Clinical trials: Endothelial Dysfunction
Pregnancy, Gestational Diabetes Mellitus (GDM)
Polyphenol Intake, Mediterranean Diet Adherence, and Oxidative Stress in Pregnancy
This study is a randomized controlled clinical trial designed to evaluate the effect of a polyphenol-rich dietary intervention during pregnancy on endothelial function, oxidative stress biomarkers, and maternal and neonatal…
- Conditions
- Pregnancy, Gestational Diabetes Mellitus (GDM), Preeclampsia, Hypertension, Pregnancy-Induced
- Trial name
- PREGPOLY (NCT07656532)
- Testing
- Natural Non-Alkalized Cocoa, Polyphenol-Rich Dietary Counseling
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Hypertrophic Cardiomyopathy, Endothelial Dysfunction
Assessment of the Relations Between Endothelial and Venous Dysfunctions and Left Ventricular Obstruction in Genetic Hypertrophic Cardiomyopathies
Left ventricular obstruction is an invalidating complication of hypertrophic cardiomyopathies (HCM), and endothelial dysfunction has also been observed in these pathologies.
- Trial name
- HCM-Vein (NCT04129905)
- Testing
- BNP blood sample test, Electrocardiogram, Holter ECG
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Endothelial Dysfunction
Enhancing Parasympathetic Activity to Improve Endothelial Dysfunction, Vascular Oxidative Stress in African Americans
Specific Aim 1: To test the hypothesis that prolonged (3-month) treatment with galantamine inhibits NADPH IsoLG-protein adducts formation and improves markers of endothelial cell (EC) dysfunction in AAs.
- Trial name
- NCT04769206
- Testing
- Galantamine, TENS 7000
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Obstructive Sleep Apnea of Adult, Hypoxia, Brain
Cerebral Blood Flow and Ventilatory Responses During Sleep in Normoxia and Intermittent Hypoxia
A prospective double blind, placebo-controlled, randomized cross-over trial to evaluate the effect of lowering cerebral blood flow on the ventilatory chemoreflexes (acute hypoxic and hypercapnic ventilatory responses).
- Conditions
- Obstructive Sleep Apnea of Adult, Hypoxia, Brain, Sleep Apnea, Sleep Disorder
- Trial name
- NCT03255408
- Testing
- Drug Lowering Cerebral Blood Flow (CBF) and Normoxia Sleep, Drug Lowering CBF and Intermittent Hypoxia Sleep
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Smoking, Endothelial Dysfunction
Electronic Hookah and Endothelial Cell Function
Electronic nicotine delivery systems (ENDS) are a rapidly growing global epidemic among adolescents and young adults. Unlike other ENDS such as e-cigarettes, e-hookahs are used through traditional water-pipes, allowing the…
- Trial name
- NCT04133376
- Testing
- Electronic hookah vaping with nicotine, Electronic hookah vaping without nicotine
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Lipoprotein Disorder, Arterial Stiffness
The Effect of Lipoprotein (a) on Arterial Stiffness, Endothelial Function and Myocardial Deformation
1. Introduction Lipoprotein(a), or Lp(a), is a type of lipoprotein that is structurally similar to LDL (low-density lipoprotein) but carries an additional protein called apolipoprotein (a). 2.
- Conditions
- Lipoprotein Disorder, Arterial Stiffness, Endothelial Dysfunction
- Trial name
- Lpa_endo (NCT07324902)
- Where
- 2 sites in Greece
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Athens
Aging, Endothelial Dysfunction
COMP-4 Supplementation and Brachial Artery FMD
In a young and healthy person, the production of nitric oxide (NO) by the endothelium, the inner lining of the blood vessel, is responsible for a) the ability of the blood vessel to dilate so it can increase its blood flow and b)…
- Conditions
- Aging, Endothelial Dysfunction, Senescence
- Trial name
- NCT05595915
- Testing
- COMP-4
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Aging, Arterial Stiffness
Inorganic Nitrate Supplementation on Cerebrovascular Aging and Arterial Stiffness Study
This study investigates the effect of dietary inorganic nitrate supplementation on 1) large elastic artery stiffness and hemodynamics and 2) cerebrovascular function in middle-aged and older adults.
- Conditions
- Aging, Arterial Stiffness, Endothelial Dysfunction, Hypertension
- Trial name
- INCA (NCT03617302)
- Testing
- Experimental: Nitrate-containing
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Gary L. Pierce, PhD
Microvascular Dysfunction, Endothelial Dysfunction
Nailfold Capillaroscopy and Endothelial Biomarkers in Healthcare Workers Exposed to Chronic Low-Dose Ionizing Radiation
Chronic occupational exposure to low-dose ionizing radiation may lead to subclinical endothelial dysfunction and early microvascular alterations in healthcare workers.
- Conditions
- Microvascular Dysfunction, Endothelial Dysfunction, Occupational Radiation Exposure
- Trial name
- NCT07363187
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Istanbul Training and Research Hospital
Aging, Blood Pressure
Inspiratory Muscle Strength Training for Lowering Blood Pressure and Improving Endothelial Function in Postmenopausal Women: Comparison With "Standard of Care" Aerobic Exercise
High blood pressure (BP) is the major modifiable risk factor for cardiovascular diseases (CVD) and related health conditions, particularly among postmenopausal (PM) women.
- Conditions
- Aging, Blood Pressure, Endothelial Dysfunction, Hypertension
- Trial name
- NCT05000515
- Testing
- High-resistance inspiratory muscle strength training, Aerobic exercise
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Obesity, Endothelial Dysfunction
Microvascular Dysfunction in Obesity
Impaired endothelial function is observed in disease states related to obesity, such as atherosclerosis, coronary artery disease, and diabetes.
- Trial name
- NCT04087655
- Testing
- Exercise
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Florida State University
Spinal Cord Injuries, Endothelial Dysfunction
Endothelial Dysfunction After SCI
This study plans to learn how endothelial cells, single cell lining of blood vessels may be dysfunctional after a spinal cord injury.
- Trial name
- EDASCI (NCT07227727)
- Testing
- Intra-arterial Infusion of Vasoactive Agents, Intra-arterial Vitamin C Infusion, Blood Sampling
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Craig Hospital
Type 2 Diabetes (T2DM), Endothelial Dysfunction
Role of Endothelial Dysfunction on Exercise Pressor Reflex in Type 2 Diabetes
Exaggerated blood pressure responses to exercise in individuals with Type 2 Diabetes significantly increase the risk of heart attack, stroke, and cardiovascular death, while also limiting exercise capacity and therapeutic…
- Trial name
- NCT07228208
- Testing
- MitoQ (mitoquinol mesylate)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Aging, Fragility
Ischemic Conditioning to Promote Microvascular Resiliency in Frail Individuals
The goal of this clinical trial is to see how small blood vessels respond to the stress of high intensity exercise, and if a safe and simple intervention called ischemic conditioning can protect blood vessels from the stress of…
- Conditions
- Aging, Fragility, Endothelial Dysfunction
- Trial name
- NCT05808686
- Testing
- Ischemic Conditioning
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Cytochrome P450 Oxidoreductase Deficiency, Hypertension
Investigation of the Etiology of Hypertension and Endothelial Damage in Patients With Cytochrome P450 Oxidoreductase Deficiency
This study investigates the etiology of hypertension and endothelial damage in patients with Cytochrome P450 Oxidoreductase (POR) deficiency.
- Conditions
- Cytochrome P450 Oxidoreductase Deficiency, Hypertension, Endothelial Dysfunction, Congenital Adrenal Hyperplasia
- Trial name
- PORENDO (NCT06756620)
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Ozge Bayrak Demirel
Mechanical Ventilation Complication, Vascular Injury
Vascular Injury in Mechanical Ventilation: a Proof-of-Concept Study
Investigation of the effect of mechanical ventilation on biomarkers of microvascular damage
- Conditions
- Mechanical Ventilation Complication, Vascular Injury, Endothelial Dysfunction
- Trial name
- NCT05538858
- Testing
- Mechanical Ventilation
- Where
- Canada
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Embolic Stroke of Undetermined Source, Endothelial Dysfunction
Impaired Endothelial Integrity in Patients With Embolic Stroke of Undetermined Source (ESUS)
The investigators will measure endothelial glycocalyx, aortic elastic properties, oxidative stress, and their association with left ventricular (LV) and left atrial (LA) function in ESUS, cardioembolic, atherosclerotic, lacunar…
- Trial name
- ESUS (NCT03609437)
- Where
- Greece
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- University of Athens
Post Traumatic Stress Disorder, Cardiovascular Diseases
NightWare and Cardiovascular Health in Women With PTSD
The purpose of this study is to determine whether NightWare therapeutic intervention improves biomarkers of vascular and renal function in premenopausal women with PTSD-related nightmares, and examine whether these improvements…
- Conditions
- Post Traumatic Stress Disorder, Cardiovascular Diseases, Autonomic Dysfunction, Vascular Stiffness
- Trial name
- NCT07021014
- Testing
- NightWare
- Where
- 2 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Optic Disc Edema, Endothelial Dysfunction
B-Complex: A Nutraceutical SANS Countermeasure
In this project, the investigators propose to test effectiveness of a daily nutraceutical supplement containing bioactive B vitamins to mitigate optic disc edema in astronauts.
- Trial name
- NCT05366933
- Testing
- Vitamin B-Complex Supplement
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- National Aeronautics and Space Administration (NASA)
Atherosclerosis, Endothelial Dysfunction
Impact of Non-surgical Periodontal Therapy in the Improvement of Early Endothelial Dysfunction in Subjects With Peri-implantitis and Peri-implant Mucositis
A double-blind randomized-controlled clinical trial is conducted in order to evaluate the impact of non-surgical periodontal treatment on endothelial dysfunction parameters in subjects with peri-implantitis/peri-implant mucositis…
- Conditions
- Atherosclerosis, Endothelial Dysfunction, Peri-Implantitis, Peri-implant Mucositis
- Trial name
- NCT05906810
- Testing
- Non-surgical periodontal treatment
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Catania