Clinical trials: Fatigue in Multiple Sclerosis
Multiple Sclerosis (MS) - Relapsing-remitting
Educational Programs Based on Healthy Habits to Improve Quality of Life and Psychosocial Profile in Women With Neurodegenerative Diseases: the ADVICE Protocol Study (Phase 2)
This phase of the project aims to compare in-person, supervised educational programs (EP) with online self-guided EPs in individuals with relapsing-remitting multiple sclerosis.
- Trial name
- ADVICE Phase 2 (NCT06884579)
- Testing
- Strength training, nutrition, and behavioral training, Self-Guided and Unsupervised Program with General Recommendations
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Universidad de Almeria
Multiple Sclerosis
Association Between Fatigue and Balance in Patients With Multiple Sclerosis
The relationship between fatigue and balance was established. Fatigue was correlated with 8 parameters of balance scales. Moreover, there was a strong correlation between the level of fatigue from one side and depression, quality…
- Trial name
- NCT04215354
- Testing
- Magnetic field, Virtual reality
- Where
- Saudi Arabia
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Imam Abdulrahman Bin Faisal University
Multiple Sclerosis
Sleep Disorders in Patients With Multiple Sclerosis
Fatigue is a frequent and disabling symptom in patients with multiple sclerosis (MS). The pathophysiology of this sign is not fully understood. Some data suggest that the fatigue is associated with sleep disorders.
- Trial name
- NCT00137904
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Multiple Sclerosis, Fatigue
MitoQ for Fatigue in Multiple Sclerosis (MS)
The purpose of this study is to determine whether MS patients who receive Oral mitoquinone (MitoQ) have less fatigue than those receiving a placebo.
- Trial name
- MitoQ (NCT04267926)
- Testing
- 20 mg MitoQ, 40mg of MitoQ
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- VA Office of Research and Development
Multiple Sclerosis
Patient Acceptable Symptomatic State and Minimal Clinically Important Difference of the Fatigue in Multiple Sclerosis (SeDiF_SEP)
Fatigue is the most common symptom and the most disabling symptom of Multiple Sclerosis, and its inefficient management can be a source of multiple consultations (increase in health costs) and a reduction in productivity (work…
- Trial name
- SeDiF_SEP (NCT03662347)
- Where
- France
- Volunteers
- 2,100 people
- Sponsor
- Central Hospital, Nancy, France
Multiple Sclerosis, Fatigue
Sleep Medical Treatment in MS Patients Suffering From Fatigue
This study evaluates the effect of an extensive sleep medical investigation and of the subsequent treatment on multiple sclerosis (MS) related fatigue (provided a previously unknown sleep disorder was found).
- Trial name
- Sleep-in-MS (NCT03759249)
- Testing
- Sleep medical treatment
- Where
- Germany
- Volunteers
- 51 people
- Sponsor
- Charite University, Berlin, Germany
Multiple Sclerosis
The Effect Of Proprioceptive Neuromuscular Facilitation Techniqueson in Patients With Multiple Sclerosis
The aim of this study is to examine the effects of PNF techniques on pain, motor function, fatigue and quality of life.
- Trial name
- NCT06102148
- Testing
- PNF Group, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Nilay Comuk Balci
Multiple Sclerosis
Study of Alternative Exercise Therapies for Progressive Multiple Sclerosis (MS)
This project will evaluate a new therapy for patients with a severe form of MS known as progressive MS. These patients are severely limited in their ability to walk and function in everyday life.
- Trial name
- NCT01097538
- Testing
- Body-weight supported treadmill training, Total body recumbent stepper training
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Hicks, Audrey, Ph.D.
Multiple Sclerosis
Effects of High-intensity Gait Training on Fatigue, Gait, and Neuroplasticity in People With Multiple Sclerosis
Nearly 1 million individuals in the United States have multiple sclerosis, which causes fatigue and problems with walking. Fatigue and walking problems are poorly treated, but exercise training, particularly high-intensity…
- Trial name
- NCT06264336
- Testing
- treadmill training
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Illinois at Chicago
Fatigue in Multiple Sclerosis
Treatment of Fatigue With Methylphenidate, Modafinil and Amantadine in Multiple Sclerosis
Randomized, placebo-controlled, crossover, 4-sequence, 4-period, double-blind (participants and investigators), multicenter trial of 3 commonly used medications for treatment of MS-related fatigue (amantadine, modafinil…
- Trial name
- TRIUMPHANT-MS (NCT03185065)
- Testing
- Amantadine, Modafinil, Methylphenidate
- Where
- 2 sites in United States
- Volunteers
- 141 people
- Sponsor
- Johns Hopkins University
Multiple Sclerosis
Telerehabilitation-based Upper Extremity Training in People With Multiple Sclerosis
In this studly, the effects of an 8-week telerehabilitation-based upper extremity training in persons with multiple sclerosis will be investigated.
- Trial name
- NCT05073731
- Testing
- Telerehabilitation-based Upper Extremity Training
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Dokuz Eylul University
Progressive Multiple Sclerosis, Fatigue
A Study of Oxidative Pathways in MS Fatigue
This is a 4-week randomized, placebo-controlled, parallel group, double-blind, single center trial on effect of N-acetyl cysteine versus placebo on fatigue in patients with progressive MS defined by McDonald criteria.
- Trial name
- NCT02804594
- Testing
- N-acetyl cysteine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of California, San Francisco
Multiple Sclerosis, Fatigue
Fatigue in Multiple Sclerosis: Evaluated With 3 MRI and Transcranial Magnetic Stimulation
The purpose of this study is to investigate fatigue in patients with multiple sclerosis (MS) and to determine the correlation between the symptom and cerebral changes.
- Trial name
- NCT00342381
- Testing
- 3,4-diaminopyridine
- Where
- Denmark
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Multiple Sclerosis
Effect of Motor Entrainment to Auditory Cues and Music During Walking on Quality of Movement and Perceived Fatigue in Persons With Multiple Sclerosis (PwMS)
The study investigates the effect of different conditions of auditory cueing and music on walking quality and perceived fatigue in persons with multiple sclerosis compared to healthy controls.
- Trial name
- NCT03281330
- Testing
- auditory cues and music during walking
- Where
- 3 sites in Belgium
- Volunteers
- 60 people
- Sponsor
- Hasselt University
Multiple Sclerosis
Effect of Acetominophen an Gait Fatigue in Multiple Sclerosis
The goal of this observational study is to compare the impact of an antipyretic, acetaminophen to a placebo on gait fatigue in persons with multiple sclerosis (MS).
- Trial name
- NCT07440446
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Hunter College of City University of New York
Multiple Sclerosis
How Does Strength Training and Balance Training Affect Gait Function and Fatigue in Patients With Multiple Sclerosis?
Introduction: Multiple sclerosis (MS) is characterized by decreased strength and motor control, and compromised gait function. Reduced walking speed, balance, and fatigue are the cardinal symptoms.
- Trial name
- NCT02870023
- Testing
- Balance training, Strength training
- Where
- Denmark
- Volunteers
- 71 people
- Sponsor
- University of Aarhus
Aromatherapy, Randomized Controlled Trial
Aromatherapy With Lavender Essential Oil in Patients With Multiple Sclerosis
The study was conducted with patients with Multiple Sclerosis (MS) who applied to the Neurology Outpatient Clinic of Atatürk University Research Hospital, met the inclusion criteria and agreed to participate in the study.
- Conditions
- Aromatherapy, Randomized Controlled Trial, Multiple Sclerosis
- Trial name
- NCT05929638
- Testing
- lavender oil
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Multiple Sclerosis
The Mediating Role of Balance in the Relationship Between Fatigue and Fear of Falling in Individuals With Multiple Sclerosis
Fatigue, balance impairment, and fear of falling are common problems in individuals with Multiple Sclerosis (MS). Previous studies have shown significant associations among these variables; however, the mechanisms underlying the…
- Trial name
- NCT07680049
- Testing
- Observational Model: Cross-Sectional
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Uskudar University
Multiple Sclerosis
Role of Microglial Activation and Norepinephrine Transporter Abnormalities in Pathogenesis of MS-related Fatigue
The overarching aim is to assess the role of microglial activation and norepinephrine transporter binding in pathogenesis of MS-related fatigue, using novel Positron Emission Tomography (PET) radiotracers, [F-18]PBR06 and…
- Trial name
- NCT04144257
- Testing
- [F-18]PBR06, [C-11]Methylreboxetine
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Brigham and Women's Hospital
Multiple Sclerosis, Covid-19
Investigation of Fatigue, Physical Activity, Sleep Quality and Anxiety Levels
Hundreds of thousands of confirmed cases have been reported worldwide, just 3 months after the first patients were identified in Wuhan, China.
- Trial name
- NCT04438954
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Ankara Yildirim Beyazıt University