Clinical trials: Endothelial Dysfunction
Metabolic Syndrome, Endothelial Dysfunction
Effect of Eplerenone on Endothelial Function in Metabolic Syndrome
Patients with the metabolic syndrome (MetSyn) are at increased risk for cardiovascular mortality and morbidity.This increased cardiovascular risk is attributed to metabolic dysregulations like impaired glucose tolerance or…
- Trial name
- MetSyn (NCT01319344)
- Testing
- Eplerenone
- Where
- 2 sites in Germany
- Volunteers
- 42 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Takotsubo Syndrome
Stress-induced Vascular Dysfunction: Evaluation of Endothelial Function in a Cohort of Patients With Takotsubo Syndrome
The aim of this prospective single-center study is to evaluate endothelial function, arterial compliance, sympathetic nervous activity at rest and after mental and physical stress, carotid atherosclerosis, oxidative stress…
- Trial name
- NCT01249599
- Testing
- blood sample analysis
- Where
- Switzerland
- Volunteers
- 44 people
- Sponsor
- University of Zurich
Left Ventriclar Mass
Metformin Reduces Left Ventricular Mass in Patients With Ischemic Heart Disease
Cardiovascular disease is the most common cause of death in the world. Most of the attention in treating ischemic heart disease (IHD) is understandably directed toward treating coronary artery disease.
- Trial name
- NCT01879293
- Testing
- Metformin
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Wuhan General Hospital of Guangzhou Military Command
Autosomal Dominant Polycystic Kidney, Hypertension
Effect of Beetroot Juice on Reducing Hypertension in Autosomal Dominant Polycystic Kidney Disease
People with autosomal dominant polycystic kidney disease (ADPKD) develop high blood pressure and kidney disease. Previous studies have shown that a commonly occurring chemical, nitric oxide (NO), is reduced in ADPKD, and may…
- Conditions
- Autosomal Dominant Polycystic Kidney, Hypertension, Endothelial Dysfunction
- Trial name
- BEET-PKD (NCT05401409)
- Testing
- Beetroot juice, Nitrate-depleted beetroot juice
- Where
- 2 sites in Australia
- Volunteers
- 60 people
- Sponsor
- Western Sydney Local Health District
Endothelial Function of Saphenous Vein Grafts
Investigation of Endothelium in Saphenous Vein Grafts
This is a single center prospective study of 30 patients undergoing elective heart bypass surgery (CABG) with at least two vein grafts from the leg (SVG).
- Trial name
- NCT01510821
- Testing
- Use of Maquet Vasoshield Pressure-limiting syringe on SVG, Use of non-regulated syringe on SVG
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Emory University
Erectile Dysfunction, Arterial Hypertension
Correlation Study of Vascular Parameters in Hypertensive Men With Erectile Dysfunction
The purpose of the study is to assess the correlation of FMD of brachial artery and carotid intima media thickness with ED severity and clinical response to vardenafil in hypertensive men.
- Conditions
- Erectile Dysfunction, Arterial Hypertension, Endothelial Dysfunction
- Trial name
- NCT01084187
- Testing
- Vardenafil
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Hospital Universitario Pedro Ernesto
Metabolic Syndrome, Predisposition to Cardiovascular Disease
Analysis of the Postprandial Effects of a Vegetable Protein Mixture Rich in Arginine, Cysteine and Leucine on Endothelial Dysfunction and Inflammation at Low Noise in Elderly People With Cardiometabolic Risk
By 2050, the expanding world population will consume two-thirds more animal protein than it consumes today. The increase in chronic diseases associated with the generalization of these consumption patterns tend to understand the…
- Trial name
- P-PROBS CM (NCT04923555)
- Testing
- Vegetable proteins (VP) rich in leucine, cystein, arginine, Animal proteins (AP), No protein (T)
- Where
- France
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Obstructive Sleep Apnea of Adult
Vascular Endothelial Dysfunction in Sleep Apnea
This double-blind placebo-controlled parallel group randomized study design will be used to test whether 4 weeks of atorvastatin 10 mg daily reduces levels of inflammatory markers in OSA patients treated with CPAP (standard of…
- Trial name
- NCT05289063
- Testing
- Atorvastatin 10mg, Continuous Positive Airway Pressure Therapy
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Columbia University
Chronic Kidney Diseases, Cardiovascular Diseases
Apelin as a Potential Treatment for Chronic Kidney Disease
Chronic kidney disease (CKD) affects 8-16% of the world's population, and is independently associated with cardiovascular disease (CVD).
- Conditions
- Chronic Kidney Diseases, Cardiovascular Diseases, Endothelial Dysfunction
- Trial name
- AlPaCKa (NCT03956576)
- Testing
- [Pyr]apelin-13
- Where
- United Kingdom
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Endothelial Dysfunction, Hemolysis Intravascular
Effects of Nitric Oxide on the Endothelium During Hemolysis.
This study is an ancillary (add-on) study to the clinical trial entitled "Effect of Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction", which has Clinical Trials.gov identifier NCT02836899.
- Conditions
- Endothelial Dysfunction, Hemolysis Intravascular, Cardiovascular Diseases, Cardiovascular Risk Factor
- Trial name
- NCT03748082
- Testing
- Nitric Oxide, Reactive Hyperemia Index, Endothelial Cells Collection
- Where
- 2 sites in United States
- Sponsor
- Massachusetts General Hospital
Polycystic Ovary Syndrome (PCOS)
Blood Vessel Function in Adolescents and Women With Polycystic Ovary Syndrome
The purpose of this study is to determine if changes in blood vessel health lead to the menstrual irregularities that women with PCOS experience.
- Trial name
- NCT01615562
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Pregnancy Complications, Endothelial Dysfunction
Oxidative Stress and Endothelial Function in Pregnancy Complications
Pregnancy complications like pre-eclampsia (PE), pregnancy induced hypertension (PIH), intra-uterine growth restriction (IUGR) and preterm labor (PTL), (i.e.
- Trial name
- ENDOPREG (NCT02603913)
- Where
- Belgium
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
End Stage Renal Disease, Endothelial Dysfunction
Cocoa Flavanols in Renal Disease
Purpose of the study is to characterize the potential acute and long-term improvement of dietary flavanols on vascular function in patients with end-stage renal disease (ESRD).
- Trial name
- NCT01412320
- Testing
- Cocoa
- Where
- Germany
- Volunteers
- 22 people
- Sponsor
- Klinik für Kardiologie, Pneumologie und Angiologie
Antiphospholipid Syndrome, Endothelial Dysfunction
The Influence of Antiphospholipid Antibodies on the Relationship Between Hyperurecemia, Gout and Metabolic Syndrome
Patients with hyperuricemia were confirmed to have higher risks of cardiovascular disease, but the exact mechanism remained to be elucidated.
- Conditions
- Antiphospholipid Syndrome, Endothelial Dysfunction, Hyperuricemia, Gout
- Trial name
- URIC (NCT01818505)
- Where
- Taiwan
- Volunteers
- 210 people
- Sponsor
- National Taiwan University Hospital
Type 2 Diabetes Mellitus, Cardiovascular Diseases
Soluble TREM-1 in Diabetes-Associated Cardiovascular Complications
Cardiovascular disease is the leading cause of illness and death among individuals with type 2 diabetes mellitus (T2DM). Chronic low-grade inflammation contributes significantly to blood vessel damage, atherosclerosis, and…
- Conditions
- Type 2 Diabetes Mellitus, Cardiovascular Diseases, Coronary Artery Disease, Heart Failure
- Trial name
- NCT07847112
- Volunteers
- 85 people
- Sponsor
- Assiut University
Endothelial Dysfunction
Effects of Dietary Nitrate on Age-related Vascular Function
Purpose of the study is to characterize the chronic effect of dietary nitrate on vascular function in healthy volunteers with particular emphasis on age-related alterations.
- Trial name
- NCT01729234
- Testing
- Nitrate
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Endothelial Dysfunction
Efficacy and Safety Study of Policosanol
The purpose of this study is to assess the clinical efficacy and safety of policosanol on elderly patients with endothelial dysfunction
- Trial name
- NCT02543099
- Testing
- policosanol
- Where
- China
- Volunteers
- 100 people
- Sponsor
- General Hospital of Chinese Armed Police Forces
Rheumatoid Arthritis, Endothelial Dysfunction
Atherosclerosis in Rheumatoid Arthritis
The purpose of this study is to investigate the link between rheumatoid arthritis and cardiovascular disease by studying inflammation, joint disease, cholesterol abnormalities, and endothelial function.
- Trial name
- NCT00990730
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Postoperative Delirium, Elective Non-Cardiac Surgery
Correlation Between Blood Biomarkers and Postoperative Delirium in Elective Non-Cardiac Surgery.
More than 20% of patients over 60 years old develop postoperative delirium following non-cardiac surgery . Delirium increases morbidity and mortality , and may lead to long-term cognitive impairment .
- Trial name
- NCT03915314
- Testing
- Neuropsychological tests
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Xuzhou Medical University
Cystic Fibrosis
Investigation of Relationship Between Vascular Functions, Exercise Capacity, and Respiratory Functions in CF
In the literature, there is no study that evaluates the endothelial function and arterial stiffness together and investigates its relationship with exercise capacity and respiratory functions in children with CF of different…
- Trial name
- NCT04259983
- Testing
- Maximal exercise test, Endothelial dysfunction assessment, Arterial stiffness assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Hacettepe University