Clinical trials: First-Episode Psychosis
First Episode Psychosis
Efficacy and Safety of Paliperidone ER in First Episode Psychosis
The aim of the study is to investigate the efficacy and safety of Paliperidone ER in patients with first episode psychosis.
- Trial name
- NCT01157585
- Testing
- paliperidone ER
- Where
- 12 sites in South Korea
- Volunteers
- 75 people
- Sponsor
- Chonbuk National University Hospital
Psychosis
Group Dialectical Behaviour Therapy (DBT) Skills Training for First Episode Psychosis
Psychosis is a serious mental health condition that can affect how a person thinks, feels, and functions in daily life, often making it harder to maintain relationships, continue education, or work.
- Trial name
- NCT07777315
- Testing
- group DBT
- Volunteers
- 32 people
- Sponsor
- Centre for Addiction and Mental Health
Schizophrenia
Sequential Multiple-Assignment Randomized Trials to Compare Antipsychotic Treatments(SMART-CAT)
This study is a sequential multiple-assignment randomized trial (RCT) of antipsychotic medication treatment in first-episode schizophrenia patients in the real-world settings.Through analysis of treatment efficacy rate and…
- Trial name
- NCT03510325
- Testing
- Phase 1: Olanzapine, Phase 1: Risperidone, Phase 1: Amisulpride
- Where
- 7 sites in China
- Volunteers
- 762 people
- Sponsor
- Shanghai Mental Health Center
Impaired Insight
Targeted Intervention Study of DTMS on Impaired Insight in Early Psychosis
Impaired insight is a key factor in the conversion of high-risk individuals to schizophrenia, but there is a lack of targeted interventions.
- Trial name
- NCT04513132
- Testing
- active-dTMS
- Where
- China
- Sponsor
- Shanghai Mental Health Center
Schizophrenia, Schizophreniform Disorders
Horyzons: Implementation and Integration in Clinical Practice
The primary aim of this trial is evaluating the barriers and enablers of implementing a digital intervention with both therapeutic content and social networking, Horyzons, as part of clinical care in first episode psychosis (FEP)…
- Conditions
- Schizophrenia, Schizophreniform Disorders, Schizoaffective Disorder, Unspecified or Other Psychotic Disorders
- Trial name
- NCT06002958
- Testing
- Horyzons USA
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of North Carolina, Chapel Hill
Schizophrenia
Quetiapine Induced Neuroplasticity in First-episode Schizophrenic Patients
Aim of the study is to assess the effect of quetiapine treatment in neuroleptic naive, first-episode schizophrenic patients on aspects of functional and structural neuroplasticity assessed by means of transcranial magnetic…
- Trial name
- NCT00554658
- Testing
- Quetiapine
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University of Regensburg
Social Phobia, Psychosis
Manualized Group Cognitive-behavioral Therapy for Social Anxiety in First Episode Psychosis
Social anxiety represents one of the most prevalent comorbid conditions in schizophrenia and related psychosis. Schizophrenia patients with comorbid social anxiety often exhibit impaired social functioning, an increased risk for…
- Trial name
- NCT02294409
- Testing
- Manualized group Cognitive-behavioral therapy (CBT) for social anxiety in first episode psychosis, Group Computer assisted cognitive remediation therapy
- Where
- Canada
- Volunteers
- 105 people
- Sponsor
- Douglas Mental Health University Institute
First-episode Psychosis
Biomarkers Predictive of Thymic Evolution and Therapeutic Response at 2 Years in Patients With a First Psychotic Episode
Psychosis is a severe, common, and disabling psychological disorder. An epidemiological study conducted in England reported an incidence of 34 new cases per 100,000 person-years, with a peak between 16 and 19 years of age.
- Trial name
- PEPAMARKER (NCT05384392)
- Testing
- Recorded interview, Clinical scales, Blood sample
- Where
- 5 sites in France
- Volunteers
- 217 people
- Sponsor
- University Hospital, Brest
Psychosis
Occupational Recovery After First Episode Psychosis
Background: To improve employment prospects for people in the chronic stages of mental illness, the gold standard is a program called Individual Placement and Support (IPS).
- Trial name
- NCT03317132
- Testing
- IPS
- Where
- Canada
- Volunteers
- 109 people
- Sponsor
- Fraser Health
Schizophrenia and Disorders With Psychotic Features, Psychotic Episode
Effectiveness of a Mindfulness-based Group Training Addressing Social Cognition in First Episode Psychosis (AGES-Mind)
The current investigation aims to compare two group intervention in patients with a first episode of psychosis, that is, people who have suffered their first psychotic episode within 5 years prior to their inclusion in the study.
- Trial name
- AGES-Mind (NCT03309475)
- Testing
- SocialMIND, Psychoeducational multicomponent intervention, Psychosocial treatment
- Where
- Spain
- Volunteers
- 59 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Schizophrenia; Psychosis, Schizo Affective Disorder
Adapted Physical Activity Program for Patients Undergoing Antipsychotic Treatment of a First Episode of Psychosis
The purpose of this PILOT feasibility study is to verify the acceptability, feasibility, and compliance to the DYNAMO-PSY program among young adults treated with antipsychotics for a first episode of psychosis (FEP).
- Conditions
- Schizophrenia; Psychosis, Schizo Affective Disorder, First Episode Psychosis (FEP)
- Trial name
- DYNAMO-PSY (NCT06643871)
- Testing
- Adapted physical activity program involving connected bikes
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier St Anne
Psychosis
Trajectories of Treatment Response as Window Into the Heterogeneity of Psychosis: a Longitudinal Multimodal Imaging Study
Psychosis is a heterogeneous disorder and present treatment only works for a limited number of patients. In order to identify new therapeutic targets, this study will longitudinally characterize the underlying pathologies in…
- Trial name
- NCT03442101
- Testing
- Patients with psychosis will be treated with known antipsychotic medication
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- University of Alabama at Birmingham
Bipolar I Disorder, Schizoaffective Disorder
Open Label Extension Study of NCT06221852
This is a 12-week open-label extension study for participants completing study NCT06221852.
- Conditions
- Bipolar I Disorder, Schizoaffective Disorder, Psychosis
- Trial name
- NCT06558201
- Testing
- Ketogenic diet
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mclean Hospital
Psychosis
EPI-MINN: Targeting Cognition and Motivation
The purpose of this study is to perform a practice-based research project designed to assess whether cognition and motivated behavior in early psychosis can be addressed as key treatment goals within real-world settings by using…
- Trial name
- NCT05112432
- Testing
- Cognitive and Social Cognitive Training, Personalized Real-Time Intervention for Motivational Enhancement (PRIME) App, Early Psychosis Coordinated Specialty Care
- Where
- 3 sites in United States
- Volunteers
- 400 people
- Sponsor
- University of Minnesota
Psychosis
Cbt for Psychosis and Affect on Psychosis Symptoms
This study aims to examine the effectiveness of cognitive behavior therapy for psychosis in first episode patients and see the outcome of CBT on psychotic symptoms.
- Trial name
- cbtpaps (NCT02653729)
- Testing
- cognitive behaviour therapy, Espidone, Olepra
- Volunteers
- 50 people
- Sponsor
- Aisha Andleeb
Psychosis, Psychological
Psychoeducative Treatment of FEP With Mobile Training. ThinkApp
The aim of the study is to evaluate the effectiveness of an online intervention through a mobile application, specifically designed for adolescents with a First Psychotic Episode (FEP), as a complement to the pharmacological and…
- Conditions
- Psychosis, Psychological, Therapy
- Trial name
- NCT03161249
- Testing
- Experimental group, Control group
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- International University of La Rioja
Schizophrenia, First-Episode
Optimization of Acute Treatment in First Episode Schizophrenia
The study is a multicenter, double-blind, randomized, parallel-group study with first episode schizophrenic patients. During a treatment phase of 8 weeks the patients are treated with Risperidone or Haloperidol.
- Trial name
- NCT00157378
- Testing
- Risperidone, Haloperidol
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Psychotic Episode
Effect of Experience Sharing and Mutual Assistance on Insight and Recovery During the First Psychotic Episode
Controlled, prospective, qualitative and quantitative trial. The goal of this trial is to evaluate the mutual assistance early intervention device efficacy and its impact on insight and personal recovery of participants living…
- Trial name
- DIPEM (NCT06263933)
- Testing
- Insight Scale, Semi-directional interviews, routine care
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre hospitalier de Ville-Evrard, France
Schizophrenia, Schizophreniform Disorder
Enhancing Cognitive Training Through Exercise Following a First Schizophrenia Episode
This is a confirmatory randomized controlled trial of the efficacy of a novel intervention combining neuroplasticity-based cognitive training with aerobic exercise, compared to the same systematic cognitive training alone.
- Conditions
- Schizophrenia, Schizophreniform Disorder, Schizoaffective Disorder
- Trial name
- CT&E-RCT (NCT02823041)
- Testing
- Cognitive Training, Aerobic Exercise, Case management and supportive psychotherapy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, Los Angeles
Psychosis
Narrative Identity and Its Relationship to Subjective Multidimensional Well-being in First Episode Psychosis
The transition between adolescence and adulthood (generally defined as ages 18 to 25) is a key developmental window for narrative identity and psychotic disorders. Narrative identity is positively associated with mental health.
- Trial name
- PEPsy-Identity (NCT06464848)
- Testing
- Narrative identity task
- Where
- France
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes