Clinical trials: Environmental Exposure, open to volunteers
Genetic Predisposition, Exposure, Environmental
Mayo Clinic Precure - Prospective Study
The goal of this observational study is to 1) better understand and predict biological processes before disease begins or is identified, 2) study genomic and environmental contributors to disease, 3) identify ways to stop disease…
- Trial name
- NCT07332598
- Where
- United States
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Healthy Adult Participants
Observational Study of Decentralized Urine Optical Interaction Patterns Associated With Environmental Microplastic and Nanoplastic Exposure
The goal of this observational study is to evaluate the feasibility and usability of at-home urine sample collection, preparation, and smartphone imaging using the EcoExposure™ platform in adults.
- Trial name
- OMNU (NCT07775495)
- Where
- 51 sites in United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Ecotera Health LLC
Asthma Childhood, Asthma
Advancing Diagnosis and Treatment of Pediatric Asthma
Asthma is one of the most common chronic diseases in children, and treatment success often depends on proper inhaler use and consistent medication adherence.
- Conditions
- Asthma Childhood, Asthma, Inhalation Spacers
- Trial name
- Care4Asthma (NCT07500246)
- Testing
- Whizz spacer system, AeroChamber Plus® Flow-Vu®
- Where
- Luxembourg
- Volunteers
- 208 people
- Sponsor
- Luxembourg Institute of Health
Health Knowledge, Environmental Exposure
Planetary Health and Environmental Justice in Construction Career Education
This study tests whether a new educational curriculum can help high school students in construction career programs better understand how building design affects community health and environmental justice.
- Conditions
- Health Knowledge, Environmental Exposure, Attitude, Practice
- Trial name
- EJT-CTE (NCT07315919)
- Testing
- Community-Centered Design Curriculum with EJT, Traditional Technical Curriculum
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Stanford University
Healthy
Measuring Environmental Tobacco and Cannabis: Pollutants and Exposures
This is an unblinded pilot study of an environmental exposure to secondhand cannabis smoke in one group of healthy nonsmokers.
- Trial name
- CAN03 (NCT06030674)
- Testing
- Secondhand cannabis emissions/smoke exposure
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Rumination
Effect of Environment on the Central and Peripheral Nervous System
The main goal of this study is to understand how different environments influence both mental responses, like overthinking (rumination), and physical reactions, such as heart rate and blood pressure, after a challenging task.
- Trial name
- RUMI (NCT06778356)
- Testing
- Built environment, Natural environment
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Vapors; Inhalation, Cancer
Addressing Tetrachloroethylene Exposure in an Impacted Community
Groundwater in Martinsville, IN, is contaminated by volatile organic compounds (VOCs), tetrachloroethylene (PCE) and trichloroethylene (TCE).
- Conditions
- Vapors; Inhalation, Cancer, Volatile Organic Compounds
- Trial name
- NCT05819996
- Testing
- Environmental educational campaign
- Where
- United States
- Volunteers
- 510 people
- Sponsor
- Purdue University
Asthma
NHALES (Natural History of Asthma With Longitudinal Environmental Sampling)
Background: Asthma is a serious clinical and public health problem. Researchers want to collect data to better understand how bacteria and other things in the environment can affect people's asthma.
- Trial name
- NCT02327897
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Tooth Extraction Site Healing, Alveolar Ridge Preservation
Biomaterials Exposed to Oral Environment: Which One is the Appropriate Option?
After tooth extraction, bone loss can compromise future dental implant treatment. Dentists often use biomaterials to preserve bone, but in many cases these materials are left exposed to the oral environment, where saliva and…
- Trial name
- NCT07589751
- Testing
- Alveolar Ridge Reconstruction
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidade Católica do Rio Grande do Sul
Asthma Acute, Respiratory
Children's Health, Respiratory Inflammation and Short-term Air Pollution
The goal of this study is to see if physical activity in high air pollution is worse than rest in high air pollution.
- Trial name
- CHERISH (NCT07431021)
- Testing
- science lesson, PE Lesson
- Where
- United Kingdom
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Pulmonary Function
Service and Health Among Deployed Veterans
The purpose of the study is to better understand the health, including lung health, of Veterans who deployed in support of Operation Enduring Freedom (OEF), Operation Iraqi Freedom (OIF), or Operation New Dawn (OND) and other…
- Trial name
- SHADE (NCT02825654)
- Where
- 6 sites in United States
- Volunteers
- 6,200 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
SDH-Related Familial Paraganglioma, SDHx-Related Syndromes
Impact of Environmental Exposures on Tumor Risk in SDHx-mutation Carriers
The primary objective of the PGL.EXPO-2 study is to test the hypothesis that exposure (occupational, environmental and/or domestic) to succinate dehydrogenase inhibitors (SDHi) could contribute to tumor emergence in subjects…
- Conditions
- SDH-Related Familial Paraganglioma, SDHx-Related Syndromes, SDH Gene Mutation, Environmental Exposure
- Trial name
- PGLEXPO2 (NCT06408402)
- Where
- 20 sites in France
- Volunteers
- 1,300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Lead Poisoning, Environmental Exposure
A Study to Assess the Efficacy of Public Health Campaigns in Reducing Lead Exposure
This clinical trial aims to evaluate the effectiveness of targeted public health campaigns in reducing lead exposure among adults living in urban communities with known environmental lead hazards.
- Trial name
- NCT07632937
- Testing
- Intensive Public Health Campaign, Standard Information Dissemination
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- International Health Strategies LLC
Brain, Aging
Biobank and Brain Health in Bordeaux.
B cube is a new generation cohort to study the determinants and natural history of brain aging, using molecular epidemiology, in a representative sample (N=2000) of the general population from the age of 55 (the approximate age…
- Conditions
- Brain, Aging, Cognitive Aging, Immunosenescence
- Trial name
- B-cube (NCT05322343)
- Testing
- Questionnaires, Fasting blood sampling., Saliva collection and nasal or nasopharyngeal swab
- Where
- France
- Volunteers
- 2,050 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Infant Development, Breast Feeding
Developmental Impacts of Microplastics Exposure in Early Life
The goal of this observational study is to characterize and evaluate micro- and nano-plastic (MNP) exposures among mothers and infants in mother-infant dyads 1 or 3 months postpartum living in Baltimore, Maryland.
- Conditions
- Infant Development, Breast Feeding, Environmental Exposure
- Trial name
- DIMPLE (NCT06107933)
- Testing
- Observational only
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Healthy
Observational Study of Exposure to Environmental Toxicants Among Firefighters
Observational, within subject study design with 1 pre and 2 post-fire exposure biomarker samples collected to assess exposure to toxicants from combustion emissions related to fighting a structural fire.
- Trial name
- NCT05643014
- Testing
- Sample collection
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Heart Failure
Project 4: ACHIEVE PATHFINDER
ACHIEVE-P4: PATHFINDER is a randomized, blinded clinical trial of portable air cleaners (PAC) provided at the time of hospital discharge to Heart Failure (HF) patients. It will be carried out at Henry Ford Hospitals.
- Trial name
- PATHFINDER (NCT06070428)
- Testing
- PAC provision at hospital discharge, Control non-intervention; PAC without filter
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Henry Ford Health System
Asthma, Chronic Obstructive Pulmonary Disease (COPD)
Lungs on Fire: Wildfire Smoke, Incident Diseases, Susceptible Populations, and Community Values in Canada
Wildfire smoke (WFS) is the leading climate-related risk in Canada and the main source of harmful air pollution. While short-term breathing problems caused by smoke are well known, there is limited knowledge on how repeated…
- Conditions
- Asthma, Chronic Obstructive Pulmonary Disease (COPD), Lung Cancer
- Trial name
- LoF (NCT07536178)
- Testing
- Woodsmoke (Lodgepole Pine) exposure, Filtered air exposure
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Allergic, Inflammatory
THREAT: Testing Harms Related to Exposure to Allergenic and Epithelial Toxins
Background: Allergic and inflammatory conditions have been increasing over the years. Many factors may play a role in this. Every day, people are exposed to pollution and chemicals in our foods, clothing, and all of the cleaning…
- Trial name
- NCT07271381
- Testing
- Environmental Exposures, Control Exposures
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cardiovascular Diseases, Risk Factor, Cardiovascular
Prospective Urban Rural Epidemiology Study
To examine the impact of health determinants at the individual (e.g. health related behaviors) and societal level (e.g. environmental factors, health related policy, quality of health systems) on health outcomes (e.g.
- Conditions
- Cardiovascular Diseases, Risk Factor, Cardiovascular, Health Behavior, Environmental Exposure
- Trial name
- PURE (NCT03225586)
- Where
- 34 sites in Argentina, Bangladesh and 23 more
- Volunteers
- 200,000 people
- Sponsor
- Population Health Research Institute