Clinical trials: Endothelial Dysfunction
AIDS
Effect on HIV Medications on EPC Cells
This is a 3 arm, non-Interventional pilot single time point cross sectional study for the duration of 1 year. Total of 30 candidates (10 in each Group) will be enrolled into three different groups taking three different…
- Trial name
- NCT03782142
- Testing
- Tenofovir, Rilpivirine, Prezcobix
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Sabyasachi Sen
Kidney Failure, Hypertension
Cardiovascular-Renal Consequences of Reducing Renal Mass After Living Kidney Donation
A reduce in renal mass may result in remnant single nephron hyperfiltration, with associated proteinuria and an accelerated loss of kidney function.
- Conditions
- Kidney Failure, Hypertension, Albuminuria, Renal Failure
- Trial name
- NCT01564966
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Istanbul University
Endothelial Dysfunction, Autonomic Dysfunction
Upper- and Lower-body Resistance Exercise With and Without Blood Flow Restriction on Hemodynamics and Vascular Function
The American College of Sports Medicine (ACSM) recommends that resistance exercise performed at greater than 70% one repetition maximum (1 RM) is necessary to induce strength gains and muscular hypertrophy (ACSM, 2009).
- Trial name
- NCT03225898
- Testing
- Resistance Exercise with Blood Flow Restriction, High-intensity Resistance Exercise
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kent State University
Endothelial Dysfunction
Comparison of the Effects of Sevoflurane and Desflurane on Endothelial Glycocalyx
The glycocalyx is a dynamic and complex biochemical structure composed of proteoglycans, glycoproteins, and soluble proteins. The glycocalyx interacts with various proteins such as albumin and orosomucoid to form a thick surface…
- Trial name
- NCT05068336
- Testing
- desflurane anesthesia, sevoflurane anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kocaeli Derince Education and Research Hospital
Type 2 Diabetes Mellitus
The Study of Exenatide Action on Vessel Function in Type 2 Diabetes and Prediabetes
The purpose of this investigation is to evaluate whether exenatide, a type 2 diabetes medication, will improve the function of the innermost part of the arterial wall called the endothelium after a fat-enriched meal and to…
- Trial name
- NCT01181986
- Testing
- Exenatide SC, Exenatide IV, Exendin-9
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Carl T. Hayden VA Medical Center
Endothelial Dysfunction
Maraviroc Abacavir STudy - Effect on Endothelial Recovery
HIV infected patients treated with abacavir might have a higher risk for the occurrence of cardiovascular events. At time of writing of this protocol the underlying mechanism is not yet elucidated, however some studies find…
- Trial name
- MASTER (NCT01389063)
- Testing
- Maraviroc
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- S.F.L. van Lelyveld
Children, Cardiovascular
Metabolic Syndrome in Children and Adolescents
The purpose of this study was to cross-sectionally evaluate nutritional status and the metabolic syndrome in a sample of school-age children 10-15 years of age from 20 public schools in Santiago, Chile.
- Conditions
- Children, Cardiovascular, Risk Factors
- Trial name
- NCT03203863
- Testing
- anthropometric measures of fatness
- Volunteers
- 3,325 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Preeclampsia, Postpartum
MSC Exosome Therapy for Post-Preeclampsia Endothelial Dysfunction
--- Why Is This Study Being Done? Women who have preeclampsia during pregnancy face a much higher risk of heart disease later in life.
- Conditions
- Preeclampsia, Postpartum, Endothelial Injury, Exosome Multiomics
- Trial name
- EXITPE (NCT07183384)
- Testing
- Mesenchymal Stem Cell-Derived Exosomes
- Where
- Indonesia
- Volunteers
- 80 people
- Sponsor
- Universitas Padjadjaran
Cardiac Arrest
Endothelial Dysfunction in Resuscitated Cardiac Arrest
Objective: Safety and efficacy of low-dose prostacyclin administration and blood pressure target in addition to standard therapy, as compared to standard therapy alone, in post-cardiac-arrest-syndrome (PCAS) patients.
- Trial name
- ENDO-RCA (NCT02685618)
- Testing
- Iloprost, Saline, Phillips M1006B, offset by -10mmHg
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Pär Johansson
Metabolic Syndrome, Atherogenic Dyslipidemia
The Dose-response Effects of High Intensity Functional Training on Metabolic Syndrome Risk Factors
This study aims to explore the dose effects of three weekly volumes of high-intensity functional training (HIFT) on apolipoprotein B (ApoB), triglyceride (TG) and cholesterol (CHOL) content of low-density lipoproteins (LDL), very…
- Conditions
- Metabolic Syndrome, Atherogenic Dyslipidemia, Insulin Resistance, Endothelial Dysfunction
- Trial name
- NCT05001126
- Testing
- HIFT 1x/week, HIFT 2x/week, HIFT 3x/week
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Gary Van Guilder
Lung Transplant
Impact of Cold Ischemia on Pulmonary Endothelial Dysfunction in Ex-vivo Pulmonary Reconditioning
The study population will be patients with planned double-lung transplant, with preoperative ex-vivo reconditioning procedure. The ex-vivo procedure will be performed for lungs considered as limit to be directly implanted…
- Trial name
- Endoth-Exvivo (NCT03987113)
- Testing
- Plasma concentration analysis during and after ex-vivo pulmonary reconditioning
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hopital Foch
Vasculogenic Erectile Dysfunction
Endothelial Markers and Tadalafil Response
This prospective cohort study will recruit eligible men attending the Urology/Andrology outpatient clinic. Baseline assessment will include demographic and clinical data, cardiovascular risk assessment, erectile-function…
- Trial name
- NCT07773103
- Testing
- Tadalafil 5mg
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Al-Azhar University
Overweight and Obesity, Endothelial Dysfunction
Influence of Walnut Intake on Vascular Function and Metabolism
This study seeks to confirm and extend previous finding that four weeks of daily intake of 40 g of walnuts improve microvascular function, increasing the reactive hyperemia index (RHI), effects which were greatest in individuals…
- Conditions
- Overweight and Obesity, Endothelial Dysfunction, Cardiovascular Risk Factor
- Trial name
- NCT03900403
- Testing
- Walnut Intake
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Corneal Endothelial Cell Dysfunction, Corneal Endothelial Cell
Safety and Efficacy of Cultivated Allogeneic Corneal Endothelial Cells Attached to a Hydrogel Substrate (Endo-Tek™) as a Treatment for Corneal Endothelial Cell Dysfunction
Primary Objective: To determine the safety and feasibility of using Endo Tek™ for the treatment of corneal endothelial disease/dysfunction.
- Trial name
- NCT07874503
- Testing
- HCEC graft
- Where
- El Salvador
- Volunteers
- 30 people
- Sponsor
- OcuCell
Endothelial Dysfunction, Bone Disease
Influence of Nitrates on Bone Remodeling and Endothelial Function in Patients With Type 2 Diabetes Mellitus
Type 2 diabetes mellitus (DM) is becoming a leading global epidemic. DM affects several systems in the body. Most of the complications encountered in DM are attributed to uncontrolled hyperglycemia or poor glycemic control.
- Trial name
- NCT02011620
- Testing
- Isosorbide-5-mononitrate
- Where
- United Kingdom
- Sponsor
- Tameside Hospital NHS Foundation Trust
Cardiac Allograft Vasculopathy, Endothelial Dysfunction
Determining the Association of Microvascular Disease as Assessed by PET and Graft Injury by Donor Derived Cell Free DNA
The goal of this research study is to understand if a blood test in people who have had heart transplants can detect and predict the following: Blockages in the small blood vessels of the heart.
- Conditions
- Cardiac Allograft Vasculopathy, Endothelial Dysfunction, Microvascular Coronary Artery Disease
- Trial name
- DEPICT (NCT05756088)
- Testing
- Blood draw to measure the levels of dd-cf DNA
- Where
- United States
- Sponsor
- Yale University
Psoriasis, Inflammation
Subclinical Impairment of Cardiovascular System in Patients With Psoriasis
A cross-sectional study will be conducted, which will include 80 young patients with psoriasis, aged 30-45 years, treated with five different types of antipsoriatic treatment, and 20 healthy patients.
- Conditions
- Psoriasis, Inflammation, Endothelial Dysfunction, Metabolic Disturbance
- Trial name
- PaS (NCT05957120)
- Where
- Slovenia
- Volunteers
- 100 people
- Sponsor
- University Medical Centre Ljubljana