Clinical trials: Evidence of Liver Transplantation
Evidence of Liver Transplantation, Rejection
Safety and Efficacy of Alemtuzumab in Pediatric Intestinal Transplantation
This open-label clinical trial will evaluate the safety and efficacy of Alemtuzumab (Campath, Bayer Corp., Pittsburgh) in children (0-17) and adults (18-25) receiving intestinal transplant.
- Conditions
- Evidence of Liver Transplantation, Rejection, ALEMTUZUMAB
- Trial name
- NCT01208337
- Testing
- Alemtuzumab
- Volunteers
- 23 people
- Sponsor
- University of Pittsburgh
Liver Cirrhosis, Hepatocellular Carcinoma
Safety Study of Liver Natural Killer Cell Therapy for Hepatoma Liver Transplantation
The objective of this study is to evaluate feasibility and safety of the adoptive transfer of activated natural killer (NK) cells extracted from cadaveric donor liver graft perfusate for liver transplant recipients with…
- Conditions
- Liver Cirrhosis, Hepatocellular Carcinoma, Evidence of Liver Transplantation
- Trial name
- MIAMINK (NCT01147380)
- Testing
- Liver NK cell inoculation
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Seigo Nishida
Evidence of Liver Transplantation, Myocardial Injury
Protective Effects of Dexmedetomidine on Myocardial Injury During Liver Transplantation
The purpose of this study was to evaluate the protective effect of dexmedetomidine on myocardial injury during liver transplantation
- Trial name
- NCT03013634
- Testing
- Dexmedetomidine, Normal saline
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Tianjin First Central Hospital
Evidence of Liver Transplantation
Changes of Macrophage Migration Inhibitory Factor During Orthotopic Liver Transplantation
Collecting blood, graft liver effluent and urine samples from patients undergoing orthotopic liver transplantation.
- Trial name
- NCT02695979
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Medical University of Vienna
Hepatocellular Carcinoma, Evidence of Liver Transplantation
Prospective Liver Tumor (ProLiT) Database
The investigators propose a prospective, web-based database (developed within the framework of Quickbase, Intuit) which will allow an evaluation of the data for patients with a liver tumour who receive a liver transplant.
- Trial name
- ProLit (NCT01607788)
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- University of Geneva, Switzerland
Blood Coagulation Disorders, Evidence of Liver Transplantation
Management of Perioperative Coagulopathy With Thromboelastometry (ROTEM) in Liver Transplant
A point-of-care bleeding management protocol based on global viscoelastic test (thromboelastometry) can change the amount of blood products used during orthotopic liver transplant.
- Conditions
- Blood Coagulation Disorders, Evidence of Liver Transplantation, Liver Cirrhosis
- Trial name
- NCT02239991
- Testing
- Thromboelastometry
- Where
- 2 sites in Brazil
- Volunteers
- 100 people
- Sponsor
- Hospital Israelita Albert Einstein
Evidence of Liver Transplantation
Uses of Immunosuppression Therapy in Patients With Liver Transplantation
Conventionally, the outcome of liver transplantation is usually reported in terms of graft and patient survival, medical and surgical complications, but lack of health-related quality of life (HRQOL) that might be associated with…
- Trial name
- NCT01834690
- Where
- Taiwan
- Volunteers
- 314 people
- Sponsor
- Chang Gung Memorial Hospital
Evidence of Liver Transplantation
The Study to Evaluate Efficacy and Safety of MY-REPT Capsule in Primary, Liver Transplantation Recipients (MYLT1)
Efficacy and safety of MY-REPT capsule in primary, liver transplantation recipients
- Trial name
- NCT01766518
- Testing
- Mycophenolate mofetil
- Where
- 3 sites in South Korea
- Volunteers
- 120 people
- Sponsor
- Chong Kun Dang Pharmaceutical
Evidence of Liver Transplantation
Safety, Efficacy of Eglandin® in Living Donor Liver Transplanted Patient (PROVISION)
The purpose of this study is to evaluate superiority of Eglandin® (Alprostadil) 720㎍compared to 360㎍ in terms of safety, efficacy in living donor liver transplant patient, peak AST levels followed by Eglandin administration were…
- Trial name
- PROVISION (NCT02350218)
- Testing
- Eglandin
- Where
- South Korea
- Volunteers
- 76 people
- Sponsor
- Asan Medical Center
Hepatitis C, Evidence of Liver Transplantation
Pilot Study of Hepatitis C Virus Entry Inhibitor (ITX 5061) in Liver Transplant Recipients
This is a phase I pilot study to determine the safety and preliminary efficacy of a novel hepatitis C virus (HCV) entry inhibitor (ITX 5061) in patients with HCV infection undergoing liver transplantation.
- Trial name
- ITX5061 (NCT01292824)
- Testing
- ITX 5061
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- University of Birmingham
HIV Infection, Liver Failure
Raltegravir in Patients With End Stage Liver Disease and in Transplant Recipients
This phase I/II, multi-center study is designed to determine the pharmacokinetic profile of Raltegravir in patients with end stage liver disease and to assess drug-drug interaction when Raltegravir is combined with…
- Conditions
- HIV Infection, Liver Failure, Evidence of Liver Transplantation
- Trial name
- LIVERAL (NCT01022476)
- Testing
- Raltegravir potassium
- Where
- France
- Volunteers
- 14 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Sequelae of Viral Hepatitis, Transplantation Infection
Randomized Phase II Study of Hepatitis C Immune Globulin Intravenous (Human), Civacir(TM), in Liver Transplantation
A Phase 2 study to evaluate safety, pharmacokinetics and efficacy of Hepatitis C Immune Globulin Intravenous (human) [Civacir(TM)] for preventing or reducing the impact of recurrent HCV infection following liver transplantation.
- Conditions
- Sequelae of Viral Hepatitis, Transplantation Infection, Evidence of Liver Transplantation
- Trial name
- NCT00473824
- Testing
- Hepatitis C Immune Globulin Intravenous (Human) 5%
- Where
- 3 sites in United States
- Volunteers
- 7 people
- Sponsor
- ADMA Biologics, Inc.
Evidence of Liver Transplantation
Impact of Melatonin in the Pretreatment of Organ Donor and the Influence in the Evolution of Liver Transplant.
Impact of melatonin on organ donor pretreatment and liver transplant recipient: prospective, randomized, double-blind trial. OBJECTIVES.
- Trial name
- NCT01860716
- Testing
- Melatonin
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Aragon Institute of Health Sciences
Evidence of Liver Transplantation, Arterial Occlusive Diseases
Clinical Benefits of B-Flow Ultrasound
The goals of this study are to evaluate the efficacy of the B-flow capability on the LOGIQ E9 system in three clinical focus areas. 1.
- Conditions
- Evidence of Liver Transplantation, Arterial Occlusive Diseases, Hypertension, Pregnancy, High Risk
- Trial name
- NCT02008097
- Testing
- GE LOGIQ E9 Ultrasound System
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Washington
End Stage Liver DIsease
Comparison of Hypothermic Versus Normothermic Ex-vivo Preservation.
Study groups: The study is a multicenter (Pisa and Milan), prospective, randomized study comparing D-HOPE (HMP) vs NMP in DCD and ECD-DBD (extended criteria brain-dead donors).
- Trial name
- DCDNet (NCT04744389)
- Testing
- Hypothermic Machine Perfusion, Normothermic Machine Perfusion
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Evidence of Liver Transplantation
Autologous Transplantation of Mesenchymal Stem Cells for Treatment of Patients With Onset of Type 1 Diabetes
Type 1 diabetes mellitus (T1DM)is characterized by the autoimmune destruction of the pancreatic β cells; as a result, patients with T1DM are dependent on exogenous insulin to control their blood glucose continuously.
- Trial name
- NCT01157403
- Testing
- Autologous transplantation
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Lu Debin
Evidence of Liver Transplantation
Study to Establish Whether the Use of T-Tube in Bile Duct Anastomosis in Liver Transplantation Decreases Morbidity
The purpose of this study was to compare the incidence and severity of biliary complications due to liver transplantation after choledochocholedochostomy with or without a T-tube.
- Trial name
- NCT01546064
- Testing
- Choledocho-choledochostomy with T-tube, Choledocho-choledochostomy without T-tube
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Hospital Universitario La Fe
Liver Tumor, Evidence of Liver Transplantation
Combination of Cryosurgery and NK Immunotherapy for Tumors in Transplanted Liver
The aim of this study is the safety and efficacy of cryosurgery plus natural killer(NK) immunotherapy to tumors in transplanted liver.
- Trial name
- NCT02849015
- Testing
- Cryosurgery, NK immunotherapy
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Fuda Cancer Hospital, Guangzhou
Evidence of Liver Transplantation
Clinical Trial of Hydrogen-Rich Celsior Solution Applied in Aging DBD Liver/Kidney Transplantation
The purpose of this study is to investigate whether hydrogen-rich Celsior solution improve the quality of aging grafts in liver/kidney transplantation.
- Trial name
- HRCSDBD (NCT02613195)
- Testing
- Hydrogen-Rich Celsior Solution
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- RenJi Hospital
Chronic Hepatitis C, Evidence of Liver Transplantation
Switch From Tacrolimus to Cyclosporin in the Treatment of Recurrent Hepatitis C After Liver Transplantation
In France, 50% of hepatitis C virus carriers develop chronic clinical hepatitis, which may lead to cirrhosis and liver transplantation.
- Trial name
- NCT00375895
- Testing
- ciclosporin
- Where
- 13 sites in France
- Volunteers
- 11 people
- Sponsor
- Rennes University Hospital