Clinical trials: Epigenetic Disorder
Cervical Cancer
Hydralazine and Valproate Plus Cisplatin Chemoradiation in Cervical Cancer
The current standard for locally advanced cervical cancer is concurrent cisplatin-based chemotherapy, however, the treatment results need to be improved.
- Trial name
- NCT00404326
- Testing
- Hydralazine and magnesium valproate, Punch biopsy of the primary tumor
- Where
- Mexico
- Volunteers
- 18 people
- Sponsor
- National Institute of Cancerología
Elevated LDL-C and High Cholesterol
A Study of STX-1150 in Participants With Elevated Low-Density Lipoprotein Cholesterol (LDL-C)
STX-1150 is an investigational therapy designed to lower LDL-C by silencing a gene called PCSK9 in the liver. STX-1150 does not edit or permanently change the gene.
- Trial name
- STX-1150-01 (NCT07428473)
- Testing
- STX-1150
- Where
- 3 sites in Australia, New Zealand
- Volunteers
- 64 people
- Sponsor
- Monash University
Parkinson Disease
Analysis of the Prognostic Role of Epigenetic Biomarkers in Relation to the Motor Decline in Parkinson's Disease
BioGenParkinson is an observational, prospective cohort study evaluating biomarkers of Parkinson's Disease (PD) progression in community-dwelling subjects aged 65 years or more, consecutively referring to INRCA outpatient clinic…
- Trial name
- BioGenPark (NCT05384522)
- Testing
- blood samples collection
- Volunteers
- 103 people
- Sponsor
- Istituto Nazionale di Ricovero e Cura per Anziani
Stress, Cognitive Impairment
Mindfulness-Based Health Promotion Program for Educators (MBHP - Educa).
In the last few decades, the world has seen a significant increase in the occurrence of occupational diseases related to Burnout Syndrome (professional exhaustion) and stress in educators.
- Conditions
- Stress, Cognitive Impairment, Burnout Syndrome
- Trial name
- Mindfulness (NCT03839030)
- Testing
- MBHP-Educa
- Where
- Brazil
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Marcelo Demarzo, MD, PhD
Urologic Cancer, Urologic Neoplasms
Genetic Testing in Upper Tract Urothelial Carcinoma (UTUC): the Epicheck Study
Background: Upper tract urothelial carcinoma (UTUC) is a rare tumor associated with bladder cancer in up to 50% of cases. Its incidence is rising due to improved detection and bladder cancer survival.
- Trial name
- NCT04702347
- Testing
- Urine biomarker
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Fundacio Puigvert
Diabetic Retinopathy, Age-Related Macular Degeneration (AMD)
Genetics and Markers of Degenerative and Inflammatory Eye Diseases
This study will identify genes that are associated with inflammation or degeneration of the retina (membrane lining the back of the eye that relays vision signals to the brain).
- Conditions
- Diabetic Retinopathy, Age-Related Macular Degeneration (AMD), Uveitis
- Trial name
- NCT00647439
- Where
- United States
- Volunteers
- 609 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Copd
The Epigenetics of Exercise and Physical Activity in COPD
This study seeks to examine genome-wide DNA methylation patterns associated with physical activity and exercise capacity from peripheral blood collected from participants with chronic obstructive pulmonary disease (COPD) before…
- Trial name
- NCT03539042
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Boston Healthcare System
Pancreatic Cancer
Trial to Improve Outcomes in Patients With Resected Pancreatic Cancer (Azacitidine)
To improve progression free survival in high risk patients with resected pancreatic adenocarcinoma who have node positive disease, margin positive disease, and/or elevation in CA 19-9 treated with CC-486 (oral azacitidine) as…
- Trial name
- NCT01845805
- Testing
- oral azacitidine, Observation
- Where
- 4 sites in United States
- Volunteers
- 49 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Systemic Lupus Erythematosus, Lupus Nephritis
Epigenetics in Lupus Nephritis
This is a translational study for the identification of epigenetic changes detectable in sera of patients suffering from Systemic Lupus erythematosus.
- Trial name
- Epi_LN (NCT04648059)
- Testing
- Blood sampling
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Göttingen
Chronic Obstructive Pulmonary Disease
Innate Immunity in COPD
Chronic Obstructive Pulmonary Disease (COPD) causes obstruction to airflow when breathing out. It is a leading cause of chronic lung disease, hospitalization and death.
- Trial name
- NCT05743582
- Testing
- Bronchoscopy for sample collection, Blood donation
- Where
- 2 sites in United Kingdom
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Cancer, Chronic Lymphocytic Leukemia
Time Restricted Eating in Haematological Malignancies
The goal of this clinical trial is to learn if time restricted eating (TRE), a form of intermittent fasting, can impact health outcomes in patients with chronic lymphocytic leukemia (CLL).
- Trial name
- NCT06862323
- Testing
- Time-Restricted Eating
- Where
- Canada
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- British Columbia Cancer Agency
Exercise Induced Asthma, House Dust Mite Allergy
Epigenetic Regulation of Exercise Induced Asthma
The purpose of this study is to investigate the micro ribonucleic acid (mRNA) profiles of patients with EIA without allergic sensitization and EIA with house dust mite sensitization compared to that of healthy controls.
- Trial name
- NCT05174689
- Testing
- Exercise challenge in the cold chamber (ECC), mRNA profile, standard diagnostic
- Where
- Germany
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Epithelial Ovarian Cancer
Study of Pembrolizumab With or Without CC-486 in Patients With Platinum-resistant Ovarian Cancer
The purpose of the study is to determine the optimal dose of CC-486 (oral azacitidine) in combination with pembrolizumab for the treatment of platinum-resistant/refractory Epithelial Ovarian Cancer (EOC).
- Trial name
- NCT02900560
- Testing
- CC-486, Pembrolizumab
- Where
- 4 sites in United States
- Volunteers
- 34 people
- Sponsor
- Translational Research in Oncology
Colorectal Cancer, Colorectal Cancer Metastatic
Comprehensive Genomic Profiling of Colorectal Cancer Patients With Isolated Liver Metastases to Understand Response & Resistance to Cancer Therapy
This is a prospective study investigating the disease course of patients with colorectal cancer that have had their cancer spread to their liver.
- Conditions
- Colorectal Cancer, Colorectal Cancer Metastatic, Hepatic Metastases
- Trial name
- COMPARISON (NCT03364621)
- Where
- 2 sites in Canada
- Volunteers
- 17 people
- Sponsor
- University Health Network, Toronto
Full Term Infants, Environmental Exposures
Epigenetic and Developmental Effects of In Utero Exposure to Environmental Toxicants
Metabolic diseases such as obesity and diabetes are modern day epidemics. Early life exposure to an adverse developmental environment, including environmental toxins, are linked to increased susceptibility to obesity, metabolic…
- Conditions
- Full Term Infants, Environmental Exposures, Adiposity
- Trial name
- NCT01815385
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Stunting, Development, Child
Methylation, mIcrobiome, NUtritional sTatus, and dEvelopment of Stunted Children
The investigators will conduct a case-control study among under-two children in Lombok Timur, West Nusa Tenggara, Indonesia. The power required to detect changes in epigenetic markers may not be sufficient in the cohort study.
- Conditions
- Stunting, Development, Child, DNA Methylation, Epigenetics
- Trial name
- MINUTES (NCT05779904)
- Where
- Indonesia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- SEAMEO Regional Centre for Food and Nutrition
Gestational Diabetes Mellitus (GDM)
Imprinting in Metabolic Diseases - Identifying Epigenetic Mechanisms in Human Gestational Diabetes Through Cell-free DNA
This clinical trials aims to investigate the impact of parental metabolism during pregnancy on fetal epigenetic signatures. The metabolic profiles of both parents will be evaluated through a blood sample collected from the father…
- Trial name
- Epi_GDM (NCT07436195)
- Testing
- Metabolic and epigenetic characterization of parents ans fetuses
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Coronary Artery Disease, Acute Coronary Syndrome
DNA Methylation Analysis in Acute Coronary Syndrome and Atrial Fibrillation: DIANA Clinical Trial
Although epigenetics has been identified as one of the most relevant pathophysiological components in the development of cardiovascular diseases, there is still considerable difficulty in finding markers of epigenetic damage…
- Conditions
- Coronary Artery Disease, Acute Coronary Syndrome, Atrial Fibrillation
- Trial name
- NCT04371809
- Testing
- DNA methylome
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Campania Luigi Vanvitelli
Acute Kidney Injury, Renal Transplantation
Detection of Plasma DNA of Renal Origin in Kidney Transplant Patients
Donor-derived cell-free DNA (dd-cfDNA) has been proposed as a potential diagnostic tool to monitor the rejection status of the kidney transplant.
- Trial name
- DART-REIN (NCT06026592)
- Testing
- determination of circulating biomarkers of renal origin circulating biomarkers of renal origin
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Asthma, Children
Early Risk of Asthma in Children Exposed to In-utero Maternal Obesity
This study seeks a better understanding of the pathogenesis of asthma in early life. The aim of this project is to determine whether the offspring of obese mothers at 3 years of life have increased the risk of asthma compared to…
- Conditions
- Asthma, Children, Obesity, Maternal
- Trial name
- NCT02903134
- Volunteers
- 240 people
- Sponsor
- Pontificia Universidad Catolica de Chile