Clinical trials: Engorgement
Vasodilation, Blood Pressure
Nitrate Supplementation and Muscle Blood Flow
The main purpose of this study is to evaluate the effects of an acute dose of dietary nitrate in the form of beetroot juice on skeletal muscle blood flow in response to dynamic knee extension exercise in healthy older adults.
- Conditions
- Vasodilation, Blood Pressure, Active Hyperemia, Aging
- Trial name
- NCT03459027
- Testing
- Super Beets, Beetroot powder
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Cardiac and Aortic Surgery, Cardiac Anaesthesia
Impact of Fluid Resuscitation on Venous Congestion in Cardiac Critically-ill Patients
The objective of this study is to assess how fluid resuscitation, in the context of fluid responsiveness, affects the incidence and progression of systemic venous congestion in critically ill cardiac patients.
- Conditions
- Cardiac and Aortic Surgery, Cardiac Anaesthesia, Venous Congestion, Fluid Resuscitation
- Trial name
- VExUS-CS (NCT07183397)
- Testing
- VExUS & Cardiac Ultrasound
- Volunteers
- 250 people
- Sponsor
- Medical University of Vienna
Cardiovascular Insufficiency, Venous Congestion
Fluid Challenge Impact in the Portal Vein Pulsatility Depending on the Fluid Responsivness Status
Portal vein pulsatility index is a marker of venous congestion evaluated by point of care ultrasound. It is associated with acute kidney injury, especially in critically ill patients. It may be considered as a dynamic marker.
- Trial name
- FLUID-REVENGE (NCT05828407)
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Hospices Civils de Lyon
Postpartum Complication
Effects of Manual Lymphatic Drainage and Therapeutic Ultrasound on Breast Engorgement
To find the combined effects of the manual lymphatic drainage with therapeutic ultrasound on breast engorgement, pain and self-efficacy in post - partum women.
- Trial name
- NCT06303232
- Testing
- MANUAL LYMPHATIC DRAINAGE, THERAPEUTIC ULTRASOUND
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Riphah International University
Congestion, Venous
Hepatic Doppler to Assess Venous Congestion During Invasive Mechanical Ventilation (DOHECOV)
The purpose of the study is to investigate venous congestion using hepatic vein doppler for ICU patients with invasive mechanical ventilastion. The primary outcome is the systolic to diastolic hepatic vein velocity ratio S/D .
- Trial name
- DOHECOV (NCT06914336)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Brest
Lactation Suppressed
Cabergoline for Lactation Inhibition After Second-Trimester Abortion or Loss
This research study investigates the use of a drug, cabergoline, given immediately after second-trimester abortion or perinatal loss to decrease breast engorgement.
- Trial name
- LISTA (NCT04701333)
- Testing
- Cabergoline 1 MG
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Stanford University
Metabolic Syndrome, Vascular Injury
Therapeutic Strategies to Reduce Endothelial Ischemia-reperfusion Injury
The objective of this clinical trial is to better understand how lactate, a naturally occurring energy substance, can be used to lessen damage to the vascular system in adults with a high cardiovascular disease risk.
- Conditions
- Metabolic Syndrome, Vascular Injury, Ischemic Preconditioning, Endothelial Function (reactive Hyperemia)
- Trial name
- NCT06825143
- Testing
- Ischemic preconditioning, Intravenous lactate infusion, No ischemic preconditioning (control)
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Gary Van Guilder
Dental Implants
Microvascular Reactivity of the Gingiva Around Implant Born Crown
Apply LSCI method for follow-up changes in regional blood flow after compression of the gingiva in order to compare the vascular reactivity of the attached gingiva at implant versus at tooth.
- Trial name
- NCT03513627
- Testing
- Post-occlusive reactive hyperemia test (PORH test)
- Where
- Hungary
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Sickle Cell Disease
Blood Flow and Pain Crises in People With Sickle Cell Disease
Background: Many people with sickle cell disease have repeated episodes of severe pain that lasts for days, requiring hospital care. These episodes, called pain crises, may be caused by changes in blood flow.
- Trial name
- NCT01568710
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Lactation Suppressed
Cabergoline for Lactation Inhibition After Early Second-Trimester Abortion or Pregnancy Loss
Breast pain following second-trimester abortion is common. Breast engorgement and milk leakage following second-trimester perinatal loss and abortion can cause both physical pain and emotional distress.
- Trial name
- eLISTA (NCT06029673)
- Testing
- Cabergoline 1 MG
- Where
- 2 sites in United States
- Volunteers
- 69 people
- Sponsor
- Stanford University
Systolic Chronic Heart Failure, Congestion, Venous
Ultrasound-assessed Internal Jugular Vein Distensibility in Advanced Chronic Heart Failure (US-IJVD in CHF)
Prospective validation of the ultrasound-assessed internal jugular vein distensibility (JVD) ratio to identify patients with systolic chronic heart failure and right atrial pressure (RAP) of 7 or less mmHg measured by the right…
- Conditions
- Systolic Chronic Heart Failure, Congestion, Venous, Advanced Heart Failure
- Trial name
- US-IJVD-CHF (NCT03874312)
- Testing
- Linear ultrasound (US) assessment of the internal jugular vein
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Niguarda Hospital
Hyperemia
Safety of Brimonidine Tartrate Ophthalmic Solution in a Population of Pediatric, Adult, and Geriatric Participants
To compare the safety and tolerability of brimonidine tartrate ophthalmic solution 0.025% versus its vehicle in a population of pediatric, adult, and geriatric participants.
- Trial name
- NCT01959243
- Testing
- Brimonidine Tartrate, Vehicle, Sodium Fluorescein
- Where
- 4 sites in United States
- Volunteers
- 507 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
Surgery--Complications, Congestive Heart Failure
The Clinical Significance of Portal Hypertension After Cardiac Surgery: a Multicenter Prospective Observational Study
Portal flow pulsatility detected by Doppler ultrasound is an echographic marker of cardiogenic portal hypertension from right ventricular failure and is associated with adverse outcomes based on previous studies performed at the…
- Conditions
- Surgery--Complications, Congestive Heart Failure, Right Heart Failure, Anesthesia
- Trial name
- TECHNO-MULTI (NCT03656263)
- Testing
- Doppler assessment of portal vein flow
- Where
- Canada
- Volunteers
- 360 people
- Sponsor
- Montreal Heart Institute
Right Ventricular Dysfunction
Right Ventricular Function Changes After CIED Implantation: The RIGHT-CIED Study
This study aims to understand how the right side of the heart changes in people who receive an implantable cardiac electronic device (CIED), such as a pacemaker, ICD, or CRT device.
- Trial name
- RIGHT-CIED (NCT07272395)
- Testing
- Multimodal Right Ventricular Evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul University - Cerrahpasa
Coronary Microvascular Disease, Myocardial Infarction
Treatment of Slow-flow After Primary Percutaneous Coronary Intervention With Flow-mediated Hyperemia
A total of 100 patients with ST-elevation myocardial infarction (STEMI) presenting slow-flow after primary-percutaneous coronary intervention (PPCI) will be randomized to pharmacologic treatment with hyperemic drugs versus…
- Trial name
- RAIN FLOW (NCT04685941)
- Testing
- Drug-mediated hyperemia, Flow-mediated hyperemia
- Where
- 5 sites in Spain
- Volunteers
- 67 people
- Sponsor
- Fundación EPIC
Capillary Leak Syndrome
Characterization of Endothelial Dysfunction as a Function of Hyperaemia of the Brachial Artery During Cardiac Surgery
The glycocalyx is a layer of proteins and complex sugars covering the endothelium of vessels. Its role as capillary filtration control is important.
- Trial name
- GLYNO (NCT02853682)
- Testing
- plasma
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Venous Congestion
VEXUS-REA : Evaluation of Ultrasound Parameters of Venous Congestion in Patients in a Medical Intensive Care Unit
Shock is a common and serious cause of admission to intensive care. Vascular filling is one of the cornerstones of shock treatment, aimed at increasing cardiac output and restoring adequate organ perfusion through rapid…
- Trial name
- VEXUS-REA (NCT07438015)
- Testing
- Venous ultrasound (inferior vena cava, portal vein, suprahepatic vein, and renal vein to calculate the VEXUS score ; femoral vein and popliteal vein)
- Where
- France
- Volunteers
- 525 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Glaucoma
A Multicenter Evaluation of Methods to Reduce Hyperemia Associated With Bimatoprost Therapy for Glaucoma or Ocular Hypertension
Evaluate the incidence of hyperemia in patients using bimatoprost and to determine if simple interventions reduce its incidence and to assess the value of detailed instruction in increasing patient compliance and willingness to…
- Trial name
- NCT00348062
- Testing
- Bimatoprost
- Where
- United States
- Sponsor
- Innovative Medical
Dry Eye Syndromes, Keratoconjunctivitis Sicca
Safety and Efficacy of KPI-121 Compared to Placebo in Subjects With Dry Eye Disease
The primary purpose of this study is to determine the efficacy and safety of KPI-121 0.25% ophthalmic suspension compared to vehicle (placebo) in subjects who have a documented clinical diagnosis of dry eye disease.
- Trial name
- STRIDE 2 (NCT02819284)
- Testing
- KPI-121 0.25% Ophthalmic Suspension, Vehicle of KPI-121 0.25% Ophthalmic Suspension
- Where
- 62 sites in United States
- Volunteers
- 909 people
- Sponsor
- Kala Pharmaceuticals, Inc.
Venous Congestion
Portal Vein Pulsatility Index to Assess Fluid Intolerance
This study uses the portal vein pulsatility index (PVPI) to assess fluid intolerance amongst fluid responders.
- Trial name
- NCT06440772
- Testing
- Ringer's Lactate Crystalloid Solutions
- Where
- Romania
- Volunteers
- 50 people
- Sponsor
- Institutul de Urgenţă pentru Boli Cardiovasculare Prof.Dr. C.C. Iliescu