Clinical trials: Fear Conditioning
PTSD, Exercise Intensity
Using Exercise to Enhance Fear Extinction Learning
The goal of the current project is to establish the efficacy and mechanisms of exercise-enhanced fear extinction retrieval and generalization in posttraumatic stress disorder (PTSD).
- Conditions
- PTSD, Exercise Intensity, Fear Extinction, Fear Conditioning
- Trial name
- NCT07548125
- Testing
- Exercise
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Josh Cisler
Neural Dynamics of the Acquisition and Retention of Fear Learning and Active Avoidance Learning
Use Electroencephalogram to Study Neural Dynamics of Fear Conditioning and Avoidance Learning Circuit in Humans
The purpose of this study is to examine which event-related potentials (ERPs) and event-related oscillations (EROs) are associated with fear conditioning, avoidance learning, and memory recall for fear and avoidance, where are…
- Trial name
- NCT06240052
- Testing
- Conditioning and active avoidance paradigm (CAAP)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Obesity
Fear Conditioning Paradigm in Obesity
Fear processing in obesity and specifically the ability to i) learn and remember threatening stimuli, and ii) implicitly (i.e., unconsciously) and explicitly (consciously) discriminate them from neutral ones, will be investigated…
- Trial name
- GenAllertOB (NCT05768659)
- Testing
- Fear Conditioning
- Where
- Italy
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Stress Disorders, Post-Traumatic
Brain Structure and Function Before and After Treatment for Post-Traumatic Stress Disorder
This study, conducted at the University of Pennsylvania and at the National Institutes of Health in Bethesda, Maryland, will examine deficits in brain structure and function in people exposed to trauma who developed…
- Trial name
- NCT00069225
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Fear
Effect of D-cycloserine on Extinction of Fear Conditioning
This study will evaluate whether the drug D-cycloserine (DCS) can improve a type of learning called classical conditioning, in which the brain learns to associate neutral stimuli with stimuli that elicit emotional or…
- Trial name
- NCT00352586
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Fear Anxiety, PTSD
Neuroimaging Memories of Fear and Safety in the Human Brain
The purpose of this research is to use functional magnetic resonance imaging (fMRI) to investigate how the brain forms associations between neutral and negative stimuli.
- Trial name
- NCT04975009
- Testing
- Fear conditioning
- Where
- 2 sites in United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Stress Disorders, Post-Traumatic
Cerebral GABA and Fear Conditioning in PTSD
Posttraumatic stress disorder (PTSD) is a common and debilitating neuropsychiatric disorder in which an acute fear response to a traumatic event does not abate.
- Trial name
- NCT01800383
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Isabelle Rosso
Anorexia, Generalized Anxiety
Overgeneralization of Conditioned Fear as a Pathogenic Marker of Anorexia Nervosa
Anorexia nervosa is a chronic mental health condition characterized by maladaptive food consumption (i.e., hypophagia) and distorted body image.
- Trial name
- NCT02148042
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Social Anxiety Disorder
Social Anxiety Virtual Reality Study
This project aims to validate a virtual reality paradigm that assesses maladaptive avoidance behavior in social anxiety disorder.
- Trial name
- SAVR (NCT04288180)
- Testing
- No intervention
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Stanford University
Healthy
Losartan and Emotion Processing
The aim of the study is to investigate the effect of losartan (50mg, single dose) on the extinction of conditioned fear
- Trial name
- NCT03396523
- Testing
- Losartan
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Obsessive-Compulsive Disorder
Fear Conditioned Response in Healthy Subjects and in OCD Patients Pre and Post Treatment With Sertraline.
24 OCD patients and 24 healthy subjects will be submitted to a two-day fear conditioning paradigm during acquisition of functional magnetic resonance imaging (fMRI).
- Trial name
- FEARCON (NCT03068429)
- Testing
- Sertraline Hydrochloride
- Where
- Brazil
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Fear, Stress
Epi-Genetic Modulators of Fear Extinction in Alcohol Dependence
Background: Researchers want to learn if people with alcohol dependence have more difficulty learning to feel calm, or learn to fear things more easily.
- Conditions
- Fear, Stress, Alcohol Dependence
- Trial name
- NCT02438969
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Insomnia, PTSD
The Effects of Orexin Antagonism on Fear Extinction in PTSD
PTSD affects approximately 22% of Veterans who have served in Iraq and Afghanistan. Symptoms of PTSD may include re-experiencing, avoidance of trauma reminders, negative thoughts or feelings, and hyperarousal, such as increased…
- Trial name
- NCT06788522
- Testing
- Suvorexant
- Where
- 2 sites in United States
- Volunteers
- 40,120 people
- Sponsor
- VA Office of Research and Development
PTSD
Effect of tDCS Timing on Safety Memory in PTSD
The primary purpose of this study is to investigate the effects of tDCS timing on extinction memory in PTSD. A total of 90 participants will be randomized equally across one of three groups: 1.
- Trial name
- NCT04152772
- Testing
- transcranial direct current stimulation
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Butler Hospital
Fear Conditioning
Cannabinoid Augmentation of Fear Response in Humans
The purpose of this double blind, randomized, controlled, proof-of-concept study is to test the effects of cannabinoid receptor augmentation on the facilitation of fear conditioning.
- Trial name
- NCT01665573
- Testing
- PF-04457845
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Yale University
Hyperalgesia, Chronic Pain Syndrome
Pain-related Fear as a Facilitator of Nocebo Hyperalgesia
Nocebo hyperalgesia is characterized by adverse pain outcomes, induced by patients' expectations. In the lab, nocebo effects are commonly studied via classical conditioning, a method that employs pairings of neutral…
- Conditions
- Hyperalgesia, Chronic Pain Syndrome, Chronic Pain, Psychogenic, Fear of Pain
- Trial name
- LFS (NCT04197154)
- Testing
- Threat manipulation (control, no threat), Threat manipulation, Conditioning of moderate pain
- Where
- Netherlands
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Anxiety Disorders
Spatial Context and Fear Learning
Background: Fear is a normal response to a threat. Learning fear can be helpful sometimes. For people with anxiety disorders, fear can be long-lasting and too intense.
- Trial name
- NCT02423044
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Posttraumatic Stress Disorder
Effects of Duloxetine on Fear Conditioning in Posttraumatic Stress Disorder (PTSD)
Chronic posttraumatic stress disorder (PTSD) is a debilitating disorder and treatment response to pharmacological interventions has been modest for these patients.
- Trial name
- NCT00763178
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Yale University
Post Traumatic Stress Disorder, Anxiety Disorders
Neuroimaging of Pavlovian Fear Conditioning Processes in Patients With Pathological Anxiety
The purpose of this study is to use functional magnetic resonance imaging to investigate how the human brain learns to form associations between neutral and emotional stimuli.
- Conditions
- Post Traumatic Stress Disorder, Anxiety Disorders, Panic Disorder, Social Phobia
- Trial name
- NCT03498599
- Testing
- Novelty facilitated extinction, Standard Extinction
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Texas at Austin
Anxiety Disorder
Effects of Verbal Instructions on Fear Extinction and Extinction Retrieval
The goal of this study is to examine if verbal instructions can improve fear extinction learning and extinction retrieval in patients with anxiety disorders (AD) and healthy controls.
- Trial name
- NCT05718271
- Testing
- Explicit instructions before extinction, Explicit instructions after extinction
- Where
- Germany
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Ruhr University of Bochum