Clinical trials: Essential Tremor
Essential Tremor
Pre-lemniscal Radiation Deep Brain Stimulation for ET
The hypothesis is that prelemniscal radiation (RaPRL) deep brain stimulation (DBS) is more effective for axial (head/neck/voice) tremor, and perhaps, appendicular tremor control in essential tremor patients.
- Trial name
- NCT00634478
- Testing
- Pre-lemniscal Radiation Deep Brain Stimulation
- Where
- United States
- Sponsor
- Medical College of Wisconsin
Essential Tremor
Safety, Efficacy, and Tolerability of NBI-827104 for the Treatment of Essential Tremor
The main objective of this study is to evaluate the efficacy, safety, and tolerability of NBI-827104 in adults with essential tremor.
- Trial name
- NCT04880616
- Testing
- NBI-827104
- Where
- Netherlands
- Volunteers
- 31 people
- Sponsor
- Neurocrine Biosciences
Essential Tremor
The Efficacy of Aldehyde Dehydrogenase Enzyme in Essential Tremor Patients: A Single-Center Study
This is a sponsor-initiated, single-arm, single-center clinical trial designed to evaluate the efficacy and safety of an ALDH-containing food supplement (PICOZYME ET) in patients with Essential Tremor (ET).
- Trial name
- NCT07238725
- Testing
- PICOZYME ET
- Where
- South Korea
- Volunteers
- 31 people
- Sponsor
- Pico Entech Co., Ltd.
Essential Tremor
Thalamic LFPs and VIM DBS in Essential Tremor: Correlation, Evolution, and Therapeutic Perspectives
The objective of this study is to characterize through spectral analysis intra-thalamic local field potentials (LFPs) recorded through implanted DBS leads during periods with and without tremor in patients suffering from severe…
- Trial name
- VIM-CLT (NCT02264925)
- Testing
- Deep Brain Stimulation with Medtronic Activa PC+S systems
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Bordeaux
Essential Tremor
Cerebellar Research in Ultrasound Stimulation
Experiment 1: Modulation of Physiological Tremor in Healthy Volunteers Thirty healthy volunteers will undergo TUS targeting the dentate nucleus in a randomized, double-blinded crossover design.
- Trial name
- CERBERUS (NCT07508696)
- Testing
- Transcranial focused ultrasound delivered to the dentate nucleus using the NeuroFUS Pro by Brainbox, Transcranial focused ultrasound delivered to the ventricles (control) using the NeuroFUS Pro by Brainbox
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Essential Tremor
A Study to Evaluate the Effectiveness and Safety of ExAblate MRgFUS on Essential Tremor
A Study to Evaluate the Effectiveness and Safety of ExAblate Transcranial MRgFUS Thalamotomy Treatment of Medication Refractory Essential Tremor Subjects The objective of this prospective, single-arm study is to test the efficacy…
- Trial name
- NCT03253991
- Testing
- MRgFUS treatment
- Where
- 11 sites in China, Japan and 1 more
- Volunteers
- 154 people
- Sponsor
- InSightec
Essential Tremor
Octanol to Treat Essential Tremor
This study will evaluate the effectiveness of 1-octanol, a substance similar to alcohol but less intoxicating, for treating essential tremor.
- Trial name
- NCT00080366
- Testing
- 1-Octanol
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson's Disease, Essential Tremor
Dexmedetomidine Effects on Microelectrode Recording in Deep Brain Stimulation
To test the hypothesis that sedation induced by Dexmedetomidine at levels appropriate for awake, DBS surgery has no significant effect on electrophysiological parameters of DBS micro-electrode recordings
- Conditions
- Parkinson's Disease, Essential Tremor, Dystonia
- Trial name
- NCT00608231
- Testing
- Dexmedetomidine Hydrochloride Infusion, Normal Saline
- Where
- United States
- Sponsor
- Vanderbilt University
Essential Tremor
Transcranial Ultrasound Therapy of Essential Tremor
Context. Essential tremor (ET) is a common disease, disabling in severe forms and resistant to drug treatment. In patients with severe ET, invasive neurosurgical technique such as deep brain stimulation of the Ventral…
- Trial name
- ULTRABRAINTher (NCT04074031)
- Testing
- Transcranial Ultrasound Therapy (Exablate® 4000 Type 1.1)
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Essential Tremor
Deep Brain Stimulation Effects in Essential Tremor
Deep Brain Stimulation (DBS) is an effective therapy for patients with medically refractory essential tremor. However, DBS programming is not standardized and multiple clinic visits are frequently required to adequately control…
- Trial name
- NCT04581941
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Florida
Preoperative Anxiety
Evaluating the Impact of Virtual Reality on Mood in Patients Undergoing Magnetic Resonance-Guided Focused Ultrasound for Medication-Refractory Essential Tremor
The primary objective of this randomized study is to evaluate the effect of a virtual reality (VR) video on pre-treatment anxiety levels in individuals undergoing magnetic resonance-guided focused ultrasound (MRgFUS) treatment…
- Trial name
- NCT07287605
- Testing
- VR headset: video number 1, VR headset: video number 2
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Sunnybrook Health Sciences Centre
Essential Tremor
A Study to Evaluate SAGE-217 in Participants With Essential Tremor
This study is a three-part, multicenter, Phase 2a study to evaluate the efficacy, safety, tolerability, and pharmacokinetics of SAGE-217 in adult participants with essential tremor.
- Trial name
- NCT02978781
- Testing
- SAGE-217
- Where
- 26 sites in United States
- Volunteers
- 34 people
- Sponsor
- Biogen
Essential Tremor
Essential 3 - Decentralized, Phase 3 Study Evaluating the Safety and Efficacy of Ulixacaltamide in Essential Tremor (ET)
The goal of this clinical study is to compare ulixacaltamide and placebo treatment in essential tremor. The main question it aims to answer is: Is ulixacaltamide a safe and efficacious treatment for patients with essential…
- Trial name
- NCT06087276
- Testing
- 60 mg ulixacaltamide
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Praxis Precision Medicines
Parkinson's Disease, Essential Tremor
Movement Disorder Quantification Algorithm Development
The purpose of this study is to collect kinematic motion data from subjects with movement disorders such as Parkinson's disease (PD) and essential tremor (ET) to develop and validate algorithms for quantifying motor symptoms such…
- Trial name
- NCT01534650
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Great Lakes NeuroTechnologies Inc.
Essential Tremor
Pregabalin (Lyrica) for the Treatment of Essential Tremor
This will be a multi-site, prospective, double-blind, randomized, placebo-controlled, crossover trial conducted over 6 months to assess the effectiveness and safety of PGB to treat symptoms of ET.
- Trial name
- NCT00584376
- Testing
- Pregabalin
- Where
- 8 sites in United States
- Volunteers
- 29 people
- Sponsor
- University of South Florida
Essential Vocal Tremor, Essential Voice Tremor
Propranolol and Botulinum Toxin for Essential Vocal Tremor
Essential tremor is the most common adult-onset movement disorder, and essential voice tremor is the vocal manifestation of essential tremor.
- Conditions
- Essential Vocal Tremor, Essential Voice Tremor, Essential Tremor, Voice Tremor
- Trial name
- NCT02111369
- Testing
- Propranolol, Botulinum Toxin
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Emory University
Parkinson Disease, Essential Tremor
Investigating the Use of Complex Pulse Shapes for DBS in Movement Disorders
Parkinson's disease and essential tremor are chronic movement disorders for which there is no cure. When medication is no longer effective, deep brain stimulation (DBS) is recommended.
- Trial name
- INSHAPE_DBS (NCT04725045)
- Testing
- Boston Scientific: Study tool computer
- Where
- Belgium
- Volunteers
- 28 people
- Sponsor
- KU Leuven
Essential Tremor
Bilateral Essential Tremor Treatment With FUS
Combined Phase II/III, multi-center, prospective, single-blinded trial. Ten (10) patients with who previously underwent successful and uncomplicated MRgFUS thalamotomy for essential tremor will undergo a contralateral treatment.
- Trial name
- BEST-FUS (NCT04501484)
- Testing
- Magnetic Resonance-guided Focused Ultrasound VIM Thalamotomy
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- University Health Network, Toronto
Essential Tremor
Simultaneous Bilateral Radiofrequency Thalamotomy for Medication-Refractory Essential Tremor
This study aims to evaluate the safety and effectiveness of simultaneous bilateral radiofrequency thalamotomy for patients with medication-refractory essential tremor (ET).
- Trial name
- NCT07066358
- Testing
- Simultaneous Bilateral RF Thalamotomy
- Where
- Japan
- Volunteers
- 5 people
- Sponsor
- Tokyo Women's Medical University
Parkinson's Disease, Essential Tremor
Evaluation of Directional Stimulation During the Implantation of Deep Brain Stimulation (DBS) Leads
The purpose of this study is to provide proof-of-concept that directional stimulation, in an intraoperative setting, is perceivable in a subject and is different from omnidirectional stimulation.
- Trial name
- NCT01764815
- Testing
- directSTN Acute lead connected to external neurostimulator
- Where
- Switzerland
- Volunteers
- 13 people
- Sponsor
- Aleva Neurotherapeutics SA