Asthma AcuteCHERISHNCT07431021
Children's Health, Respiratory Inflammation and Short-term Air Pollution
A study testing science lesson and PE Lesson in people with Asthma Acute and Respiratory, run by Queen Mary University of London at 1 site in United Kingdom.
Trial summary
The goal of this study is to see if physical activity in high air pollution is worse than rest in high air pollution. Read more about this study
- Who is it for?
- Ages 7 to 11 yearsHealthy volunteers can take part
- Conditions the study is for
- Asthma Acute, Respiratory
- What is being tested?
- science lesson and PE Lesson
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 330 participants
- Where
- 1 siteUnited Kingdom
- Study dates
- 20 Oct 2025to 1 Jul 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 7 to 11 years
- All sexes
- Healthy volunteers accepted
- Child
Who may be able to join
- Attending schools in Central and East London that have been recruited to the study
Who cannot join
- Not able to engage with PE lessons on safety grounds, reported by their parents.
- Children with learning or physical disabilities sufficient for them to be unable to give informed assent to the study, or to carry out study procedures
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Abigail Whitehouse, MD,PhD contact
United Kingdom1 site, 1 recruiting
- Recruiting
Faculty of Medicine and Dentistry
London, E1 2AB
James Scales, 07533897264, j.scales@qmul.ac.uk
About this study
The goal of this study is to see if physical activity in high air pollution is worse than rest in high air pollution.
Read the detailed description
The study will recruit a total of 330 children from 10 primary schools split into two groups: "higher pollution" and "lower pollution" schools. The team shall invite children in years 3 to 6 to take part in the study and consent will be provided by parents following information sheets sent home in school bags and parent evening presentations.
After the team have received written permission from parents. The study team will visit the school on two days. On the first day the study team will perform lung health assessment in a dedicated classroom. The assessment will involve, measuring children's height and weight, a breathing test (photo and a snot sample collected by squirting a small bit of saline water up one nostril and catching the snot in a cup.
Children will then take part in a PE lesson or a sedentary science lesson in a random order in their school playground while wearing activity monitors - like a Fitbit- to track their physical activity. The session is designed to be just like a typical outdoor science or PE lesson and will be exactly the same at all schools. Air pollution levels in the playground will be monitored during this time.
Once the PE lesson has finished the children will perform the same health assessment immediately after the lesson and again on a second day. The team shall compare the change in these scores between higher and lower pollution schools. The breathing tests will tell us if the has been any change in lung health and the snot samples will tell us about the pollution the children have breathed and how their bodies try to fight it. Participating will take about 4 hours total.
- Conditions
- Asthma Acute, Respiratory
- Being tested
- science lesson, PE Lesson
- Keywords
- air pollution, physical activity, children, exercise, no2, Public health, air quality, pollution, paediatric, exposure, environment
- Medical subject headings
- Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
science lessonBehavioural
children have a 90 minute science lesson outdoors
PE LessonBehavioural
CHildren have a 90 minute PE lesson outdoors
| Study group | Role | What they receive |
|---|---|---|
| Physical activity | Experimental | PE Lesson Receives: Behavioral: PE Lesson |
| Sedenary | Active comparator | Science lesson Receives: Behavioral: science lesson |
What is being measured
The primary outcome is the main question the study is designed to answer.
"Airway resistance" measured by Oscillometry at R5
measured as oscillometery R5
Measured: Pre-24 hour post exposure
Secondary outcomes (2)
"Small airway resistance" measured by Oscillometry at R5-20
Measured by oscillometry R5-20
Measured: pre- 24 hour post exposure
Immune responses as measured by Il6 in nasal lavage
Immune response as measured by Il6 in nasal lavage
Measured: pre-24 hour post exposure
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Feb 2026
- Study start20 Oct 2025
- Primary completion1 Jul 2027 (estimated)
- Study completion1 Jul 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Asthma AcuteStudies of the same condition, open and under way.
- More trials run by Queen Mary University of LondonThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Single group
- Model description
- mixed methods. crossover of conditions (physical activity (PE) Vs Sedentary (science)
- Masking
- None (open label)
- Enrolment
- 330 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Queen Mary University of London
- Sponsor type
- University, hospital or other
- Collaborators
- Imperial College London
- Responsible party
- Sponsor
- Investigators
- James Scales, PhD, Principal investigator, Queen Mary University LondonAbigail Whitehouse, PhD, MD, Principal investigator, QMUL
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07431021
- Sponsor's protocol ID
- QME25.1220
- Other IDs
- G-002887
- Acronym
- CHERISH
- Status last verified
- Jun 2026
- First submitted
- 3 Feb 2026
- Last updated
- 15 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 15 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Children's Health, Respiratory Inflammation and Short-term Air Pollution
- ClinicalTrials.gov ID
- NCT07431021
- Acronym / sponsor ID
- CHERISH / QME25.1220
- Conditions
- Asthma Acute, Respiratory
- Keywords
- air pollution, physical activity, children, exercise, no2, Public health, air quality, pollution
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 330 participants (estimated)
- Lead sponsor
- Queen Mary University of LondonUniversity, hospital or other
- Collaborators
- Imperial College London
- Study start
- 20 Oct 2025 (actual)
- Primary completion
- 1 Jul 2027 (estimated)
- Study completion
- 1 Jul 2027 (estimated)
- First posted
- 24 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this study is to see if physical activity in high air pollution is worse than rest in high air pollution.
Detailed description
The study will recruit a total of 330 children from 10 primary schools split into two groups: "higher pollution" and "lower pollution" schools. The team shall invite children in years 3 to 6 to take part in the study and consent will be provided by parents following information sheets sent home in school bags and parent evening presentations.
After the team have received written permission from parents. The study team will visit the school on two days. On the first day the study team will perform lung health assessment in a dedicated classroom. The assessment will involve, measuring children's height and weight, a breathing test (photo and a snot sample collected by squirting a small bit of saline water up one nostril and catching the snot in a cup.
Children will then take part in a PE lesson or a sedentary science lesson in a random order in their school playground while wearing activity monitors - like a Fitbit- to track their physical activity. The session is designed to be just like a typical outdoor science or PE lesson and will be exactly the same at all schools. Air pollution levels in the playground will be monitored during this time.
Once the PE lesson has finished the children will perform the same health assessment immediately after the lesson and again on a second day. The team shall compare the change in these scores between higher and lower pollution schools. The breathing tests will tell us if the has been any change in lung health and the snot samples will tell us about the pollution the children have breathed and how their bodies try to fight it. Participating will take about 4 hours total.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- mixed methods. crossover of conditions (physical activity (PE) Vs Sedentary (science)
| Arm | Type | Receives |
|---|---|---|
| Physical activity | Experimental | Behavioral: PE LessonPE Lesson |
| Sedenary | Active comparator | Behavioral: science lessonScience lesson |
Who may qualify
- Ages
- 7 to 11 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child
Key inclusion criteria (1 listed)
- Attending schools in Central and East London that have been recruited to the study
Key exclusion criteria (2 listed)
- Not able to engage with PE lessons on safety grounds, reported by their parents.
- Children with learning or physical disabilities sufficient for them to be unable to give informed assent to the study, or to carry out study procedures
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| science lessonchildren have a 90 minute science lesson outdoors | Behavioural | Sedenary |
| PE LessonCHildren have a 90 minute PE lesson outdoors | Behavioural | Physical activity |
Primary outcome
"Airway resistance" measured by Oscillometry at R5
Time frame: Pre-24 hour post exposure
measured as oscillometery R5
2 secondary outcomes
"Small airway resistance" measured by Oscillometry at R5-20
Time frame: pre- 24 hour post exposure
Immune responses as measured by Il6 in nasal lavage
Time frame: pre-24 hour post exposure
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Jun 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Abigail Whitehouse, MD,PhD contact
James Scales, PhD principal investigator
Queen Mary University London
Abigail Whitehouse, PhD, MD principal investigator
QMUL
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing science lesson and PE Lesson in people with Asthma Acute and Respiratory, run by Queen Mary University of London at 1 site in United Kingdom.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 15 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United Kingdom. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact James Scales, PhD (+447533897264, j.scales@qmul.ac.uk), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
"Airway resistance" measured by Oscillometry at R5 (time frame: Pre-24 hour post exposure). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Jun 2026.