Clinical trials: Fertility Issues
Infertility
Prospective, Randomized, Controlled, Clinical Study on Tolerability and Efficacy of hMG-IBSA
Purpose of the study is the evaluation of the tolerability (both local and systemic) and the clinical efficacy (in terms oocytes recovered) of subcutaneously versus intramuscularly administered Merional® (IBSA, Lugano - CH) in…
- Trial name
- NCT00464607
- Testing
- hMG-IBSA, Ovarian stimulation
- Where
- 4 sites in Italy
- Volunteers
- 160 people
- Sponsor
- IBSA Institut Biochimique SA
Infertility, Female, Anti-Mullerian Hormone Deficiency
Pregnancy Prediction Using Anti-Müllerian Hormone in Intrauterine Insemination Cycles
The goal of this study is to compare the cumulative pregnancy rates after 4 artificial inseminations with donor (IAD) in non-sterile women with plasma AMH levels > and < 1.1 ng/mL.
- Trial name
- NCT06263192
- Testing
- Intrauterine insemination
- Where
- Spain
- Volunteers
- 342 people
- Sponsor
- Jose Antonio Moreno
Infertility Unexplained, Infertility, Male
Comparison of the Effect of Microchip and Density Gradient Methods in Intrauterine Insemination Cycles
Microfluidic chips are one of the methods of sperm separation to eliminate DNA fragmentation in sperm. It is thought that the separation of sperm by centrifugation in the classical gradient density (Percoll) method used in sperm…
- Trial name
- NCT04144244
- Testing
- MicroFluidic Sperm Sorting Chips, Gradient-Density Centrifugation
- Where
- Turkey (Türkiye)
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Infertility
Fertilizations With Immotile Sperm: Pentoxyphylline Activation Alone, or With Chemical Oocyte Activation
Immotile sperm is a rather frequent problem encountered in IVF patients. Treatment is usually based on inducing motility with pentoxyphylline (PXN) followed by ICSI.
- Trial name
- PXN (NCT02051075)
- Testing
- PXN sperm treatment, Sperm activation with PXN and oocyte activation
- Where
- Israel
- Sponsor
- Rambam Health Care Campus
ICSI AZOOSPERMIA VARICOCELE
Outcome of ICSI Using Cryopreserved Testicular Sperm From Infertile Men With Varicocele-associated Azoospermia
This study will include cryopreserved sperm from infertile azoospermic men, with proven diagnosis of varicocele (clinical \& sonographic), which will be used for ICSI in an ART program in Sohag.
- Trial name
- NCT02306499
- Testing
- ICSI
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Sohag University
Infertility, Female
Time-lapse Monitoring of Early Embryo Development After Ovarian Stimulation During Infertility Treatment
The number of children conceived by assisted reproductive technology is increasing in Nordic countries as well as worldwide. An important factor of success in treatment of infertility is a short "time to pregnancy" with impact on…
- Trial name
- NCT01882166
- Testing
- fostimon, puregon
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- St. Olavs Hospital
Infertility,Female
G-CSF and PRP in Patients With Recurrent Implantation Failure
The aim of this randomized controlled trial is to determine whether granulocyte colony-stimulating factor and platelet-rich plasma can be used to enhance the IVF-ET outcomes in patients with recurrent implantation failure
- Trial name
- NCT04411212
- Testing
- Granulocyte colony-stimulating factor and platelet-rich plasma group, Control group
- Where
- Egypt
- Volunteers
- 112 people
- Sponsor
- Riyadh Fertility and Reproductive Health center
Infection of Total Knee Joint Prosthesis, Aseptic Loosening of Prosthetic Joint
Surgical / Economic Effect of the Aquamantys System in Blood Management for Aseptic and Septic Revision TKA
To assess the surgical and economic effectiveness of the Aquamantys System in managing intra- and post-operative blood loss, and reducing transfusion needs in patients undergoing both aseptic and septic revision total knee…
- Trial name
- NCT02266407
- Testing
- Aquamantys System
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medtronic Surgical Technologies
Recurrent Implantation Faliure, Infertility
Subendometrial Injection Versus Intrauterine Infusion of Platelet Rich Plasma for Women With Recurrent Implantation Failure
Aim of this study is to compare the effectiveness of subendometrial PRP injection \& intrauterine PRP infusion in women with recurrent implantation failure in comparison with a control group .
- Trial name
- NCT07306871
- Testing
- Platelet rich plasma, No intervention /standard care
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Minia University
Phimosis, Foreskin; Tightness
Safety and Efficacy of the Sterile Single-use Circular Stapling Device CIRCCURER II (Jiangxi Langhe Medical Instrument Co., Ltd., Guangzhou, China)
Evaluation of the safety and efficacy of the sterile single-use circular stapling device CIRCCURER II (Jiangxi Langhe Medical Instrument Co., Ltd., Guangzhou, China) in comparison with circumcision in adults patients with…
- Conditions
- Phimosis, Foreskin; Tightness, Redundant Prepuce
- Trial name
- CiCi-2021 (NCT04902898)
- Testing
- Circumcision in adults using sterile single-use circular stapling device, Circumcision in adults
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- University of Thessaly
Infertility, Female
Double Trigger in Patients With Low Proportion of Mature Oocytes
The aim of this randomized controlled trial is to determine whether co-administration of GnRH agonist and hCG for final oocyte maturation ( 40 and 34 h prior to oocyte retrieval , respectively) can increase the number of mature…
- Trial name
- NCT04407052
- Testing
- Double trigger, HCG trigger
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Riyadh Fertility and Reproductive Health center
Female Infertility
Progesterone on the Day of Ovulation Induction is Associated With Pregnancy Outcome
Progesterone levels measured in blood/serum of patients on the day of ovulation induction following controlled ovarian stimulation for in vitro fertilization may be associated with pregnancy outcome.
- Trial name
- ProgBBN (NCT01426152)
- Where
- Germany
- Volunteers
- 2,555 people
- Sponsor
- Bollmann Bruckner Noss
Healthy
Bioequivalence Trial of Liquid Versus Freeze-Dried Pergoveris® in Pituitary Suppressed Healthy Premenopausal Female Subjects
Some women cannot have children because they cannot produce enough follicle stimulating hormone (FSH) and luteinising hormone (LH).
- Trial name
- NCT02317809
- Testing
- Liquid pergoveris, Freeze-dried pergoveris
- Where
- Germany
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Merck KGaA, Darmstadt, Germany
Anovulation, Polycystic Ovary Syndrome
Ovarian Laser Treatment in Women With Polycystic Ovarian Syndrome: A Randomized Study on the Laser Dose
BACKGROUND: A new effective way, transvaginal ultrasound-guided ovarian interstitial laser-coagulation treatment, in management of anovulation in patients with polycystic ovary syndrome (PCOS), has been presented in the data…
- Conditions
- Anovulation, Polycystic Ovary Syndrome, Infertility
- Trial name
- NCT00643708
- Testing
- ovarian interstitial laser treatment
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Shen-Zhen City Maternity and Child Healthcare Hospital
Male Infertility
Post-operative Pain Control of Testicular Sperm Extraction Using Liposomal Bupivacaine
The study is a drug trial comparing the post-operative pain control provided by liposomal bupivacaine (a local anesthetic) against standard bupivacaine (a different formulation of the local anesthetic) for men undergoing…
- Trial name
- NCT03802864
- Testing
- Liposomal Bupivacaine, Standard Bupivacaine
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Weill Medical College of Cornell University
Infertility
Study to Estimate Seedchrony's Predictive Capacity in the Success of Embryo Implantation.
In Vitro Fertilization (IVF) success is below 40%, with Embryo Transfer the leading cause of IVF failure. This clinical investigation aims to evaluate if the levels of an intrauterine biomarker dissolved in the uterine fluid…
- Trial name
- Seedchrony02 (NCT06259084)
- Testing
- Seedchrony
- Where
- Spain
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Manina Medtech
Male Infertility Due to Azoospermia
Round Spermatid Injection Protocol
To evaluate embryology outcomes after application of a technique known as round spermatid injection (ROSI) into donor oocytes in a high-volume clinical infertility practice.
- Trial name
- ROSI (NCT04053309)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Reproductive Medicine Associates of New Jersey
Subfertility
Oral Dydrogesterone as Luteal Phase Support in Natural Cycle FET
This randomised double-blinded controlled trial aims to compare the live birth rate in natural FET cycles with and without oral dydrogesterone as luteal phase support.
- Trial name
- NCT03859921
- Testing
- Dydrogesterone
- Where
- China
- Volunteers
- 716 people
- Sponsor
- The University of Hong Kong
Male Infertility, Female Infertility
IMSI in Couples With Previous Implantation Failures
There is a lack of clarity regarding the justification to instruct the couple to shift from intracytoplasmic sperm injection (ICSI) to intracytoplasmic morphologically selected sperm injection (IMSI).
- Trial name
- NCT02107521
- Testing
- Intracytoplasmic morphologically selected sperm injection, Intracytoplasmic sperm injection
- Where
- Brazil
- Volunteers
- 25 people
- Sponsor
- Sapientiae Institute
Infertility, Female
A New Revolutionary 3-Injection- Protocol in Infertile Women
This is a prospective randomised study of the evaluation of the clinical IVF results after following a new revolutionary 3-Injection- Protocol for controlled ovarian stimulation in infertile women.
- Trial name
- NCT03877185
- Testing
- Live birth rate
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assisting Nature
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