Clinical trials: Fibrin Sealant
Hernia, Ventral Hernia
A Study of Fibrin Sealant Plus Silver Microparticles to Prevent Incisional Hernias Following Abdominal Surgery
Incisional hernias are a frequent consequence of abdominal surgery. Current clinical efforts are primarily focused on improving repair materials and surgical techniques to correct these hernias instead of the optimal solution…
- Conditions
- Hernia, Ventral Hernia, Abdominal Hernia
- Trial name
- HiP_1 (NCT02584153)
- Testing
- Fibrin Sealant, Silver Microparticles
- Sponsor
- Hobart Harris
Hip Replacement Surgery
Efficacy and Safety of Fibrin Sealant Vapor Heated Solvent/Detergent Treated (FS VH S/D) for Hemostasis in Subjects Undergoing Total Hip Replacement
The purpose of the study is to monitor the safety of FS VH S/D and evaluate whether FS VH S/D is superior to standard treatment in reducing blood loss in subjects undergoing total hip replacement with cement-free hip prostheses.
- Trial name
- NCT00161902
- Testing
- Fibrin Sealant Vapor-Heated Solvent/Detergent-treated
- Where
- 7 sites in Austria, Germany and 1 more
- Sponsor
- Baxter Healthcare Corporation
Diabetic Foot Ulcers, Diabetic Wound
The Effect of Combination Therapy of Oral MB and PRP-FG in Patients With Non-healing Diabetic Foot Ulcer
The aim of this study is to evaluate the chance of non-healing diabetic foot ulcers repair by improving the condition of lack of oxygen or hypoxia in the wound area caused by diabetes using methylene blue along with the use of…
- Trial name
- NCT05850611
- Testing
- Methylene Blue, Milk (control), Methylene Blue and Platelet-Rich Plasma-Fibrin Glue
- Where
- Iran
- Volunteers
- 20 people
- Sponsor
- Mashhad University of Medical Sciences
Periodontitis
Effect of Fibrin Sealant on Early Wound Healing
The aim of this randomized controlled clinical trial is to compare wound healing after the use of fibrin sealant and sutures for gum surgeries.
- Trial name
- FS (NCT01538927)
- Testing
- Fibrin Sealant, Suture
- Where
- India
- Volunteers
- 15 people
- Sponsor
- Chhattisgarh Dental College and Research Institute
Hemorrhage
The EVARREST® Fibrin Sealant Patch Liver Study
To evaluate the safety and hemostatic effectiveness of EVARREST® Fibrin Sealant Patch (EVARREST) versus standard of care treatment (SoC) in controlling parenchymal bleeding during hepatic surgery.
- Trial name
- NCT01993888
- Testing
- EVARREST® Fibrin Sealant Patch, Standard of Care (SoC)
- Where
- 17 sites in United States, Australia and 2 more
- Volunteers
- 102 people
- Sponsor
- Ethicon, Inc.
Adjunct to Hemostasis During Vascular Surgery
Efficacy and Safety of TISSEEL Lyo Compared to Manual Compression as an Adjunct to Haemostasis
The primary objective of the study is to evaluate the efficacy of TISSEEL Lyo for haemostasis in patients receiving peripheral vascular prosthetic expanded polytetrafluoroethylene (ePTFE) conduits, as compared to a control arm…
- Trial name
- NCT04083807
- Testing
- TISSEEL Lyo, Manual compression with surgical gauze pads
- Where
- 5 sites in Russia
- Volunteers
- 104 people
- Sponsor
- Baxter Healthcare Corporation
Spinal Cord Injury
Cethrin in Acute Cervical Spinal Cord Injury
This is a multicenter, randomized, double-blind, placebo-controlled Phase IIb/III study designed to evaluate the efficacy and safety of Cethrin as a treatment for acute cervical spinal cord injury.
- Trial name
- NCT02053883
- Testing
- Cethrin (BA-210)
- Sponsor
- BioAxone BioSciences, Inc.
Healthy Volunteers Only
Efficacy of Buccal Pad of Fat, Advanced Platelet Rich Fibrin, Fibrin Glue and Oxidized Cellulose Plug in Management of Oro-Antral Communication, Comparative Clinical Study
Evaluation of the efficacy of different treatment protocols in the management of Oro-Antral Communications.
- Trial name
- OAC (NCT06220877)
- Testing
- Buccal Pad of Fat, A-PRF, fibrin glue
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- October 6 University
Pterygium
Evaluation of Tranilast to Treat Pterygium Before Excision
Recurrent or secondary pterygium often has often a growing fibrovascular tissue more exuberant than the primary. Histological findings differ from the primary, since the typical changes in the degenerate connective tissue are…
- Trial name
- TPS (NCT01003613)
- Testing
- Tranilast, and Tissucol, Beriplast P
- Where
- Brazil
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Gildasio Castello de Almeida Junior
Seroma
Fibrin Glue in Inguinal Lymphadenectomy
Seroma is one of the most common encountered morbidities after inguinal lymph node dissection (ILND). It can cause not only much nuisance to both patients and doctors but also its presence can lead to many complications.
- Trial name
- NCT04666051
- Testing
- Application of fibrin glue sealant
- Volunteers
- 32 people
- Sponsor
- Menoufia University
Degenerative Arthritis
Efficacy and Safety Study of TissueGene-C Mixed With Fibrin-glue for the Patients With Degenerative Arthritis
The purpose of this study is to determine whether TissueGene-C, allogeneic human chondrocytes expressing Transforming Growth Factor(TGF)-b1, mixed with fibrin-glue is effective and safe in patients with degenerative arthritis.
- Trial name
- NCT01825811
- Testing
- TissueGene-C (Low dose), TissueGene-C (High dose)
- Where
- 6 sites in South Korea
- Volunteers
- 18 people
- Sponsor
- Kolon Life Science
Adjunct to Hemostasis in Vascular Surgery (Synthetic Vascular Grafts)
Fibrin Sealant Vascular Surgery Study
The purpose of this study is to evaluate the efficacy and safety of Fibrin Sealant, Vapor Heated, Solvent/Detergent-treated with 500 IU/ml thrombin and synthetic aprotinin (FS VH S/D 500 s-apr) for hemostasis in participants…
- Trial name
- NCT00576420
- Testing
- FS VH S/D 500 s-apr, 60-seconds polymerization time, FS VH S/D 500 s-apr, 120-seconds polymerization time, Manual compression with surgical gauze pads
- Where
- 11 sites in United States
- Volunteers
- 101 people
- Sponsor
- Baxter Healthcare Corporation
Melanoma
Fibrin Melanoma Axillary Node Study in Patients With Melanoma
Primary Objective: To determine whether the use of a fibrin sealant applied to axillary soft tissues following node dissection can result in earlier drain removal.
- Trial name
- NCT00504582
- Testing
- Fibrin Sealant
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- M.D. Anderson Cancer Center
Facial Rhytidectomy (Face-lift)
Efficacy and Safety Study of Fibrin Sealant With 4 IU/mL Thrombin, Vapor Heated, Solvent Detergent Treated (FS VH S/D 4) in Face-Lift Procedures
The primary objective of this study is to evaluate the efficacy and safety of fibrin sealant with 4 IU/mL thrombin, vapor heated, solvent detergent treated (FS VH S/D 4) when used to reduce early postoperative bruising in…
- Trial name
- NCT00708071
- Testing
- Fibrin Sealant with 4 IU/ml Thrombin, Vapor-Heated, Solvent Detergent Treated Containing Synthetic Aprotinin (FS VH S/D 4)
- Where
- 6 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Baxter Healthcare Corporation
Pacemaker Implantation, Pocket Hematoma and Bleeding
Pocket Haematoma Prevention in Patients Who Required Implantation/Replacement of a Pacemaker or Implantable Cardiac Defibrillator. The PHP Study.
The aim of this study is to demonstrate the efficacy of fibrin sealant (Tissucol-Baxter) in preventing pocket haematoma and subsequent complications in patients undergoing pacemaker or ICD implantation/replacement which cannot…
- Conditions
- Pacemaker Implantation, Pocket Hematoma and Bleeding, Antiplatelet Therapy or Oral Anticoagulants
- Trial name
- PHP (NCT01127984)
- Testing
- tissucol, drainage system
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Careggi Hospital
Enterocutaneous Fistulas, Intra-abdominal Infection
Autologous Fibrin Glues for Fistulas Closure
Adjuvant use of fibrin glue in the fistula tract may promote healing in low-output enterocutaneous fistulas. However, there are only few studies that report autologous glue application in a larger patient group or…
- Trial name
- NCT01561066
- Testing
- Autologous platelet-rich fibrin glue (PRFG), Octreotide
- Where
- China
- Volunteers
- 122 people
- Sponsor
- Jinling Hospital, China
Hernia, Inguinal
Use of Human Fibrin Glue Versus Staples for Mesh Fixation in Laparoscopic Transabdominal Preperitoneal Hernioplasty
Inguinal hernia repairs belong to the most common surgical procedures worldwide. Increasingly they are performed using endoscopical techniques (laparoscopy).
- Trial name
- TISTA (NCT01641718)
- Testing
- Tissue glue, Staples
- Where
- Switzerland
- Volunteers
- 82 people
- Sponsor
- Sascha Müller
Esophageal Stricture, Endoscopic Submucosal Dissection
Local Triamcinolone Injection Combined With Fibrin Glue Spray in Preventing Esophageal Stricture After Big-range Endoscopic Submucosal Dissection for Esophageal Early Cancer
Endoscopic submucosal dissection (ESD) is the main treatment for esophageal early cancer. But post-ESD stricture has a serious impact on quality of life.When the lesion range reaches up to 3/4 circumferential mucosal defect or…
- Conditions
- Esophageal Stricture, Endoscopic Submucosal Dissection, Early Esophageal Cancer or Precancerous Lesions Treated With Endoscopic Resection
- Trial name
- NCT06840561
- Testing
- Local triamcinolone injection combined with fibrin glue spray
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Sun Yat-Sen University Cancer Center
Surgery
Use of Fibrin Glue in Vitreoretinalsurgery
To study the Safety and Efficacy of the use of fibrin glue in vitreoretinal surgery
- Trial name
- fibringlue (NCT01022164)
- Testing
- fibrin glue
- Where
- Mexico
- Volunteers
- 50 people
- Sponsor
- Asociación para Evitar la Ceguera en México
Ptosis, Eyelid, Ptosis; Eyelid, Congenital
Modified Müller's Muscle-conjunctival Resection Internal Ptosis Repair Using Fibrin Glue
Fibrin glue is widely used in ophthalmology for homeostasis and tissue recovery. It is commonly used in ocular surface surgeries such as pterygium removal and conjunctival lesions excisions.
- Conditions
- Ptosis, Eyelid, Ptosis; Eyelid, Congenital, Surgical Procedure, Unspecified
- Trial name
- NCT03392272
- Testing
- Using of Tisseel fibrin glue, Using sutures
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Sheba Medical Center