Clinical trials: Fissure in Ano
Fissure in Ano
The Use of Platelet-rich Plasma in the Treatment of Chronic Anal Fissure
use of platelet rich plasma had good effect in treating chronic wounds. healing of perianal fissure could be prolonged and associated with pain.
- Trial name
- NCT05837403
- Testing
- Platelet rich plasma injection, Nitroglycerin ointment
- Where
- Iraq
- Volunteers
- 460 people
- Sponsor
- Al-Kindy College of Medicine
Hemorrhoids, Anal Fissure
Effects of Sodium Pentaborat Based Gel on Perianal Benign Diseases
New produced and patented sodium pantaborat based gel will be use for treatment of benign perianal diseases (hemooroidal disease, anal fissura anda perianal fistula)
- Conditions
- Hemorrhoids, Anal Fissure, Perianal Fistula
- Trial name
- NCT03780998
- Testing
- Life7
- Volunteers
- 250 people
- Sponsor
- SB Istanbul Education and Research Hospital
Hemorrhoid Pain, Haemorrhoid Inflammation
Efficacy and Safety of CONAN® Proctological Cream for Treatment of Haemorrhoidal Disease
Aim of the study is to assess the efficacy, safety and tolerability of CONAN® (Proctological Cream, Medical Device, Omikron Italia Srl) on most frequent symptoms in grade 1-2 of haemorrhoidal disease and anal fissures.
- Trial name
- NCT05984641
- Testing
- CONAN® Proctological Cream
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Omikron Italia S.r.l.
Chronic Anal Fissure
Combined Method of Surgical Treatment of Anal Fissure
The purpose of this study is to improve treatment outcomes for patients with chronic anal fissure.
- Trial name
- NCT07268261
- Testing
- excision of the anal fissure with further relaxation of the internal sphincter with botulinum toxin A
- Where
- Russia
- Volunteers
- 122 people
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Chronic Anal Fissure
Outcomes of the Use of CO2 (Carbon Dioxide) Laser in the Treatment of Chronic Anal Fissure
Outcomes of using CO2 (Carbon Dioxide) laser in the management of chronic anal fissure as an alternative to conventional methods
- Trial name
- NCT03872765
- Testing
- Laser surgery
- Volunteers
- 236 people
- Sponsor
- University of Nineveh
Pain, Postoperative
Sitz Bath vs no Sitz Bath in Acute Anal Fissure Treatment
To compare the efficacy of 'sitz bath' and 'no sitz bath' treatment in terms of pain improvement, rate of cure and fissure healing in Acute Anal Fissure.
- Trial name
- NCT05666648
- Testing
- Sitz Bath
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Combined Military Hospital Quetta
Chronic Anal Fissure
Perianal Versus Endoanal Application of Glyceryl Trinitrate 0.4% Ointment for Chronic Anal Fissure
Perianal topical nitroglycerin has been widely used as a means for avoiding surgery in patients with anal fissure. However, nitroglycerin has not been universally accepted for this application because of inconsistency of efficacy…
- Trial name
- NCT01132391
- Testing
- Rectogesic® (glyceryl trinitrate 0.4% ointment)
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital General Universitario Elche
Fissure in Ano, Rectal Diseases
Diltiazem Ointment With Lidocaine vs. Nifedipine Ointment With Lidocaine Ointment for Treatment of Chronic Anal Fissure
Anal fissure is a common anorectal diseases characterized by tear of the anoderm from the dentate line to the anal verge leading to pain and bleeding during and post defecation.
- Conditions
- Fissure in Ano, Rectal Diseases, Rectal Bleed
- Trial name
- NCT04887818
- Testing
- 2% Diltiazem ointment with 1.5% lidocaine, 0.3% Nifedipine ointment with 1.5% lidocaine
- Where
- Canada
- Volunteers
- 430 people
- Sponsor
- University of Calgary
Anal Fissure
Posterolateral Versus Lateral Internal Anal Sphincterotomy for Chronic Anal Fissure
The present study aimed to compare the standard lateral internal sphincterotomy at 3 o'clock with posterolateral internal sphincterotomy at 5 o'clock in regards healing time, postoperative recurrence and complications…
- Trial name
- NCT03426449
- Testing
- posterolateral sphincterotomy, lateral sphincterotomy
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Mansoura University
Anal Fissure, Constipation
Efficacy of Polyethylene Glycol vs Lactulose With Isabgol in Acute Fissure-in-Ano: PEGASIS Trial
The existing literature stresses the better efficacy of polyethylene glycol (PEG) over other stool softeners like lactulose or isabgol to improve functional constipation.
- Trial name
- PEGASIS (NCT05341180)
- Testing
- Polyethylene Glycol, Isabgol + Lactulose
- Where
- India
- Volunteers
- 144 people
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Anal Fissure
Efficacy Study of Dysport® in the Treatment of Anal Fissure.
To evaluate the effect on healing rates of two different prognostic factors in patients treated with Dysport® for anal fissure: duration of fissure and dose of study drug
- Trial name
- NCT00210444
- Testing
- Botulinum toxin type A
- Where
- 7 sites in Czechia, Poland and 2 more
- Volunteers
- 168 people
- Sponsor
- Ipsen
Hemorrhoid, Anal Fistulas
Effect of Listening to Standardized Music Sequences on Preventing Postoperative Pain in Proctologic Surgery
The study, "Effect of Listening to Standardized Music Sequences on Preventing Postoperative Pain in Proctologic Surgery," aims to evaluate the impact of preoperative listening to standardized music sequences on postoperative pain…
- Conditions
- Hemorrhoid, Anal Fistulas, MUSICAL THERAPY, Anal Fissure and Fistula
- Trial name
- MUSICOPROCTO (NCT06798155)
- Testing
- Standardized Music Listening Therapy
- Where
- 2 sites in Reunion
- Volunteers
- 550 people
- Sponsor
- Clinique Saint-Vincent
Perianal Crohn Disease, Perianal Fistula
The Impact of Perianal Disease on Patient's Sex Life
Perianal diseases, such as perianal abcesses, anal fistulae and perianal Crohn's disease, are often associated with significant physical symptoms, including pain and chronic drainage.
- Conditions
- Perianal Crohn Disease, Perianal Fistula, Fistula in Ano, Perianal Abscess
- Trial name
- SEXTON (NCT07519850)
- Testing
- Patient Reported Outcome Assessment (Questionnaires)
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- AHEPA University Hospital
Anal Fissure Chronic
Pulsed Electromagnetic Field on Chronic Anal Fissure Healing
The purpose of this study is to find the effect of Pulsed Electromagnetic Field on chronic Anal fissure healing. Included both male and female aged 30-60 suffering from Anal fissure symptoms.
- Trial name
- PEMF (NCT07729709)
- Testing
- PEMS, Lidocaine and general advice, Lidocaine cream and general advice
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Galala University
Anal Fissure Chronic
Comparison of Botulinum Toxin Injection and Lateral Internal Sphincterotomy in Chronic Anal Fissure Management
This study aims to compare two commonly used treatments for chronic anal fissure: botulinum toxin injection and lateral internal sphincterotomy.
- Trial name
- BOT-LIS-CAF (NCT07568314)
- Testing
- Botulinum Toxin Type A (BOTOX) Injection, Lateral Internal Sphincterotomy
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- Islamabad Medical and Dental College
Anal Fissure Chronic, PRP
Short Term Results of Platelet-rich Plasma in the Treatment of Chronic Anal Fissure
Autologous PRP currently has many uses in surgical and medical therapy. Compared with other regenerative therapies, PRP is easy-to-prepare, low-cost, and does not require complex equipment.
- Trial name
- NCT04320498
- Testing
- prp injection, Anrecta, sitz bath
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- KTO Karatay University
Fissure in Ano
Pediatrics Anal Fissures Treatment With Polyethylene Glycol
To evaluate whether effectively treating anal fissure-associated constipation using oral PEG alone can eliminate the inconvenience of add topical agent such as DTZ.
- Trial name
- NCT02419534
- Testing
- Polyethylene glycol, Polyethylene glycol with Diltiazem
- Where
- Saudi Arabia
- Volunteers
- 46 people
- Sponsor
- King Saud University
Fissure in Ano, Pain
A Study to Determine the Effect of Nitroglycerin Ointment 0.4% (Cellegesic) on the Pain Associated With Chronic Anal Fissures
Anal fissure is a solitary ulcer in the squamous epithelium of the anus causing intense anal pain especially during defecation and for 1 or 2 hours afterwards.
- Trial name
- NCT00522041
- Testing
- Cellegesic
- Volunteers
- 248 people
- Sponsor
- Forest Laboratories
Chronic Anal Fissure
Conventional Lateral Internal Sphincterotomy, V-Y Anoplasty and Tailored Lateral Internal Sphincterotomy With V-YF in Treatment of Chronic Anal Fissure(CAF)
The investigators compared conventional lateral internal sphincterotomy (CLIS), V-Y anal flap, and combined tailored lateral internal sphincterotomy with V-Y anal flap (TLIS with V-YF) in a randomized prospective study in…
- Trial name
- CAF (NCT01500889)
- Testing
- Group I: Conventional Lateral internal sphincterotomy:, GroupII: V-Y advancement flap, GroupIII: Tailored LIS with V-Y advancement flap
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Mansoura University
Hemorrhoids, Fissure in Ano
Pre-Emptive Analgesia in Ano-Rectal Surgery
The perianal region is the region around the anus. Administering a pain medication before a surgery starts is called preemptive analgesia.
- Conditions
- Hemorrhoids, Fissure in Ano, Rectal Fistula, Anal Condyloma
- Trial name
- PEAARS (NCT02402543)
- Testing
- Gabapentin, Ketamine, Acetaminophen
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- University of Vermont