Clinical trials: Excessive Dynamic Airway Collapse
Excessive Dynamic Airway Collapse, Tracheobronchomalacia
Symptomatic Treatment of Excessive Dynamic Airway Collapse Using Daytime Portable Continuous Positive Airway Pressure
The aim of this study is to assess the benefit of a portable ventilator generating positive end-expiratory pressure on exercise tolerance in patients with Excessive dynamic airway collapse (EDAC) and tracheobronchomalacia (TBM).
- Trial name
- EPOC (NCT02763631)
- Testing
- Experimental: Treatment, Experimental: Run In Phase
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Excessive Central Airways Collapse, Respiratory Disease
Portable Continuous Positive Airways Pressure (CPAP) in Excessive Central Airway Collapse (ECAC) Study
This study will investigate the role of a portable Continues Positive Airway Pressure device (pCPAP) in management of patients with symptomatic Excessive Central Airway Collapse (ECAC).
- Conditions
- Excessive Central Airways Collapse, Respiratory Disease, Tracheobronchomalacia, Excessive Dynamic Airway Collapse
- Trial name
- NCT06072872
- Testing
- Use of portable CPAP
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Airway Disease
Characterisation of Large Airway Collapse During Exercise (LACE)
The large central airways (i.e. trachea and bronchi) act as a conduit to enable lower airway ventilation but also facilitate airway clearance during dynamic manoeuvres, such as coughing.
- Trial name
- LACE (NCT04264052)
- Testing
- CBE & MRI
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Tracheobronchomalacia, Excessive Dynamic Airway Collapse
Airway Stents for Excessive Dynamic Airway Collapse
Airway stents are used as standard of care to identify which patients with excessive dynamic airway collapse will benefit from a definitive surgical treatment.
- Trial name
- NCT02982876
- Testing
- Dynamic Flexible Bronchoscopy, Rigid Bronchoscopy, Stent placement
- Volunteers
- 50 people
- Sponsor
- Beth Israel Deaconess Medical Center
Tracheobronchomalacia, Excessive Dynamic Airway Collapse
Effect of CPAP on 6-Minute Walk Test Outcomes in Patients With ECAC
The purpose of this protocol is to perform a prospective, randomized, double-blinded, pacebo-controlled clinical trial to determine the influence of a non-invasive positive pressure ventilation device on exercise capacity and…
- Trial name
- NCT04217603
- Testing
- Continuous positive airway pressure (CPAP) device
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Beth Israel Deaconess Medical Center