Clinical trials: Familial Cancer
Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Choriocarcinoma
Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia
This phase I/II clinical trial is studying the side effects and best dose of gamma-secretase inhibitor RO4929097 and to see how well it works in treating young patients with relapsed or refractory solid tumors, CNS tumors…
- Conditions
- Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Choriocarcinoma, Childhood Central Nervous System Germinoma, Childhood Central Nervous System Mixed Germ Cell Tumor
- Trial name
- NCT01088763
- Testing
- gamma-secretase/Notch signalling pathway inhibitor RO4929097, diagnostic laboratory biomarker analysis, pharmacological study
- Where
- 12 sites in United States, Canada
- Volunteers
- 129 people
- Sponsor
- National Cancer Institute (NCI)
Familial Adenomatous Polyposis
Trial of Exercise Therapy in Familial Adenomatous Polyp (FAP)
The purpose of this phase 1a/b trial is to find out what amount of exercise would be best to use for preventing recurrence of colorectal polyps.
- Trial name
- NCT06641310
- Testing
- Exercise Therapy
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- University of Michigan Rogel Cancer Center
Childhood Cancer
FAMily Oriented Support (FAMOS): Psychosocial Intervention for Childhood Cancer Survivors and Their Families
To investigate whether a home-based psychosocial family intervention that takes place shortly after ending the primary medical treatment can help families adjust to their cancer-related psychological issues.
- Trial name
- NCT02200731
- Testing
- FAMOS: psychosocial family intervention
- Where
- Denmark
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Pernille Bidstrup
CDK Gene Mutation, Metastatic Malignant Neoplasm in the Brain
Genetic Testing in Guiding Treatment for Patients With Brain Metastases
This phase II trial studies how well genetic testing works in guiding treatment for patients with solid tumors that have spread to the brain.
- Conditions
- CDK Gene Mutation, Metastatic Malignant Neoplasm in the Brain, Metastatic Malignant Solid Neoplasm, NTRK Family Gene Mutation
- Trial name
- NCT03994796
- Testing
- Abemaciclib, PI3K Inhibitor paxalisib, Entrectinib
- Where
- 435 sites in United States
- Volunteers
- 50 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Acute Lymphoblastic Leukemia, Leukemia, Acute Myeloid (AML), Child
Safety Study of Gene Modified Donor T-cells Following TCRαβ+ Depleted Stem Cell Transplant
This study will evaluate pediatric patients with malignant or non-malignant blood cell disorders who are having a blood stem cell transplant depleted of T cell receptor (TCR) alfa and beta cells that comes from a partially…
- Conditions
- Acute Lymphoblastic Leukemia, Leukemia, Acute Myeloid (AML), Child, Lymphoma, Non-Hodgkin, Myelodysplastic Syndrome
- Trial name
- NCT02065869
- Testing
- BPX-501 T cells, Rimiducid
- Where
- 4 sites in Italy, United Kingdom
- Volunteers
- 187 people
- Sponsor
- Bellicum Pharmaceuticals
Colorectal Cancer, Breast Cancer
Health Information Technology (HIT) Enhanced Family History Documentation and Management in Primary Care
We evaluated whether collection of risk factors to generate an electronic health record (EHR)-linked personalized health risk appraisal (HRA) for coronary heart disease (CHD), diabetes, breast and colorectal cancer (CRC) was…
- Conditions
- Colorectal Cancer, Breast Cancer, Coronary Heart Disease, Diabetes
- Trial name
- NCT01468675
- Testing
- Intervention
- Where
- United States
- Volunteers
- 6,075 people
- Sponsor
- Brigham and Women's Hospital
HBV, HCC
Real-world Study on Liver Cancer Risk in Chronic Hepatitis B Patients With Family History of Liver Cancer
This study is a prospective, multicenter, real-world cohort study designed to compare the long-term outcomes of chronic hepatitis B patients with a family history of HBV-related hepatocellular carcinoma (HCC) who receive PEG…
- Trial name
- NCT07007286
- Testing
- ETV,TDF,TAF,TMF combination with PEG IFNα-2b, ETV,TDF,TAF or TMF
- Where
- 555 sites in China
- Volunteers
- 1,500 people
- Sponsor
- Peking University First Hospital
Gastric Cancer, Helicobacter Pylori Infection
Gastric Cancer Prevention in the Family Members by Helicobacter Pylori Eradication
This study evaluate whether treatment of Helicobacter pylori infection reduces the incidence of gastric cancer in subjects with family history of gastric cancer.
- Conditions
- Gastric Cancer, Helicobacter Pylori Infection, Family Members
- Trial name
- NCT01678027
- Testing
- LAC triple therapy
- Where
- South Korea
- Volunteers
- 1,838 people, healthy volunteers welcome
- Sponsor
- National Cancer Center, Korea
Childhood Burkitt Lymphoma, Childhood Central Nervous System Germ Cell Tumor
Ispinesib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Lymphoma
This phase I trial is studying the side effects and best dose of ispinesib in treating young patients with relapsed or refractory solid tumors or lymphoma.
- Conditions
- Childhood Burkitt Lymphoma, Childhood Central Nervous System Germ Cell Tumor, Childhood Choroid Plexus Tumor, Childhood Craniopharyngioma
- Trial name
- NCT00363272
- Testing
- ispinesib, laboratory biomarker analysis, pharmacological study
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Hereditary Pancreatitis, Hereditary Pancreatic Cancer
Quality Control Study of MR Based Screening of Individual With Increased Risk for Pancreas Cancer.
Early detection of pre-cancerous lesions or early stage pancreatic cancer seems to have a positive impact in survival for patients with an increased genetic risk to develop pancreas cancer.
- Trial name
- NCT02078245
- Testing
- MRI
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska University Hospital
Prostate Cancer, Hereditary Prostate Cancer
Targeted Prostate Cancer Screening in Men With BRCA1/2 Mutations
This interventional study is a follow-up component of the IMPACT project, which aims to identify men at increased hereditary risk of prostate cancer.
- Trial name
- IMPACT (NCT07416812)
- Testing
- Targeted Prostate Cancer Screening, Telephone Follow-Up Interview
- Where
- Slovenia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Institute of Oncology Ljubljana
Pancreas Cancer
International CAPS Registry: Pancreas Cancer Cases in Surveillance Programs
Various centers around the world are currently investigating the feasibility and yield of surveillance for pancreatic cancer in high-risk individuals.
- Trial name
- CAPS Registry (NCT02703545)
- Volunteers
- 58 people
- Sponsor
- Johns Hopkins University
Cancer, Cancer Metastatic
Real Word European Registry of NTRK Fusions and Other Rare Actionable Fusions (TRacKING)
This registry will make it possible to describe real life management of patients with rare actionable fusions and to better understand these cancers.
- Conditions
- Cancer, Cancer Metastatic, NTRK Gene Fusion Overexpression, NTRK Family Gene Mutation
- Trial name
- TRacKING (NCT04921553)
- Testing
- Data collection and quality of life questionnaire
- Where
- 41 sites in Austria, Czechia and 9 more
- Volunteers
- 500 people
- Sponsor
- Centre Leon Berard
Osteosarcoma
Biology of Osteosarcoma (BOOST) Registry and Biobank
Osteosarcoma is very rare cancer of the bone. The investigator started the BOOST registry and biobank to make sure every patient has the opportunity to participate in research.
- Trial name
- BOOST (NCT03225872)
- Where
- United States
- Volunteers
- 362 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
FAP, Familial Adenomatous Polyposis
Investigation of β-hydroxybutyrate Supplementation as Chemoprevention in Familial Adenomatous Polyposis
The aim of this study is to evaluate the potential of BHB supplementation as a novel strategy to impede the development and progression of intestinal adenomas in individuals with FAP, thus potentially reducing the need for…
- Trial name
- BHB-FAP (NCT06578637)
- Testing
- R-1,3-Butanediol (10G-A), R-1,3-Butanediol (20G-A), R-1,3-Butanediol (30G-A)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Cancer
Trajectories of Regenerating Family Resilience in Adolescents With Cancer
Family resilience is an important strength to help family to manage life challenge successfully, and to reorganize family function.
- Trial name
- NCT01395680
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Brain and Central Nervous System Tumors, Intraocular Melanoma
Monoclonal Antibody Therapy in Treating Patients With Leptomeningeal Cancer
RATIONALE: Monoclonal antibodies can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells.
- Conditions
- Brain and Central Nervous System Tumors, Intraocular Melanoma, Lung Cancer, Melanoma (Skin)
- Trial name
- NCT00003022
- Testing
- iodine I 131 monoclonal antibody 3F8
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cancer
FAmily CEntered (FACE) Advance Care Planning for Teens With Cancer
Advance Care Planning (ACP) prepares patients and their loved ones for future health care decisions, including end-of-life decisions.
- Trial name
- FACE (NCT01670461)
- Testing
- FACE, Standard of Care (SOC) Control
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Maureen Lyon
Hereditary Cancer Syndromes
Trial of Combined Obstetric Carrier Screening and Hereditary Cancer Screening
The investigators hypothesize that pregnancy and preconception care may be a feasible and effective time to offer inherited cancer risk screening.
- Trial name
- FOCUS (NCT07052266)
- Testing
- MyRisk Hereditary Cancer Test
- Where
- 5 sites in United States
- Volunteers
- 550 people
- Sponsor
- Weill Medical College of Cornell University
Diabetes, Heart Disease
Family Health History in Diverse Care Settings (FHH)
The outcome of this research will be a demonstration that family health history (FHH) risk data can be used efficiently to deliver more effective healthcare in geographically and ethnically diverse clinical care environments.
- Conditions
- Diabetes, Heart Disease, Cancer
- Trial name
- FHH (NCT01956773)
- Testing
- MeTree
- Where
- 5 sites in United States
- Volunteers
- 2,620 people, healthy volunteers welcome
- Sponsor
- Duke University