Clinical trials: Exposome
Early Menopause
Singapore Population Research on Integrated exposoMe & Early Menopause
Brief Summary The goal of this observational study is to learn how environmental factors, lifestyle choices, and social conditions affect the timing of menopause in Asian women aged 40-50 years living in Singapore.
- Trial name
- SG-PRIME (NCT07100639)
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Institute for Human Development and Potential (IHDP), Singapore
Exposure, Health Behavior
Advancing Tools for Human Early Lifecourse Exposome Research and Translation- Adolescence Follow-up of the HELIX Subcohort
ATHLETE will set up a prospective Europe-wide exposome cohort covering the first 2 decades of the life course, which will integrate data on the external, chemical, physical,behavioral, and social domains of the exposome, as well…
- Conditions
- Exposure, Health Behavior, Environment
- Trial name
- ATHLETE (NCT05158010)
- Testing
- HELIX's follow-up
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Exposure to Environmental Pollution
Characterization of Persistent Organic Pollutants Exposure During Preconception and Preimplantation Development.
In order to evaluate if gametes and preimplantation embryos are in vivo exposed to environmental chemicals, the detection of 6 molecules representative of 3 persistent organic pollutants families will be performed in the mucosa…
- Trial name
- TUBPOP (NCT04628091)
- Testing
- Sampling on surgery day
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Toulouse
Exposure to Pollution
Chemometers to Determine the Environmental and Human Exposome by Mixtures of Pollutants
Motivation of this study Human life is full of chemicals: They support the provision of cure, clothes, shelter, transportation and even nourishment of the world population.
- Trial name
- EXPOSO-METER (NCT05927077)
- Testing
- planned surgery for weight reduction
- Where
- Germany
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Helmholtz Centre for Environmental Research - UFZ
Health Adult Subjects, Exposure Occupational
French Military Firefighters to Assess Relationships Between Exposome and Health.
The aim of the study is to describe professional exposures and health events among French military firefighters (both active-duty personnel and veterans) and identify potential relationships between the exposome (the total…
- Conditions
- Health Adult Subjects, Exposure Occupational, Health Behavior, Risky, Occupational Health
- Trial name
- COMITEX-BSPP (NCT07270627)
- Where
- France
- Volunteers
- 1,811 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Stroke
Biodiversity and Human Functioning Following Acquired Cerebrovascular Lesions - Phase 2 (EspertaMente)
Grounded in the exposome framework and the bio-psycho-social model of health, this study investigated the effects of artificial light simulating natural sunlight on autonomic regulation, cognitive-motor performance and brain…
- Trial name
- EspertaMente (NCT07758257)
- Testing
- Artificial Light
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Dr. Franco Molteni
Autism Spectrum Disorder, Neurodevelopmental Disorders
Platform for the Prospective Mother-child Study of the Determinants of Neurodevelopmental Disorders
Neurodevelopmental disorders such as attention deficit disorder with or without hyperactivity, autism spectrum disorder, language and social communication disorder, motor coordination disorder, learning disorder (dyslexia…
- Trial name
- MARIANNE (NCT05681923)
- Testing
- Questionnaires, Biospecimen collection, Neurodevelopmental assessment visit
- Where
- France
- Volunteers
- 7,320 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Chronic Obstructive Pulmonary Disease, Asthma
A Cohort for Inflammatory Respiratory Diseases: From Phenotyping to Personalised Medicine
Chronic inflammatory pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD), bronchiectasis, cystic fibrosis (CF), primary ciliary dyskinesia (PCD) and interstitial lung diseases (ILD) are…
- Conditions
- Chronic Obstructive Pulmonary Disease, Asthma, Bronchiectasis, Cystic Fibrosis
- Trial name
- PALMIRE (NCT07274631)
- Testing
- Non applicable
- Where
- France
- Volunteers
- 470 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Healthy Volunteer Children
Socioeconomic Determinants of the Chemical Exposome and Its Genotoxic Effects in Children
PESTIFOL will include children over 8 and under 12 years old of different socioeconomic positions (SEP), mostly living in the region of Pays de la Loire.
- Trial name
- PESTIFOL (NCT06314633)
- Testing
- Hair cut, Socio-economic questionnaires
- Where
- France
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Institut Cancerologie de l'Ouest
Healthy Volunteer
Following of Atmospheric Pollution Exposure During Pregnancy and Effects on Health
The SEPAGES couple-child cohort is coordinated by an Inserm (French National Institute of Health and Medical Research) team of environmental epidemiology.
- Trial name
- SEPAGES-1337 (NCT02852499)
- Testing
- Urine sampling, Carry a GPS and BET, Carry pollution sensor
- Where
- France
- Volunteers
- 1,010 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Preterm Birth, Neurodevelopmental Disorders
Guangzhou Preterm and Term Birth Cohort Study
The Guangzhou Preterm-Term Birth Cohort (GPTBC) is a prospective observational study of how early-life nutrition, environmental exposures, and family factors relate to the health and development of preterm and term infants and…
- Conditions
- Preterm Birth, Neurodevelopmental Disorders, Overweight, Obesity
- Trial name
- GPTBC (NCT07756177)
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Difference Between Coastal and Inland Populations
The Coastal Exposome: a Study of Sea Air Inhalation and Possible Links to Health
The research aims to understand oceans as crucial contributors to human health in coastal environments. Oceans produce marine spray aerosols that contain a mixture of microbiota and natural biological molecules (biogenics).
- Trial name
- NCT06477627
- Testing
- no intervention
- Where
- Belgium
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University Ghent
Rosacea
M89PF in Rosacea Associated With Erythema and Sensitive Skin
Rosacea is a common facial dermatosis, with flares induced by exposome factors. M89PF containing Vichy mineralizing water, probiotic fractions, hyaluronic acid, niacinamide and tocopherol repairs the skin barrier and reinforces…
- Trial name
- NCT05562661
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Cirrhoses, Liver, Carcinoma Liver
ProspEXPO : Study of the Associations Between Hepatocellular Carcinoma and Chemical and Psychosocial Environmental EXPOsome
The aim of the study is to build up a bio-collection of biological samples from patients with cirrhosis. Further work using this bio-collection will permit to describe the influence of different exposome factors (nutrition…
- Trial name
- ProspEXPO (NCT07119957)
- Testing
- Blood, urine and stool biocollection
- Where
- 4 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Angers
Aging, Mortality
Human Observatory Study
The Human Observatory Study is a prospective observational and ecological surveillance study building a continuously-updating world model for human health, disease, and death at the individual and population level.
- Conditions
- Aging, Mortality, All-cause Mortality, Life Expectancy
- Trial name
- HOS (NCT07646782)
- Testing
- Multi-Domain Ecological and Clinical Data Linkage
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Longevity Metrics, Inc.
Pulmonary Arterial Hypertension (PAH), Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
What is the Role of the Exposome in Pulmonary Hypertension
Pulmonary arterial hypertension (PAH) is a rare and incurable disease affecting people of all ages. It is characterized by obstructive remodeling of the small pulmonary arteries, responsible for an increase in pulmonary arterial…
- Trial name
- EXPOSPAH (NCT07172334)
- Testing
- Questionnaires, Samples
- Where
- 10 sites in France
- Volunteers
- 150 people
- Sponsor
- Poitiers University Hospital
Healthy Adult Participants
Urban Exposome and Biological Age
The goal of this observational study is to evaluate the impact of the urban exposome, including air pollution and lifestyle-related stressors, on biological aging, inflammatory pathways, oxidative stress, and DNA methylation…
- Trial name
- IDEA (NCT07817836)
- Where
- Italy
- Volunteers
- 151 people
- Sponsor
- University of Pavia
Anosmia, Chronic Obstructive Pulmonary Disease
Firefighter's Longitudinal Airway and Respiratory Exposome/Multiome Study (FLARES)
Background: Exposure to smoke increases the risk of many diseases. People can be exposed to dangerous levels of smoke during wildfires. Also, smoke from fires that burn manmade materials may contain toxic chemicals.
- Conditions
- Anosmia, Chronic Obstructive Pulmonary Disease, Hyposmia, Chronic Rhinosinusitis
- Trial name
- NCT07867184
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Type 2 Diabetes
Enhancing Diabetes Care: Exposome &Amp; Sensors
The study aims to integrate various data types, such as electronic health records, wearable device data, and environmental data, to create a comprehensive, personalized diabetes care model.
- Trial name
- NCT06989008
- Testing
- Observational Study: Relationships Among Glucose, Physical Activity and Environmental Influences
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Illinois Chicago
Hospital Acquired Infection, Ventilator-associated Pneumonia
Study on Dynamic Environmental Exposome of ICU and the Establishment of Microbial Transmission Model Between Environment and Host
HAI (Hospital-acquired infection) is very common in ICU，and lack of understanding of environmental exposure omics and environment-host microbial interactions restricts the prevention and control of HAI.
- Trial name
- NCT05877625
- Testing
- Expectoration care
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Peking University Third Hospital