Clinical trials: Fat Disorder
Dyslipidemia
Bergamot and Cardio-Metabolic Risk Factors
Bergamot-derived products have shown significant effects on plasma lipids. We aim in the present study to evaluate the effect of bergamot on several cardio-metabolic risk markers.
- Trial name
- NCT02205567
- Testing
- Bergamot-derived product
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- University of Palermo
Adolescent Obesity, Hypertension,Essential
Treatment and Handling Severe Obesity-Related Comorbidities in Adolescents Through Exercise
The main objective of this project is to analyze the effect of a tailor-made, one-to-one, exercise program (aiming to treat and handle obesity-related comorbidities in adolescents with severe obesity at high risk of…
- Conditions
- Adolescent Obesity, Hypertension,Essential, Non-Alcoholic Fatty Liver Disease, Dyslipidemias
- Trial name
- THOR-X (NCT06520800)
- Testing
- Treatment and handling obesity-related comorbidities in adolescents through exercise
- Volunteers
- 24 people
- Sponsor
- University of Lisbon
Metabolic Syndrome, Obesity
Low-intensity Exercise in Metabolic Syndrome
People with metabolic syndrome (MetS) are characterized by a lower quality of life in terms of reduced vital activity, emotional state, and social functioning.
- Conditions
- Metabolic Syndrome, Obesity, Hypertension, Hyperlipidemias
- Trial name
- NCT04346836
- Testing
- Low-intensity, general-fitness exercises, Psychoeducation
- Where
- Poland
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Wroclaw University of Health and Sport Sciences
Type 2 Diabetes
Impact of Empaglifozine on Cardiac Ectopic Fat
There is substantial evidence supporting the fact that ectopic fat accumulation is an important contributor to type 2 diabetes complications and cardiovascular risk [1].
- Trial name
- EMPACEF (NCT03118336)
- Testing
- Empagliflozin 10Mg Tab
- Where
- France
- Volunteers
- 56 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Obesity
Harmonic Versus Electro Surgery in Lower Body Lift Procedures
The objective of this study is to determine if the use of The Harmonic™ (an ultrasonic surgical instrument) in Lower Body Lift procedures reduces volume and duration of wound drainage after surgery when compared to Electro…
- Trial name
- LBL (NCT00522171)
- Testing
- The Harmonic™ ultrasonic scalpel
- Where
- 2 sites in United States, Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ethicon Endo-Surgery
Dyslipidemias
Effect of Aerobic Training and Moringa Oleifera on Dyslipidemia and Cardiac Endurance
Aerobic training is essential for maintaining and improving physical performance and has a positive effect on physiological functions as well as anthropometric characteristics.
- Trial name
- NCT04164771
- Testing
- Aerobic training and Moringa Oleifera
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Hypothyroidism, Hyperthyroidism
Brown Adipose Tissue Activity and Thyroid Hormone
Rationale: During the last decades, research in possible therapies for existing obesity and developmental factors causing obesity has explosively increased.
- Conditions
- Hypothyroidism, Hyperthyroidism, Obesity
- Trial name
- NCT02499471
- Testing
- Levothyroxine therapy (137.75 ± 23.75 μg/day)
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- Maastricht University Medical Center
Hypercholesterolaemia
Non-interventional Study (NIS) to Assess Reaching of Cholesterol Target Values in Patients Treated With HMG-CoA Reductase Inhibitors
This is a multi-centre non-interventional study of patients who are treated with any HMGCoA reductase inhibitor available in Croatia (rosuvastatin, simvastatin, atorvastatin and fluvastatin) for at least 6 months.
- Trial name
- NCT01257971
- Where
- 27 sites in Croatia
- Volunteers
- 1,868 people
- Sponsor
- AstraZeneca
Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease
Fat Metabolism in OSA and COPD
Obstructive sleep apnea (OSA) is the most common type of sleep apnea and is caused by an obstruction of the upper airways. The obstruction results in periods of intermittent hypoxia and re-oxygenation, which lead to increased…
- Conditions
- Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease, Obesity
- Trial name
- NCT02157844
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Dyslipidemias
A Clinical Pharmacology Study of K-877 Controlled Release Tablet
A study to compare the efficacy, safety, and pharmacokinetics of K-877 controlled release tablets with a current normal K-877 tablet in dyslipidemia.
- Trial name
- NCT04079530
- Testing
- K-877 IR 0.2 mg/day, K-877 CR 0.4 mg/day, K-877 CR 0.8 mg/day
- Where
- Japan
- Volunteers
- 60 people
- Sponsor
- Kowa Company, Ltd.
Fatty Liver, Dyslipidemias
Atorvastatin Versus Vitamin E in Treatment of Non-alcoholic Fatty Liver Disease
The purpose of the study is to compare the impact of atorvastatin 20mg qd and Vitamin E 300mg qd therapy on liver fat content in patients with type 2 diabetes associated with high LDL-C and non-alcoholic fatty liver disease.
- Conditions
- Fatty Liver, Dyslipidemias, Diabetes Mellitus
- Trial name
- NCT01720719
- Testing
- atorvastatin, Vitamin E
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Xin Gao
Soft Tissue Sarcoma
APX005M and Doxorubicin in Advanced Sarcoma
This phase II clinical trial will evaluate the safety and efficacy of adding APX005M (a CD40 agonistic monoclonal antibody) to doxorubicin for the treatment of patients with advanced soft tissue sarcoma.
- Trial name
- NCT03719430
- Testing
- Doxorubicin, APX005M
- Where
- 3 sites in United States
- Volunteers
- 27 people
- Sponsor
- Alexander Z. Wei, MD
Obesity
Effect of Conjugated Linoleic Acid Supplement on Body Composition
The purpose of this clinical trial is to examine the effects of a low and high dose of conjugated linoleic acid supplement on body composition in obese humans.
- Trial name
- NCT00347373
- Testing
- Tonalin Conjugated linoleic acid (dietary supplement)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of North Carolina
Type II Diabetes Mellitus
Effects of a Spiced Meat Patty on Inflammation in Men With Type 2 Diabetes
Polyphenols belong to the largest group of secondary metabolites produced by plants, mainly, in response to biotic or abiotic stresses such as infections, wounding, UV irradiation, exposure to ozone, pollutants, and other hostile…
- Trial name
- NCT01076829
- Testing
- Spice polyphenols
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Familial Hypercholesterolemia
Soy Food Intervention Trial
Familial hypercholesterolemia (FH MIM#143890), an inherited disorder of lipoprotein metabolism, is a risk for early cardiovascular disease (CVD).
- Trial name
- SOYFIT (NCT00924339)
- Testing
- soy protein diet, rapeseed oil
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Type 2 Diabetes, Hyperlipidemias
The Medicines Advice Service Evaluation
The purpose of this study is to find out whether talking to a pharmacist on the telephone can help to support people taking medicine for a long-term condition.
- Trial name
- NCT01864239
- Testing
- Medicines Advice Service
- Where
- United Kingdom
- Volunteers
- 677 people
- Sponsor
- University College, London
HIV, Dyslipidemia
Trial To Assess The Lipid-Lowering Effect Of Adding Tenofovir/Emtricitabine Co-Formulation Vs Placebo To Hiv-1-Infected Subjects With Dyslipidemia And Sustained Viral Load Suppression Under Monotherapy With Ritonavir-Boosted Protease Inhibitors
This is a phase IV, multicenter, prospective, randomised, crossover, double blind, placebo-controlled and proof of concept clinical trial.
- Trial name
- NCT01458977
- Testing
- Truvada® (300 mg tenofovir disoproxil fumarato/200 mg emtricitabine)
- Where
- 3 sites in Spain
- Volunteers
- 48 people
- Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
Hyperlipidemia
A Randomized, Double-Blinded Study of Simvastatin 20 mg/Day Versus Vytorin 10/20 in Subjects With Lipid Profiles Not Meeting Current NCEP Guidelines, Following a Low-Carbohydrate Diet
People who follow a low-carbohydrate diet typically experience a decrease in triglycerides and increase in HDL-C level, but fail to lower their LDL cholesterol (LDL-C). Such patients may require lipid-lowering therapy.
- Trial name
- LOCUST (NCT00566267)
- Testing
- simvastatin 20 mg/ezetimibe
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Type 2 Diabetes
The Effect of Vitamin D Supplementation on Glucose Metabolism in Non-Diabetic African American Adults
Type 2 diabetes is more common among African Americans than Caucasians. African Americans are also at a higher risk for lower levels of vitamin D compared to other ethnic groups.
- Trial name
- AVIS (NCT01141192)
- Testing
- vitamin D3, cholecalciferol, Inactive comparator
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Augusta University
Diabetes Mellitus, Type 2, Hypertension
The Effect of Progressive Resistance Exercise Training (PRET) on CVRF in Adults With ID.
Thanks to improved healthcare, the life expectancy of people with ID is increasing and is approaching that of the general population.
- Conditions
- Diabetes Mellitus, Type 2, Hypertension, Hypercholesterolemia, Obesity
- Trial name
- PRET (NCT06579898)
- Testing
- Progressive resistance exercise training
- Where
- 3 sites in Netherlands
- Volunteers
- 36 people
- Sponsor
- Erasmus Medical Center
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