Clinical trials: Esmolol
Hypotension, Surgery-Complications
The Effects of Nicardipine and Esmolol Applied for Controlled Hypotension
In this study, the effects of nicardipine and esmolol applied for controlled hypotension in rhinoplasty on hemodynamics and regional renal oxygenation will be investigated.
- Conditions
- Hypotension, Surgery-Complications, Oxygen Deficiency
- Trial name
- NCT05430724
- Testing
- Controlled hypotention
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Yuzuncu Yil University
Cardioplegia Solution Adverse Reaction
Outcome of Esmolol Potassium Cardioplegia Compared to Potassium Cardioplegia in Patients With Solitary Valvular Disease; Randomized Controlled Study
Perioperative myocardial injury remains one of the most serious complications of cardiac surgery. Numerous factors have been implicated during the pathogenesis process, including the technique of cardiac surgery, induction of…
- Trial name
- NCT04306913
- Testing
- Esmolol, Potassium Cardioplegic Solution
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Kasr El Aini Hospital
Post-mastectomy Pain Syndrome
Effects of Intraoperative Esmolol on Post-mastectomy Pain Syndrome
Chronic postoperative pain is an entity that is usually neglected by anesthetists, but several studies show that the choice of anesthetic technique may interfere with this prevalence.
- Trial name
- NCT03965442
- Testing
- Control, Esmolol
- Where
- Brazil
- Volunteers
- 66 people
- Sponsor
- Hospital de Base
Septic Shock
Pilot Phase II Study: Hemodynamic Tolerance and Anti-inflammatory Effects of Esmolol During the Treatment of Septic Shock
The purpose of this study is : to evaluate the hemodynamic tolerance of esmolol titrated to obtain a lowering of heart rate of 10% or 20%.
- Trial name
- THANE (NCT02120404)
- Testing
- Esmolol administration
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Sinusitis
Esmolol vs. Labetalol in Endoscopic Sinus Surgery
The purpose of this study is to compare esmolol and labetalol bleeding and intra-operative visibility scores in functional endoscopic sinus surgery.
- Trial name
- NCT03661346
- Testing
- Labetalol, Esmolol
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Cardiac Surgery
Esmolol in Cardiac Surgery
This large randomized double-blind clinical trial (esmolol vs placebo) will enroll patients undergoing cardiac surgery to study the additive cardiac protection of this therapeutic strategy.
- Trial name
- BREVI (NCT00959569)
- Testing
- Esmolol
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Università Vita-Salute San Raffaele
Cirrhosis, Diabetes Mellitus
Efficacy of Esmolol in the Identification of Cardiovascular Disorders by Cirrhosis, Diabetes Mellitus and Cardiotoxic Treatments
The purpose of this study is to assess the superiority of esmolol echocardiography over conventional echocardiography in the diagnosis of subclinical myocardial involvement associated with diabetes mellitus 2, cirrhosis and…
- Conditions
- Cirrhosis, Diabetes Mellitus, Oncologic Disorders
- Trial name
- CIBERbBECHO (NCT05769868)
- Testing
- Esmolol Injection [Brevibloc]
- Where
- 6 sites in Spain
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Consorcio Centro de Investigación Biomédica en Red (CIBER)
Pain, Acute, Pain, Postoperative
The Impact of Esmolol Administration on Postoperative Recovery
The aim of this study will be to investigate the effect of a continuous infusion of low dose esmolol on intraoperative and postoperative opioid consumption, as well as on postoperative recovery and chronic pain
- Conditions
- Pain, Acute, Pain, Postoperative, Pain, Chronic Post-Surgical, Esmolol
- Trial name
- esmolol (NCT05567822)
- Testing
- Esmolol Hydrochloride, normal saline
- Where
- Greece
- Volunteers
- 70 people
- Sponsor
- Aretaieion University Hospital
Hypertension
Esmolol or Nitroglycerin Infusion for Blood Pressure Control Prior to Cardiopulmonary Bypass (CPB) in Cardiac Surgery
This is an investigator initiated, sponsored, open label, prospective randomized controlled trial to be performed in adult patients undergoing scheduled cardiac surgery.
- Trial name
- NCT01212874
- Testing
- nitroglycerin, esmolol
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Loma Linda University
Patient's Satisfaction, Depth of Anesthesia
The Effect of Esmolol Versus Dexmedetomidine on Postoperative Pain Control in Endoscopic Sinus Surgery: A Randomized Trial
Hypotensive techniques are associated with certain disadvantages. Hence, anesthesiologists are still in search of drugs with fewer side effects.
- Trial name
- NCT05703048
- Testing
- Esmolol Esterase, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Tanta University
Frailty, Esmolol
Effects of Low-dose Esmolol on Myocardial Injury After Non-cardiac Surgery in Elderly Frail Patients
This topic will focus on the following questions: 1. Part one: To clarify the relationship between preoperative frailty and myocardial injury (cTnT ≥0.03) after non-cardiac surgery in elderly patients; To further explore the…
- Conditions
- Frailty, Esmolol, Myocardial Injury
- Trial name
- NCT05635877
- Testing
- Esmolol
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Yongtao Sun
Septic Shock, Stress Response
Effect of Dexmedetomidine vs Esmolol or Placebo on Cerebral Hemodynamics in Septic Shock
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Some researchers proposed that the dysregulated response or organ dysfunction can be lessened by reducing the stress…
- Conditions
- Septic Shock, Stress Response, Cerebral Hemodynamics
- Trial name
- NCT06169475
- Testing
- Dexmedetomidine Hydrochloride, Esmolol Hydrochloride
- Where
- China
- Volunteers
- 14 people
- Sponsor
- Xinchen Wang
Tachycardia, Hypertension
A Comparison of the Perioperative Hemodynamic Effects of Remifentanil and Esmolol in Intracranial Surgery
It was hypothesized that the use of esmolol as an alternative to remifentanil with sevoflurane inhalation anesthesia during intracranial surgery, could provide better hemodynamic conditions and cause lesser side effects in the…
- Conditions
- Tachycardia, Hypertension, Myocardial Ischemia
- Trial name
- NCT01628562
- Testing
- Esmolol, Remifentanil
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Diskapi Teaching and Research Hospital
Intubation
Hemodynamic Response to Intubation
This study investigates the effects of dexmedetomidine and esmolol given intravenously before intubation on sympathetic response caused by intubation itself.
- Trial name
- NCT02844894
- Testing
- Dexmedetomidine, Esmolol
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ufuk University
Intracranial Hypertension, Endotracheal Intubation
Lidocaine, Dexmedetomidine, Esmolol and Magnesium Effect on Optic Nerve Sheath Diameter After Laryngoscopy
This clinical trial aims to compare the effects of lidocaine, dexmedetomidine, esmolol, and magnesium on optic nerve sheath diameter and hemodynamic response to laryngoscopy.
- Conditions
- Intracranial Hypertension, Endotracheal Intubation, Optic Nerve Sheath Diameter, General Anesthesia
- Trial name
- NCT06254534
- Testing
- optic nerve ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Haseki Training and Research Hospital
Beta Blocker, Hemodynamic Instability
The Effects of Esmolol on the Hemodynamic Response to Orotracheal Extubation
Beta-blockers are useful tools for the prevention of hemodynamic instability in the manipulation of airways. The main objective of the present study is to evaluate the effectiveness of using esmolol in attenuating hemodynamic…
- Trial name
- NCT04264286
- Testing
- Prophylactic esmolol
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hospital de Base
Hemorrhagic Stroke
Esmolol for the Treatment of Hypertension After Intracerebral Hemorrhage Study (ETHICHS)
Because of its pharmacokinetic characteristics, such as short half-life and its safety profile, esmolol hydrochloride is a beta blocker suitable for venous use in the form of continuous infusion.
- Trial name
- ETHICHS (NCT03743103)
- Testing
- Brevibloc, 10 Mg/mL Intravenous Solution, Nitroprusside, Sodium
- Where
- 7 sites in Brazil
- Volunteers
- 20 people
- Sponsor
- Cristália Produtos Químicos Farmacêuticos Ltda.
Septic Shock, Hypotension
Esmolol to Treat the Hemodynamic Effects of Septic Shock
The main purpose of this study is to determine the effects of controlling the heart rate of patients with septic shock using an intravenous medication called esmolol.
- Conditions
- Septic Shock, Hypotension, Tachycardia
- Trial name
- NCT02369900
- Testing
- Esmolol, Saline
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Beth Israel Deaconess Medical Center
Hemodynamic Instability
Comparison of Effects of Scalp Block and Intravenous Esmolol on Hemodynamic Response Following the Skull Pins Application for Elective Supratentorial Craniotomy
The goal of this clinical trial is to compare hemodynamic response (MAP, SBP, DBP and HR) between scalp block and intravenous esmolol while skull pins application in patients undergoing elective supratentorial craniotomy under…
- Trial name
- NCT06268275
- Testing
- Scalp block, Esmolol
- Where
- Thailand
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Rhinoplasty, Depth of Anesthesia
Processed EEG Monitoring During Controlled Hypotension in Patients Undergoing Rhinoplasty
This prospective observational study evaluates intraoperative processed electroencephalography parameters in adult patients undergoing elective rhinoplasty under total intravenous anesthesia with controlled hypotension.
- Conditions
- Rhinoplasty, Depth of Anesthesia, Surgical Bleeding, Postoperative Recovery
- Trial name
- NCT07671781
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Gazi University