Clinical trials: Epistaxis Nosebleed
Hereditary Hemorrhagic Telangiectasia, Epistaxis
Effects of Pazopanib on Hereditary Hemorrhagic Telangiectasia Related Epistaxis and Anemia (Paz)
During the Efficacy Study (Part B), the investigators will study whether Pazopanib, taken daily for 24 weeks, will reduce the severity of nose bleeds in patients with hereditary hemorrhagic telangiectasia (HHT).
- Conditions
- Hereditary Hemorrhagic Telangiectasia, Epistaxis, Anemia, Nosebleed
- Trial name
- Paz (NCT03850964)
- Testing
- Pazopanib
- Where
- 11 sites in United States
- Volunteers
- 71 people
- Sponsor
- Cure HHT
Hereditary Hemorrhagic Telangiectasia, Nosebleeds
Sirolimus for Nosebleeds in HHT
This pilot study is to determine the safety and efficacy of oral sirolimus (blood trough level 6-10ng/ml) in patients with HHT that are experiencing moderate or severe epistaxis.
- Conditions
- Hereditary Hemorrhagic Telangiectasia, Nosebleeds, Epistaxis
- Trial name
- NCT05269849
- Testing
- Sirolimus
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Unity Health Toronto
Epistaxis Nosebleed, Greater Palatine Foramen
Management of Epistaxis Comparing Nasal Packing Versus Greater Palatine Foramen Block
The goal of this pilot randomized controlled trial is to compare pain relief efficacy while using nasal packing versus greater palatine foramen block (GPFB) in the management of acute episodes of epistaxis.
- Trial name
- ANPvsGPF block (NCT07421622)
- Testing
- Greater Palatine Foramen Block with 2% xylocaine with adrenaline, Anterior Nasal Packing
- Volunteers
- 40 people
- Sponsor
- Sheikh Zayed Federal Postgraduate Medical Institute
Epistaxis Nosebleed
Treatment of Nosebleeds in the Emergency Department With Powder Tranexamic Acid
Nosebleeds are very common, occurring in 60% of the population; in some patients, nosebleeds are a life-threatening emergency. To stop a nosebleed in the emergency department, doctors usually have to burn the nose (called…
- Trial name
- Bloody SIMPLE (NCT06997796)
- Testing
- Tranexamic Acid
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Dr. Anne Conlin
Hereditary Hemorrhagic Telangiectasia, Epistaxis Nosebleed
Tacrolimus Trial for Hereditary Hemorrhagic Telangiectasia (HHT)
This study will investigate the effectiveness of oral low-dose tacrolimus for the treatment of recurrent nasal hemorrhage in HHT subjects.
- Trial name
- NCT04646356
- Testing
- Tacrolimus capsule (low-dose)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Unity Health Toronto
Epistaxis Nosebleed
Coblation Versus Bipolar Diathermy in Management of Refractory Idiopathic Recurrent Anterior Epistaxis in Children.
The aim of this study is to compare the outcomes of coblation technique versus bipolar technique in management of RAE in children regarding the following: 1. Efficacy of each method to stop bleeding. 2. Technical feasibility. 3.
- Trial name
- NCT06651840
- Testing
- bipolar diathermy "Standard technique"., coblation technique.
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Assiut University
Atmospheric Pressure; Adverse Effect, Epistaxis Nosebleed
Atmospheric Pressure and Epistaxis Relationship
In this study, investigators aim to understand the relationship between changes in atmospheric pressure and blood pressure, and to investigate whether these changes have an impact on the etiology of epistaxis.
- Trial name
- NCT06531577
- Where
- Turkey (Türkiye)
- Volunteers
- 600 people
- Sponsor
- Saglik Bilimleri Universitesi
Epistaxis Nosebleed
Tranexamic Acid Versus Blood Stopper Treatments in Epistaxis Management
In this randonmized controlled trial, aim to compare the effectiveness of local administration of tranexamic acid and blood stopper (Ankaferd®) on cessation of bleeding in epistaxis patients.
- Trial name
- NCT06490653
- Testing
- Blood Stopper (Ankaferd)
- Volunteers
- 186 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
Epistaxis Nosebleed
Nasal Compression Device Study for Epistaxis
This study will explore how a nasal compression device compares to manual compression for stopping anterior nosebleeds. This will be a non-randomized controlled trial enrolling participants presenting to medical care for anterior…
- Trial name
- NCT05789264
- Testing
- Nasal Compression Device, Routine Care
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- NasaClip
Epistaxis Nosebleed, Pharyngeal Bleeding
Guidewire Use in Nasotracheal Intubation
During nasotracheal intubation, nasopharyngeal trauma and associated bleeding may occur. The investigators think that some of this bleeding is due to trauma to the posterior wall of the nasopharynx.
- Trial name
- NCT05937516
- Testing
- Nasotracheal intubation with conventionally, Nasotracheal intubation with angled ETT using guidewire
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Nosebleed (Epistaxis) - Posterior or Anterior
Long Term Results and Complications After Epistaxis Treatment
The aim of this study is to find the most agreeable and in the long term most efficient treatment for epistaxis.
- Trial name
- NCT02127554
- Where
- Switzerland
- Volunteers
- 591 people
- Sponsor
- University of Zurich
Hereditary Hemorrhagic Telangiectasia (HHT), Nosebleeds
Ranibizumab for the Management of Recurrent Nosebleeds in Patients With Hereditary Hemorrhagic Telangiectasia (HHT)
This study is for patients with recurrent epistaxis (nosebleeds) as a result of Hereditary Hemorrhagic Telangiectasia (HHT). The aim is to determine if ranibizumab, topically applied will diminish epistaxis in patients with HHT…
- Trial name
- NCT01406639
- Testing
- Ranibizumab
- Sponsor
- University of California, San Diego