (PEG) over other stool softeners like lactulose or isabgol to improve functional constipation.
- Trial name
- PEGASIS (NCT05341180)
- Testing
- Polyethylene Glycol, Isabgol + Lactulose
- Where
- India
- Volunteers
- 144 people
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar