Clinical trials: Exposure
HIV Prevention, Pre-Exposure Prophylaxis (PrEP)
Starting HIV Prevention Medicine (PrEP) During an Emergency Department Visit With a Peer Navigator
The goal of this study is to learn whether adults who visit a hospital emergency department (ED) find it acceptable to start HIV pre-exposure prophylaxis (PrEP) during that same visit, with help from a peer navigator.
- Trial name
- RAPID Response (NCT07901101)
- Testing
- RAPID Response peer navigation, Emtricitabine/tenofovir disoproxil fumarate (F/TDF)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Blast or Combat Exposure, Head Injury Trauma
Pre-post Evaluation of the Safety and Efficacy of Ibogaine-Magnesium Therapy in Veterans With Repeated Blast Exposure
A Pre-post Study Evaluating the Safety and Efficacy of Ibogaine-Magnesium Therapy in Veterans with Sequelae of Repeated Blast Exposure.
- Trial name
- NCT04313712
- Testing
- ibogaine with magnesium treatment
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Stanford University
Knee Osteoarthritis, Anxiety
Comparison of Music and Ambient Noise Cancellation in Patients Undergoing Total Knee Arthroplasty (TKA)
The aim of this clinical trial is to compare the effects of music and ambient noise cancellation during total knee arthroplasty and to analyse the effects on patients.
- Conditions
- Knee Osteoarthritis, Anxiety, Post Operative Pain, Noise Exposure
- Trial name
- TKA (NCT06401018)
- Testing
- No noise cancellation and no music playing, Noise cancelled but not allowed to listen to music, Music is played but noise is not cancelled
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Ankara City Hospital Bilkent
Exposure
Sample Collection Registry for Quality Control of Biological and Environmental Specimens and Assay Development and Testing
Background: Researchers are interested in developing a registry protocol to obtain biologic and environmental samples anonymously from adult volunteers for use in laboratory tests and studies.
- Trial name
- NCT01087307
- Where
- United States
- Volunteers
- 5,326 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
HIV, Pregnancy
Evaluating the Healthy Families PrEP Program for Women at Risk for HIV
Study investigators developed and piloted a counselling intervention, Healthy Families-PrEP, that supports women to use HIV prevention strategies while trying for and during pregnancy.
- Conditions
- HIV, Pregnancy, Pre-Exposure Prophylaxis of HIV Infection
- Trial name
- HFPT (NCT06746675)
- Testing
- Healthy Families PrEP Counselling Intervention
- Where
- Uganda
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- Yale University
Cardiovascular Diseases (CVD), Metabolic Syndrome
Ambient Air and Noise Effect on Cardiovascular Health Risk and Lifestyle Intervention to Attenuate It (METSGREEN)
This study, combining both an observational study and an interventional clinical trial, aims to assess how exposure to ultrafine particulate matter (PM0.1) and noise pollution affects the risk of cardiovascular diseases and…
- Conditions
- Cardiovascular Diseases (CVD), Metabolic Syndrome, Air Pollution Exposure, Environmental Exposure
- Trial name
- METSGREEN (NCT07111208)
- Testing
- Green Space Activity Group - Daily Physical Activity, Mediterranean Diet Group - Dietary Intervention
- Where
- 2 sites in Lithuania
- Volunteers
- 180 people
- Sponsor
- Regina Grazuleviciene
Kidney Stone, Nephrolithiasis
Trial to Assess the Efficacy of EMPAgliflozin and Personalized Dietary Counseling for Kidney STONE Prevention
The aim of this randomized trial with a 2-by-2 factorial design is to test the efficacy of the SGLT2 inhibitor empagliflozin and personalized dietary counseling based on 24-hr urine collection results and dietary assessments for…
- Conditions
- Kidney Stone, Nephrolithiasis, Dietary Exposure
- Trial name
- EMPASTONE (NCT06653738)
- Testing
- Empagliflozin 10 MG, Personalized dietary counseling, Generic dietary counseling
- Where
- 21 sites in France, Germany and 2 more
- Volunteers
- 400 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Operator Radiation Exposure
Operator Radiation Exposure During Image-Guided Robotic-Assisted Bronchoscopy: A Multicenter Prospective Cohort Study
This is a multicenter, single-arm, prospective, observational study designed to evaluate bronchoscopist radiation exposure during standard-of-care image-guided robotic-assisted bronchoscopy (RAB) for sampling of a single…
- Trial name
- NCT07318402
- Where
- 4 sites in United States
- Volunteers
- 350 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Exposure
Intervention to Reduce Exposure to Environmental COntaminant (IRECO)
Main objective The intervention study IRECO aims to (1) modify habits of personal care product use for the participants and (2) evaluate the impact of those modification on urinary concentration for the following compounds…
- Trial name
- NCT04919434
- Testing
- IRECO
- Where
- France
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Radiation Exposure
Randomized Trial of Next Generation Fluoroscopy System vs. Conventional Fluoroscopy System in Endoscopy
Fluoroscopy is an integral part of both basic and advanced gastrointestinal endoscopy procedures. Given the risks of radiation exposure and inherent limitations of preventive measures, there is a need for additional effective…
- Trial name
- NCT07594132
- Testing
- Fluoroscopy-guided endoscopic procedure
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Orlando Health, Inc.
Influenza, Human, Respiratory Tract Infections
A Study to Confirm Efficacy of a Single Dose of Baloxavir Marboxil in the Post-exposure Prophylaxis (PEP) of Influenza Virus Infection in Chinese Participants
The main purpose of the study is to evaluate the efficacy of a single dose of baloxavir marboxil compared with placebo in the PEP of influenza virus infection with respect to symptomatic, laboratory-confirmed influenza in…
- Conditions
- Influenza, Human, Respiratory Tract Infections, Post-exposure Prophylaxis
- Trial name
- Pearlstone (NCT07827599)
- Testing
- Baloxavir marboxil
- Where
- 8 sites in China
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Malignant Melanoma of Skin, Other and Unspecified Malignant Neoplasm of Skin
Using an Artificial Intelligence (AI) Tool for Melanoma Diagnosis
The purpose of this study is to learn whether a computer-based support tool called DEXI (Dermoscopy EXplainable Intelligence) can help dermatologists decide whether a lesion may be melanoma, a serious type of skin cancer.
- Conditions
- Malignant Melanoma of Skin, Other and Unspecified Malignant Neoplasm of Skin, Melanoma in Situ, Carcinoma in Situ of Skin
- Trial name
- NCT07890415
- Testing
- Clinical decision support tool
- Where
- 8 sites in United States
- Volunteers
- 14,000 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Human Immunodeficiency Virus (HIV), HIV Pre-Exposure Prophylaxis
A Study of MK-8527 to Prevent Human Immunodeficiency Virus Type 1 (HIV-1) (MK-8527-010)
Researchers are looking for new medicines to prevent HIV-1 (Human Immunodeficiency Virus Type 1) infection. The goals of this study are to learn: If taking MK-8527 once a month works to prevent HIV-1 infection better than a…
- Trial name
- NCT07071623
- Testing
- MK-8527, Emtricitabine/tenofovir disoproxil (FTC/TDF)
- Where
- 30 sites in Kenya, South Africa and 1 more
- Volunteers
- 4,580 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Apexogenesis, Pulp Exposure, Dental
Bioceramic Repair Materials in Apexogenesis of Immature Permanent Molars
The present study was conducted to compare the clinical, radiographic, and tomographic outcomes of apexogenesis using Bio-C Repair and Biofactor MTA in immature permanent first molars with vital asymptomatic pulp exposure.
- Conditions
- Apexogenesis, Pulp Exposure, Dental, MTA Vital Tooth Pulpotomy, Cone Beam Computed Tomography
- Trial name
- NCT07883239
- Testing
- Bioceramic Repair Pulpotomy (BIO-C® REPAIR), Mineral Trioxide Aggregate Pulpotomy (Biofactor MTA)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Tanta University
HIV Prevention, HIV Pre-exposure Prophylaxis
Enhancing PrEP Uptake and Retention Among Latine TGW and GBM in the South Using Long-Acting Injectable PrEP
The purpose of this project is to test a culturally-tailored, community-delivered long-acting injectable PrEP (lenacapavir) program for Latine gay and bisexual men (GBM) and transgender women (TGW).
- Conditions
- HIV Prevention, HIV Pre-exposure Prophylaxis, HIV Prevention Program, HIV Prevention and Care
- Trial name
- INCLUSION (NCT07218211)
- Testing
- Lenacapavir long-acting
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Duke University
Prostate Cancer, Pesticide Exposures
Agriculture Health Study
The "Agricultural Health Study" (AHS) is a collaborative effort between the National Cancer Institute and the National Institute of Environmental Health Sciences. The U.S.
- Conditions
- Prostate Cancer, Pesticide Exposures, Lymphoma, Multiple Myeloma
- Trial name
- NCT00352924
- Where
- United States
- Volunteers
- 89,655 people
- Sponsor
- National Cancer Institute (NCI)
Pre-Exposure Prophylaxis of HIV Infection
Pre-Exposure Prophylaxis Study of Lenacapavir and Emtricitabine/Tenofovir Alafenamide in Adolescent Girls and Young Women at Risk of HIV Infection
The goal of this study is to evaluate the efficacy of the study drugs, lenacapavir (LEN) and emtricitabine/tenofovir alafenamide (F/TAF) in preventing HIV infection, in adolescent girls and young women (AGYW).
- Trial name
- PURPOSE 1 (NCT04994509)
- Testing
- Oral Lenacapavir (LEN), Subcutaneous (SC) Lenacapavir (LEN), F/TAF
- Where
- 28 sites in South Africa, Uganda
- Volunteers
- 5,368 people, healthy volunteers welcome
- Sponsor
- Gilead Sciences
Dietary Exposure
Tasting Plant Forward Meals
This study aims to examine how the amount of potato and form of potato within a meal impacts intake and acceptability of other non-starchy vegetables.
- Trial name
- NCT07202988
- Testing
- vegetable combination 1, vegetable combination 2, vegetable combination 3
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sara Maksi
PSMA-positive Metastatic Castration Resistant Prostate Cancer (mCRPC) With Prior Exposure to One Prior ARPI Who Are Candidates for Taxane-based Chemotherapy
A Phase Ib/II Open-label Study of AMO959 With Lutetium (177Lu) Vipivotide Tetraxetan (AAA617) in Combination With ARPI in Adult Participants With PSMA-positive mCRPC
The purpose of this phase Ib/II study is to (a) in Phase Ib evaluate the safety, tolerability, and pharmacokinetics (PK) of AMO959 when given in combination with lutetium (177Lu) vipivotide tetraxetan (also known as…
- Trial name
- NCT07226986
- Testing
- AMO959, AAA617, Enzalutamide
- Where
- 25 sites in United States, Australia and 5 more
- Volunteers
- 123 people
- Sponsor
- Novartis Pharmaceuticals
Reversible Pulpitis, Dental Caries
Effect of Hemostatic Agents on TheraCal PT Pulpotomy Success in Primary Molars
Dental caries in primary teeth can sometimes lead to inflammation of the dental pulp, the soft tissue inside the tooth. When the pulp remains capable of healing, pulpotomy may be performed to preserve the tooth until its natural…
- Conditions
- Reversible Pulpitis, Dental Caries, Primary Molar Pulpotomy, Dental Pulp Exposure
- Trial name
- CEHA-TP RCT (NCT07876934)
- Testing
- 2.5% Sodium Hypochlorite applied to pulpal tissue/stumps for 3 minutes to achieve hemostasis prior to TheraCal PT placement during primary molar pulpotomy and 15% Ferric Sulfate (Astringedent™ 15.5%)
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Reem Mohamed Gaber