Clinical trials: First Episode Psychosis
Schizophrenia / Schizoaffective Disorder, First Episode Psychosis (FEP)
French Minds Cohort: a French Longitudinal and Multimodal Cohort of Patients With Major Mood Disorders, Psychotic Disorders, Autism Spectrum Disorders, and Healthy Controls
The goal of this study is to learn whether people living with severe psychiatric disorders can be grouped into more homogeneous subgroups, across usual diagnostic categories, based on two key dimensions: social withdrawal and…
- Conditions
- Schizophrenia / Schizoaffective Disorder, First Episode Psychosis (FEP), Bipolar Disorder (BD), Major Depressive Disorder (MDD
- Trial name
- FRENCH-MINDS (NCT07881016)
- Testing
- 3T Brain MRI, Biological Sampling, Clinical, Cognitive and Digital Assessments
- Where
- 17 sites in France
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Fondation FondaMental
Psychosis, Schizophrenia
Normobaric Oxygen Therapy for Individuals With First-Episode Psychosis
Single-blind, randomized controlled trial of normobaric oxygen therapy among individuals with first-episode psychosis: Effects on symptomatology and cognition.
- Conditions
- Psychosis, Schizophrenia, First-episode Psychosis
- Trial name
- NCT04368039
- Testing
- Normobaric Oxygen
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Nicholas Breitborde
First Episode Psychosis
Artificial Intelligence to Measure Adherence to Oral Medication
The aims of this project is to use an artificial intelligence (AI) smartphone app to provide support for medication adherence by patients with first episode psychosis.
- Trial name
- NCT04046497
- Testing
- Smartphone App, Usual Care
- Where
- 5 sites in United States
- Volunteers
- 139 people
- Sponsor
- Northwell Health
Sleep, Physical Activity
On Track for Wellness (OTW) Stepped Wedge Cluster Randomized Trial
This study will evaluate a program called On Track for Wellness (OTW) which is being adopted by the Illinois Department of Human Services' Division of Behavioral Health \& Recovery (DBHR) for use in all state-funded early…
- Conditions
- Sleep, Physical Activity, First Episode Psychosis
- Trial name
- OTW (NCT07387705)
- Testing
- On Track for Wellness
- Where
- United States
- Volunteers
- 365 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Psychosis, First Episode Psychosis
Stratification and Treatment in Early Psychosis Study - ENHANCE
The purpose of this study is: To investigate whether the response to antipsychotic treatment can be enhanced by adding cannabidiol (CBD) to the existing treatment, compared to placebo, in participants with a first episode of…
- Conditions
- Psychosis, First Episode Psychosis, Psychotic Disorders, Psychotic Episode
- Trial name
- STEP-ENHANCE (NCT06778564)
- Testing
- CBD 100 mg/mL Oral Solution
- Where
- 17 sites in Austria, Germany and 7 more
- Volunteers
- 250 people
- Sponsor
- University of Oxford
First-Episode Psychosis
Trial to Increase FEP Attendance
Individuals with first-episode psychosis (FEP) are at high-risk for several poor functional and clinical outcomes, including suicide.
- Trial name
- NCT05967195
- Testing
- Financial Incentive and Text-Messages
- Where
- 3 sites in United States
- Volunteers
- 145 people
- Sponsor
- University of Pennsylvania
First Episode Psychosis (FEP), Clinical High Risk for Psychosis (CHR)
Reducing the Duration of Untreated Psychosis in the United States: The Impact of Screening and Systematic Communication
The goal of this project is to investigate whether a systematic screening approach enhanced by an innovative model of communicating information about psychosis and treatment options to patients and families (ComPsych) can reduce…
- Trial name
- EaSIE (NCT05509998)
- Testing
- Screening Method (SM), Screening and Communication Method (SCM)
- Where
- United States
- Volunteers
- 912 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
First Episode Psychosis (FEP), Psychosis
Mobile Application-Based Interventions for Cannabis Use in Young Adults With First Episode Psychosis
Psychotic disorders affect approximately 4% of Canadians and have a significant impact on individuals' well-being, their families and social networks, and healthcare systems.
- Conditions
- First Episode Psychosis (FEP), Psychosis, Schizophreni-form Disorder, Dependence Addictive
- Trial name
- Mobile Health (NCT07811466)
- Testing
- CHAMPS, I Can Change
- Volunteers
- 550 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Engagement, Patient, First Episode Psychosis
Optimizing Engagement in Services for First-Episode Psychosis
This study will compare a 12-session behavioral activation (BA) intervention modified for first-episode psychosis (FEP) to usual community mental health care (i.e., treatment-as-usual; TAU) delivered over 6 months with a sample…
- Trial name
- NCT05310838
- Testing
- Behavioral Activation for First Episode Psychosis, Treatment As Usual
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- California State University, San Bernardino
First Episode Psychosis (FEP)
Enhancing Cognitive and Work/School Outcomes in First Episode Psychosis Using Cognitive Self-Management Strategies
The goal of this pilot cluster randomized trial is to understand if adding a standardized cognitive self-management program, Thinking Skills for Work-Cognitive Self-Management Strategies (CSM) to Coordinated Specialty Care…
- Trial name
- NCT07749105
- Testing
- Thinking Skills for Work-Cognitive Self-Management Program (CSM), Treatment as Usual (TAU)
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- Boston University Charles River Campus
First Episode Psychosis, Youth
Pilot RCT of Self-stigma Treatment for First Episode Psychosis
The overall purpose of the proposed exploratory intervention development application, is to conduct research that will inform the adaptation and preliminary testing of NECT modified for youth (aged 15-24) with first episode…
- Trial name
- NECT-YA (NCT04889911)
- Testing
- Narrative Enhancement and Cognitive Therapy- Young Adult, Combined with Coordinated Specialty Care, Coordinated Specialty Care
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- John Jay College of Criminal Justice, City University of New York
Schizophrenia, First-Episode Psychosis
Using mHealth to Optimize Pharmacotherapy Regimens
This project will use a smartphone technology to improve medication prescribing for individuals with FEP. We will collect real-time symptom and functioning data via smartphones to provide prescribers and other clinical team…
- Trial name
- NCT04248517
- Testing
- mHealth Intervention
- Where
- 4 sites in United States
- Volunteers
- 23 people
- Sponsor
- New York State Psychiatric Institute
First Episode Psychosis (FEP)
California Collaborative Network to Promote Data Driven Care and Improve Outcomes in Early Psychosis
The proposed project seeks to create a California early psychosis network using a core assessment battery of valid, low burden measures and mHealth technology platform to collect client-level data, visualize data via clinician…
- Trial name
- EPI-CAL (NCT04007510)
- Testing
- EPI-CAL data network, Community DUP Assessment Tool
- Where
- United States
- Volunteers
- 1,329 people
- Sponsor
- University of California, Davis
First Episode Psychosis
OnTrackNY's Learning Healthcare System
This application proposes OnTrackNY as a regional scientific hub for the Early Psychosis Intervention Network (EPINET) program as part of the National Institute of Mental Health (NIMH)'s creation of a national learning health…
- Trial name
- NCT04021719
- Testing
- Stakeholder feedback, Data infrastructure
- Where
- United States
- Volunteers
- 2,100 people
- Sponsor
- New York State Psychiatric Institute
Clinical High Risk, Early Psychosis
Digital Strategies to Advance Help-Seeking - Aim 3
This proposal aims to establish a Digital Laboratory focused on advancing help-seeking and expediting treatment initiation in youth ages 12-29 who are at Clinical High-Risk (CHR) for developing psychosis.
- Conditions
- Clinical High Risk, Early Psychosis, First Episode Psychosis
- Trial name
- NCT06774417
- Testing
- Digital nudge
- Where
- United States
- Volunteers
- 25,000 people
- Sponsor
- Columbia University
First-episode Psychosis
Biomarkers Predictive of Thymic Evolution and Therapeutic Response at 2 Years in Patients With a First Psychotic Episode
Psychosis is a severe, common, and disabling psychological disorder. An epidemiological study conducted in England reported an incidence of 34 new cases per 100,000 person-years, with a peak between 16 and 19 years of age.
- Trial name
- PEPAMARKER (NCT05384392)
- Testing
- Recorded interview, Clinical scales, Blood sample
- Where
- 5 sites in France
- Volunteers
- 217 people
- Sponsor
- University Hospital, Brest
First Episode Psychosis (FEP), Caregiver Burden
Psychoeducation Program for Family Caregivers Coordinated by an APRN
The aim of this study is to assess the impact of implementing a specific family program coordinated by APRNs, covering the 5 levels of the family care pyramid through a consultation, an individual psychoeducation program and a…
- Conditions
- First Episode Psychosis (FEP), Caregiver Burden, Nurse Practitioners, IMPACT OF A NEW PSYCHOEDUCATION PROGRAM COORDINATED BY AN ADVANCED PRACTICE NURSE ON THE BURDEN OF FAMILY CAREGIVERS OF PATIENTS WITH A FIRST PSYCHOTIC EPISODE
- Trial name
- APIPEP (NCT07041463)
- Testing
- Psychoeducation program coordinated by an APRN, Usual Care
- Where
- 5 sites in France
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Hôpital le Vinatier
At-risk Mental States, First Episode Psychosis (FEP)
The Influence of Tennis in Early Intervention
This study involves two groups of participants: one participating in an intervention focused on self-esteem-and thus primarily psychological-and the other on self-esteem and tennis-and thus involving physical activity.
- Trial name
- ITIP (NCT07633899)
- Testing
- Tennis ( physical activity), Self-esteem program
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Centre Hospitalier Esquirol
First Episode Psychosis (FEP)
Digital Heart Rate Variability Biofeedback Intervention for First Episode Psychosis
The objective of the current study is to assess the impact of a five-week digital heart rate variability biofeedback (HRV-B) intervention or music listening on the well-being of first episode psychosis patients.
- Trial name
- NCT07628699
- Testing
- Heart Rate Variability Biofeedback, Music Listening
- Where
- Hong Kong
- Volunteers
- 80 people
- Sponsor
- The University of Hong Kong
First Episode Psychosis
Recovery With Exogenous Ketones and Antipsychotics
The RECAP project will evaluate the clinical and metabolic effects of adding exogenous ketones to antipsychotic (AP) treatment in young adults with a first episode of psychosis (FEP).
- Trial name
- RECAP (NCT07122531)
- Testing
- Medium chain triglyceride oil
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Université de Sherbrooke