Clinical trials: Essential Tremor, open to volunteers
Essential Tremor
The Encora X1™ in a Real World Observational Study
This research is a post-market study designed to evaluate the long-term, real-world impact of the Encora X1™ on your daily life.
- Trial name
- NCT07911488
- Testing
- Encora X1
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Encora, Inc.
Tremor, Essential Tremor
Stereotactic Radiosurgery for Essential Tremor and Parkinsonian Tremor
The purpose of this study is to determine the changes in quality of life and degree of tremor for patients with essential tremor or Parkinsonian tremor who are treated by stereotactic radiosurgery (SRS).
- Conditions
- Tremor, Essential Tremor, Parkinson Disease, Radiosurgery
- Trial name
- NCT01734122
- Testing
- Questionnaires / Observational Assessments
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Vanderbilt University Medical Center
Essential Tremor
A Study of Wearable Device in Essential Tremor Patients
The purpose of this research is to observe the daily loss of benefit from DBS therapy by performing a standardized set of tasks throughout the day while wearing an Apple Watch to collect movement and other physiological data.
- Trial name
- NCT05976074
- Testing
- Apple Watch, BrainRISE app
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Essential Tremor
Temporal Interference for Essential Tremor
This single-center prospective study aims to investigate the treatment efficacy of temporal interference (TI) in essential tremor patients aged 30-70.
- Trial name
- NCT07016425
- Testing
- Temporal Interference
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Liankun_Ren
Essential Tremor
Transcranial Temporal Interference Stimulation (tTIS) To Modulate Essential Tremor
The goal of this proof-of-concept study is to examine the effects of a relatively new, non-invasive electrical current-based technique, transcranial temporal interference stimulation (tTIS), in patients with Essential Tremor…
- Trial name
- TremorTIS (NCT07531238)
- Testing
- Transcranial temporal interference stimulation, Tremor monitoring through Inertial Measurement Units (IMUs)
- Where
- Switzerland
- Volunteers
- 6 people
- Sponsor
- University Hospital, Geneva
Essential Tremor
Chinese ET Registry (CETR)
The purpose of the Chinese Essential Tremor Registry (CETR) is to develop a database of patients with Essential tremor in China.
- Trial name
- NCT04198246
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Xiangya Hospital of Central South University
Parkinson Disease, Essential Tremor
Motor Network Physiology
The brain networks controlling movement are complex, involving multiple areas of the brain. Some neurological disorders, like Parkinson's disease (PD) and essential tremor (ET), cause abnormalities in these brain networks.
- Trial name
- NCT04957095
- Testing
- Apomorphine Injectable Solution, Subcortical Stimulation
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Texas Southwestern Medical Center
Essential Tremor
The STEREO-DBS ET Study: 7-Tesla MRI Brain Network Analysis for Deep Brain Stimulation in Essential Tremor
Rationale: Deep brain stimulation (DBS) of the thalamus is an effective surgical treatment for the patients with advanced essential tremor, despite optimal pharmacological treatment.
- Trial name
- STEREO-ET (NCT05909839)
- Testing
- 7T MRI network analysis for deep brain stimulation in essential tremor
- Where
- Netherlands
- Volunteers
- 500 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Essential Tremor (ET)
Motor and Non-Motor Effects of Low-Intensity Focused Ultrasound (LIFU) as a Neuromodulation Tool in Essential Tremor
This study investigates the motor and non-motor effects of Low-Intensity Focused Ultrasound (LIFU) as a non-invasive neuromodulation technique in patients with essential tremor (ET) and refractory tremor.
- Trial name
- LIFU-ET (NCT07484152)
- Testing
- Low-Intensity Focused Ultrasound (LIFU) - NeuroFUS PRO
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo General Hospital
Essential Tremor
Functional Brain Network Changes in Patients Undergoing Deep Brain Stimulation for Essential Tremor
The purpose of this study is to collect electrophysiological data related to functional brain network changes in patients undergoing deep brain stimulation for the treatment of essential tremor.
- Trial name
- TRaNCE (NCT06293638)
- Testing
- Alcohol, Alprazolam, Cold Therapy
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Essential Tremor, Essential Tremor, Movement Disorders
A Study to Evaluate the Safety and Efficacy of Staged Bilateral Magnetic Resonance-Guided Focused Ultrasound Thalamotomy for the Treatment of Essential Tremor
The objective of this prospective, single-arm, open-label study is to asses the safety and efficacy of the staged bilateral thalamotomy using transcranial magnetic resonance guided focused ultrasound system ExAblate 4000…
- Trial name
- ET-Bi-MRgFUS (NCT06676501)
- Testing
- ExAblate
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Chinese PLA General Hospital
Parkinson Disease, Essential Tremor
Clinical Outcomes for Deep Brain Stimulation
The object of this study is to longitudinally collect clinical outcomes of patients receiving deep brain stimulation for movement disorders with the objective of making retrospective comparisons and tracking of risks, benefits…
- Conditions
- Parkinson Disease, Essential Tremor, Dystonia
- Trial name
- NCT03992625
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Washington University School of Medicine
Traumatic Brain Injury, Stroke
Long-term Brain Stimulation of the Motor Ventral Thalamus (VOP/VIM) to Improve Motor Function
This study aims to recruit patients already implanted with Deep Brain Stimulation (DBS) for movement disorders to complete tasks assessing parameters of motor output, speech, and swallowing functions, both with and without…
- Conditions
- Traumatic Brain Injury, Stroke, Brain Disease, Movement Disorders (Incl Parkinsonism)
- Trial name
- NCT07056348
- Testing
- Deep Brain Stimulation (DBS) of the Motor Thalamus
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jorge Gonzalez-Martinez
Essential Tremor, Upper Extremity Essential Tremor
Coordinated Reset Deep Brain Stimulation for Essential Tremor
Deep brain stimulation (DBS) is a surgical procedure for the treatment of Essential Tremor (ET). A novel approach to current DBS approaches is called coordinated reset DBS (CR-DBS) which uses different patterns of stimulation at…
- Trial name
- NCT05897775
- Testing
- Deep brain stimulation
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Minnesota
Essential Tremor, Parkinson's Disease (PD)
Attention and Eye Movement in Parkinson's Disease
The goal of this observational and interventional study is to understand how therapeutic deep brain stimulation (DBS) affects attention, perception and cognition in participants with Parkinson's disease (PD) and non-PD movement…
- Conditions
- Essential Tremor, Parkinson's Disease (PD), Dystonias
- Trial name
- NCT06899022
- Testing
- Normal therapeutic DBS, Reduced current DBS, Reduced frequency DBS
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Essential Tremor
Proof of Concept Study on BP1.4979 Effect on Essential Tremor
The goal of this clinical trial is to learn if drug BP1.4979 works to treat essential tremors in adults. It will also learn about the safety of drug BP1.4979.
- Trial name
- NCT07074002
- Testing
- BP1.4979
- Where
- 14 sites in France
- Volunteers
- 50 people
- Sponsor
- Bioprojet
Dystonia, Parkinson Disease
Lesioning Procedures for Movement Disorders
Dystonia is a rare syndrome with varying etiologies. Similarly, tremor conditions refractory to medical management and disabling that they need surgical interventions are rare in our setting.
- Conditions
- Dystonia, Parkinson Disease, Essential Tremor
- Trial name
- NCT06352268
- Testing
- Pallidal, subthalamic or thalamic lesioning
- Where
- India
- Volunteers
- 250 people
- Sponsor
- All India Institute of Medical Sciences
Essential Tremor, Parkinsons Disease (PD)
Effects of Microelectrode-based Brain Stimulation in Humans
The currently available treatments of Parkinson's disease (PD) and Essential Tremor (ET) are inadequate and accompanied by adverse side effects making the treatment much less effective.
- Trial name
- HDBS (NCT07820189)
- Testing
- High Definition Brain Stimulation (HDBS)
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Lund University
Essential Tremor
Safety and Effectiveness of Unilateral MR-Guided Focused Ultrasound Thalamotomy for Essential Tremor
Essential tremor (ET) is one of the most common movement disorders, significantly impacting patients' quality of life. Many patients do not respond well to medication or cannot tolerate side effects, leaving limited treatment…
- Trial name
- BJGB-ET (NCT07006740)
- Testing
- MR-guided Focused Ultrasound Thalamotomy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- meishanshan
Essential Tremor
Cerebellar Research in Ultrasound Stimulation
Experiment 1: Modulation of Physiological Tremor in Healthy Volunteers Thirty healthy volunteers will undergo TUS targeting the dentate nucleus in a randomized, double-blinded crossover design.
- Trial name
- CERBERUS (NCT07508696)
- Testing
- Transcranial focused ultrasound delivered to the dentate nucleus using the NeuroFUS Pro by Brainbox, Transcranial focused ultrasound delivered to the ventricles (control) using the NeuroFUS Pro by Brainbox
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- KU Leuven