Clinical trials: Familial Diffuse Gastric Cancer
Stomach Neoplasms, Stomach Cancer
Hereditary Gastric Cancer Syndromes: An Integrated Genomic and Clinicopathologic Study of the Predisposition to Gastric Cancer
Background: Gastric cancers are cancers of the stomach. Hereditary ones are passed from parent to child. Researchers want to gather data about hereditary gastric cancers.
- Conditions
- Stomach Neoplasms, Stomach Cancer, Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS), Hereditary Diffuse Gastric Cancer (HDGC)
- Trial name
- NCT03030404
- Where
- United States
- Volunteers
- 733 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Li Fraumeni Syndrome, Lynch Syndrome
Inherited Cancer Early Diagnosis (ICED) Study
ICED is a prospective sample collection research study, aiming to develop or validate a blood/urine biomarker which could potentially detect cancers early in individuals at high risk of developing cancers, due to certain germline…
- Conditions
- Li Fraumeni Syndrome, Lynch Syndrome, Hereditary Diffuse Gastric Cancer, Cowden Syndrome
- Trial name
- ICED (NCT06163365)
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Lynch Syndrome, FAP
Hereditary Colorectal and Associated Tumor Registry Study
After informed consent, participants will be asked to complete a medical/family history questionnaire and provide a blood sample.
- Conditions
- Lynch Syndrome, FAP, Hereditary Diffuse Gastric Cancer, Juvenile Polyposis Syndrome
- Trial name
- NCT00633607
- Testing
- Research Registry
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- University of Pittsburgh
Hereditary Diffuse Gastric Cancer
Biopsy Technique for Endoscopic Surveillance of Hereditary Diffuse Gastric Cancer
Germline mutation in e-cadherin gene (CDH1) is found in approximately 25% to 30% of individuals fulfilling the clinical criteria for hereditary diffuse gastric cancer (HDGC).
- Trial name
- NCT03950908
- Testing
- Single bite biopsy technique, Double bite biopsy technique
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- University of Cambridge
Hereditary Cancer Syndrome
CfDNA in Hereditary And High-risk Malignancies 2
The goal of this study is to understand the performance of an experimental blood test that aims to detect early tumors in patients with hereditary cancer syndromes.
- Trial name
- CHARM2 (NCT06726642)
- Testing
- Cell-free DNA analysis
- Where
- 8 sites in Canada
- Volunteers
- 1,000 people
- Sponsor
- University Health Network, Toronto
Gastric Cancer, Gastric Neoplasms
Confocal Endoscopic Microscopy for Detection of Early Stage Gastric Cancer in Subjects With Hereditary Diffuse Gastric Cancer Syndrome
Background: People with hereditary gastric cancer syndrome are at increased risk of getting cancer in their stomach. These people should have regular endoscopies and biopsies to check for cancer if they are choosing to keep their…
- Trial name
- NCT03648879
- Testing
- Endoscope+Cellvizio(R) 100 microscope
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- National Cancer Institute (NCI)
Malignant Neoplasm of Stomach, Carcinoma, Diffuse Type
Screening for Familial Gastric Cancer in First Degree Relatives
The purpose of this study is to determine whether staining of the gastric mucosa increases the number of detected (pre)malignant foci of intestinal and diffuse type gastric cancer, in first degree relatives of individuals with…
- Conditions
- Malignant Neoplasm of Stomach, Carcinoma, Diffuse Type, Intestinal Type Adenocarcinoma of Stomach, Relative (Related Person)
- Trial name
- FamGaCan (NCT01727908)
- Testing
- Endoscopy with staining of the mucosa
- Where
- Netherlands
- Volunteers
- 79 people
- Sponsor
- Radboud University Medical Center
Cancer Gene Mutation, Gastric Cancer
CTNNA1 Familial Expansion Study
The goal of the CAFÉ Study is to determine the cancer risks associated with germline CTNNA1 loss-of-function variants.
- Conditions
- Cancer Gene Mutation, Gastric Cancer, Breast Cancer
- Trial name
- CAFÉ (NCT05126290)
- Testing
- Collection of personal and family history from CAFÉ Study participants
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Hereditary Diffuse Gastric Cancer
Liquid Biopsies for the Personalized Management of Patients with Hereditary Diffuse Gastric Cancer
Activating somatic mutations and methylation profiles identified by liquid biopsies could identify CDH1 and CTNNA1 pathogenic variants carriers with invasive diffuse gastric cancer undetectable by upper G-I endoscopy.
- Trial name
- LISA-HDGC (NCT04253106)
- Testing
- Liquid biopsies (blood, gastric fluid).
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris