Clinical trials: Fertility, open to volunteers
Retained Products of Conception
Removal of Intrauterine Retained Products of Conception (RPOC) After Miscarriage Guided by Hysteroscopy Trial. A Randomized Controlled Trial.
Rationale: Elective immediate dilation and curettage (D\&C) for miscarriage is associated with the occurrence of intrauterine adhesions (IUA). IUAs may be associated with subsequent subfertility and premature birth.
- Trial name
- RIGHT (NCT04804332)
- Testing
- Operative hysteroscopy, Expectant management
- Where
- Belgium
- Volunteers
- 244 people
- Sponsor
- University Hospital, Ghent
Pregnancy Complications, Contraception
Impact of the Microbiome on Time to Pregnancy and Pregnancy Outcomes in Fertile Women Attempting to Conceive
This study aims to investigate the microbiome of women with previously proven fertility who plan to become pregnant.
- Conditions
- Pregnancy Complications, Contraception, Pregnancy Loss, Fertility
- Trial name
- SweBioFertil (NCT05127252)
- Testing
- Vaginal and rectal microbiome and metabolome
- Where
- 2 sites in Sweden
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Fertility Preservation, Cancer Remission
Long-term Evaluation of Fertility Preservation Options in Women in Cancer Remission or Haematological Pathology
Cancer treatments, despite their increasing effectiveness, carry a significant risk of gamete toxicity. Women of reproductive age are commonly offered fertility preservation (FP) before starting their treatment.
- Conditions
- Fertility Preservation, Cancer Remission, Reproductive Outcomes, Reproductive Health
- Trial name
- FERT-ISSUES (NCT07312058)
- Where
- France
- Volunteers
- 102 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Fertility, Fertility, Male
Plan A Occlusion and Reversal System Feasibility Study
Prospective, multicenter, single-arm, open label, interventional clinical trial investigating the safety and effectiveness of the Plan A Male Contraceptive System to occlude the vas deferens to block the passage of sperm and then…
- Conditions
- Fertility, Fertility, Male, Healthy Male Adults
- Trial name
- NCT07361120
- Testing
- Occlusion System
- Where
- 3 sites in Australia, Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Next Life Sciences
Endometriosis, Infertility
Pesticides and Infertility: Oxidative Stress Via Circulating Cell-free DNA and Gut/Genital Microbiome Signatures in Women With Endometriosis
This project PestiEndoMicro aims to provide an innovative approach, studying endometriosis under the genital and gut microbiota scope.
- Conditions
- Endometriosis, Infertility, Female Fertility, Cell Free DNA
- Trial name
- PestiEndoMicro (NCT07471373)
- Testing
- Circulating DNA analysis, Vaginal microbiota analysis, Endometrial microbiota analysis
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Rheumatic Diseases, Fertility Disorders
Medically Assisted Fertilization Techniques in Systemic Immunoreumatologic Diseases
Systemic rheumatological diseases often occur in young women of childbearing age and can therefore impact fertility. There are diseases, such as arthritis, which present no contraindication to assisted reproductive techniques…
- Conditions
- Rheumatic Diseases, Fertility Disorders, Pregnancy, High Risk, Pregnancy Complications
- Trial name
- NCT05807256
- Testing
- collection and analysis of treatments and procedures already performed by normal clinical practice
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- IRCCS San Raffaele
Infertility
Food Intake Among Women and Men in Fertility Treatment
Worldwide infertility is highly prevalent and lifestyle factors, such as food intake, could have an essential role in the success of a fertility treatment.
- Trial name
- Food&Fertility (NCT05454046)
- Testing
- Food intake among women and men in fertility treatment
- Where
- 8 sites in Denmark
- Volunteers
- 4,000 people
- Sponsor
- Aalborg University Hospital
Infertility, Male, Cancer
Spermatogonial Stem Cell (SSC) Transplant and Testicular Tissue Grafting
Spermatogonial stem cell transplantation through ultrasound guided rete testis injection and testicular tissue grafting will be performed for participants who have frozen testicular tissue prior to gonadotoxic therapy.
- Conditions
- Infertility, Male, Cancer, Autoimmune Disorder
- Trial name
- NCT04452305
- Testing
- Spermatogonial Stem Cell Transplant and Testicular Tissue Grafting
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Pittsburgh
Sickle Cell Anemia
Serial Assessment of Fertility Experiences
The SAFE study is a long-term research project that watches people with sickle cell anemia (SCA) over time. The main goal is to see how a medicine called hydroxyurea affects their growth, puberty, and ability to have children.
- Trial name
- SAFE (NCT07116772)
- Where
- 3 sites in Dominican Republic, Jamaica and 1 more
- Volunteers
- 250 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Endometrial Neoplasms, Endometrial Neoplasm Malignant
Fertility-sparing Therapy for Patients With Stage IA Endometrial Cancer
The goal of this clinical trial is to explore the feasibility and outcome of fertility-sparing therapy in Stage IA G1-G2 Endometrial Cancer with less than 1/2 myometrial invasion.
- Conditions
- Endometrial Neoplasms, Endometrial Neoplasm Malignant, Endometrial Neoplasm Malignant Stage I, Carcinoma, Endometrioid
- Trial name
- NCT05945407
- Testing
- Indication-extended Fertility-sparing Therapy
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Peking University People's Hospital
Primary Ciliary Dyskinesia (PCD), Fertility
Developing Resource Interventions for Healthcare Professionals and Patients to Improve Knowledge About Fertility in Primary Ciliary Dyskinesia
This project will involve working with people with PCD and medical professionals to develop resources that will help patients and the people providing their care to better understand fertility and pregnancy safety in people with…
- Conditions
- Primary Ciliary Dyskinesia (PCD), Fertility, Pregnancy, Health Information Exchange
- Trial name
- REPRoDUCE (NCT07531277)
- Testing
- Online educational resource, Toolkit for healthcare professionals
- Volunteers
- 30 people
- Sponsor
- University of Southampton
Melanoma, Fertility
MELAFERT: Impact of Adjuvant Therapy on FERTility in Patients With Resected MELAnoma at High Risk of Relapse.
Melanoma survivorship in reproductive-age women is increasing due to the advent of effective therapies in the curative setting. However, while the impact on fertility and ovarian function of chemotherapy agents is well known…
- Trial name
- NCT07092670
- Testing
- Dabrafenib + Trametinib, Pembrolizumab, Nivolumab
- Where
- 10 sites in Italy
- Volunteers
- 270 people
- Sponsor
- Intergruppo Melanoma Italiano
Endometrial Hyperplasia, Grade 1 Endometrial Cancer
Uterine Preservation Via Lifestyle Transformation
Up to 60% of endometrial cancer cases are attributed to obesity, in part because obesity promotes development of atypical endometrial hyperplasia (AEH), and up to 40% of women with AEH go on to develop endometrial cancer.
- Trial name
- NCT05903131
- Testing
- Telemedicine behavioral weight intervention, Progestin, Enhanced usual care
- Where
- 3 sites in United States
- Volunteers
- 96 people
- Sponsor
- Washington University School of Medicine
Cervical Cancers
Iparomlimab and Tuvonralimab Combined With Paclitaxel and Cisplatin as Neoadjuvant Therapy for CC
Currently, the survival rate of locally advanced cervical cancer is low, posing a significant challenge in the treatment of cervical cancer.
- Trial name
- NCT06878222
- Testing
- Neoadjuvant Chemotherapy, Immunotherapy, Radical surgery
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Obstetrics & Gynecology Hospital of Fudan University
Breast Neoplasms, Pregnancy
PREgnancy and FERtility Registry
The PREgnancy and FERtility (PREFER) study is a comprehensive program aiming to optimize care and improve knowledge around the topics of fertility preservation and pregnancy issues in young breast cancer patients.
- Conditions
- Breast Neoplasms, Pregnancy, Fertility Preservation
- Trial name
- PREFER (NCT02895165)
- Where
- 23 sites in Italy
- Volunteers
- 1,000 people
- Sponsor
- IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
Cervical Cancer
FIGO 2018 Stage IB2 Cervical Cancer Treated With Neoadjuvant Chemotherapy Followed by Fertility Sparing Surgery
This study will include patients with invasive cervical cancer that wish to keep their fertility as much as possible in the future after treatment.
- Trial name
- NCT04016389
- Testing
- Cisplatin, Carboplatin, Paclitaxel
- Where
- 4 sites in United States, Canada
- Volunteers
- 31 people
- Sponsor
- University Health Network, Toronto
Elective Fertility Preservation
Study of the Prevalence of Endometriosis and Adenomyosis
Our study aims to assess the prevalence of adenomyosis and endometriosis in patients consulting for elective fertility preservation through the diagnosis of these pathologies by transvaginal pelvic ultrasound.
- Trial name
- PrevADEOSE (NCT06211569)
- Testing
- Usual follow-up
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Vitrification, Egg Donor
Validation of Donor Oocytes Semi-automated Vitrification
Oocyte vitrification is an effective method of freezing which has been authorized in France since 2011. The arrival of this technique has led to real improvements in the survival rate of oocytes after warming compared to that…
- Conditions
- Vitrification, Egg Donor, Fertility, Assisted Reproductive Technology
- Trial name
- GAVIDO (NCT06238570)
- Testing
- Gavi, Merck® (automated vitrification instrument), Vitrolife system
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Clermont-Ferrand
Fertility Preservation
Follicular Flushing Versus Direct Aspiration in Transabdominal Oocyte Retrieval
The goal of this observational study is to learn whether rinsing the egg sacs (follicles) during egg collection helps doctors collect more eggs in women with low egg reserve.
- Trial name
- NCT07877025
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Centrum Clinic IVF Center
Predisposition, Genetic, Cancer
Investigating the Role of Genetics in Disease Predisposition
Gametogenesis is the production of sperm and eggs; it takes place through the process of meiosis. Gametogenesis is subject to the acquisition of mutations as with other processes in the body.
- Conditions
- Predisposition, Genetic, Cancer, Mutation, Fertility Disorders
- Trial name
- NCT06584994
- Testing
- sample collection
- Where
- United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- The Wellcome Sanger Institute