Clinical trials: First Responders
PTSD Symptoms, Anxiety Symptoms
Clinician Supported Mobile App to Reduce Mental Health Symptoms Among World Trade Center Responders in Florida
This study examines mental health challenges among World Trade Center (WTC) General Responders, who continue to experience significant psychological trauma from the WTC collapse.
- Conditions
- PTSD Symptoms, Anxiety Symptoms, Depression Symptoms, Sleep Disturbance
- Trial name
- PTSDCoach911 (NCT06648928)
- Testing
- Clinician Supported PTSD Coach, Self Managed PTSD Coach
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Florida International University
Multiple Myeloma (MM)
Response Adapted Therapy With Bortezomib/Dexamethasone Followed by Addition of Lenalidomide in Non Responders as Initial Treatment for Patients With Multiple Myeloma
The purpose of this study is to see if researchers could get the same good results with less toxicity by using this new approach.
- Trial name
- NCT01919086
- Testing
- Bortezomib, Dexamethasone, Lenalidomide
- Where
- 7 sites in United States
- Volunteers
- 30 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
PTSD, Anxiety
Exploring Medically Perceived Benefits, Use and Interest in Psychedelics and Cannabinoids
The primary objective of this study is to collect insights from first responders and military personnel on their need for, use of, and interest in physical and/or mental health medical marijuana or psychedelic-assisted therapy…
- Conditions
- PTSD, Anxiety, Anxiety Disorders, Depression
- Trial name
- EMPOWER (NCT04965740)
- Testing
- Cannabis
- Where
- Canada
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Empower Research Inc
Psychological Stress
A Daily Coping Toolkit for Medical Personnel and First-Responders During COVID-19 Pandemic
During the current COVID-19 Pandemic, all communities are relying heavily on medical personnel and first-responders to maintain high levels of psychological and occupational functioning.
- Trial name
- NCT04398277
- Testing
- Daily Coping Toolkit
- Where
- 3 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Kent State University
Cardiac Arrest, Sudden
Impact of the Organization of the First Responders in the Remote Areas on Cardiac Arrest Victim Survival
Emergency medical services (EMS) provide emergency care not only in the urban but also in the remote areas which could be up to 40 minutes from the EMS station.
- Trial name
- NCT04485390
- Testing
- Basic life support witn use of an AED before EMS
- Volunteers
- 150 people
- Sponsor
- University Medical Centre Maribor
Workplace Stress, Mental Health
The Effects of Stress & Irregular Shift Hours on First Responders
First Responders are expected to maintain high-performance levels under extreme conditions. However, constant intense workplace stress, physical work demands, and irregular shift hours are taking a severe toll on frontline…
- Conditions
- Workplace Stress, Mental Health, HRV, EEG
- Trial name
- NCT05659277
- Testing
- Workplace Stress and Irregular shift hours
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Endominance
Anxiety
A Study Comparing Immediate Treatment to Deferred Treatment With the Fisher Wallace (FW) Stimulator FW-200 Device for the Treatment of Self-reported Anxiety in First Responders
The goal of this clinical trial is to learn if the Fisher Wallace Stimulator FW-200 experimental device is effective at treating self-reported anxiety in first responders.
- Trial name
- NCT07093736
- Testing
- FW-200
- Where
- 2 sites in United States
- Volunteers
- 220 people
- Sponsor
- Fisher Wallace Laboratories
Traumatic Brain Injury, PTSD - Post Traumatic Stress Disorder
HBOT Effects on First Responders' Cognition and Well-Being
The goal of this study is to examine changes in cognitive functioning and post-concussive symptoms following hyperbaric oxygen therapy (HBOT) in current and former first responders with a history of traumatic brain injury.
- Conditions
- Traumatic Brain Injury, PTSD - Post Traumatic Stress Disorder, Anxiety, Depression
- Trial name
- NCT07852728
- Testing
- Hyperbaric Oxygen Therapy (HBOT)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Summit Hyperbarics and Wellness
Mental Health Wellness 1
Building Partnerships With First Responders to Improve Delivery and Access of Mental Health Services
This study will conduct qualitative interviews with firefighters and EMTs/ paramedics across Arkansas. To address this aim, opt-in methods will be used to recruit a diverse group of firefighters and emergency medical…
- Trial name
- NCT03801408
- Where
- United States
- Volunteers
- 145 people
- Sponsor
- University of Arkansas
Stress Disorders, Post-Traumatic
EEG Personalized Transcranial Magnetic Stimulation (eTMS) for Post-Traumatic Stress Disorder
This is an open-label safety pilot study of the Electroencephalogram (EEG) Transcranial Magnetic Stimulation (eTMS) treatment for Post-Traumatic Stress Disorder (PTSD).
- Trial name
- NCT06081309
- Testing
- EEG-based personalized TMS
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Wave Neuroscience
Resilience and Mental Health of First Responders
First Responder Safety Training (FiRST)
As a result of chronic exposures to traumatic and stressful events, first responders are at elevated risk for experiencing post-traumatic stress disorder (PTSD) and other mental health problems.
- Trial name
- FiRST (NCT07478250)
- Testing
- Worker Resilience Training Program, Fire and Medical Safety (FAMS)
- Where
- 2 sites in United States
- Volunteers
- 800 people
- Sponsor
- Stony Brook University
Posttraumatic Stress Disorder
Couple HOPES and COVID-19
Posttraumatic Stress Disorder (PTSD) will be a severe problem in Canada in the wake of COVID-19, especially for Military Members, Veterans, First Responders, and Healthcare Workers (MVFH).
- Trial name
- HOPES (NCT04763681)
- Testing
- Couple HOPES Guided, Internet-Delivered, Self-Help Intervention
- Where
- Canada
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- York University
HIV Infections, Hepatitis C, Chronic
Treatment of Chronic Hepatitis C With PEG Interferon alfa2a and Ribavirin in HIV-infected Patients
Combination of PEG interferon and ribavirin is the standard treatment of chronic hepatitis C. Efficacy of this treatment has never been evaluated in HCV-HIV infected patients, who have previously been treated with a first line…
- Conditions
- HIV Infections, Hepatitis C, Chronic, Treatment Failure
- Trial name
- ROCO2 (NCT00221650)
- Testing
- Peginterferon alfa2a, Ribavirin
- Where
- France
- Volunteers
- 17 people
- Sponsor
- University Hospital, Bordeaux
Cardiac Arrest, Sudden, Heart Arrest
Influence of the Education in Layperson in Out of Hospital Resuscitation
Cardiac arrest occurs frequently and the outcome after out-of-hospital resuscitation is often fatal. Disturbing is that more than half of the surviving patients suffer from permanent impairment of cognitive functions, such…
- Trial name
- NCT02473679
- Where
- Switzerland
- Volunteers
- 1,662 people
- Sponsor
- University of Zurich
Critical Illness
Differences in Care Provided in Intensive Care Units (ICUs) With Physician Versus Nurse Practitioner First Responders
The purpose of this study is to evaluate and compare outcomes of patients that have received care in medical intensive care units in a tertiary care facility with two different models; the traditional model including resident…
- Trial name
- NCT01323816
- Testing
- Medically directed care
- Where
- United States
- Volunteers
- 3,659 people
- Sponsor
- Naeem Ali, MD
Posttraumatic Stress Symptoms, Burnout
FLOAT for Healthcare PTSS
This early-stage pilot trial aims to examine the feasibility, tolerability, and safety of Floatation-REST, or Reduced Environmental Stimulation Therapy via floatation in frontline healthcare workers, first responders, and…
- Conditions
- Posttraumatic Stress Symptoms, Burnout, Burnout, Healthcare Workers, First Responders
- Trial name
- PTSS FLOAT (NCT07710417)
- Testing
- Floatation-REST, Documentary
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Laureate Institute for Brain Research, Inc.
Trauma
Examining the Effectiveness of EAL
This quasi-experiment will evaluate the effectiveness of Equine Assisted Learning for reducing symptoms associated with trauma exposure among public safety personnel (e.g., fire fighters, police, paramedics, etc.).
- Trial name
- EAL (NCT05579717)
- Testing
- Equine Assisted Learning
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- McMaster University
Out-Of-Hospital Cardiac Arrest
Cardiac Arrest in Residential Areas With Mobile First-responder Activation
The study aims to increase proportions of bystander defibrillation during out-of-hospital cardiac arrest (hereof referred to as cardiac arrest) in residential areas with a high density of cardiac arrests.
- Trial name
- CARAMBA (NCT04446585)
- Testing
- Automated External Defibrillator (AED), Training in cardiopulmonary resuscitation and AED use, Activation of citizen responders
- Where
- Denmark
- Volunteers
- 260 people
- Sponsor
- Emergency Medical Services, Capital Region, Denmark
Wellbeing
Testing a Novel Attention Based Training Prevention Strategy for First Responders: FirstFocus a Mobile App
First responders are frequently exposed to high-stress and traumatic events, putting them at increased risk for mental health challenges such as posttraumatic stress disorder, anxiety, and depression.
- Trial name
- NCT07247149
- Testing
- Attention Bias Modification
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Palo Alto University
Stress, Resilience and Mental Health of First Responders
Mindfulness in Motion Targeted to Sustaining the Mental and Physical Resilience of First Responders
High levels of chronic and recurrent workplace stress can profoundly impact the physical, mental, and emotional health of first responders.
- Conditions
- Stress, Resilience and Mental Health of First Responders, Work Engagement, Musculoskeletal Discomfort
- Trial name
- NCT07502092
- Testing
- Mindfulness in Motion for First Responders
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Ohio State University