Clinical trials: Febrile Illness Acute
Acute Febrile Illness, Bacterial Infections
AI-Guided Proteomic Biomarker Panel for Differentiating Bacterial and Viral Infections in Acute Febrile Illness
This study is a proteomics-based diagnostic biomarker study conducted on the same patient cohort as the transcriptomic biomarker study (NCT065529754).
- Conditions
- Acute Febrile Illness, Bacterial Infections, Viral Infections, Sepsis
- Trial name
- NCT07205575
- Testing
- Proteomic Biomarker Panel
- Where
- China
- Volunteers
- 394 people
- Sponsor
- Qilu Hospital of Shandong University
Malaria, Fever
Cluster Randomised Trial of Malaria RDTs Used by CHWs in Afghanistan
Malaria is a common, but decreasing, cause of fever in endemic areas. The use of rapid diagnostic tests could improve treatment of malaria at the local community level. Deployment of these tests is, however, a considerable cost.
- Conditions
- Malaria, Fever, Acute Febrile Illness, Pneumonia
- Trial name
- NCT01403350
- Testing
- Malaria Rapid Diagnostic test
- Where
- 3 sites in Afghanistan
- Volunteers
- 2,421 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Acute Respiratory Infections, Febrile Illnesses
The Fever Clinic Acute Respiratory Cohort
This prospective cohort study aims to characterize the natural progression and outcomes of acute respiratory infections among patients presenting to fever clinics.
- Conditions
- Acute Respiratory Infections, Febrile Illnesses, Community-acquired Pneumonia, Viral Respiratory Tract Infections
- Trial name
- FACTS (NCT07278700)
- Testing
- No intervention involved
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Fudan University
Acute Febrile Illness, Melioidosis
Diagnostic Accuracy of the DPP II Assay
Burkholderia pseudomallei is responsible for melioidosis, a disease that can present a range of signs and symptoms and can be treated by a specific drug regimen.
- Conditions
- Acute Febrile Illness, Melioidosis, Diagnoses Disease
- Trial name
- NCT04299412
- Testing
- DPP Fever Panel II assay
- Where
- Australia
- Volunteers
- 104 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Fever, Orthostatic Hypotension
Orthostatic Hypotension in Children With Acute Febrile Illness
Objective:to determent if children suffering from acute febrile illness has higher rate of orthostatic hypotension compared with children with no febrile illness. Design: a prospective cohort study.
- Trial name
- NCT00452712
- Testing
- All subjects will have their blood pressure measured in supine position (after 5 minute of rest) and after 3 minute of standing.
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Assaf-Harofeh Medical Center
Febrile Illness Acute
Treatment of Febrile Infectious Disease Among Children in Hadera District Given the Final Diagnosis. Descriptive Study
Study goal - to describe pediatric patients with febrile disease that administered to the emergency department (ED) of hillel-yaffe hospital, according to arrival diagnosis, ED diagnosis, given therapy, and therapy concordance…
- Trial name
- NCT02313532
- Where
- Israel
- Volunteers
- 500 people
- Sponsor
- Hillel Yaffe Medical Center
Malaria, Dengue
Validation of a CDSA Strategy to Reduce Antibiotic Prescription in Senegal
This trial aims to validate a novel clinical care strategy based on a electronic clinical decision support algorithm (CDSA) combined with point of care rapid diagnostic tests by evaluating its impact on antibiotic prescription…
- Conditions
- Malaria, Dengue, Influenza -Like Illness, Diarrhea
- Trial name
- NCT05050825
- Testing
- Patient clinical management based on the CDSA strategy
- Where
- 4 sites in Senegal
- Volunteers
- 470 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Febrile Illness Acute, Biomarkers
Clinical Aspects, Management and Surveillance of Febrile Illnesses in DRC
The epidemiology and outcome of febrile illnesses in the Democratic Republic of Congo (DRC) is poorly documented. The FIKI² study, a prospective observational study of community-acquired febrile illnesses coordinated by ITM and…
- Conditions
- Febrile Illness Acute, Biomarkers, Surveillance
- Trial name
- FI-CARE (NCT07345286)
- Where
- Democratic Republic of the Congo
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Acute Febrile Illness
Evaluation of the DPP II Assay in Laos
Fever is the most frequent symptom in patients seeking care globally. Several causative agents of febrile illness have been described with a high prevalence in South East Asia.
- Trial name
- NCT04299607
- Testing
- DPP Fever Panel II assay and DPP Micro Readers
- Where
- Laos
- Volunteers
- 300 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Acute Diarrhea, Acute Respiratory Infection
Improving Nighttime Access to Care and Treatment (Part 2)
Children in resource-limited settings who develop illness at night are often isolated from pre-emergency care, resulting in progression to an emergency because families are forced to wait until morning to seek care.
- Conditions
- Acute Diarrhea, Acute Respiratory Infection, Acute Febrile Illness
- Trial name
- INACT2 (NCT03943654)
- Testing
- MotoMeds Healthline- illness assessment and treatment recommendation for non-emergent cases by telephone
- Where
- Haiti
- Volunteers
- 391 people
- Sponsor
- University of Florida
Acute Febrile Illnesses
Validation of Promising Biomarker Assays to Assess Their Diagnostic Performance Characteristics
This project aims to evaluate the performance characteristics of rapid tests to differentiate bacterial from non-bacterial infection in febrile adults and children presenting at OPDs (outpatient departments) i.e.("fever triage…
- Trial name
- NCT03047642
- Testing
- Biomarker assay
- Where
- 3 sites in Brazil, Gabon and 1 more
- Volunteers
- 2,000 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Acute Febrile Illness, Use of Antimicrobial Agents
Comparison of Rates of Antimicrobial Use in Febrile Patients With or Without the Use of C-reactive Protein Blood Test
In Health Posts of rural areas operated by the Government of Nepal, there are limitations of tests to differentiate between bacterial and viral infections.
- Conditions
- Acute Febrile Illness, Use of Antimicrobial Agents, C-reactive Protein Level
- Trial name
- CREATIB (NCT05292508)
- Testing
- C-reactive Protein Rapid Diagnostic Test
- Where
- Nepal
- Volunteers
- 924 people
- Sponsor
- Patan Academy of Health Sciences
Acute Febrile Illness
Acute Undifferentiated Fever in Ethiopia
A cross-sectional study on acute undifferentiated fever and the utility of biomarkers in differentiating bacterial from viral infection among acute febrile patients in Gondar, northwest Ethiopia.
- Trial name
- NCT04268732
- Where
- 2 sites in Belgium, Ethiopia
- Volunteers
- 200 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Acute Febrile Illness
The Etiology of Acute Febrile Illness Requiring Hospitalization
This study is an observational cohort study of hospitalized patients with fever. This study will collect demographic data, history of illness, signs and symptoms, results of laboratory tests, clinical course, treatment and…
- Trial name
- AFIRE (NCT02763462)
- Where
- 8 sites in Indonesia
- Volunteers
- 1,492 people
- Sponsor
- Ina-Respond
Acute Watery Diarrhea, Dysentery/Febrile Diarrhea
Trial Evaluating Ambulatory Treatment of Travelers' Diarrhea
The purpose of the trial is to develop the evidence on relative efficacy of 3 available single-dose loperamide adjuncted regimens for watery diarrhea and a single-dose regimen, with and without loperamide, for dysentery/febrile…
- Trial name
- TrEAT TD (NCT01618591)
- Testing
- Single dose rifaximin 1650 mg, Single dose azithromycin 500 mg, Single dose levofloxacin 500 mg
- Where
- 5 sites in Afghanistan, Djibouti and 3 more
- Volunteers
- 384 people
- Sponsor
- Uniformed Services University of the Health Sciences
Dengue
A Cohort Study to Determine the Incidence of Dengue Fever and to Build Capacity for Dengue Vaccine Trials in Dengue-endemic Regions of South Asia
The purpose of this study is to determine the incidence of dengue fever and to build capacity for dengue vaccine trials in dengue-endemic regions of South Asia.
- Trial name
- NCT02570152
- Testing
- Blood sample collection
- Where
- Sri Lanka
- Volunteers
- 2,004 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Fever
Biomarkers of Mortality and Morbidity in Children Hospitalized With Fever
The objective of this study is to identify clinically informative biomarkers of host defense pathways with potential utility as diagnostic and prognostic tools among children hospitalized with acute febrile illness in a…
- Trial name
- NCT04726826
- Testing
- Diagnostic and prognostic biomarkers
- Where
- Uganda
- Volunteers
- 2,500 people
- Sponsor
- University of Alberta
Acute Febrile Illness
Clinical Study of Transcriptome-based Diagnostic Biomarker for Acute Febrile Illness
Acute febrile illness is the main cause of outpatient visits，and bacterial and viral infections remains the most common cause. The diagnosis of infection is still based on symptoms and traditional techniques, resulting in overuse…
- Trial name
- NCT06552975
- Testing
- Infection
- Where
- China
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Qilu Hospital of Shandong University
Febrile Illness, Acute Cardiovascular Disease
Medication List in and Out of Hospital
30 patients acute hospitalized to medical ward and their medication records are examined. It is to be recorded how the investigators find information about medicine use by the reception when they do not follow the patient.
- Conditions
- Febrile Illness, Acute Cardiovascular Disease, Acute Respiratory Disease
- Trial name
- NCT01288846
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- University of Oslo
Acute Febrile Illness
Electronic Algorithms Based on Host Biomarkers to Manage Febrile Children
Health professionals in developing countries have limited ability to identify children at risk of dying and those in need of antibiotics.
- Trial name
- e-POCT (NCT02225769)
- Testing
- Management of febrile children using e-POCT, Management of febrile children using ALMANACH
- Where
- Tanzania
- Volunteers
- 3,192 people
- Sponsor
- Swiss Tropical & Public Health Institute