Clinical trials: Euploid Embryos
Balanced Chromosomal Translocation
Predicting Normal vs. Carrier Status in Euploid Embryos of Translocation Carriers
The purpose of this study is to assess the accuracy of predicting the normal or carrier status of human embryos resulting from in vitro-fertilization (IVF) from patients carrying a balanced translocation.
- Trial name
- NCT02178865
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Reproductive Medicine Associates of New Jersey
Fertility
INtensity of OVarian Stimualtion and Euploid Embryos
This randomized trial was designed as a no-inferiority trial aiming to evaluate if the intensity of stimulation (a milder vs a more intense approach) may have an impact on the number of euploid embryos and the morpho kinetic…
- Trial name
- INOVEE (NCT06154083)
- Testing
- Follitropin-delta (Rekovelle) 20 mcg/day from D1, Follitropin-delta (Rekovelle) 15 mcg/day from D1
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- Fundación Santiago Dexeus Font
Euploid Embryos
Embryo Aneuploidies and Morphokinetics in Ovarian Stimulated and Non Stimulated IVF Cycles
The purpose of this study is to compare the number of euploid embryos obtained per metaphase II oocyte in unstimulated (modified natural cycles) and stimulated IVF cycles.
- Trial name
- AMOS (NCT03128580)
- Where
- 3 sites in Spain
- Volunteers
- 40 people
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Midazolam Overdose
Measurement of Midazolam Levels in Follicular Fluid
To determine the impact of Midazolam levels in follicular fluid on morpho-kinetics and morpho-genetics. The reason to measure Midazolam levels in larger size follicles in this study is to maximize the chances to get a mature…
- Trial name
- NCT03049293
- Testing
- Midazolam
- Where
- United Arab Emirates
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Infertility, Female
Impact of Endometrial Compaction in Euploid Frozen Embryo Transfers
The purpose of this pilot study is to evaluate whether a decrease in endometrial thickness (compaction) prior to progesterone exposure (endogenous or exogenous) to the day before a single frozen embryo transfer has an impact on…
- Trial name
- NCT04330066
- Testing
- Abdominal ultrasound measurement of the endometrial lining
- Where
- United States
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- Boston IVF
Infertility, Female
Descriptive Analysis of Serum Immunological Markers During an Euploid Frozen Embryo Transfer in a Natural Cycle.
To describe the peripheral serum levels of the anti-inflammatory cytokines IL-4 (Interleukin-4), IL-10 (Interleukin-10), TGF-ß1 (Transforming Growth Factor beta1), the pro-inflammatory cytokines IL-17 (Interleukin-17), IFγ…
- Trial name
- NCT05473273
- Testing
- Endometrin 100Mg Vaginal Insert, Estradiol Valerate
- Where
- United Arab Emirates
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Infertility Due to Nonimplantation
Impact of Endometrial Compaction on Reproductive Outcomes After Cryotransfer of Euploid Embryos in a Natural Cycle
Multicenter prospective observational cohort study, comparing ongoing pregnancy rates in natural cycles for euploid embryo transfer in patients who present endometrial compaction at the time of the transfer versus those who have…
- Trial name
- Compaction (NCT05960370)
- Testing
- Observational non intervention study
- Where
- Spain
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Instituto Bernabeu
Infertility, Implantation Rate
Hyaluronan-enriched Medium and Euploid Blastocyst Transfers
It has been proposed that enriching transfer media with hyaluronan (EmbryoGlue medium) improves pregnancy outcomes compared with media containing lower concentrations of this molecule.
- Conditions
- Infertility, Implantation Rate, Clinical Pregnancy Rate, Live Birth Rate
- Trial name
- GluePloid (NCT06165367)
- Testing
- EmbryoGlue Medium
- Where
- United Arab Emirates
- Volunteers
- 783 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Infertility, Male Factor Infertility
A Randomized Clinical Trial Comparing Embryo Euploidy Rates Following Ultrashort Versus Standard Abstinence
This research is being done to determine if producing sperm after an ultrashort period of abstinence (1 hour of abstinence) will be effective in improving the rates of embryos with normal chromosomes (structures that carry…
- Trial name
- NCT07062237
- Testing
- Ultrashort abstinence, Standard abstinence
- Where
- United States
- Volunteers
- 187 people
- Sponsor
- UConn Health
Vitamin D Deficiency
Follicular Fluid, Bioavailable Vitamin D and Embryo Quality Markers
To determine the correlation between bioavailable Vitamin D values and euploid status of the embryos in larger size follicles from UAE women undergoing in vitro fertilization procedures.
- Trial name
- NCT03073720
- Where
- United Arab Emirates
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Infertility, Preimplantation Genetic Diagnosis/Screening
Estradiol, Progesterone and Endometrial Thickness in Frozen Euploid Embryo Transfer
The development and improvement in Preimplantation genetic diagnosis/screening (PGS) in association with the efficacy and security of vitrification and trophectoderm biopsy, more efficient stimulation schemes and laboratory…
- Conditions
- Infertility, Preimplantation Genetic Diagnosis/Screening, Miscarriage
- Trial name
- NCT03395665
- Testing
- Estradiol level, Progesterone level, Endometrial thickness
- Where
- Spain
- Volunteers
- 299 people
- Sponsor
- Fundacion Dexeus
Pregnancy
Idealizing Pregnancy Outcome With Single Blastocyst Transfer in a FET Cycle
Single embryo transfer (SET) has been advocated as a means of reducing the risk of multiple pregnancies, but has meant a reduction in pregnancy risk per embryo transfer.
- Trial name
- NCT01987856
- Testing
- Blastocyst morphology
- Where
- Turkey (Türkiye)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Antalya IVF
Infertility, Recurrent Pregnancy Loss
Comparison of Standard ART Practice vs. Trophectoderm Biopsy and Whole Chromosome Analysis
We propose to perform a clinical randomized trial to evaluate the effect of blastocyst biopsy and whole chromosome analysis by Next Generation Sequencing (NGS) in comparison to standard Assisted Reproductive Technologies (ART)…
- Trial name
- NCT01946945
- Testing
- Next Generation Sequencing after Blastocyst biopsy
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Reprogenetics
Infertility, Aneuploidy
The Effect of Acupuncture on Pregnancy Rates in Women Undergoing in Vitro Fertilization With Preimplantation Genetic Screening
While IVF offers an effective treatment for infertility, a significant proportion of IVF cycles still result in failed implantation and early miscarriage.
- Trial name
- NCT03981120
- Testing
- Laser and Traditional Acupuncture
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Infertility, Endometriosis
Comparison Elagolix vs Depot Leuprolide Prior to Frozen Embryo Transfers in Patients With Endometriosis
Patients who have been previously surgically diagnosed with endometriosis and have embryos predicted to be euploid after in vitro fertilization will be divided into 2 groups via randomization.
- Trial name
- NCT04445025
- Testing
- Elagolix 200 MG, Leuprolide Acetate 3.75 MG/ML, Lab work
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Colorado Center for Reproductive Medicine
Fertility, Implantation, Embryo
Cycle-to-cycle Variability of Progesterone in the Endometrium in Patients Undergoing an Euploid Blastocyst Transfer in a Hormone Replacement Therapy (HRT) Cycle (PROMICOFET)
This study looks at progesterone, a hormone that prepares the womb lining (endometrium) for pregnancy, in women having a frozen embryo transfer after IVF.
- Trial name
- PROMICOFET (NCT07818278)
- Testing
- Oestrogel® 0.75 mg (estradiol transdermal gel), Progesterone 200 mg vaginal capsules, Endometrial biopsy
- Where
- Belgium
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Infertility Assisted Reproductive Technology
The Impact of Uterine Immunity and Its Alterations on the Embryo Implantation Process
Evaluation of uterine immunity, histological picture, and endometrial microbiome for embryo implantation
- Trial name
- UTIMEE (NCT07120958)
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Momo Fertilife
Infertility
Subcutaneous Progesterone in Frozen- Thawed Single Euploid Blastocyst Transfer.
This is a multicenter, randomized, double-blind, double-dummy, active-controlled, non-inferiority clinical study in women aged 35 to 42 years.
- Trial name
- PROGRESS (NCT04549116)
- Testing
- Progesterone-IBSA Injectable Solution, Progesterone Vaginal Gel with Applicator
- Where
- 24 sites in United States
- Volunteers
- 688 people
- Sponsor
- IBSA Institut Biochimique SA
Infertility, Implantation
Impact of a Previous CS on the Ongoing Pregnancy Rate in Single Euploid Frozen Embryo Transfer (ET)
As embryo ploidy is a crucial factor not only for implantation but also for maintenance of a pregnancy, the aim of this study is to evaluate the impact of the CS / isthmocele on the ongoing pregnancy rates and the implantation…
- Trial name
- NCT05798624
- Testing
- Ultrasound between 6+0 and 6+7 weeks of pregnancy - With Isthmocele, Ultrasound between 6+0 and 6+7 weeks of pregnancy - Without Isthmocele, Ultrasound between 6+0 and 6+7 weeks of pregnancy
- Where
- United Arab Emirates
- Volunteers
- 1,050 people
- Sponsor
- ART Fertility Clinics LLC
Fertility
Association Between Euploid Embryo Grade and Maternal Age
Background: Advanced maternal age (AMA) is associated with a reduction in live birth rate (LBR) after ART cycles. The main reason for this reduction is the lower number of oocytes aspirated, the number of developing embryos and…
- Trial name
- NCT06454058
- Where
- United States
- Volunteers
- 502 people
- Sponsor
- Inception Fertility Research Institute, LLC